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Volumn 14, Issue 2, 2012, Pages 113-125

Treatment of behavioral and psychological symptoms of Alzheimer's disease

Author keywords

Aggression; Agitation; Alzheimer's disease; Assessment; Atypical antipsychotics; BPSD; Infection; Pain; Person centered care; Psychological interventions; Psychosis; Risperidone; Staff training; Symptoms; Treatment

Indexed keywords

ANTIDEPRESSANT AGENT; ARIPIPRAZOLE; ATYPICAL ANTIPSYCHOTIC AGENT; CARBAMAZEPINE; CHOLINESTERASE INHIBITOR; CITALOPRAM; DONEPEZIL; HALOPERIDOL; MEMANTINE; NEUROLEPTIC AGENT; OLANZAPINE; PLACEBO; PRAZOSIN; PROMAZINE; QUETIAPINE; RISPERIDONE; THIORIDAZINE; TIOTIXENE; VALPROIC ACID; XANOMELINE;

EID: 84862792198     PISSN: 10928480     EISSN: 15343138     Source Type: Journal    
DOI: 10.1007/s11940-012-0166-9     Document Type: Review
Times cited : (59)

References (62)
  • 3
    • 0025279913 scopus 로고
    • Psychiatric phenomena in Alzheimer's disease. IV. Disorders of behaviour
    • Burns A, Jacoby R, Levy R. Psychiatric phenomena in Alzheimer's disease. IV: disorders of behaviour. Br J Psych. 1990;157:86-94. (Pubitemid 20208666)
    • (1990) British Journal of Psychiatry , vol.157 , Issue.JULY , pp. 86-94
    • Burns, A.1    Jacoby, R.2    Levy, R.3
  • 6
    • 34248229332 scopus 로고    scopus 로고
    • Neuropsychiatric symptoms (behavioral and psychological symptoms of dementia) and the development of dementia treatments
    • DOI 10.1017/S104161020700484X, PII S104161020700484X
    • Lyketsos CG. Neuropsychiatric symptoms (behavioral and psychological symptoms of dementia) and the development of dementia treatments. Int Psychogeriatr. 2007;19:409-20. (Pubitemid 46707421)
    • (2007) International Psychogeriatrics , vol.19 , Issue.3 , pp. 409-420
    • Lyketsos, C.G.1
  • 9
    • 0029940694 scopus 로고    scopus 로고
    • A follow up study of depression in the carers of dementia sufferers
    • Ballard CG, Patel A, Solis M, Lowe K, Wilcock G. A follow up study of depression in the carers of dementia sufferers. BMJ. 1996;312:947. (Pubitemid 26111786)
    • (1996) British Medical Journal , vol.312 , Issue.7036 , pp. 947
    • Ballard, C.G.1    Eastwood, C.2    Gahir, M.3    Wilcock, G.4
  • 11
    • 0025142124 scopus 로고
    • Psychiatric symptoms and nursing home placement of patients with Alzheimer's disease
    • Steele C, Rovner B, Chase GA, Folstein M. Psychiatric symptoms and nursing home placement of patients with Alzheimer's disease. Am J Psych. 1990;147:1049-51. (Pubitemid 20257519)
    • (1990) American Journal of Psychiatry , vol.147 , Issue.8 , pp. 1049-1051
    • Steele, C.1    Rovner, B.2    Chase, G.A.3    Folstein, M.4
  • 12
    • 0032972823 scopus 로고    scopus 로고
    • Correlates of psychotic symptoms among elderly outpatients
    • DOI 10.1002/(SICI)1099-1166(199905)14:5<379::AID-GPS924>3.0.CO;2-7
    • Holroyd S, Laurie S. Correlates of psychotic symptoms among elderly outpatients. Int J Geriatric Psych. 1999;14:379-84. (Pubitemid 29271529)
    • (1999) International Journal of Geriatric Psychiatry , vol.14 , Issue.5 , pp. 379-384
    • Holroyd, S.1    Laurie, S.2
  • 13
    • 0032721739 scopus 로고    scopus 로고
    • Association among visual hallucinations, visual acuity, and specific eye pathologies in Alzheimer's disease: Treatment implications
    • Chapman FM, Dickinson J, McKeith I, Ballard C. Association among visual hallucinations, visual acuity, and specific eye pathologies in Alzheimer's disease: treatment implications. Am J Psych. 1999;156:1983-5.
