Anti-inflammatory and anti-atherogenic properties of adiponectin

Biochimie

Volumn 94, Issue 10, 2012, Pages 2137-2142

  Ohashi, Koji ^a   Ouchi, Noriyuki ^a   Matsuzawa, Yuji ^b  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

Adiponectin; Atherosclerosis; Chronic inflammation; Macrophage

Indexed keywords

ADIPONECTIN; APOLIPOPROTEIN E; CYCLOOXYGENASE 2; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GAMMA INTERFERON; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; MACROPHAGE ELASTASE; PLATELET DERIVED GROWTH FACTOR AA; PLATELET DERIVED GROWTH FACTOR BB; REACTIVE OXYGEN METABOLITE; STAT6 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ACUTE HEART INFARCTION; ADIPOSE TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ATHEROGENESIS; ATHEROSCLEROSIS; BINDING KINETICS; BIOTRANSFORMATION; BODY MASS; CARDIOVASCULAR RISK; CD4+ T LYMPHOCYTE; CELL MIGRATION; CELL PROLIFERATION; CHRONIC INFLAMMATION; CORONARY ARTERY DISEASE; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; HYPOADIPONECTINEMIA; IMMUNE RESPONSE; INHIBITION KINETICS; MACROPHAGE; NONHUMAN; PHENOTYPE; PREDICTIVE VALUE; PROTECTION; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; REVIEW; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; UPREGULATION; VASCULAR ENDOTHELIUM; VASODILATATION;

ADIPONECTIN; ANIMALS; ATHEROSCLEROSIS; ENDOTHELIUM; HUMANS; INFLAMMATION; MACROPHAGES; MYOCYTES, SMOOTH MUSCLE;

EID: 84866072974     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2012.06.008     Document Type: Review

References (81)

1. J.M. Friedman A war on obesity, not the obese Science 299 2003 856 858 (Pubitemid 36182435)
2. M.P. Reilly, and D.J. Rader The metabolic syndrome: more than the sum of its parts? Circulation 108 2003 1546 1551 (Pubitemid 37187778)
3. T. Funahashi, T. Nakamura, I. Shimomura, K. Maeda, H. Kuriyama, M. Takahashi, Y. Arita, S. Kihara, and Y. Matsuzawa Role of adipocytokines on the pathogenesis of atherosclerosis in visceral obesity Internal Medicine 38 1999 202 206
4. Y. Matsuzawa, T. Funahashi, and T. Nakamura The concept of metabolic syndrome: contribution of visceral fat accumulation and its molecular mechanism Journal of Atherosclerois and Thrombosis 18 2011 629 639
5. N. Ouchi, J.L. Parker, J.J. Lugus, and K. Walsh Adipokines in inflammation and metabolic disease Nature Reviews Immunology 11 2011 85 97
6. G.S. Hotamisligil, N.S. Shargill, and B.M. Spiegelman Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance Science 259 1993 87 91 (Pubitemid 23036092)
7. I. Shimomura, T. Funahashi, M. Takahashi, K. Maeda, K. Kotani, T. Nakamura, S. Yamashita, M. Miura, Y. Fukuda, K. Takemura, K. Tokunaga, and Y. Matsuzawa Enhanced expression of PAI-1 in visceral fat: possible contributor to vascular disease in obesity Nature Medicine 2 1996 800 803 (Pubitemid 26225097)
8. K. Maeda, K. Okubo, I. Shimomura, T. Funahashi, Y. Matsuzawa, and K. Matsubara cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1) Biochemical and Biophysical Research Communications 221 1996 286 289 (Pubitemid 26136463)
