Mechanisms of endothelial dysfunction in obesity

Clinica Chimica Acta

Volumn 360, Issue 1-2, 2005, Pages 9-26

  Avogaro, Angelo ^a   De Kreutzenberg, Saula Vigili ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

Adipose tissue; Endothelial dysfunction; Endothelium; Obesity

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; ARGININE; ENDOTHELIN RECEPTOR ANTAGONIST; FATTY ACID; HIGH DENSITY LIPOPROTEIN; INTERLEUKIN 6; LEPTIN; LOW DENSITY LIPOPROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; RESISTIN; TUMOR NECROSIS FACTOR ALPHA;

ADIPOSE TISSUE; CALORIC RESTRICTION; CARDIOTOXICITY; CARDIOVASCULAR INFLAMMATION; CELL FUNCTION; CEREBROVASCULAR ACCIDENT; CHRONIC DISEASE; CYTOKINE RELEASE; DISEASE ASSOCIATION; DISEASE SEVERITY; ENDOTHELIUM LESION; FATTY ACID BLOOD LEVEL; FUNCTIONAL ASSESSMENT; GLUCOSE INTOLERANCE; HORMONE RELEASE; HUMAN; HYPERINSULINEMIA; HYPERLEPTINEMIA; HYPERTENSION; HYPERTRIGLYCERIDEMIA; INCIDENCE; ISCHEMIC HEART DISEASE; LIPOPROTEIN BLOOD LEVEL; METABOLIC REGULATION; METABOLIC SYNDROME X; METHODOLOGY; MOLECULAR MECHANICS; MORBIDITY; MORTALITY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; OXIDATIVE STRESS; PATHOGENESIS; PERIPHERAL VASCULAR DISEASE; PREGNANCY DIABETES MELLITUS; PRIORITY JOURNAL; REVIEW; STROKE; THROMBOSIS; WEIGHT REDUCTION;

ADIPOSE TISSUE; ENDOTHELIUM, VASCULAR; HUMANS; INFLAMMATION; OBESITY; OXIDATIVE STRESS;

EID: 24144498067     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cccn.2005.04.020     Document Type: Review

References (155)

1. G.A. Bray Medical consequence of obesity J Clin Endocrinol Metab 89 2004 2583 2589
2. N. Abate Insulin resistance and obesity: the role of fat distribution pattern Diabetes Care 19 1996 292 294
3. G. Howard, D.H. O'Leary, and D. Zaccaro Insulin sensitivity and atherosclerosis: the Insulin Resistance Atherosclerosis Study (IRAS) Investigators Circulation 93 1996 1809 1817
4. N.M. Kaplan The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension Arch Intern Med 149 1989 1514 1520
5. A. Peters, J.J. Barendregt, F. Willenkens, J.P. Mackenbach, A. Al Mamun, and L. Bonneaux Obesity in the adulthood and its consequences for life expectancy: a life-table analysis Ann Intern Med 138 2003 24 32
6. National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) 2002 Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 106 (2002) 3143-3421.