    • (1999) Am J Psych. , vol.156 , pp. 1983-1985
    • Chapman, F.M.1    Dickinson, J.2    McKeith, I.3    Ballard, C.4
  • 14
    • 37049006506 scopus 로고    scopus 로고
    • The utility of pain assessment for analgesic use in persons with dementia
    • DOI 10.1016/j.pain.2007.03.023, PII S0304395907001376
    • Cohen-Mansfield J, Lipson S. The utility of pain assessment for analgesic use in persons with dementia. Pain. 2008;134:16-23. (Pubitemid 350251001)
    • (2008) Pain , vol.134 , Issue.1-2 , pp. 16-23
    • Cohen-Mansfield, J.1    Lipson, S.2
  • 15
    • 84857404382 scopus 로고    scopus 로고
    • Efficacy of treating pain to reduce behavioural disturbances in residents of nursing homes with dementia: Cluster randomised clinical trial
    • Class B evidence. This novel cluster RCT in 60 nursing home units demonstrates the value of stepped analgesia in significantly improving agitation and pain, in comparison to usual care over 8 weeks
    • Husebo B, Ballard C, Sandvik R, Nilsen OB, Aarsland D. Efficacy of treating pain to reduce behavioural disturbances in residents of nursing homes with dementia: cluster randomised clinical trial. BMJ. 2011;343:d4065 (Class B evidence). This novel cluster RCT in 60 nursing home units demonstrates the value of stepped analgesia in significantly improving agitation and pain, in comparison to usual care over 8 weeks.
    • (2011) BMJ , vol.343
    • Husebo, B.1    Ballard, C.2    Sandvik, R.3    Nilsen, O.B.4    Aarsland, D.5
  • 16
    • 33745843336 scopus 로고    scopus 로고
    • Position statement of the American Association for geriatric psychiatry regarding principles of care for patients with dementia resulting from Alzheimer disease
    • DOI 10.1097/01.JGP.0000221334.65330.55
    • Lyketsos CG, Colenda CC, Beck C, et al. Position statement of the American Association for Geriatric Psychiatry regarding principles of care for patients with dementia due to Alzheimer disease. Am J Geriatr Psych. 2006;14:561-72. (Pubitemid 44036480)
    • (2006) American Journal of Geriatric Psychiatry , vol.14 , Issue.7 , pp. 561-572
    • Lyketsos, C.G.1    Colenda, C.C.2    Beck, C.3    Blank, K.4    Doraiswamy, M.P.5    Kalunian, D.A.6    Yaffe, K.7
  • 18
    • 0031457097 scopus 로고    scopus 로고
    • Management of verbally disruptive behaviors in nursing home residents
    • Class B evidence
    • Cohen-Mansfield J, Werner P. Management of verbally disruptive behaviors in nursing home residents. J Gerontol Series A-Biol Sci Med Sci. 1997;52:369-77 (Class B evidence).
    • (1997) J Gerontol Series A-Biol Sci Med Sci. , vol.52 , pp. 369-377
    • Cohen-Mansfield, J.1    Werner, P.2
  • 19
    • 69449084096 scopus 로고    scopus 로고
    • Brief psychosocial therapy for the treatment of agitation in alzheimer disease (The CALM-AD Trial)
    • Class C evidence
    • Ballard C, Brown R, Fossey J, et al. Brief psychosocial therapy for the treatment of agitation in alzheimer disease (The CALM-AD Trial). Am J Geriatr Psychiatr. 2009;17:726-33 (Class C evidence).
    • (2009) Am J Geriatr Psychiatr. , vol.17 , pp. 726-733
    • Ballard, C.1    Brown, R.2    Fossey, J.3
  • 20
    • 2442576068 scopus 로고    scopus 로고
    • Psychosocial approaches to challenging behaviour in dementia: A controlled trial
    • Canberra: Office for Older Australians, Class B evidence
    • Bird M. Psychosocial approaches to challenging behaviour in dementia: a controlled trial. In: Report to the Commonwealth Department of Health and Ageing. Canberra: Office for Older Australians 2002. (Class B evidence).