9. J.M. Friedman, and J.L. Halaas Leptin and the regulation of body weight in mammals Nature 395 1998 763 770 (Pubitemid 28485436)
10. N. Ouchi, S. Kihara, Y. Arita, Y. Okamoto, K. Maeda, H. Kuriyama, K. Hotta, M. Nishida, M. Takahashi, M. Muraguchi, Y. Ohmoto, T. Nakamura, S. Yamashita, T. Funahashi, and Y. Matsuzawa Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway Circulation 102 2000 1296 1301
11. N. Ouchi, S. Kihara, T. Funahashi, Y. Matsuzawa, and K. Walsh Obesity, adiponectin and vascular inflammatory disease Current Opinion in Lipidology 14 2003 561 566 (Pubitemid 41623184)
12. N. Ouchi, A. Higuchi, K. Ohashi, Y. Oshima, N. Gokce, R. Shibata, Y. Akasaki, A. Shimono, and K. Walsh Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity Science 329 2010 454 457
13. M.Y. Donath, and S.E. Shoelson Type 2 diabetes as an inflammatory disease Nature Reviews Immunology 11 2011 98 107
14. E.S. Androulakis, D. Tousoulis, N. Papageorgiou, C. Tsioufis, I. Kallikazaros, and C. Stefanadis Essential hypertension: is there a role for inflammatory mechanisms? Cardiology in Review 17 2009 216 221
15. K.J. Moore, and I. Tabas Macrophages in the pathogenesis of atherosclerosis Cell 145 2011 341 355
16. C. Weber, A. Zernecke, and P. Libby The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models Nature Reviews Immunology 8 2008 802 815
17. M. Zeyda, J. Huber, G. Prager, and T.M. Stulnig Inflammation correlates with markers of T-cell subsets including regulatory T cells in adipose tissue from obese patients Obesity (Silver Spring) 19 2011 743 748
18. J.G. Neels, and J.M. Olefsky Inflamed fat: what starts the fire? Journal of Clinical Investigation 116 2006 33 35 (Pubitemid 43121788)
19. H. Xu, G.T. Barnes, Q. Yang, G. Tan, D. Yang, C.J. Chou, J. Sole, A. Nichols, J.S. Ross, L.A. Tartaglia, and H. Chen Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance Journal of Clinical Investigation 112 2003 1821 1830 (Pubitemid 38063705)
20. C.N. Lumeng, J.L. Bodzin, and A.R. Saltiel Obesity induces a phenotypic switch in adipose tissue macrophage polarization Journal of Clinical Investigation 117 2007 175 184 (Pubitemid 46048464)
21. T. Enomoto, K. Ohashi, R. Shibata, A. Higuchi, S. Maruyama, Y. Izumiya, K. Walsh, T. Murohara, and N. Ouchi Adipolin/C1qdc2/CTRP12 protein functions as an adipokine that improves glucose metabolism Journal of Biological Chemistry 286 2011 34552 34558
22. Z. Wei, J.M. Peterson, X. Lei, L. Cebotaru, M.J. Wolfgang, G.C. Baldeviano, and G.W. Wong C1q/TNF-related Protein-12 (CTRP12), a novel adipokine that improves insulin sensitivity and glycemic control in mouse models of obesity and diabetes Journal of Biological Chemistry 287 2012 10301 10315
23. P.E. Scherer, S. Williams, M. Fogliano, G. Baldini, and H.F. Lodish A novel serum protein similar to C1q, produced exclusively in adipocytes Journal of Biological Chemistry 270 1995 26746 26749
