The role of invariant NKT cells in organ-specific autoimmunity

Frontiers in Bioscience - Landmark

Volumn 19, Issue 8, 2014, Pages 1240-1250

  Di Pietro, Caterina ^a   Falcone, Marika ^a  

^a Diabetes Research Institute   (Italy)

Author keywords

Autoimmune diseases; Cytokines; Dendritic cells; Immune tolerance; Natural killer T cells; Review

Indexed keywords

CYTOKINE;

AUTOIMMUNE DISEASE; AUTOIMMUNITY; DENDRITIC CELL; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; NATURAL KILLER T CELL; REGULATORY T LYMPHOCYTE;

AUTOIMMUNE DISEASES; AUTOIMMUNITY; CYTOKINES; DENDRITIC CELLS; HUMANS; IMMUNE TOLERANCE; NATURAL KILLER T-CELLS; T-LYMPHOCYTES, REGULATORY;

EID: 84904559470     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/4279     Document Type: Article

References (74)

1. K. H. Sonoda, M. Exley, S. Snapper, S. P. Balk & J. Stein-Streilein: CD1-reactive natural killer T cells are required for development of systemic tolerance through an immune-privileged site. J Exp Med 190, 1215-1226 (1999)
2. M. Brigl, L. Bry, S. C. Kent, J. E. Gumperz & M. B. Brenner: Mechanism of CD1d-restricted natural killer T cell activation during microbial infection. Nat Immunol 4, 1230-1237 (2003) (Pubitemid 37540692)
3. E. E. Nieuwenhuis, T. Matsumoto, M. Exley, R. A. Schleipman, J. Glickman, D. T. Bailey, N. Corazza, S. P. Colgan, A. B. Onderdonk, R. S. Blumberg: CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung. Nat Med 8, 588-593 (2002) (Pubitemid 34633436)
4. C. Ronet, S. Darche, M. Leite de Moraes, S. Miyake, T. Yamamura, J. A. Louis, L. H. Kasper, D. Buzoni-GaTel: NKT cells are critical for the initiation of an inflammatory bowel response against Toxoplasma gondii. J Immunol 175, 899-908 (2005) (Pubitemid 41094973)
5. N. Y. Crowe, J. M. Coquet, S. P. Berzins, K. Kyparissoudis, R. Keating, D. G. Pellicci, Y. Hayakawa, D. I. Godfrey, M. J. Smyth: Differential antitumor immunity mediated by NKT cell subsets in vivo. J Exp Med 202, 1279-1288 (2005) (Pubitemid 41586958)
6. D. I. Godfrey & M. Kronenberg: Going both ways: immune regulation via CD1d-dependent NKT cells. J Clin Invest 114, 1379-1388 (2004) (Pubitemid 40385565)
7. K. Shimizu, A. Goto, M. Fukui, M. Taniguchi & S. Fujii: Tumor cells loaded with alpha-galactosylceramide induce innate NKT and NK cell-dependent resistance to tumor implantation in mice. J Immunol 178, 2853-2861 (2007) (Pubitemid 46333163)
8. L. Wu, V. V. Parekh, C. L. Gabriel, D. P. Bracy, P. A. Marks-Shulman, R. A. Tamboli, S. Kim, Y. V. Mendez-Fernandez, G. S. Besra, J. P. Lomenick, B. Williams, D. H. Wasserman, L. Van Kaer: Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice. Proc Natl Acad Sci U S A 109, E1143-1152 (2012)
9. L. Van Kaer, V. V. Parekh, & L. Wu: Invariant natural killer T cells as sensors and managers of inflammation. Trends Immunol 34, 50-58 (2013)
10. H. Kitamura, K. Iwakabe, T. Yahata, S. Nishimura, A. Ohta, Y. Ohmi, M. Sato, K. Takeda, K. Okumura, L. Van Kaer, T. Kawano, M. Taniguchi, T. Nishimura: The natural killer T (NKT) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells. J Exp Med 189, 1121-1128 (1999)
11. Y. F. Yang, M. Tomura, S. Ono, T. Hamaoka & H. Fujiwara: Requirement for IFN-gamma in IL-12 production induced by collaboration between v (alpha) 14 (+) NKT cells and antigen-presenting cells. Int Immunol 12, 1669-1675 (2000) (Pubitemid 32007723)