    • (2002) Report to the Commonwealth Department of Health and Ageing
    • Bird, M.1
  • 21
    • 33645571637 scopus 로고    scopus 로고
    • Effect of enhanced psychosocial care on antipsychotic use in nursing home residents with severe dementia: Cluster randomised trial
    • DOI 10.1136/bmj.38782.575868.7C
    • Fossey J, Ballard C, Juszczak E, et al. Effect of enhanced psychosocial care on antipsychotic use in nursing home residents with severe dementia: cluster randomised trial. BMJ. 2006;332:756-8 (Class B evidence). (Pubitemid 44365651)
    • (2006) British Medical Journal , vol.332 , Issue.7544 , pp. 756-758
    • Fossey, J.1    Ballard, C.2    Juszczak, E.3    James, I.4    Alder, N.5    Jacoby, R.6    Howard, R.7
  • 23
    • 62549128208 scopus 로고    scopus 로고
    • Caring for aged dementia care resident study (CADRES) of person-centred care, dementia-care mapping, and usual care in dementia: A cluster-randomised trial
    • Class B evidence. This large cluster RCT demonstrates significant improvements in agitation with person-centered care training and Dementia Care Mapping in comparison to usual care over 4 months
    • Chenoweth L, King MT, Jeon YH, et al. Caring for Aged Dementia Care Resident Study (CADRES) of person-centred care, dementia-care mapping, and usual care in dementia: a cluster-randomised trial. Lancet Neurol. 2009;8:317-25. (Class B evidence). This large cluster RCT demonstrates significant improvements in agitation with person-centered care training and Dementia Care Mapping in comparison to usual care over 4 months.
    • (2009) Lancet Neurol. , vol.8 , pp. 317-325
    • Chenoweth, L.1    King, M.T.2    Jeon, Y.H.3
  • 27
    • 33745737632 scopus 로고    scopus 로고
    • Neuroleptic drugs in dementia: Benefits and harm
    • DOI 10.1038/nrn1926, PII NRN1926
    • Ballard C, Howard R. Neuroleptic drugs in dementia: benefits and harm. Nat Rev Neurosci. 2006;7:492-500 (Class A evidence). (Pubitemid 44012289)
    • (2006) Nature Reviews Neuroscience , vol.7 , Issue.6 , pp. 492-500
    • Ballard, C.1    Howard, R.2
  • 28
    • 0025878224 scopus 로고
    • Neuroleptic drugs in the management of behavioral symptoms of Alzheimer's disease
    • Class C evidence
    • Tune LE, Steele C, Cooper T. Neuroleptic drugs in the management of behavioral symptoms of Alzheimer's disease. Psych Clinics North America. 1991;14:353-73 (Class C evidence).
    • (1991) Psych Clinics North America , vol.14 , pp. 353-373
    • Tune, L.E.1    Steele, C.2    Cooper, T.3
  • 29
    • 0034712552 scopus 로고    scopus 로고
    • QTc-interval abnormalities and psychotropic drug therapy in psychiatric patients
    • Reilly JG, Ayis SA, Ferrier IN, Jones SJ, Thomas SHL. QTc-interval abnormalities and psychotropic drug therapy in psychiatric patients. Lancet. 2000;355:1048-52 (Class C evidence). (Pubitemid 30162807)
    • (2000) Lancet , vol.355 , Issue.9209 , pp. 1048-1052
    • Reilly, J.G.1    Ayis, S.A.2    Ferrier, I.N.3    Jones, S.J.4    Thomas, S.H.L.5
  • 30
    • 38449111254 scopus 로고    scopus 로고
    • Antipsychotic medication dispensing and risk of death in veterans and war widows 65 years and older
    • Class C evidence
    • Hollis J, Grayson D, Forrester L, Brodaty H, Touyz S, Cumming R. Antipsychotic medication dispensing and risk of death in veterans and war widows 65 years and older. Am J Geriatric Psych 2007;932-41. (Class C evidence).
