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Volumn 17, Issue 1, 2014, Pages 22-29

Emerging approaches to target tumor metabolism

Author keywords

[No Author keywords available]

Indexed keywords

AG 221; AGI 5198; AGI 6780; ANTINEOPLASTIC AGENT; AZD 3965; CB 839; ISOCITRATE DEHYDROGENASE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; LACTATE DEHYDROGENASE; MONOCARBOXYLATE TRANSPORTER; UNCLASSIFIED DRUG; TUMOR MARKER;

EID: 84904599432     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2014.07.001     Document Type: Review
Times cited : (19)

References (65)
  • 1
    • 79953158399 scopus 로고    scopus 로고
    • Exploring the genomes of cancer cells: Progress and promise
    • M.R. Stratton Exploring the genomes of cancer cells: progress and promise Science 331 2011 1553 1558
    • (2011) Science , vol.331 , pp. 1553-1558
    • Stratton, M.R.1
  • 2
    • 84875758730 scopus 로고    scopus 로고
    • Lessons from the cancer genome
    • L.A. Garraway, and E.S. Lander Lessons from the cancer genome Cell 153 2013 17 37
    • (2013) Cell , vol.153 , pp. 17-37
    • Garraway, L.A.1    Lander, E.S.2
  • 4
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • J.G. Paez, P.A. Jänne, and J.C. Lee et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy Science 304 2004 1497 2004
    • (2004) Science , vol.304 , pp. 1497-2004
    • Paez, J.G.1    Jänne, P.A.2    Lee, J.C.3
  • 5
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • P.B. Chapman, A. Hauschild, and C. Robert et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation N Engl J Med 364 2011 2507 2516
    • (2011) N Engl J Med , vol.364 , pp. 2507-2516
    • Chapman, P.B.1    Hauschild, A.2    Robert, C.3
  • 6
    • 80053386829 scopus 로고    scopus 로고
    • Effect of crizotinib on overall survival in patients with advanced non-small-cell lung caner harbouring ALK gene rearrangement: A retrospective analysis
    • A.T. Shaw, B.Y. Yeap, and B.J. Solomon et al. Effect of crizotinib on overall survival in patients with advanced non-small-cell lung caner harbouring ALK gene rearrangement: a retrospective analysis Lancet Oncol 12 2011 1004 1012
    • (2011) Lancet Oncol , vol.12 , pp. 1004-1012
    • Shaw, A.T.1    Yeap, B.Y.2    Solomon, B.J.3
  • 7
    • 84885957225 scopus 로고    scopus 로고
    • Genome-based cancer therapeutics: Targets, kinase drug resistance and future strategies for precision oncology
    • P. Workman, B. Al-Lazikani, and P.A. Clarke Genome-based cancer therapeutics: targets, kinase drug resistance and future strategies for precision oncology Curr Opin Pharmacol 13 2013 486 496
    • (2013) Curr Opin Pharmacol , vol.13 , pp. 486-496
    • Workman, P.1    Al-Lazikani, B.2    Clarke, P.A.3
  • 8
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 2011 646 674
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 11
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • D.W. Parsons, S. Jones, and X. Zhang et al. An integrated genomic analysis of human glioblastoma multiforme Science 321 2008 1807 1812
    • (2008) Science , vol.321 , pp. 1807-1812
    • Parsons, D.W.1    Jones, S.2    Zhang, X.3
  • 12
    • 60849115270 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations in gliomas
    • H. Yan, D.W. Parsons, and G. Jin et al. IDH1 and IDH2 mutations in gliomas N Engl J Med 360 2009 765 773
    • (2009) N Engl J Med , vol.360 , pp. 765-773
    • Yan, H.1    Parsons, D.W.2    Jin, G.3
  • 13
    • 70149093912 scopus 로고    scopus 로고
    • Recurring mutations found by sequencing an acute myeloid leukemia genome