24. Y. Arita, S. Kihara, N. Ouchi, M. Takahashi, K. Maeda, J. Miyagawa, K. Hotta, I. Shimomura, T. Nakamura, K. Miyaoka, H. Kuriyama, M. Nishida, S. Yamashita, K. Okubo, K. Matsubara, M. Muraguchi, Y. Ohmoto, T. Funahashi, and Y. Matsuzawa Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity Biochemical and Biophysical Research Communications 257 1999 79 83 (Pubitemid 29299050)
25. M. Ryo, T. Nakamura, S. Kihara, M. Kumada, S. Shibazaki, M. Takahashi, M. Nagai, Y. Matsuzawa, and T. Funahashi Adiponectin as a biomarker of the metabolic syndrome Circulation Journal 68 2004 975 981 (Pubitemid 39540124)
26. K. Kishida, K.K. Kim, T. Funahashi, Y. Matsuzawa, H.C. Kang, and I. Shimomura Relationships between circulating adiponectin levels and fat distribution in obese subjects Journal of Atherosclerois and Thrombosis 18 2011 592 595
27. M. Adamczak, A. Wiecek, T. Funahashi, J. Chudek, F. Kokot, and Y. Matsuzawa Decreased plasma adiponectin concentration in patients with essential hypertension American Journal of Hypertension 16 2003 72 75 (Pubitemid 36078595)
28. Y. Iwashima, T. Katsuya, K. Ishikawa, N. Ouchi, M. Ohishi, K. Sugimoto, Y. Fu, M. Motone, K. Yamamoto, A. Matsuo, K. Ohashi, S. Kihara, T. Funahashi, H. Rakugi, Y. Matsuzawa, and T. Ogihara Hypoadiponectinemia is an independent risk factor for hypertension Hypertension 43 2004 1318 1323 (Pubitemid 38691756)
29. K. Hotta, T. Funahashi, N.L. Bodkin, H.K. Ortmeyer, Y. Arita, B.C. Hansen, and Y. Matsuzawa Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys Diabetes 50 2001 1126 1133 (Pubitemid 32374544)
30. N. Ouchi, S. Kihara, Y. Arita, K. Maeda, H. Kuriyama, Y. Okamoto, K. Hotta, M. Nishida, M. Takahashi, T. Nakamura, S. Yamashita, T. Funahashi, and Y. Matsuzawa Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin Circulation 100 1999 2473 2476 (Pubitemid 30005109)
31. Y. Okamoto, E.J. Folco, M. Minami, A.K. Wara, M.W. Feinberg, G.K. Sukhova, R.A. Colvin, S. Kihara, T. Funahashi, A.D. Luster, and P. Libby Adiponectin inhibits the production of CXC receptor 3 chemokine ligands in macrophages and reduces T-lymphocyte recruitment in atherogenesis Circulation Research 102 2008 218 225 (Pubitemid 351651126)
32. K. Ohashi, S. Kihara, N. Ouchi, M. Kumada, K. Fujita, A. Hiuge, T. Hibuse, M. Ryo, H. Nishizawa, N. Maeda, K. Maeda, R. Shibata, K. Walsh, T. Funahashi, and I. Shimomura Adiponectin replenishment ameliorates obesity-related hypertension Hypertension 47 2006 1108 1116 (Pubitemid 44289168)
33. N. Maeda, I. Shimomura, K. Kishida, H. Nishizawa, M. Matsuda, H. Nagaretani, N. Furuyama, H. Kondo, M. Takahashi, Y. Arita, R. Komuro, N. Ouchi, S. Kihara, Y. Tochino, K. Okutomi, M. Horie, S. Takeda, T. Aoyama, T. Funahashi, and Y. Matsuzawa Diet-induced insulin resistance in mice lacking adiponectin/ACRP30 Nature Medicine 8 2002 731 737 (Pubitemid 34778727)
34. R. Shibata, K. Sato, D.R. Pimentel, Y. Takemura, S. Kihara, K. Ohashi, T. Funahashi, N. Ouchi, and K. Walsh Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms Nature Medicine 11 2005 1096 1103 (Pubitemid 41486832)
35. R. Shibata, N. Ouchi, M. Ito, S. Kihara, I. Shiojima, D.R. Pimentel, M. Kumada, K. Sato, S. Schiekofer, K. Ohashi, T. Funahashi, W.S. Colucci, and K. Walsh Adiponectin-mediated modulation of hypertrophic signals in the heart Nature Medicine 10 2004 1384 1389 (Pubitemid 40022722)