    • (2007) Am J Geriatric Psych. , pp. 932-941
    • Hollis, J.1    Grayson, D.2    Forrester, L.3    Brodaty, H.4    Touyz, S.5    Cumming, R.6
  • 32
    • 33644922637 scopus 로고    scopus 로고
    • Efficacy and adverse effects of atypical antipsychotics for dementia: Meta-analysis of randomized, placebo-controlled trials
    • Class A evidence
    • Schneider LS, Dagerman K, Insel PS. Efficacy and adverse effects of atypical antipsychotics for dementia: meta-analysis of randomized, placebo-controlled trials. Am J Geriatric Psych. 2006;14:191-210 (Class A evidence).
    • (2006) Am J Geriatric Psych. , vol.14 , pp. 191-210
    • Schneider, L.S.1    Dagerman, K.2    Insel, P.S.3
  • 33
    • 33847132248 scopus 로고    scopus 로고
    • Quetiapine to treat agitation in dementia: A randomized, double-blind, placebo-controlled study
    • DOI 10.2174/156720507779939805
    • Zhong KX, Tariot PN, Mintzer J, Minkwitz MC, Devine NA, et al. Quetiapine to treat agitation in dementia: a randomized double-blind placebo controlled study. Curr Alzheimer Res. 2007;4:81-93 (Class B evidence). (Pubitemid 46293886)
    • (2007) Current Alzheimer Research , vol.4 , Issue.1 , pp. 81-93
    • Zhong, K.X.1    Tariot, P.N.2    Mintzer, J.3    Minkwitz, M.C.4    Devine, N.A.5
  • 34
    • 37849034448 scopus 로고    scopus 로고
    • Aripiprazole for the treatment of psychoses in institutionalized patients with Alzheimer dementia: A multicenter, randomized, double-blind, placebo-controlled assessment of three fixed doses
    • Class B evidence
    • Mintzer JE, Tune LE, Breder CD, et al. Aripiprazole for the treatment of psychoses in institutionalized patients with Alzheimer dementia: a multicenter, randomized, double-blind, placebo-controlled assessment of three fixed doses. Am J Geriatric Psych. 2007;15:918-31 (Class B evidence).
    • (2007) Am J Geriatric Psych. , vol.15 , pp. 918-931
    • Mintzer, J.E.1    Tune, L.E.2    Breder, C.D.3
  • 35
    • 20244384575 scopus 로고    scopus 로고
    • Quetiapine and rivastigmine and cognitive decline in Alzheimer's disease: Randomized double blind placebo controlled trial
    • Class B evidence
    • Ballard C, Margallo-Lana M, Juszczak E, et al. Quetiapine and rivastigmine and cognitive decline in Alzheimer's disease: randomized double blind placebo controlled trial. BMJ. 2005;330:874 (Class B evidence).
    • (2005) BMJ , vol.330 , pp. 874
    • Ballard, C.1    Margallo-Lana, M.2    Juszczak, E.3
  • 36
    • 43249092442 scopus 로고    scopus 로고
    • Investigators DART AD. A randomized, blinded, placebo-controlled trial in dementia patients continuing or stopping neuroleptics (the DART-AD trial)
    • Class B evidence
    • Ballard C, Lana MM, Theodoulou M, et al. Investigators DART AD. A randomized, blinded, placebo-controlled trial in dementia patients continuing or stopping neuroleptics (the DART-AD trial). PLoS Medicine/Public Library of Science. 2008;5:76 (Class B evidence).
    • (2008) PLoS Medicine/Public Library of Science , vol.5 , pp. 76
    • Ballard, C.1    Lana, M.M.2    Theodoulou, M.3
  • 37
    • 33749618085 scopus 로고    scopus 로고
    • CATIE-AD Study Group. Effectiveness of atypical antipsychotic drugs in patients with Alzheimer's disease
    • Class B evidence
    • Schneider LS, Tariot PN, Dagerman KS, et al. CATIE-AD Study Group. Effectiveness of atypical antipsychotic drugs in patients with Alzheimer's disease. New Engl J Med. 2006;355:1525-3830 (Class B evidence).