12. M. Tomura, W. G. Yu, H. J. Ahn, M. Yamashita, Y. F. Yang, S. Ono, T. Hamaoka, T. Kawano, M. Taniguchi, Y. Koezuka, H. Fujiwara. A novel function of Valpha14+CD4+NKT cells: stimulation of IL-12 production by antigen-presenting cells in the innate immune system. J Immunol 163, 93-101 (1999) (Pubitemid 29295829)
13. M. Falcone, B. Yeung, L. Tucker, E. Rodriguez & N. Sarvetnick: A defect in interleukin 12-induced activation and interferon gamma secretion of peripheral natural killer T cells in nonobese diabetic mice suggests new pathogenic mechanisms for insulin-dependent diabetes mellitus. J Exp Med 190, 963-972 (1999) (Pubitemid 29480825)
14. L. S. Metelitsa, O. V. Naidenko, A. Kant, H. W. Wu, M. J. Loza, B. Perussia, M. Kronenberg, R. C. Seeger: Human NKT cells mediate antitumor cytotoxicity directly by recognizing target cell CD1d with bound ligand or indirectly by producing IL-2 to activate NK cells. J Immunol 167, 3114-3122 (2001) (Pubitemid 32852549)
15. M. Brigl, R. V. Tatituri, G. F Watts, V. Bhowruth, E. A. Leadbetter, N. Barton, N. R. Cohen, F. F. Hsu, G. S. Besra, M. B. Brenner: Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection. J Exp Med 208, 1163-1177 (2011)
16. C. Paget, T. Mallevaey, A. O. Speak, D. Torres, J. Fontaine, K. C. Sheehan, M. Capron, B. Ryffel, C. Faveeuw, M. Leite de Moraes, F. Platt, F. Trottein: Activation of invariant NKT cells by toll-like receptor 9-stimulated dendritic cells requires type I interferon and charged glycosphingolipids. Immunity 27, 597-609 (2007) (Pubitemid 47628833)
17. T. Selvanantham, N. K. Escalante, M. Cruz Tleugabulova, S. Fiévé, S. E. Girardin, D. J. Philpott, T. Mallevaey: Nod1 and Nod2 enhance TLR-mediated invariant NKT cell activation during bacterial infection. J Immunol 191, 5646-5654 (2013)
18. M. Kronenberg & Y. Kinjo: Innate-like recognition of microbes by invariant natural killer T cells. Curr Opin Immunol 21, 391-396 (2009)
19. D. Zhou, J. Mattner, C. Cantu 3rd, N. Schrantz, N. Yin, Y. Gao, Y. Sagiv, K. Hudspeth, Y. P. Wu, T. Yamashita, S. Teneberg, D. Wang, R. L. Proia, S. B. Levery, P. B. Savage, L. Teyton, A. Bendelac: Lysosomal glycosphingolipid recognition by NKT cells. Science 306, 1786-1789 (2004) (Pubitemid 39601398)
20. T. Plati, I. Visigalli, A. Capotondo, M. Buono, L. Naldini, M. P. Cosma, A. Biffi: Development and maturation of invariant NKT cells in the presence of lysosomal engulfment. Eur J Immunol 39, 2748-2754 (2009)
21. B. Wei, G. Wingender, D. Fujiwara, D. Y. Chen, M. McPherson, S. Brewer, J. Borneman, M. Kronenberg, J. Braun: Commensal microbiota and CD8+ T cells shape the formation of invariant NKT cells. J Immunol 184, 1218-1226 (2010)
22. Y. Kinjo, D. Wu, G. Kim, G. W. Xing, M. A. Poles, D. D. Ho, M. Tsuji, K. Kawahara, C. H. Wong, M. Kronenberg: Recognition of bacterial glycosphingolipids by natural killer T cells. Nature 434, 520-525 (2005) (Pubitemid 40477061)
23. Y. Kinjo, E. Tupin, D. Wu, M. Fujio, R. Garcia-Navarro, M. R. Benhnia, D. M. Zajonc, G. Ben-Menachem, G. D. Ainge, G. F. Painter, A. Khurana, K. Hoebe, S. M. Behar, B. Beutler, I. A. Wilson, M. Tsuji, T. J. Sellati, C. H. Wong, M. Kronenberg: Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria. Nat Immunol 7, 978-986 (2006) (Pubitemid 44263912)
