메뉴 건너뛰기




Volumn 87, Issue 9, 2002, Pages 4198-4202

A polymorphism in the human agouti-related protein is associated with late-onset obesity

Author keywords

[No Author keywords available]

Indexed keywords

AGOUTI RELATED PROTEIN; ALANINE; HUMAN AGOUTI RELATED PROTEIN; ISOPROTEIN; THREONINE; UNCLASSIFIED DRUG;

EID: 18544363922     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2002-011834     Document Type: Article
Times cited : (84)

References (44)
  • 1
    • 0033821404 scopus 로고    scopus 로고
    • The hypothalamus and the regulation of energy homeostasis: Lifting the lid on a black box
    • Williams G, Harrold JA, Cutler DJ 2000 The hypothalamus and the regulation of energy homeostasis: lifting the lid on a black box. Proc Nutr Soc 59:385-396
    • (2000) Proc Nutr Soc , vol.59 , pp. 385-396
    • Williams, G.1    Harrold, J.A.2    Cutler, D.J.3
  • 2
    • 0033782054 scopus 로고    scopus 로고
    • Neuropeptides and obesity
    • Beck B 2000 Neuropeptides and obesity. Nutrition 16:916-923
    • (2000) Nutrition , vol.16 , pp. 916-923
    • Beck, B.1
  • 3
    • 0030764741 scopus 로고    scopus 로고
    • Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
    • Ollmann MM, Wilson BD, Yang YK, Kerns JA, Chen Y, Gantz I, Barsh GS 1997 Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278:135-138
    • (1997) Science , vol.278 , pp. 135-138
    • Ollmann, M.M.1    Wilson, B.D.2    Yang, Y.K.3    Kerns, J.A.4    Chen, Y.5    Gantz, I.6    Barsh, G.S.7
  • 4
    • 0030893647 scopus 로고    scopus 로고
    • Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice
    • Shutter JR, Graham M, Kinsey AC, Scully S, Luthy R, Stark KL 1997 Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice. Genes Dev 11:593-602
    • (1997) Genes Dev , vol.11 , pp. 593-602
    • Shutter, J.R.1    Graham, M.2    Kinsey, A.C.3    Scully, S.4    Luthy, R.5    Stark, K.L.6
  • 10
    • 0033969423 scopus 로고    scopus 로고
    • Effects of streptozotocin-induced diabetes and insulin treatment on the hypothalamic melanocortin system and muscle uncoupling protein 3 expression in rats
    • Havel PJ, Hahn TM, Sindelar DK, Baskin DG, Dallman MF, Weigle DS, Schwartz MW 2000 Effects of streptozotocin-induced diabetes and insulin treatment on the hypothalamic melanocortin system and muscle uncoupling protein 3 expression in rats. Diabetes 49:244-252
    • (2000) Diabetes , vol.49 , pp. 244-252
    • Havel, P.J.1    Hahn, T.M.2    Sindelar, D.K.3    Baskin, D.G.4    Dallman, M.F.5    Weigle, D.S.6    Schwartz, M.W.7
  • 11
    • 13344280346 scopus 로고    scopus 로고
    • Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice
    • Schwartz MW, Baskin DG, Bukowski TR, et al. 1996 Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45:531-535
    • (1996) Diabetes , vol.45 , pp. 531-535
    • Schwartz, M.W.1    Baskin, D.G.2    Bukowski, T.R.3
  • 12
    • 0032443807 scopus 로고    scopus 로고
    • The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice
    • Broberger C, Johansen J, Johansson C, Schalling M, Hokfelt T 1998 The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice. Proc Natl Acad Sci USA 95:15043-15048
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 15043-15048
    • Broberger, C.1    Johansen, J.2    Johansson, C.3    Schalling, M.4    Hokfelt, T.5
  • 13
    • 0033017571 scopus 로고    scopus 로고
    • The role of agouti-related protein in regulating body weight
    • Wilson BD, Ollmann MM, Barsh GS 1999 The role of agouti-related protein in regulating body weight. Mol Med Today 5:250-256
    • (1999) Mol Med Today , vol.5 , pp. 250-256
    • Wilson, B.D.1    Ollmann, M.M.2    Barsh, G.S.3
  • 14
    • 0032872203 scopus 로고    scopus 로고
    • Involvement of agouti-related protein, an endogenous antagonist of hypothalamic melanocortin receptor, in leptin action