    • (2006) New Engl J Med. , vol.355 , pp. 1525-3830
    • Schneider, L.S.1    Tariot, P.N.2    Dagerman, K.S.3
  • 38
    • 26844538114 scopus 로고    scopus 로고
    • Risk of death with atypical antipsychotic drug treatment for dementia: Meta-analysis of randomized placebo-controlled trials
    • DOI 10.1001/jama.294.15.1934
    • Schneider LS, Dagerman KS, Insel P. Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials. JAMA. 2005;294:1934-43 (Class A evidence). (Pubitemid 41464695)
    • (2005) Journal of the American Medical Association , vol.294 , Issue.15 , pp. 1934-1943
    • Schneider, L.S.1    Dagerman, K.S.2    Insel, P.3
  • 39
    • 58649100881 scopus 로고    scopus 로고
    • DARTAD investigators. The dementia antipsychotic withdrawal trial (DART-AD): Long-term follow-up of a randomized placebo-controlled trial
    • Class A evidence. This 12-month RCT with longer-term open follow-up demonstrated that the increased mortality risk associated with antipsychotics in people with Alzheimer's disease persists over longer periods of treatment
    • Ballard C, Hanney ML, Theodoulou M, et al. DARTAD investigators. The dementia antipsychotic withdrawal trial (DART-AD): long-term follow-up of a randomized placebo-controlled trial. Lancet Neurol. 2009;8:151-7. (Class A evidence). This 12-month RCT with longer-term open follow-up demonstrated that the increased mortality risk associated with antipsychotics in people with Alzheimer's disease persists over longer periods of treatment.
    • (2009) Lancet Neurol. , vol.8 , pp. 151-157
    • Ballard, C.1    Hanney, M.L.2    Theodoulou, M.3
  • 40
    • 67650888591 scopus 로고    scopus 로고
    • Délusion symptômes and réponse to antipsychotic treatment are associâtes with the 5-HT2A receptor polymorphism (102T/C) in Alzheimer's diseases: A 3-year follow-up longitudinal study
    • Class C evidence
    • Angelucci F, Bernadini S, Gravina P, et al. Délusion symptômes and réponse to antipsychotic treatment are associâtes with the 5-HT2A receptor polymorphism (102T/C) in Alzheimer's diseases: a 3-year follow-up longitudinal study. J Alzheim Dis. 2009;17:203-11 (Class C evidence).
    • (2009) J Alzheim Dis. , vol.17 , pp. 203-211
    • Angelucci, F.1    Bernadini, S.2    Gravina, P.3
  • 41
    • 73449086289 scopus 로고    scopus 로고
    • Serotonin transporter triallelic genotype and response to citalopram and risperidone in dementia with behavioral symptoms
    • Class B evidence
    • Dombrovski AY, Mulsant BH, Ferrell RE, et al. Serotonin transporter triallelic genotype and response to citalopram and risperidone in dementia with behavioral symptoms. Int Clin Psychopharmacol. 2010;25(1):37-45 (Class B evidence).