    • E.R. Mardis, L. Ding, and D.J. Dooling et al. Recurring mutations found by sequencing an acute myeloid leukemia genome N Engl J Med 361 2009 1058 1066
    • (2009) N Engl J Med , vol.361 , pp. 1058-1066
    • Mardis, E.R.1    Ding, L.2    Dooling, D.J.3
  • 14
    • 72049125350 scopus 로고    scopus 로고
    • Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
    • L. Dang, D.W. White, and S. Gross et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate Nature 462 2009 739 744
    • (2009) Nature , vol.462 , pp. 739-744
    • Dang, L.1    White, D.W.2    Gross, S.3
  • 15
    • 77649305610 scopus 로고    scopus 로고
    • The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
    • P.S. Ward, J. Patel, and D.R. Wise et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate Cancer Cell 17 2010 225 234
    • (2010) Cancer Cell , vol.17 , pp. 225-234
    • Ward, P.S.1    Patel, J.2    Wise, D.R.3
  • 16
    • 78650019179 scopus 로고    scopus 로고
    • Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
    • M.E. Figueroa, O. Abdel-Wahab, and C. Lu et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation Cancer Cell 18 2010 553 567
    • (2010) Cancer Cell , vol.18 , pp. 553-567
    • Figueroa, M.E.1    Abdel-Wahab, O.2    Lu, C.3
  • 17
    • 84858796262 scopus 로고    scopus 로고
    • IDH mutations impair histone demethylation and results in a block to cell differentiation
    • C. Lu, P.S. Ward, and G.S. Kapoor et al. IDH mutations impair histone demethylation and results in a block to cell differentiation Nature 483 2012 474 478
    • (2012) Nature , vol.483 , pp. 474-478
    • Lu, C.1    Ward, P.S.2    Kapoor, G.S.3
  • 18
    • 78651463452 scopus 로고    scopus 로고
    • Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases
    • W. Xu, H. Yang, and Y. Liu et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases Cancer Cell 19 2011 17 30
    • (2011) Cancer Cell , vol.19 , pp. 17-30
    • Xu, W.1    Yang, H.2    Liu, Y.3
  • 19
    • 84877620952 scopus 로고    scopus 로고
    • Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation
    • F. Wang, J. Travins, and B. DeLaBarre et al. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation Science 340 2013 622 626
    • (2013) Science , vol.340 , pp. 622-626
    • Wang, F.1    Travins, J.2    Delabarre, B.3
  • 20
    • 84877632013 scopus 로고    scopus 로고
    • An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells
    • D. Rohle, J. Popovici-Muller, and N. Palaskas et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells Science 340 2013 626 630
    • (2013) Science , vol.340 , pp. 626-630
    • Rohle, D.1    Popovici-Muller, J.2    Palaskas, N.3
  • 21
    • 84875496294 scopus 로고    scopus 로고
    • (R)-2-Hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible
    • J.-A. Losman, R.E. Looper, and P. Koivunen et al. (R)-2-Hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible Science 339 2013 1621 1625
    • (2013) Science , vol.339 , pp. 1621-1625
    • Losman, J.-A.1    Looper, R.E.2    Koivunen, P.3
  • 23
    • 70350728803 scopus 로고    scopus 로고
    • MYC-induced cancer cell energy metabolism and therapeutic opportunities
    • C.V. Dang, A. Le, and P. Gao MYC-induced cancer cell energy metabolism and therapeutic opportunities Clin Cancer Res 15 2009 6479 6483
    • (2009) Clin Cancer Res , vol.15 , pp. 6479-6483
    • Dang, C.V.1    Le, A.2    Gao, P.3
  • 24
    • 56749184298 scopus 로고    scopus 로고
    • Reflecting on 25 years with MYC
    • N. Meyer, and L.Z. Penn Reflecting on 25 years with MYC Nat Rev Cancer 8 2008 976 990
    • (2008) Nat Rev Cancer , vol.8 , pp. 976-990
    • Meyer, N.1    Penn, L.Z.2
  • 25
