Adiponectin-It's all about the modifications

International Journal of Biochemistry and Cell Biology

Volumn 42, Issue 6, 2010, Pages 785-788

  Simpson, Fiona ^a   Whitehead, Jonathan P ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Adipokines; Adiponectin; Diabetes; Obesity; Post translational modification

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ADIPOCYTOKINE; ADIPONECTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST;

CARDIOVASCULAR DISEASE; CLINICAL TRIAL; HUMAN; MOLECULAR WEIGHT; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PROTEIN GLYCOSYLATION; PROTEIN METABOLISM; PROTEIN MULTIMERIZATION; PROTEIN PROCESSING; PROTEIN SECRETION; PROTEIN SYNTHESIS; SHORT SURVEY; SIALYLATION;

ADIPONECTIN; ANIMALS; CARDIOVASCULAR DISEASES; DIABETES MELLITUS, TYPE 2; HUMANS; PPAR GAMMA; PROTEIN MULTIMERIZATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECOMBINANT PROTEINS; THIAZOLIDINEDIONES;

EID: 77953806826     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2009.12.021     Document Type: Short Survey

References (24)

1. Frizzell N., Rajesh M., Jepson M.J., Nagai R., Carson J.A., Thorpe S.R., et al. Succination of thiol groups in adipose tissue proteins in diabetes: succination inhibits polymerization and secretion of adiponectin. J Biol Chem 2009, 284:25772-25778.
2. Hada Y., Yamauchi T., Waki H., Tsuchida A., Hara K., Yago H., et al. Selective purification and characterization of adiponectin multimer species from human plasma. Biochem Biophys Res Commun 2007, 356:487-493.
3. Higgins L.S., Mantzoros C.S. The development of INT131 as a selective PPARgamma modulator: approach to a safer insulin sensitizer. PPAR Res 2008, 936906.
4. Kawano J., Arora R. The role of adiponectin in obesity, diabetes, and cardiovascular disease. J Cardiometab Syndr 2009, 4:44-49.
5. Liu M., Zhou L., Xu A., Lam K.S., Wetzel M.D., Xiang R., et al. A disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerization. Proc Natl Acad Sci USA 2008, 105:18302-18307.
6. Pajvani U.B., Du X., Combs T.P., Berg A.H., Rajala M.W., Schulthess T., et al. Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications for metabolic regulation and bioactivity. J Biol Chem 2003, 278:9073-9085.
7. Pajvani U.B., Hawkins M., Combs T.P., Rajala M.W., Doebber T., Berger J.P., et al. Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. J Biol Chem 2004, 279:12152-12162.
8. Qiang L., Wang H., Farmer S.R. Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-Lα. Mol Cell Biol 2007, 27:4698-4707.
9. Radjainia M., Wang Y., Mitra A.K. Structural polymorphism of oligomeric adiponectin visualized by electron microscopy. J Mol Biol 2008, 381:419-430.
10. Richards A.A., Colgrave M.L., Jialiang Z., Webster J., Simpson F., Preston E., et al. Sialic acid modification of adiponectin is not required for multimerization or secretion but determines half-life in circulation. Mol Endocrinol 2009, 24:229-239.
11. Richards A.A., Stephens T., Charlton H.K., Jones A., Macdonald G.A., Prins J.B., et al. Adiponectin multimerisation is dependent on conserved lysines in the collagenous domain: evidence for regulation of multimerisation by alterations in post-translational modifications. Mol Endocrinol 2006, 20:1673-1687.
12. Sato C., Yasukawa Z., Honda N., Matsuda T., Kitajima K. Identification and adipocyte differentiation-dependent expression of the unique disialic acid residue in an adipose tissue-specific glycoprotein, adipo Q. J Biol Chem 2001, 276:28849-28856.
13. Scherer P.E. Adipose tissue: from lipid storage compartment to endocrine organ. Diabetes 2006, 55:1537-1545.
14. Schraw T., Wang Z.V., Halberg N., Hawkins M., Scherer P.E. Plasma adiponectin complexes have distinct biochemical characteristics. Endocrinology 2008, 149:2270-2282.
15. Shapiro L., Scherer P.E. The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor. Curr Biol 1998, 8:335-340.
16. Shetty S., Kusminski C.M., Scherer P.E. Adiponectin in health and disease: evaluation of adiponectin-targeted drug development strategies. Trends Pharmacol Sci 2009, 30:234-239.
17. Tsao T.-S., Tomas E., Murrey H.E., Hug C., Lee D.H., Ruderman N.B., et al. Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity: different oligomers activate different signal transduction pathways. J Biol Chem 2003, 278:50810-50817.
18. Waki H., Yamauchi T., Kamon J., Ito Y., Uchida S., Kita S., et al. Impaired multimerization of human adiponectin mutants associated with diabetes: molecular structure and multimer formation of adiponectin. J Biol Chem 2003, 278:40352-40363.
19. Wang Y., Lam K.S., Yau M.-H., Xu A. Post-translational modifications of adiponectin: mechanisms and functional implications. Biochem J 2008, 409:623-633.
20. Wang Y., Lam K.S.L., Chan L., Chan K.W., Lam J.B.B., Lam M.C., et al. Posttranslational modifications on the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high-molecular-weight oligomeric complex. J Biol Chem 2006, 281:16391-16400.
21. Wang Y., Xu A., Knight C., Xu L.Y., Cooper G.J.S. Hydroxylation and glycosylation of the four conserved lysine residues in the collagenous domain of adiponectin: potential role in the modulation of its insulin-sensitizing activity. J Biol Chem 2002, 277:19521-19529.
22. Wang Z.V., Schraw T.D., Kim J.-Y., Khan T., Rajala M.W., Follenzi A., et al. Secretion of the adipocyte-specific secretory protein adiponectin critically depends on thiol-mediated protein retention. Mol Cell Biol 2007, 27:3716-3731.
23. Yamauchi T., Kamon J., Ito Y., Tsuchida A., Yokomizo T., Kita S., et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 2003, 423:762-769.
24. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature 1994, 372:425-432.