    • (2010) Int Clin Psychopharmacol. , vol.25 , Issue.1 , pp. 37-45
    • Dombrovski, A.Y.1    Mulsant, B.H.2    Ferrell, R.E.3
  • 42
    • 0037425565 scopus 로고    scopus 로고
    • Efficacy of cholinesterase inhibitors in the treatment of neuropsychiatric symptoms and functional impairment in Alzheimer disease: A meta-analysis
    • DOI 10.1001/jama.289.2.210
    • Trinh NH, Hoblyn J, Mohanty S, Yaffe K. Efficacy of cholinesterase inhibitors in the treatment of neuropsychiatric symptoms and functional impairment in Alzheimer disease: a meta-analysis. JAMA. 2003;289:210-6 (Class A evidence). (Pubitemid 36068709)
    • (2003) Journal of the American Medical Association , vol.289 , Issue.2 , pp. 210-216
    • Trinh, N.-H.1    Hoblyn, J.2    Mohanty, S.3    Yaffe, K.4
  • 46
    • 19144372322 scopus 로고    scopus 로고
    • Effects of memantine on behavioural symptoms in Alzheimer's disease patients: An analysis of the Neuropsychiatric Inventory (NPI) data of two randomised, controlled studies
    • DOI 10.1002/gps.1341
    • Gauthier S, Wirth Y, Mobius HJ. Effects of memantine on behavioural symptoms in Alzheimer's disease patients: an analysis of the Neuropsychiatric Inventory (NPI) data of two randomised, controlled studies. Int J Geriatr Psych. 2005;20:459-64 (Class B evidence). (Pubitemid 40716339)
    • (2005) International Journal of Geriatric Psychiatry , vol.20 , Issue.5 , pp. 459-464
    • Gauthier, S.1    Wirth, Y.2    Mobius, H.J.3
  • 48
    • 44249126470 scopus 로고    scopus 로고
    • Improvement in behavioural symptoms in patients with moderate to severe Alzheimer's disease by memantine: A pooled data analysis
    • DOI 10.1002/gps.1949
    • Gauthier S, Loft H, Cummings J. Improvement in behavioural symptoms in patients with moderate to severe Alzheimer's disease by memantine: a pooled data analysis. Int J Geriatr Psych. 2008;23:537-45 (Class B evidence). (Pubitemid 351722115)
    • (2008) International Journal of Geriatric Psychiatry , vol.23 , Issue.5 , pp. 537-545
    • Gauthier, S.1    Loft, H.2    Cummings, J.3
  • 49
    • 42249111378 scopus 로고    scopus 로고
    • Memantine for agitation/aggression and psychosis in moderately severe to severe Alzheimer's disease: A pooled analysis of 3 studies
    • Wilcock GK, Ballard CG, Cooper JA, Loft H. Memantine for agitation/aggression and psychosis in moderately severe to severe Alzheimer's disease: a pooled analysis of 3 studies. J Clin Psych. 2008;69:341-8 (Class B evidence). (Pubitemid 351549385)
    • (2008) Journal of Clinical Psychiatry , vol.69 , Issue.3 , pp. 341-348
    • Wilcock, G.K.1    Ballard, C.G.2    Cooper, J.A.3    Loft, H.4
  • 51
    • 38449107464 scopus 로고    scopus 로고
    • A doubleblind comparison of citalopram and risperidone for the treatment of behavioral and psychotic symptoms associated with dementia
    • Class B evidence
    • Pollock BG, Mulsant BH, Rosen J, et al. A doubleblind comparison of citalopram and risperidone for the treatment of behavioral and psychotic symptoms associated with dementia. Am J Geriatr Psych. 2007;15:942-52 (Class B evidence).
    • (2007) Am J Geriatr Psych. , vol.15 , pp. 942-952
    • Pollock, B.G.1    Mulsant, B.H.2    Rosen, J.3
  • 52
    • 0842325104 scopus 로고    scopus 로고
    • A randomized, placebo-controlled study of the efficacy and safety of sertraline in the treatment of the behavioral manifestations of Alzheimer's disease in outpatients treated with donepezil
    • DOI 10.1002/gps.998
    • Finkel SI, Mintzer JE, Dysken M, Krishnan KRR, Burt T, McRae T. A randomized, placebo-controlled study of the efficacy and safety of sertraline in the treatment of the behavioral manifestations of Alzheimer's disease in outpatients treated with donepezil. Int J Geriatr Psych. 2004;19:9-18 (Class B evidence). (Pubitemid 38180687)
    • (2004) International Journal of Geriatric Psychiatry , vol.19 , Issue.1 , pp. 9-18
    • Finkel, S.I.1    Mintzer, J.E.2    Dysken, M.3    Krishnan, K.R.R.4    Burt, T.5    McRae, T.6
  • 53
    • 0034649447 scopus 로고    scopus 로고
    • Treatment of agitation in AD: A randomized, placebo-controlled clinical trial
    • Class B evidence
    • Teri L, Logsdon RG, Peskind E, et al. Treatment of agitation in AD: a randomized, placebo-controlled clinical trial. Neurol. 2000;55:1271-8 (Class B evidence).