    • 84892623549 scopus 로고    scopus 로고
    • MYC-driven aggressive B-cell lymphomas: Pathogenesis and classification
    • G. Ott, A. Rosenwald, and E. Campo MYC-driven aggressive B-cell lymphomas: pathogenesis and classification Blood 122 2013 3884 3891
    • (2013) Blood , vol.122 , pp. 3884-3891
    • Ott, G.1    Rosenwald, A.2    Campo, E.3
  • 26
    • 84902661182 scopus 로고    scopus 로고
    • The N-Myc oncogene: Maximizing its targets, regulation, and therapeutic potential
    • H. Beltran The N-Myc oncogene: maximizing its targets, regulation, and therapeutic potential Mol Cancer Res 12 2014 815 822
    • (2014) Mol Cancer Res , vol.12 , pp. 815-822
    • Beltran, H.1
  • 27
    • 84862984571 scopus 로고    scopus 로고
    • Finding cancer's weakest link
    • N.M. Sodire, and G.I. Evan Finding cancer's weakest link Oncotarget 2 2011 1307 1313
    • (2011) Oncotarget , vol.2 , pp. 1307-1313
    • Sodire, N.M.1    Evan, G.I.2
  • 34
    • 0029087937 scopus 로고
    • Evidence from transgenic mice that myc regulates hepatic glycolysis
    • A. Valera, A. Pujol, X. Gregori, E. Riu, J. Visa, and F. Bosch Evidence from transgenic mice that myc regulates hepatic glycolysis FASEB J 9 1995 1067 1078
    • (1995) FASEB J , vol.9 , pp. 1067-1078
    • Valera, A.1    Pujol, A.2    Gregori, X.3    Riu, E.4    Visa, J.5    Bosch, F.6
  • 35
    • 33744783432 scopus 로고    scopus 로고
    • Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
    • DOI 10.1016/j.ccr.2006.04.023, PII S1535610806001450
    • V.R. Fantin, J. St-Pierre, and P. Leder Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance Cancer Cell 9 2006 425 434 (Pubitemid 43832190)
    • (2006) Cancer Cell , vol.9 , Issue.6 , pp. 425-434
    • Fantin, V.R.1    St-Pierre, J.2    Leder, P.3
  • 41
    • 84883182637 scopus 로고    scopus 로고
    • Disrupting proton dynamics and energy metabolism for cancer therapy
    • S.K. Parks, J. Chiche, and J. Pouysségur Disrupting proton dynamics and energy metabolism for cancer therapy Nat Rev Cancer 13 2013 611 623
    • (2013) Nat Rev Cancer , vol.13 , pp. 611-623
    • Parks, S.K.1    Chiche, J.2    Pouysségur, J.3
  • 42
    • 74349094033 scopus 로고    scopus 로고
    • AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10
    • M.J. Ovens, A.J. Davie, M.C. Wilson, C.M. Murray, and A.P. Halestrap AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10 Biochem J 425 2010 523 530
    • (2010) Biochem J , vol.425 , pp. 523-530
    • Ovens, M.J.1    Davie, A.J.2    Wilson, M.C.3    Murray, C.M.4    Halestrap, A.P.5
  • 49
    • 84866894408 scopus 로고    scopus 로고
    • Comprehensive genomic characterization of squamous cell lung cancers
    • The Cancer Genome Atlas Research Network
    • The Cancer Genome Atlas Research Network Comprehensive genomic characterization of squamous cell lung cancers Nature 489 2012 519 525
    • (2012) Nature , vol.489 , pp. 519-525
  • 53
    • 84878572136 scopus 로고    scopus 로고
    • Toward clinical application of the Keap1-Nrf2 pathway
    • T. Suzuki, H. Motohashi, and M. Yamamoto Toward clinical application of the Keap1-Nrf2 pathway Trends Pharmacol Sci 34 2013 340 346
    • (2013) Trends Pharmacol Sci , vol.34 , pp. 340-346
    • Suzuki, T.1    Motohashi, H.2    Yamamoto, M.3
  • 54
    • 84875740314 scopus 로고    scopus 로고
    • Integrative analysis of complex cancer genomics and clinical profiles using cBioPortal
    • G.J. Aksoy, U. Dogrusoz, and G. Dresdner et al. Integrative analysis of complex cancer genomics and clinical profiles using cBioPortal Sci Signal 6 2013 1
    • (2013) Sci Signal , vol.6 , pp. 1
    • Aksoy, G.J.1    Dogrusoz, U.2    Dresdner, G.3