36. N. Ouchi, H. Kobayashi, S. Kihara, M. Kumada, K. Sato, T. Inoue, T. Funahashi, and K. Walsh Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells Journal of Biological Chemistry 279 2004 1304 1309 (Pubitemid 38082655)
37. R. Shibata, N. Ouchi, S. Kihara, K. Sato, T. Funahashi, and K. Walsh Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of amp-activated protein kinase signaling Journal of Biological Chemistry 279 2004 28670 28674 (Pubitemid 38900150)
38. H. Chen, M. Montagnani, T. Funahashi, I. Shimomura, and M.J. Quon Adiponectin stimulates production of nitric oxide in vascular endothelial cells Journal of Biological Chemistry 278 2003 45021 45026 (Pubitemid 37377262)
39. H. Kobayashi, N. Ouchi, S. Kihara, K. Walsh, M. Kumada, Y. Abe, T. Funahashi, and Y. Matsuzawa Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin Circulation Research 94 2004 e27 e31
40. K. Ohashi, N. Ouchi, K. Sato, A. Higuchi, T.O. Ishikawa, H.R. Herschman, S. Kihara, and K. Walsh Adiponectin promotes revascularization of ischemic muscle through a cyclooxygenase 2-dependent mechanism Molecular and Cellular Biology 29 2009 3487 3499
41. K. Ohashi, J.L. Parker, N. Ouchi, A. Higuchi, J.A. Vita, N. Gokce, A.A. Pedersen, C. Kalthoff, S. Tullin, A. Sams, R. Summer, and K. Walsh Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype Journal of Biological Chemistry 285 2010 6153 6160
42. Y. Arita, S. Kihara, N. Ouchi, K. Maeda, H. Kuriyama, Y. Okamoto, M. Kumada, K. Hotta, M. Nishida, M. Takahashi, T. Nakamura, I. Shimomura, M. Muraguchi, Y. Ohmoto, T. Funahashi, and Y. Matsuzawa Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell Circulation 105 2002 2893 2898 (Pubitemid 34666104)
43. N. Ouchi, and K. Walsh Adiponectin as an anti-inflammatory factor Clinica Chimica Acta 380 2007 24 30 (Pubitemid 46498041)
44. M. Kumada, S. Kihara, S. Sumitsuji, T. Kawamoto, S. Matsumoto, N. Ouchi, Y. Arita, Y. Okamoto, I. Shimomura, H. Hiraoka, T. Nakamura, T. Funahashi, and Y. Matsuzawa Association of hypoadiponectinemia with coronary artery disease in men Arteriosclerosis, Thrombosis, and Vascular Biology 23 2003 85 89 (Pubitemid 36091630)
45. T. Pischon, C.J. Girman, G.S. Hotamisligil, N. Rifai, F.B. Hu, and E.B. Rimm Plasma adiponectin levels and risk of myocardial infarction in men Journal of the American Medical Association 291 2004 1730 1737 (Pubitemid 38489895)
46. M.B. Schulze, I. Shai, E.B. Rimm, T. Li, N. Rifai, and F.B. Hu Adiponectin and future coronary heart disease events among men with type 2 diabetes Diabetes 54 2005 534 539
47. X.Y. Wang, Y.H. Guo, and L.J. Guo Association between plasma adiponectin levels and coronary lesion complexity Beijing Da Xue Xue Bao 39 2007 599 602
48. F. Otsuka, S. Sugiyama, S. Kojima, H. Maruyoshi, T. Funahashi, K. Matsui, T. Sakamoto, M. Yoshimura, K. Kimura, S. Umemura, and H. Ogawa Plasma adiponectin levels are associated with coronary lesion complexity in men with coronary artery disease Journal of the American College of Cardiology 48 2006 1155 1162 (Pubitemid 44345143)