7. M.P. Stern Diabetes and cardiovascular disease. The "common soil" hypothesis Diabetes 44 4 1995 369 374
8. M. Higgins, W. Kannel, R. Garrison, J. Pinsky, and J.D. Stokes Hazards of obesity-the Framingham experience Acta Med Scand Suppl 723 1988 23 36
9. L. Lapidus, C. Bengtsson, I. Hallssrom, and P. Bjorntorp Obesity, adipose tissue distribution and health in women. Results from a population study in Gothenburg, Sweden Appetite 13 1989 25 35
10. J.E. Manson, G.A. Colditz, and M.J. Stampfer A prospective study of obesity and risk of coronary heart disease in women N Engl J Med 322 1990 882 889
11. J.D. Curb, and E.B. Marcus Body fat, coronary heart disease, and stroke in Japanese men Am J Clin Nutr 53 1991 1612S 1615S
12. C.M. Beard, A. Orencia, T. Kottke, and D.J. Ballard Body mass index and the initial manifestation of coronary heart disease in women aged 40-59 years [published erratum appears in Int J Epidemio 21 (1992) 1037] Int J Epidemiol 21 1992 656 664
13. X. Jouven, M. Desnos, C. Guerot, and P. Ducimetiere Predicting sudden death in the population: the Paris Prospective: Study 1 Circulation 99 1999 1978 1983
14. H. Schulte, P. Cullen, and G. Assmann Obesity, mortality and cardiovascular disease in the Munster Heart Study (PROCAM) Atherosclerosis 144 1999 199 209
15. I.M. Hodgson, M.L. Wahlqvist, N.D. Balazs, and J.A. Boxall Coronary atherosclerosis in relation to body fatness and its distribution Int J Obes Relat Metab Disord 18 1994 41 46
16. L.T. Clark, M.M. Karve, K.T. Rones, B. Chang-De Moranville, S. Atluri, and J.G. Feldman Obesity, distribution of body fat and coronary heart disease in black women Am J Cardiol 73 1994 895 896
17. M.L. Kortelainen Association between cardiac pathology and fat tissue distribution in an autopsy series of men without premortem evidence of cardiovascular disease Int J Obes Relat Metab Disord 20 1996 245 252
18. F.I. Nieto, M. Szklo, and G.W. Comstock Childhood weight and growth rate as predictors of adult mortality Am J Epidemiol 136 1992 201 213
19. A. Must, P.F. Jacques, G.E. Dallal, Ci Bajerna, and W.H. Dietz Long-term morbidity and mortality of overweight adolescents. A follow-up of the Harvard Growth Study of 1922 to 1935 N Engl J Med 327 1992 1350 1355
20. K.M. Rexrode, C.H. Hennekens, and W.C. Willett A prospective study of body mass index, weight change and risk of stroke in women JAMA 277 1997 1539 1545
21. A.R. Folsom, M.L. Rasmussen, and L.E. Chambless Prospective associations of fasting insulin, body fat distribution, and diabetes with risk of ischemia stroke. The Atherosclerosis Risk in Communities (ARIC) Study Investigators Diabetes Care 22 1999 1077 1083
22. L. Sjòstrom, B. Larsson, and L. Backman Swedish obese subjects (SOS). Recruitment for an intervention study and a selected description of the obese state Int J Obes Relat Metab Disord 16 1992 465 479
23. P. Vallance Nitric oxide Biologist (London) 48 4 2001 153 158
24. J.J. Hwa, L. Ghibaudi, P. Williams, and M. Chatterjee Comparison of acetylcholine-dependent relaxation in large and small arteries of rat mesenteric vascular bed Am J Physiol 266 1994 H952 H958
25. G. Wu, and S.M. Morris Jr. Arginine metabolism: nitric oxide and beyond J Biochem 336 Pt 1 1998 1 17
26. A. Simon, L. Plies, A. Habermeier, U. Martine, M. Reining, and E.I. Closs Role of neutral amino acid transport and protein breakdown for substrate supply of nitric oxide synthase in human endothelial cells Circ Res 93 9 2003 813 820
27. D. Fulton, J.P. Gratton, and T.J. McCabe Regulation of endothelium-derived nitric oxide production by the protein kinase Akt Nature 399 6736 1999 597 601
28. K. Channon Tetrahydrobiopterin regulator of endothelial nitric oxide synthase in vascular disease Trends Cardiovasc Med. 14 8 2004 323 327
29. J.P. Gratton, P. Bernatchez, and W.C. Sessa Caveolae and caveolins in the cardiovascular system Circ Res 94 11 2004 1408 1417