    • Ebihara K, Ogawa Y, Katsuura G, et al. 1999 Involvement of agouti-related protein, an endogenous antagonist of hypothalamic melanocortin receptor, in leptin action. Diabetes 48:2028-2033
    • (1999) Diabetes , vol.48 , pp. 2028-2033
    • Ebihara, K.1    Ogawa, Y.2    Katsuura, G.3
  • 15
    • 0031589551 scopus 로고    scopus 로고
    • ART (protein product of agouti-related transcript) as an antagonist of MC-3 and MC-4 receptors
    • Fong TM, Mao C, MacNeil T, et al. 1997 ART (protein product of agouti-related transcript) as an antagonist of MC-3 and MC-4 receptors. Biochem Biophys Res Commun 237:629-631
    • (1997) Biochem Biophys Res Commun , vol.237 , pp. 629-631
    • Fong, T.M.1    Mao, C.2    MacNeil, T.3
  • 17
    • 0035904455 scopus 로고    scopus 로고
    • The gene structure and minimal promoter of the human agouti related protein
    • Brown AM, Mayfield DK, Volaufova J, Argyropoulos G 2001 The gene structure and minimal promoter of the human agouti related protein. Gene 277:231-238
    • (2001) Gene , vol.277 , pp. 231-238
    • Brown, A.M.1    Mayfield, D.K.2    Volaufova, J.3    Argyropoulos, G.4
  • 19
    • 0029900899 scopus 로고    scopus 로고
    • Reflections on STAT3, STAT5, and STAT6 as fat STATs
    • Darnell Jr JE 1996 Reflections on STAT3, STAT5, and STAT6 as fat STATs. Proc Natl Acad Sci USA 93:6221-6224
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 6221-6224
    • Darnell J.E., Jr.1
  • 20
    • 0032915413 scopus 로고    scopus 로고
    • Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting
    • Mizuno TM, Mobbs CV 1999 Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting. Endocrinology 140:814-817
    • (1999) Endocrinology , vol.140 , pp. 814-817
    • Mizuno, T.M.1    Mobbs, C.V.2
  • 21
    • 0033316562 scopus 로고    scopus 로고
    • Physiological and anatomical circuitry between agouti-related protein and leptin signaling
    • Wilson BD, Bagnol D, Kaelin CB, et al. 1999 Physiological and anatomical circuitry between agouti-related protein and leptin signaling. Endocrinology 140:2387-2397
    • (1999) Endocrinology , vol.140 , pp. 2387-2397
    • Wilson, B.D.1    Bagnol, D.2    Kaelin, C.B.3
  • 22
    • 0033200153 scopus 로고    scopus 로고
    • Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: Evidence of a cellular basis for the adipostat
    • Cowley MA, Pronchuk N, Fan W, Dinulescu DM, Colmers WF, Cone RD 1999 Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat. Neuron 24:155-163
    • (1999) Neuron , vol.24 , pp. 155-163
    • Cowley, M.A.1    Pronchuk, N.2    Fan, W.3    Dinulescu, D.M.4    Colmers, W.F.5    Cone, R.D.6
  • 23
    • 0034037278 scopus 로고    scopus 로고
    • The central melanocortin system affects the hypothalamo-pituitary thyroid axis and may mediate the effect of leptin
    • Kim MS, Small CJ, Stanley SA, et al. 2000 The central melanocortin system affects the hypothalamo-pituitary thyroid axis and may mediate the effect of leptin. J Clin Invest 105:1005-1011
    • (2000) J Clin Invest , vol.105 , pp. 1005-1011
    • Kim, M.S.1    Small, C.J.2    Stanley, S.A.3
  • 24
    • 0000573907 scopus 로고    scopus 로고
    • Hypothalamic localization of the feeding effect of agouti-related peptide and α-melanocyte-stimulating hormone
    • Kim MS, Rossi M, Abusnana S, et al. 2000 Hypothalamic localization of the feeding effect of agouti-related peptide and α-melanocyte-stimulating hormone. Diabetes 49:177-182
    • (2000) Diabetes , vol.49 , pp. 177-182
    • Kim, M.S.1    Rossi, M.2    Abusnana, S.3
  • 25
    • 0034456997 scopus 로고    scopus 로고
    • Agouti-related protein-like immunoreactivity: Characterization of release from hypothalamic tissue and presence in serum