49. F. Takemoto, H. Katori, N. Sawa, J. Hoshino, T. Suwabe, S. Nakanishi, S. Arai, S. Fukuda, K. Kodaka, M. Shimada, C. Yamazaki, K. Yokoyama, Y. Nakano, T. Funahashi, Y. Ubara, A. Yamada, K. Takaichi, and S. Uchida Plasma adiponectin: a predictor of coronary heart disease in hemodialysis patients - a Japanese prospective eight-year study Nephron Clinical Practice 111 2009 c12 c20
50. M. Ai, S. Otokozawa, B.F. Asztalos, C.C. White, L.A. Cupples, K. Nakajima, S. Lamon-Fava, P.W. Wilson, Y. Matsuzawa, and E.J. Schaefer Adiponectin: an independent risk factor for coronary heart disease in men in the Framingham offspring study Atherosclerosis 217 2011 543 548
51. D.A. Lawlor, G. Davey Smith, S. Ebrahim, C. Thompson, and N. Sattar Plasma adiponectin levels are associated with insulin resistance, but do not predict future risk of coronary heart disease in women Journal of Clinical Endocrinology and Metabolism 90 2005 5677 5683 (Pubitemid 41415475)
52. R.S. Lindsay, H.E. Resnick, J. Zhu, M.L. Tun, B.V. Howard, Y. Zhang, J. Yeh, and L.G. Best Adiponectin and coronary heart disease: the Strong Heart Study Arteriosclerosis, Thrombosis, and Vascular Biology 25 2005 e15 e16
53. N. Sattar, G. Wannamethee, N. Sarwar, J. Tchernova, L. Cherry, A.M. Wallace, J. Danesh, and P.H. Whincup Adiponectin and coronary heart disease: a prospective study and meta-analysis Circulation 114 2006 623 629 (Pubitemid 44252303)
54. G.A. Laughlin, E. Barrett-Connor, S. May, and C. Langenberg Association of adiponectin with coronary heart disease and mortality: the Rancho Bernardo study American Journal of Epidemiology 165 2007 164 174 (Pubitemid 46096378)
55. Y. Okamoto, S. Kihara, N. Ouchi, M. Nishida, Y. Arita, M. Kumada, K. Ohashi, N. Sakai, I. Shimomura, H. Kobayashi, N. Terasaka, T. Inaba, T. Funahashi, and Y. Matsuzawa Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice Circulation 106 2002 2767 2770 (Pubitemid 35396973)
56. T. Yamauchi, J. Kamon, H. Waki, Y. Imai, N. Shimozawa, K. Hioki, S. Uchida, Y. Ito, K. Takakuwa, J. Matsui, M. Takata, K. Eto, Y. Terauchi, K. Komeda, M. Tsunoda, K. Murakami, Y. Ohnishi, T. Naitoh, K. Yamamura, Y. Ueyama, P. Froguel, S. Kimura, R. Nagai, and T. Kadowaki Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis Journal of Biological Chemistry 278 2003 2461 2468 (Pubitemid 36801322)
57. N. Kubota, Y. Terauchi, T. Yamauchi, T. Kubota, M. Moroi, J. Matsui, K. Eto, T. Yamashita, J. Kamon, H. Satoh, W. Yano, P. Froguel, R. Nagai, S. Kimura, T. Kadowaki, and T. Noda Disruption of adiponectin causes insulin resistance and neointimal formation Journal of Biological Chemistry 277 2002 25863 25866 (Pubitemid 34967064)
58. M. Matsuda, I. Shimomura, M. Sata, Y. Arita, M. Nishida, N. Maeda, M. Kumada, Y. Okamoto, H. Nagaretani, H. Nishizawa, K. Kishida, R. Komuro, N. Ouchi, S. Kihara, R. Nagai, T. Funahashi, and Y. Matsuzawa Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis Journal of Biological Chemistry 277 2002 37487 37491