30. F.H. Nystrom, and M.J. Quon Insulin signalling: metabolic pathways and mechanisms for specificity Cell Signal 11 1999 563 574
31. K. Cusi, K. Maezono, and A. Osman Insulin resistance differentially affects the PI3kinase- and MAPkinase-mediated signaling in human muscle J Clin Invest 105 2000 311 320
32. T. Munzel, R. Feil, A. Mulsch, S.M. Lohmann, F. Hofmann, and U. Walter Physiology and pathophysiology of vascular signaling controlled by guanosine 3′,5′-cyclic monophosphate-dependent protein kinase Circulation 108 18 2003 2172 2183
33. J.L. Balligand, and P.J. Cannon Nitric oxide synthases and cardiac muscle. Autocrine and paracrine influences Arterioscler Thromb Vasc Biol 17 10 1997 1846 1858
34. J. Su, S. Zhang, J. Tse, P.M. Scholz, and H.R. Weiss Alterations in nitric oxide-cGMP pathway in ventricular myocytes from obese leptin-deficient mice Am J Physiol Heart Circ Physiol 285 5 2003 H2111 H2117
35. T.J. Anderson Nitric oxide, atherosclerosis and the clinical relevance of endothelial dysfunction Heart Fail Rev 8 1 2003 71 86
36. R. Busse, G. Edwards, M. Feletou, I. Fleming, P.M. Vanhoutte, and A.H. Weston EDHF: bringing the concepts together Trends Pharmacol Sci 23 8 2002 374 380
37. E.E. Kershaw, and J.S. Flier Adipose tissue as an endocrine organ J Clin Endocrinol Metab 89 6 2004 2548 2556
38. A.E. Caballero Endothelial dysfunction in obesity and insulin resistance: a road to diabetes and heart disease Obes Res 11 11 2003 1278 1289
39. O. Hamdy, S. Ledbury, and C. Mullooly Lifestyle modification improves endothelial function in obese subjects with the insulin resistance syndrome Diabetes Care 26 7 2003 2119 2125
40. M.L. Correia, and W.G. Haynes Leptin, obesity and cardiovascular disease Curr Opin Nephrol Hypertens 13 2 2004 215 223
41. M. Carlyle, O.B. Jones, J.J. Kuo, and J.E. Hall Chronic cardiovascular and renal actions of leptin: role of adrenergic activity Hypertension 39 2 Pt 2 2002 496 501
42. A. Bouloumie, T. Marumo, M. Lafontan, and R. Busse Leptin induces oxidative stress in human endothelial cells FASEB J 13 10 1999 1231 1238
43. N.F. Chu, J.B. Chang, and S.M. Shieh Plasma leptin, fatty acids, and tumor necrosis factor-receptor and insulin resistance in children Obes Res 11 4 2003 532 540
44. M. Bullo, P. Garcia-Lorda, I. Megias, and J. Salas-Salvado Systemic inflammation, adipose tissue tumor necrosis factor, and leptin expression Obes Res 11 4 2003 525 531
45. G. Lembo, C. Vecchione, and L. Fratta Leptin induces direct vasodilation through distinct endothelial mechanisms Diabetes 49 2 2000 293 297
46. C. Vecchione, A. Maffei, and S. Colella Leptin effect on endothelial nitric oxide is mediated through Akt-endothelial nitric oxide synthase phosphorylation pathway Diabetes 51 1 2002 168 173
47. K. Matsuda, H. Teragawa, Y. Fukuda, K. Nakagawa, Y. Higashi, and K. Chayama Leptin causes nitric-oxide independent coronary artery vasodilation in humans Hypertens Res 26 2 2003 147 152
48. K. Tsuda, and I. Nishio Role of leptin in regulating nitric oxide production and membrane microviscosity Circulation 109 22 2004 e316 [author reply e316]
49. J. Beltowski, J. Jochem, G. Wojcicka, and K. Zwirska-Korczala Influence of intravenously administered leptin on nitric oxide production, renal hemodynamics and renal function in the rat Regul Pept 120 1-3 2004 59 67
50. C.A. Mastronardi, W.H. Yu, and S.M. McCann Resting and circadian release of nitric oxide is controlled by leptin in male rats Proc Natl Acad Sci U S A 99 8 2002 5721 5726
51. C.M. Steppan, E.J. Brown, and C.M. Wright A family of tissue-specific resistin-like molecules Proc Natl Acad Sci U S A 98 2 2001 502 506
52. Verma S, Li SH, Wang CH, et al. Resistin promotes endothelial cell activation: further evidence of adipokine-endothelial interaction. Circulation. 2003;108(6):736-40. Electronic publication 2003 Jul 21. Erratum in: Circulation. 2004 May 11;109(18):2254.