    • Li JY, Finniss S, Yang YK, et al. 2000 Agouti-related protein-like immunoreactivity: characterization of release from hypothalamic tissue and presence in serum. Endocrinology 141:1942-1950
    • (2000) Endocrinology , vol.141 , pp. 1942-1950
    • Li, J.Y.1    Finniss, S.2    Yang, Y.K.3
  • 26
    • 0034455775 scopus 로고    scopus 로고
    • Hypophysiotropic thyrotropin-releasing hormone-synthesizing neurons in the human hypothalamus are innervated by neuropeptide Y, agouti-related protein, and α-melanocyte-stimulating hormone
    • Mihaly E, Fekete C, Tatro JB, Liposits Z, Stopa EG, Lechan RM 2000 Hypophysiotropic thyrotropin-releasing hormone-synthesizing neurons in the human hypothalamus are innervated by neuropeptide Y, agouti-related protein, and α-melanocyte-stimulating hormone. J Clin Endocrinol Metab 85:2596-2603
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 2596-2603
    • Mihaly, E.1    Fekete, C.2    Tatro, J.B.3    Liposits, Z.4    Stopa, E.G.5    Lechan, R.M.6
  • 27
    • 0034017845 scopus 로고    scopus 로고
    • Regulation of leptin receptor, POMC and AGRP gene expression by photoperiod and food deprivation in the hypothalamic arcuate nucleus of the male Siberian hamster (Phodopus sungorus)
    • Mercer JG, Moar KM, Ross AW, Morgan PJ 2000 Regulation of leptin receptor, POMC and AGRP gene expression by photoperiod and food deprivation in the hypothalamic arcuate nucleus of the male Siberian hamster (Phodopus sungorus). Appetite 34:109-111
    • (2000) Appetite , vol.34 , pp. 109-111
    • Mercer, J.G.1    Moar, K.M.2    Ross, A.W.3    Morgan, P.J.4
  • 29
    • 17744381543 scopus 로고    scopus 로고
    • Association between an agouti-related protein gene polymorphism and anorexia nervosa
    • Vink T, Hinney A, van Elburg AA, et al. 2001 Association between an agouti-related protein gene polymorphism and anorexia nervosa. Mol Psychiatry 6:325-38
    • (2001) Mol Psychiatry , vol.6 , pp. 325-338
    • Vink, T.1    Hinney, A.2    Van Elburg, A.A.3
  • 30
    • 0034905674 scopus 로고    scopus 로고
    • Mutational analysis of melanocortin-4 receptor, agouti-related protein, and α-melanocyte-stimulating hormone genes in severely obese children
    • Dubern B, Clement K, Pelloux V, et al. 2001 Mutational analysis of melanocortin-4 receptor, agouti-related protein, and α-melanocyte-stimulating hormone genes in severely obese children. J Pediatr 139:204-209
    • (2001) J Pediatr , vol.139 , pp. 204-209
    • Dubern, B.1    Clement, K.2    Pelloux, V.3
  • 32
    • 0030938401 scopus 로고    scopus 로고
    • Reproducibility of anthropometric and body composition measurements: The HERITAGE Family Study
    • Wilmore JH, Stanforth PR, Domenick MA, et al. 1997 Reproducibility of anthropometric and body composition measurements: the HERITAGE Family Study. Int J Obes Relat Metab Disord 21:297-303
    • (1997) Int J Obes Relat Metab Disord , vol.21 , pp. 297-303
    • Wilmore, J.H.1    Stanforth, P.R.2    Domenick, M.A.3
  • 33
    • 0033191450 scopus 로고    scopus 로고
    • Body fat, resting and exercise blood pressure and the angiotensinogen M235T polymorphism: The heritage family study
    • Rankinen T, Gagnon J, Perusse L, et al. 1999 Body fat, resting and exercise blood pressure and the angiotensinogen M235T polymorphism: the heritage family study. Obes Res 7:423-430
    • (1999) Obes Res , vol.7 , pp. 423-430
    • Rankinen, T.1    Gagnon, J.2    Perusse, L.3
  • 34
    • 0032838231 scopus 로고    scopus 로고
    • Alterations in body weight and composition consequent to 20 wk of endurance training: The HERITAGE Family Study
    • Wilmore JH, Despres JP, Stanforth PR, et al. 1999 Alterations in body weight and composition consequent to 20 wk of endurance training: the HERITAGE Family Study. Am J Clin Nutr 70:346-352