59. N. Ouchi, M. Ohishi, S. Kihara, T. Funahashi, T. Nakamura, H. Nagaretani, M. Kumada, K. Ohashi, Y. Okamoto, H. Nishizawa, K. Kishida, N. Maeda, A. Nagasawa, H. Kobayashi, H. Hiraoka, N. Komai, M. Kaibe, H. Rakugi, T. Ogihara, and Y. Matsuzawa Association of hypoadiponectinemia with impaired vasoreactivity Hypertension 42 2003 231 234 (Pubitemid 37093465)
60. C. Kobashi, M. Urakaze, M. Kishida, E. Kibayashi, H. Kobayashi, S. Kihara, T. Funahashi, M. Takata, R. Temaru, A. Sato, K. Yamazaki, N. Nakamura, and M. Kobayashi Adiponectin inhibits endothelial synthesis of interleukin-8 Circulation Research 97 2005 1245 1252
61. Y.J. Chen, L.Q. Zhang, G.P. Wang, H. Zeng, B. Lu, X.L. Shen, Z.P. Jiang, and F.P. Chen Adiponectin inhibits tissue factor expression and enhances tissue factor pathway inhibitor expression in human endothelial cells Thrombosis and Haemostasis 100 2008 291 300
62. R. Ouedraogo, X. Wu, S.Q. Xu, L. Fuchsel, H. Motoshima, K. Mahadev, K. Hough, R. Scalia, and B.J. Goldstein Adiponectin suppression of high-glucose-induced reactive oxygen species in vascular endothelial cells: evidence for involvement of a cAMP signaling pathway Diabetes 55 2006 1840 1846 (Pubitemid 44324141)
63. R. Ouedraogo, Y. Gong, B. Berzins, X. Wu, K. Mahadev, K. Hough, L. Chan, B.J. Goldstein, and R. Scalia Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo Journal of Clinical Investigation 117 2007 1718 1726 (Pubitemid 46871356)
64. R. Summer, C.A. Fiack, Y. Ikeda, K. Sato, D. Dwyer, N. Ouchi, A. Fine, H.W. Farber, and K. Walsh Adiponectin deficiency: a model of pulmonary hypertension associated with pulmonary vascular disease American Journal of Physiology - Lung Cellular and Molecular Physiology 297 2009 L432 L438
65. J.M. Konter, J.L. Parker, E. Baez, S.Z. Li, B. Ranscht, M. Denzel, F.F. Little, K. Nakamura, N. Ouchi, A. Fine, K. Walsh, and R.S. Summer Adiponectin attenuates lipopolysaccharide-induced acute lung injury through suppression of endothelial cell activation Journal of Immunology 188 2012 854 863
66. Y. Wang, K.S. Lam, J.Y. Xu, G. Lu, L.Y. Xu, G.J. Cooper, and A. Xu Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner Journal of Biological Chemistry 280 2005 18341 18347 (Pubitemid 41389081)
67. Y. Okamoto, Y. Arita, M. Nishida, M. Muraguchi, N. Ouchi, M. Takahashi, T. Igura, Y. Inui, S. Kihara, T. Nakamura, S. Yamashita, J. Miyagawa, T. Funahashi, and Y. Matsuzawa An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls Hormone and Metabolic Research 32 2000 47 50 (Pubitemid 30143606)
68. N. Ouchi, S. Kihara, Y. Arita, M. Nishida, A. Matsuyama, Y. Okamoto, M. Ishigami, H. Kuriyama, K. Kishida, H. Nishizawa, K. Hotta, M. Muraguchi, Y. Ohmoto, S. Yamashita, T. Funahashi, and Y. Matsuzawa Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages Circulation 103 2001 1057 1063 (Pubitemid 32200177)
69. M. Kumada, S. Kihara, N. Ouchi, H. Kobayashi, Y. Okamoto, K. Ohashi, K. Maeda, H. Nagaretani, K. Kishida, N. Maeda, A. Nagasawa, T. Funahashi, and Y. Matsuzawa Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages Circulation 109 2004 2046 2049 (Pubitemid 38620209)