53. Y. Matsuzawa, T. Funahashi, S. Kihara, and I. Shimomura Adiponectin and metabolic syndrome Arterioscler Thromb Vasc Biol 24 1 2004 29 33
54. P.J. Boyle What are the effects of peroxisome proliferator-activated receptor agonists on adiponectin, tumor necrosis factor-alpha, and other cytokines in insulin resistance? Clin Cardiol 27 7 Suppl. 4 2004 IV11 IV16
55. B.J. Goldstein, and R. Scalia Adiponectin: a novel adipokine linking adipocytes and vascular function J Clin Endocrinol Metab 89 6 2004 2563 2568
56. H. Chen, M. Montagnani, T. Funahashi, I. Shimomura, and M.J. Quon Adiponectin stimulates production of nitric oxide in vascular endothelial cells J Biol Chem 278 45 2003 45021 45026
57. R. Shibata, N. Ouchi, S. Kihara, K. Sato, T. Funahashi, and K. Walsh Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of amp-activated protein kinase signaling J Biol Chem 279 27 2004 28670 28674
58. E. Brakenhielm, N. Veitonmaki, and R. Cao Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis Proc Natl Acad Sci U S A 101 8 2004 2476 2481
59. N. Ouchi, M. Ohishi, and S. Kihara Association of hypoadiponectinemia with impaired vasoreactivity Hypertension 42 3 2003 231 234
60. M. Kumada, S. Kihara, S. Sumitsuji CAD Study Group Coronary artery disease. Association of Hypoadiponectinemia with Coronary Artery Disease in Men Arterioscler Thromb Vasc Biol 23 1 2003 85 89
61. J.M. Fernandez-Real, A. Castro, and G. Vazquez Adiponectin is associated with vascular function independent of insulin sensitivity Diabetes Care 27 3 2004 739 745
62. C.A. Bursill, K.M. Channon, and D.R. Greaves The role of chemokines in atherosclerosis: recent evidence from experimental models and population genetics Curr Opin Lipidol 15 2 2004 145 149
63. P. Sartipy, and D.J. Loskutoff Monocyte chemoattractant protein 1 in obesity and insulin resistance Proc Natl Acad Sci U S A 100 12 2003 7265 7270
64. K.H. Hong, J. Ryu, and K.H. Han Monocyte chemoattractant protein-1-induced angiogenesis is mediated by vascular endothelial growth factor-A Blood 2004 [Electronic publication ahead of print]
65. H. Shallo, T.P. Plackett, S.A. Heinrich, and E.J. Kovacs Monocyte chemoattractant protein-1 (MCP-1) and macrophage infiltration into the skin after burn injury in aged mice Burns 29 7 2003 641 647
66. J.S. Yudkin Adipose tissue, insulin action and vascular disease: inflammatory signals Int J Obes Relat Metab Disord 27 Suppl. 3 2003 S25 S28
67. G.S. Hotamisligil Inflammatory pathways and insulin action Int J Obes Relat Metab Disord 27 Suppl. 3 2003 S53 S55
68. H. Xu, G.T. Barnes, and Q. Yang Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance J Clin Invest 112 12 2003 1821 1830
69. S.P. Weisberg, D. McCann, M. Desai, M. Rosenbaum, R.L. Leibel, and A.W. Ferrante Jr. Obesity is associated with macrophage accumulation in adipose tissue J Clin Invest 112 12 2003 1796 1808
70. F. Mercurio, and A.M. Manning Multiple signals converging on NF-kappaB Curr Opin Cell Biol 11 2 1999 226 232
71. Y. Paz, I. Frolkis, and D. Pevni Effect of tumor necrosis factor-alpha on endothelial and inducible nitric oxide synthase messenger ribonucleic acid expression and nitric oxide synthesis in ischemic and nonischemic isolated rat heart J Am Coll Cardiol 42 7 2003 1299 1305
72. J.M. Dodd-o, L.E. Welsh, and J.D. Salazar Effect of NADPH oxidase inhibition on cardiopulmonary bypass-induced lung injury Am J Physiol Heart Circ Physiol 287 2 2004 H927 H936
73. H.D. Anderson, D. Rahmutula, and D.G. Gardner Tumor necrosis factor-alpha inhibits endothelial nitric-oxide synthase gene promoter activity in bovine aortic endothelial cells J Biol Chem 279 2 2004 963 969