    • (2000) Neurol. , vol.55 , pp. 1271-1278
    • Teri, L.1    Logsdon, R.G.2    Peskind, E.3
  • 55
    • 84903152110 scopus 로고    scopus 로고
    • A pilot randomized trial of carbamazepine for behavioral symptoms in treatment-resistant outpatients with Alzheimer disease
    • DOI 10.1176/appi.ajgp.9.4.400
    • Olin JT, Fox LS, Pawluczyk S, Taggart NA, Schneider LS. A pilot randomized trial of carbamazepine for behavioral symptoms in treatment-resistant outpatients with Alzheimer disease. Am J Geriatr Psych. 2001;9:400-5 (Class B evidence). (Pubitemid 33015127)
    • (2001) American Journal of Geriatric Psychiatry , vol.9 , Issue.4 , pp. 400-405
    • Olin, J.T.1    Fox, L.S.2    Pawluczyk, S.3    Taggart, N.A.4    Schneider, L.S.5
  • 56
    • 68349084783 scopus 로고    scopus 로고
    • Management of agitation and aggression associated with Alzheimer disease
    • Class A evidence
    • Ballard CG, Gauthier S, Cummings JL, et al. Management of agitation and aggression associated with Alzheimer disease. Nat Rev Neurosci. 2009;5:245-55 (Class A evidence).
    • (2009) Nat Rev Neurosci. , vol.5 , pp. 245-255
    • Ballard, C.G.1    Gauthier, S.2    Cummings, J.L.3
  • 57
    • 38949131833 scopus 로고    scopus 로고
    • Anticonvulsants for the treatment of behavioral and psychological symptoms of dementia: A literature review
    • DOI 10.1017/S1041610207006540, PII S1041610207006540
    • Konovalov S, Muralee S, Tampi RR. Anticonvulsants for the treatment of behavioral and psychological symptoms of dementia: a literature review. Int Psychogeriatr. 2008;20:293-308 (Class A evidence). (Pubitemid 351230232)
    • (2008) International Psychogeriatrics , vol.20 , Issue.2 , pp. 293-308
    • Konovalov, S.1    Muralee, S.2    Tampi, R.R.3
  • 58
    • 0033668441 scopus 로고    scopus 로고
    • Delusions associated with elevated muscarinic binding in dementia with Lewy bodies
    • Ballard C, Piggott M, Johnson M, et al. Delusions associated with elevated muscarinic binding in dementia with Lewy bodies. Annals of Neurol. 2000;48:868-76.
    • (2000) Annals of Neurol. , vol.48 , pp. 868-876
    • Ballard, C.1    Piggott, M.2    Johnson, M.3
  • 60
    • 34447118214 scopus 로고    scopus 로고
    • Aggressive behavior and neuroleptic medication are associated with increased number of alpha1-adrenoceptors in patients with Alzheimer disease
    • Sharp SI, Ballard CG, Chen CP, Francis PT. Aggressive behavior and neuroleptic medication are associated with increased number of alpha1-adrenoceptors in patients with Alzheimer disease. Am J Geriatric Psych. 2007;15:435-7.
    • (2007) Am J Geriatric Psych. , vol.15 , pp. 435-437
    • Sharp, S.I.1    Ballard, C.G.2    Chen, C.P.3    Francis, P.T.4
  • 61
    • 69449092485 scopus 로고    scopus 로고
    • Prazosin for the treatment of behavioral symptoms in patients with Alzheimer disease with agitation and aggression
    • Class B evidence. This small but interesting preliminary RCT highlights prazosin as a potential novel treatment for BPSD
    • Wang LY, Shofer JB, Rohde K, et al. Prazosin for the treatment of behavioral symptoms in patients with Alzheimer disease with agitation and aggression. Am J Geriatr Psychiatr. 2009;17:744-51. (Class B evidence). This small but interesting preliminary RCT highlights prazosin as a potential novel treatment for BPSD.
    • (2009) Am J Geriatr Psychiatr. , vol.17 , pp. 744-751
    • Wang, L.Y.1    Shofer, J.B.2    Rohde, K.3
  • 62
    • 84862785718 scopus 로고    scopus 로고
    • Accessed 30 Nov. 2011
    • www.alzheimers.org.uk/bpsdguide. Accessed 30 Nov. 2011.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.