  • 55
    • 84880967722 scopus 로고    scopus 로고
    • Integrated molecular analysis of clear-cell renal cell carcinoma
    • Y. Sato, T. Yoshizato, and Y. Shiraishi et al. Integrated molecular analysis of clear-cell renal cell carcinoma Nat Genet 45 2013 860 867
    • (2013) Nat Genet , vol.45 , pp. 860-867
    • Sato, Y.1    Yoshizato, T.2    Shiraishi, Y.3
  • 56
    • 84862786878 scopus 로고    scopus 로고
    • Somatic mutations of the KEAP1 gene in common solid cancers
    • N.J. Yoo, H.R. Kim, and Y.R. Kim et al. Somatic mutations of the KEAP1 gene in common solid cancers Histopathology 60 2012 943 952
    • (2012) Histopathology , vol.60 , pp. 943-952
    • Yoo, N.J.1    Kim, H.R.2    Kim, Y.R.3
  • 57
    • 84863764614 scopus 로고    scopus 로고
    • Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming
    • Y. Mitsuishi, K. Taguchi, and Y. Kawatini et al. Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming Cancer Cell 22 2012 66 79
    • (2012) Cancer Cell , vol.22 , pp. 66-79
    • Mitsuishi, Y.1    Taguchi, K.2    Kawatini, Y.3
  • 58
    • 54249087596 scopus 로고    scopus 로고
    • RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy
    • A. Singh, S. Boldin-Adamsky, and R.K. Thimmulappa et al. RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy Cancer Res 68 2008 7975 7984
    • (2008) Cancer Res , vol.68 , pp. 7975-7984
    • Singh, A.1    Boldin-Adamsky, S.2    Thimmulappa, R.K.3
  • 59
    • 63549121490 scopus 로고    scopus 로고
    • NRF2 and KEAP1 mutations: Permanent activation of an adaptive response in cancer
    • J.D. Hayes, and M. McMahon NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer Trends Biochem Sci 34 2009 176 188
    • (2009) Trends Biochem Sci , vol.34 , pp. 176-188
    • Hayes, J.D.1    McMahon, M.2
  • 60
    • 66149168685 scopus 로고    scopus 로고
    • Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer
    • S. Homma, Y. Ishii, and Y. Morishima et al. Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer Clin Cancer Res 15 2009 3423 3432
    • (2009) Clin Cancer Res , vol.15 , pp. 3423-3432
    • Homma, S.1    Ishii, Y.2    Morishima, Y.3
  • 61
    • 84856756216 scopus 로고    scopus 로고
    • Nrf2 knockdown by shRNA inhibits tumour growth and increases efficacy of chemotherapy in cervical cancer
    • X. Ma, J. Zhang, and S. Liu et al. Nrf2 knockdown by shRNA inhibits tumour growth and increases efficacy of chemotherapy in cervical cancer Cancer Chemother Pharmacol 69 2012 485 494
    • (2012) Cancer Chemother Pharmacol , vol.69 , pp. 485-494
    • Ma, X.1    Zhang, J.2    Liu, S.3
  • 62
    • 84885944468 scopus 로고    scopus 로고
    • The emerging role of the Nrf2-Keap1 signaling pathway in cancer
    • M.C. Jaramillo, and D.D. Zhang The emerging role of the Nrf2-Keap1 signaling pathway in cancer Genes Dev 27 2013 2179 2191
    • (2013) Genes Dev , vol.27 , pp. 2179-2191
    • Jaramillo, M.C.1    Zhang, D.D.2
  • 63
    • 82755161958 scopus 로고    scopus 로고
    • Silencing disease genes in the laboratory and the clinic
    • J.K. Watts, and D.R. Corey Silencing disease genes in the laboratory and the clinic J Pathol 226 2012 365 379
    • (2012) J Pathol , vol.226 , pp. 365-379
    • Watts, J.K.1    Corey, D.R.2
  • 64
    • 84856389509 scopus 로고    scopus 로고
    • RNA-based therapeutics: Current progress and future prospects
    • J.C. Burnett, and J.J. Rossi RNA-based therapeutics: current progress and future prospects Chem Biol 19 2012 60 71
    • (2012) Chem Biol , vol.19 , pp. 60-71
    • Burnett, J.C.1    Rossi, J.J.2


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