74. A. Aljada, H. Ghanim, E. Assian, and P. Dandona Tumor necrosis factor-α inhibits insulin-induced increase in endothelial nitric oxide synthase and reduces insulin receptor content and phosphorylation in human aortic endothelial cell Metabolism 51 2002 487 491
75. S.F. Yan, S. Ogawa, D.M. Stern, and D.J. Pinsky Hypoxia-induced modulation of endothelial cell properties: regulation of barrier function and expression of interleukin-6 Kidney Int 51 2 1997 419 425
76. P.M. Ridker, N. Rifai, M.J. Stampfer, and C.H. Hennekens Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men Circulation 18 101 15 2000 1767 1772
77. S. Devaraj, S.K. Venugopal, U. Singh, and I. Jialal Hyperglycemia induces monocytic release of interleukin-6 via induction of protein kinase C-{alpha} and -{beta} Diabetes 54 1 2005 85 91
78. S. Wassmann, M. Stumpf, and K. Strehlow Interleukin-6 induces oxidative stress and endothelial dysfunction by overexpression of the angiotensin II type 1 receptor Circ Res 94 4 2004 534 541
79. J.S. Yudkin, C.D. Stehouwer, J.J. Emeis, and S.W. Coppack C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol 19 4 1999 972 978
80. L. Niskanen, D.E. Laaksonen, and K. Nyyssonen Inflammation, abdominal obesity, and smoking as predictors of hypertension Hypertension 44 6 2004 859 865
81. I. Lemieux, A. Pascot, and D. Prud'homme Elevated C-reactive protein: another component of the atherothrombotic profile of abdominal obesity Arterioscler Thromb Vasc Biol 21 6 2001 961 967
82. V. Pasceri, J.T. Willerson, and E.T. Yeh Direct proinflammatory effect of C-reactive protein on human endothelial cells Circulation 102 18 2000 2165 2168
83. U. Ikeda, M. Takahashi, and K. Shimada C-reactive protein directly inhibits nitric oxide production by cytokine-stimulated vascular smooth muscle cells J Cardiovasc Pharmacol 42 5 2003 607 611
84. W. Droge Free radicals in the physiological control of cell function Physiol Rev 82 1 2002 47 95
85. D. Cooper, K.Y. Stokes, A. Tailor, and D.N. Granger Oxidative stress promotes blood cell-endothelial cell interactions in the microcirculation Cardiovasc Toxicol 2 3 2002 165 180
86. K.K. Griendling, and G.A. FitzGerald Oxidative stress and cardiovascular injury: Part I. Basic mechanisms and in vivo monitoring of ROS Circulation 108 16 2003 1912 1916
87. H. Cai, K.K. Griendling, and D.G. Harrison The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases Trends Pharmacol Sci 24 9 2003 471 478
88. E. Pagnin, G. Fadini, R. de Toni, A. Tiengo, L. Calo, and A. Avogaro Diabetes induces p66shc gene expression in human peripheral blood mononuclear cells: relationship with oxidative stress J Clin Endocrinol Metab 2004 (Nov 23) [Electronic publication ahead of print]
89. A. Avogaro, E. Pagnin, and L. Calo Monocyte NADPH oxidase subunit p22(phox) and inducible hemeoxygenase-1 gene expressions are increased in type II diabetic patients: relationship with oxidative stress J Clin Endocrinol Metab 88 4 2003 1753 1759
90. G. Ceolotto, M. Bevilacqua, and I. Papparella Insulin generates free radicals by an NAD(P)H, phosphatidylinositol 3′-kinase-dependent mechanism in human skin fibroblasts ex vivo Diabetes 53 5 2004 1344 1351
91. P. Mohanty, W. Hamouda, R. Garg, A. Aljada, H. Ghanim, and P. Dandona Glucose challenge stimulates reactive oxygen species (ROS) generation by leucocytes J Clin Endocrinol Metab 85 8 2000 2970 2973
92. H. Urakawa, A. Katsuki, and Y. Sumida Oxidative stress is associated with adiposity and insulin resistance in men J Clin Endocrinol Metab 88 10 2003 4673 4676
93. S. Furukawa, T. Fujita, and M. Shimabukuro Increased oxidative stress in obesity and its impact on metabolic syndrome J Clin Invest 114 12 2004 1752 1761