    • (1999) Am J Clin Nutr , vol.70 , pp. 346-352
    • Wilmore, J.H.1    Despres, J.P.2    Stanforth, P.R.3
  • 35
    • 0033987736 scopus 로고    scopus 로고
    • Mutation nomenclature extensions and suggestions to describe complex mutations: A discussion
    • den Dunnen, JT, Antonarakis SE 2000 Mutation nomenclature extensions and suggestions to describe complex mutations: a discussion. Hum Mutat 15:7-12
    • (2000) Hum Mutat , vol.15 , pp. 7-12
    • Den Dunnen, J.T.1    Antonarakis, S.E.2
  • 36
    • 0026356891 scopus 로고
    • Predicting coiled coils from protein sequences
    • Lupas A, Van Dyke M, Stock J 1991 Predicting coiled coils from protein sequences. Science 252:1162-1164
    • (1991) Science , vol.252 , pp. 1162-1164
    • Lupas, A.1    Van Dyke, M.2    Stock, J.3
  • 37
    • 0030004228 scopus 로고    scopus 로고
    • Prediction and analysis of coiled-coil structures
    • Lupas A 1996 Prediction and analysis of coiled-coil structures. Methods Enzymol 266:513-525
    • (1996) Methods Enzymol , vol.266 , pp. 513-525
    • Lupas, A.1
  • 39
    • 17744396287 scopus 로고    scopus 로고
    • Plasma levels of agouti-related protein are increased in obese men
    • Katsuki A, Sumida Y, Gabazza EC, et al. 2001 Plasma levels of agouti-related protein are increased in obese men. J Clin Endocrinol Metab 86:1921-1924
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 1921-1924
    • Katsuki, A.1    Sumida, Y.2    Gabazza, E.C.3
  • 40
    • 0035965317 scopus 로고    scopus 로고
    • Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients
    • Morra M, Simarro-Grande M, Martin M, et al. 2001 Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients. J Biol Chem 276:36809-36816
    • (2001) J Biol Chem , vol.276 , pp. 36809-36816
    • Morra, M.1    Simarro-Grande, M.2    Martin, M.3
  • 41
    • 0037059741 scopus 로고    scopus 로고
    • Biochemical analysis of a missense mutation in aceruloplasminemia
    • Hellman NE, Kono S, Miyajima H, Gitlin JD 2002 Biochemical analysis of a missense mutation in aceruloplasminemia. J Biol Chem 277:1375-1380
    • (2002) J Biol Chem , vol.277 , pp. 1375-1380
    • Hellman, N.E.1    Kono, S.2    Miyajima, H.3    Gitlin, J.D.4
  • 42
    • 0035094232 scopus 로고    scopus 로고
    • Immediate and prolonged patterns of agouti-related peptide-(83-132)-induced c-Fos activation in hypothalamic and extrahypothalamic sites
    • Hagan MM, Benoit SC, Rushing PA, Pritchard LM, Woods SC, Seeley RJ 2001 Immediate and prolonged patterns of agouti-related peptide-(83-132)-induced c-Fos activation in hypothalamic and extrahypothalamic sites. Endocrinology 142:1050-1056
    • (2001) Endocrinology , vol.142 , pp. 1050-1056
    • Hagan, M.M.1    Benoit, S.C.2    Rushing, P.A.3    Pritchard, L.M.4    Woods, S.C.5    Seeley, R.J.6
  • 43
    • 0035815523 scopus 로고    scopus 로고
    • Effect of agouti-related protein delivered to the dorsomedial nucleus of the hypothalamus on intake of a preferred versus a non-preferred diet
    • Wirth MM, Giraudo SQ 2001 Effect of agouti-related protein delivered to the dorsomedial nucleus of the hypothalamus on intake of a preferred versus a non-preferred diet. Brain Res 897:169-174
    • (2001) Brain Res , vol.897 , pp. 169-174
    • Wirth, M.M.1    Giraudo, S.Q.2
  • 44
    • 0035007332 scopus 로고    scopus 로고
    • Opioid receptor involvement in the effect of AgRP-(83-132) on food intake and food selection
    • Hagan MM, Rushing PA, Benoit SC, Woods SC, Seeley RJ 2001 Opioid receptor involvement in the effect of AgRP-(83-132) on food intake and food selection. Am J Physiol 280:R814-R821
    • (2001) Am J Physiol , vol.280
    • Hagan, M.M.1    Rushing, P.A.2    Benoit, S.C.3    Woods, S.C.4    Seeley, R.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.