70. T. Yokota, K. Oritani, I. Takahashi, J. Ishikawa, A. Matsuyama, N. Ouchi, S. Kihara, T. Funahashi, A.J. Tenner, Y. Tomiyama, and Y. Matsuzawa Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages Blood 96 2000 1723 1732 (Pubitemid 30661055)
71. N. Yamaguchi, J.G. Argueta, Y. Masuhiro, M. Kagishita, K. Nonaka, T. Saito, S. Hanazawa, and Y. Yamashita Adiponectin inhibits Toll-like receptor family-induced signaling FEBS Letters 579 2005 6821 6826 (Pubitemid 41773693)
72. A. Higuchi, K. Ohashi, S. Kihara, K. Walsh, and N. Ouchi Adiponectin suppresses pathological microvessel formation in retina through modulation of tumor necrosis factor-alpha expression Circulation Research 104 2009 1058 1065
73. R. Summer, F.F. Little, N. Ouchi, Y. Takemura, T. Aprahamian, D. Dwyer, K. Fitzsimmons, B. Suki, H. Parameswaran, A. Fine, and K. Walsh Alveolar macrophage activation and an emphysema-like phenotype in adiponectin-deficient mice American Journal of Physiology - Lung Cellular and Molecular Physiology 294 2008 L1035 L1042
74. S. Gordon Alternative activation of macrophages Nature Reviews Immunology 3 2003 23 35 (Pubitemid 37328697)
75. V. Bourlier, A. Zakaroff-Girard, A. Miranville, S. De Barros, M. Maumus, C. Sengenes, J. Galitzky, M. Lafontan, F. Karpe, K.N. Frayn, and A. Bouloumie Remodeling phenotype of human subcutaneous adipose tissue macrophages Circulation 117 2008 806 815 (Pubitemid 351640682)
76. F. Lovren, Y. Pan, A. Quan, P.E. Szmitko, K.K. Singh, P.C. Shukla, M. Gupta, L. Chan, M. Al-Omran, H. Teoh, and S. Verma Adiponectin primes human monocytes into alternative anti-inflammatory M2 macrophages American Journal of Physiology - Heart and Circulatory Physiology 299 2010 H656 H663
77. P. Mandal, B.T. Pratt, M. Barnes, M.R. McMullen, and L.E. Nagy Molecular mechanism for adiponectin-dependent M2 macrophage polarization: link between the metabolic and innate immune activity of full-length adiponectin Journal of Biological Chemistry 286 2011 13460 13469
78. J. Fukushima, Y. Kamada, H. Matsumoto, Y. Yoshida, H. Ezaki, T. Takemura, Y. Saji, T. Igura, S. Tsutsui, S. Kihara, T. Funahashi, I. Shimomura, S. Tamura, S. Kiso, and N. Hayashi Adiponectin prevents progression of steatohepatitis in mice by regulating oxidative stress and Kupffer cell phenotype polarization Hepatology Research 39 2009 724 738
79. Y. Takemura, N. Ouchi, R. Shibata, T. Aprahamian, M.T. Kirber, R.S. Summer, S. Kihara, and K. Walsh Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies Journal of Clinical Investigation 117 2007 375 386 (Pubitemid 46203966)
80. R. Licht, J.W. Dieker, C.W. Jacobs, W.J. Tax, and J.H. Berden Decreased phagocytosis of apoptotic cells in diseased SLE mice Journal of Autoimmunity 22 2004 139 145 (Pubitemid 38252970)
81. N. Komai, Y. Morita, T. Sakuta, A. Kuwabara, and N. Kashihara Anti-tumor necrosis factor therapy increases serum adiponectin levels with the improvement of endothelial dysfunction in patients with rheumatoid arthritis Modern Rheumatology 17 2007 385 390 (Pubitemid 47593486)