94. P. Dandona, P. Mohanty, and H. Ghanim The suppressive effect of dietary restriction and weight loss in obese on the generation of reactive oxygen species by leukocytes, lipid peroxidation, and protein carbonylation J Clin Endocrinol Metab 86 2001 355 362
95. G. Davì, M.T. Guagnano, and G. Ciabattoni Platelet activation in obese woman. Role of inflammation and oxidant stress JAMA 288 2002 2008 2014
96. J.L. Evans, I.D. Goldfine, B.A. Maddux, and G.M. Grodsky Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes Endocr Rev 23 5 2002 599 622
97. D. Sorescu, K. Szocs, and K.K. Griendling NAD(P)H oxidases and their relevance to atherosclerosis Trends Cardiovasc Med 11 2001 124 131
98. T. Inoguchi, P. Li, and F. Umeda High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells Diabetes 49 2002 1939 1945
99. F. Cosentino, K. Hishikawa, Z.S. Katusic, and T.F. Luscher High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells Circulation 96 1 1997 25 28
100. S. Engeli, J. Janke, and K. Gorzelniak Regulation of the nitric oxide system in human adipose tissue J Lipid Res 45 9 2004 1640 1648
101. Y. Jang, J.H. Lee, E.Y. Cho, N.S. Chung, D. Topham, and B. Balderston Differences in body fat distribution and antioxidant status in Korean men with cardiovascular disease with or without diabetes Am J Clin Nutr 73 1 2001 68 74
102. C. Nakao, T. Ookawara, and Y. Sato Extracellular superoxide dismutase in tissues from obese (ob/ob) mice Free Radic Res 33 3 2000 229 241
103. R.H. Boger Asymmetric dimethylarginine (ADMA) modulates endothelial function-therapeutic implications Vasc Med 8 3 2003 149 151
104. M. Saitoh, T. Osanai, and T. Kamada High plasma level of asymmetric dimethylarginine in patients with acutely exacerbated congestive heart failure: role in reduction of plasma nitric oxide level Heart Vessels 18 4 2003 177 182
105. H.M. Eid, H. Arnesen, E.M. Hjerkinn, T. Lyberg, and I. Seljeflot Relationship between obesity, smoking, and the endogenous nitric oxide synthase inhibitor, asymmetric dimethylarginine Metabolism 53 12 2004 1574 1579
106. H.A. Coleman, M. Tare, and H.C. Parkington Endothelial potassium channels, endothelium-dependent hyperpolarization and the regulation of vascular tone in health and disease Clin Exp Pharmacol Physiol 31 9 2004 641 649
107. M.R. Dashwood, and J.C. Tsui Endothelin-1 and atherosclerosis: potential complications associated with endothelin-receptor blockade Atherosclerosis 160 2 2002 297 304
108. M. Barton, R. Carmona, and H. Morawietz Obesity is associated with tissue-specific activation of renal angiotensin-converting enzyme in vivo: evidence for a regulatory role of endothelin Hypertension 35 1 Pt 2 2000 329 336
109. T. Traupe, M. Lang, and W. Goettsch Obesity increases prostanoid-mediated vasoconstriction and vascular thromboxane receptor gene expression J Hypertens 20 11 2002 2239 2245
110. T. Traupe, L.V. D'Uscio, K. Muenter, H. Morawietz, W. Vetter, and M. Barton Effects of obesity on endothelium-dependent reactivity during acute nitric oxide synthase inhibition: modulatory role of endothelin Clin Sci (Lond) 103 Suppl. 48 2002 13S 15S
111. H.O. Steinberg, G. Paradisi, G. Hook, K. Crowder, J. Cronin, and A.D. Baron Free fatty acid elevation impairs insulin-mediated vasodilation and nitric oxide production Diabetes 49 7 2000 1231 1238
112. S.V. de Kreutzenberg, C. Crepaldi, and S. Marchetto Plasma free fatty acids and endothelium-dependent vasodilation: effect of chain-length and cyclooxygenase inhibition J Clin Endocrinol Metab 85 2 2000 793 798
113. B.M. Egan, E.L. Greene, and T.L. Goodfriend Nonesterified fatty acids in blood pressure control and cardiovascular complications Curr Hypertens Rep 3 2 2001 107 116
114. G. Lu, T.A. Morinelli, K.E. Meier, S.A. Rosenzweig, and B.M. Egan Oleic acid-induced mitogenic signaling in vascular smooth muscle cells. A role for protein kinase C Circ Res 79 3 1996 611 618
115. B.M. Egan, G. Lu, and E.L. Greene Vascular effects of non-esterified fatty acids: implications for the cardiovascular risk factor cluster Prostaglandins Leukot Essent Fat Acids 60 5-6 1999 411 420
116. S.V. de Kreutzenberg, M. Puato, and E. Kiwanuka Elevated non-esterified fatty acids impair nitric oxide independent vasodilation, in humans: evidence for a role of inwardly rectifying potassium channels Atherosclerosis 169 1 2003 147 153
117. J.Y. Jeremy, D.P. Mikhailidis, and P. Dandona Simulating the diabetic environment modifies in vitro prostacyclin synthesis Diabetes 32 1983 217 221
118. T.J. Anderson Assessment and treatment of endothelial dysfunction in humans J Am Coll Cardiol 34 3 1999 631 638
119. L. Castillo, T.C. de Rojas, and T.E. Chapman Splanchnic metabolism of dietary arginine in relation to nitric oxide synthesis in normal adult man Proc Natl Acad Sci U S A 90 1 1993 193 197
120. A. Avogaro, G. Toffolo, E. Kiwanuka, S.V. de Kreutzenberg, P. Tessari, and C. Cobelli L-arginine-nitric oxide kinetics in normal and type 2 diabetic subjects: a stable-labelled 15N arginine approach Diabetes 52 3 2003 795 802
121. A.D. Blann, and C.N. McCollum von Willebrand factor, endothelial cell damage and atherosclerosis Eur J Vasc Surg 8 1 1994 10 15
122. J.B. Meigs, F.B. Hu, N. Rifai, and J.E. Manson Biomarkers of endothelial dysfunction and risk of type 2 diabetes mellitus JAMA 291 16 2004 1978 1986
123. S. Blankenberg, S. Barbaux, and L. Tiret Adhesion molecules and atherosclerosis Atherosclerosis 170 2 2003 191 203
124. U. Landmesser, B. Hornig, and H. Drexler Endothelial function: a critical determinant in atherosclerosis? Circulation 109 21 Suppl. 1 2004 II27 II33
125. M. Vasa, S. Fichtlscherer, and A. Aicher Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease Circ Res 89 1 2001 E1 E7
126. G.P. Fadini, M. Miorin, and M. Facco Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitus JACC 45 9 2005 1449 1457
127. H.O. Steinberg, H. Chaker, R. Leaming, A. Johnson, G. Brechtel, and A.D. Baron Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance J Clin Invest 97 11 1996 2601 2610
128. G. Arcaro, M. Zamboni, and L. Rossi Body fat distribution predicts the degree of endothelial dysfunction in uncomplicated obesity Int J Obes Relat Metab Disord 23 9 1999 936 942
129. F. Perticone, R. Ceravolo, and M. Candigliota Obesity and body fat distribution induce endothelial dysfunction by oxidative stress: protective effect of vitamin C Diabetes 50 1 2001 159 165
130. A.D. Baron Insulin resistance and vascular function J Diabetes Complicat 16 1 2002 92 102
131. R.T. de Jongh, E.H. Serne, R.G. IJzerman, G. de Vries, and C.D. Stehouwer Impaired microvascular function in obesity: implications for obesity-associated microangiopathy, hypertension, and insulin resistance Circulation 109 21 2004 2529 2535
132. S. Vigili de Kreutzenberg, E. Kiwanuka, A. Tiengo, and A. Avogaro Visceral obesity is characterized by impaired nitric oxide-independent vasodilation Eur Heart J 24 13 2003 1210-5
133. M. Hashimoto, M. Akishita, and M Eto The impairment of flow-mediated vasodilatation in obese men with visceral fat accumulation Int J Obes Relat Metab Disord 22 5 1998 477 484
134. Y. Higashi, S. Sasaki, K. Nakagawa, H. Matsuura, K. Chayama, and T. Oshima Effect of obesity on endothelium-dependent, nitric oxide-mediated vasodilation in normotensive individuals and patients with essential hypertension Am J Hypertens 14 10 2001 1038 1045
135. K.J. Mather, A. Lteif, H.O. Steinberg, and A.D. Baron Interactions between endothelin and nitric oxide in the regulation of vascular tone in obesity and diabetes Diabetes 53 8 2004 2060 2066
136. K.J. Mather, B. Mirzamohammadi, A. Lteif, H.O. Steinberg, and A.D. Baron Endothelin contributes to basal vascular tone and endothelial dysfunction in human obesity and type 2 diabetes Diabetes 51 12 2002 3517 3523
137. S. Nielsen, J.R. Halliwill, M.J. Joyner, and M.D. Jensen Vascular response to angiotensin II in upper body obesity Hypertension 44 4 2004 435 441
138. J. Al Suwaidi, S.T. Higano, S. Hamasaki, D.R. Holmes, and A. Lerman Association between obesity and coronary atherosclerosis and vascular remodeling Am J Cardiol 88 11 2001 1300 1303
139. J. Al Suwaidi, S.T. Higano, D.R. Holmes Jr., R. Lennon, and A. Lerman Obesity is independently associated with coronary endothelial dysfunction in patients with normal or mildly diseased coronary arteries J Am Coll Cardiol 37 6 2001 1523 1528
140. D. Benchimol, B. Dubroca, and V. Bernard Short- and long-term risk factors for sudden death in patients with stable angina Int J Cardiol 76 2-3 2000 147 156
141. P.M. Skidmore, and J.W. Yarnell The obesity epidemic: prospects for prevention QJM 97 12 2004 817 825
142. I. Lissau Overweight and obesity epidemic among children. Answer from European countries Int J Obes Relat Metab Disord 28 Suppl 3 2004 S10 S15
143. M. Nishina, T. Kikuchi, H. Yamazaki, K. Kameda, M. Hiura, and M. Uchiyama Relationship among systolic blood pressure, serum insulin and leptin, and visceral fat accumulation in obese children Hypertens Res 26 4 2003 281 288
144. P. Tounian, Y. Aggoun, and B. Dubern Presence of increased stiffness of the common carotid artery and endothelial dysfunction in severely obese children: a prospective study Lancet 358 9291 2001 1400 1404
145. K.S. Woo, P. Chook, and C.W. Yu Overweight in children is associated with arterial endothelial dysfunction and intima-media thickening Int J Obes Relat Metab Disord 28 7 2004 852 857
146. O. Hamdy, S. Ledbury, and C. Mullooly Lifestyle modification improves endothelial function in obese subjects with the insulin resistance syndrome Diabetes Care 26 7 2003 2119 2125
147. A. Sciacqua, M. Candigliota, and R. Ceravolo Weight loss in combination with physical activity improves endothelial dysfunction in human obesity Diabetes Care 26 6 2003 1673 1678
148. M. Raitakari, T. Ilvonen, and M. Ahotupa Weight reduction with very-low-caloric diet and endothelial function in overweight adults: role of plasma glucose Arterioscler Thromb Vasc Biol 24 1 2004 124 128
149. K.S. Woo, P. Chook, and C.W. Yu Effects of diet and exercise on obesity-related vascular dysfunction in children Circulation 109 16 2004 1981 1986
150. R.D. Brook, R.L. Bard, and L. Glazewski Effect of short-term weight loss on the metabolic syndrome and conduit vascular endothelial function in overweight adults Am J Cardiol 93 8 2004 1012 1016
151. R. Marfella, K. Esposito, and M. Siniscalchi Effect of weight loss on cardiac synchronization and proinflammatory cytokines in premenopausal obese women Diabetes Care 27 1 2004 (Jan) 47 52
152. K. Esposito, A. Pontillo, and C. Di Palo Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial JAMA 289 14 2003 1799 1804
153. R. Garg, Y. Kumbkarni, and A. Aljada Troglitazone reduces reactive oxygen species generation by leukocytes and lipid peroxidation and improves flow-mediated vasodilatation in obese subjects Hypertension 36 2000 430 435
154. P. Dandona, A. Aljada, and A. Chaudhuri Vascular reactivity and thiazolidinediones Am J Med 115 8A 2003 81S 86S
155. K.K. Koh, J.W. Son, and J.Y. Ahn Simvastatin combined with ramipril treatment in hypercholesterolemic patients Hypertension 44 2 2004 180 185