24. Y. Kinjo, P. Illarionov, J. L. Vela, B. Pei, E. Girardi, X. Li, Y. Li, M. Imamura, Y. Kaneko, A. Okawara, Y. Miyazaki, A. Gómez-Velasco, P. Rogers, S. Dahesh, S. Uchiyama, A. Khurana, K. Kawahara, H. Yesilkaya, P. W. Andrew, C. H. Wong, K. Kawakami, V. Nizet, G. S. Besra, M. Tsuji, D. M. Zajonc, M. Kronenberg: Invariant natural killer T cells recognize glycolipids from pathogenic Grampositive bacteria. Nat Immunol 12, 966-974 (2011)
25. M. Taniguchi, M. Harada, S. Kojo, T. Nakayama & H. Wakao: The regulatory role of Valpha14 NKT cells in innate and acquired immune response. Annu Rev Immunol 21, 483-513 (2003) (Pubitemid 37174539)
26. S. Fujii, K. Liu, C. Smith, A. J. Bonito, R. M. & Steinman: The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation. J Exp Med 199, 1607-1618 (2004) (Pubitemid 38821994)
27. D. V. Baev, S. Caielli, F. Ronchi, M. Coccia, F. Facciotti, K. E. Nichols, M. Falcone: Impaired SLAMSLAM homotypic interaction between invariant NKT cells and dendritic cells affects differentiation of IL-4/IL-10-secreting NKT2 cells in nonobese diabetic mice. J Immunol 181, 869-877 (2008)
28. D. Ly, Q. S. Mi, S. Hussain & T. L. Delovitch: Protection from type 1 diabetes by invariant NK T cells requires the activity of CD4+CD25+ regulatory T cells. J Immunol 177, 3695-3704 (2006) (Pubitemid 44359901)
29. R. Liu, A. La Cava, X. F. Bai, Y. Jee, M. Price, D. I. Campagnolo, P. Christadoss, T. L. Vollmer, L. Van Kaer, F. D. Shi: Cooperation of invariant NKT cells and CD4+CD25+ T regulatory cells in the prevention of autoimmune myasthenia. J Immunol 175, 7898-7904 (2005) (Pubitemid 41798350)
30. J. M. Coquet, S. Chakravarti, K. Kyparissoudis, F. W. McNab, L. A. Pitt, B. S. McKenzie, S. P. Berzins, M. J. Smyth, D. I. Godfrey: Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1.-NKT cell population. Proc Natl Acad Sci U S A 105, 11287-11292 (2008)
31. A. V. Rachitskaya, A. M. Hansen, R. Horai, Z. Li, R. Villasmil, D. Luger, R. B. Nussenblatt, R. R. Caspi: Cutting edge: NKT cells constitutively express IL-23 receptor and RORgammat and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion. J Immunol 180, 5167-5171 (2008)
32. M. L. Michel, D. Mendes-da-Cruz, A. C. Keller, M. Lochner, E. Schneider, M. Dy, G. Eberl, M. C. Leite-de-Moraes: Critical role of ROR-gammat in a new thymic pathway leading to IL-17-producing invariant NKT cell differentiation. Proc Natl Acad Sci U S A 105, 19845-19850 (2008)
33. Y. Simoni, A. S. Gautron, L. Beaudoin, L. C. Bui, M. L. Michel, X. Coumoul, G. Eberl, M. Leite-de-Moraes, A. Lehuen: NOD mice contain an elevated frequency of iNKT17 cells that exacerbate diabetes. Eur J Immunol 41, 3574-3585 (2011)
34. P. Dellabona, E. Padovan, G. Casorati, M. Brockhaus & A. Lanzavecchia: An invariant V alpha 24-J alpha Q/V beta 11 T cell receptor is expressed in all individuals by clonally expanded CD4-8-T cells. J Exp Med 180, 1171-1176 (1994)
35. T. Yoshimoto & W. E. Paul: CD4pos, NK1.1.pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J Exp Med 179, 1285-1295 (1994)
36. K. Miyamoto, S. Miyake & T. Yamamura: A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells. Nature 413, 531-534 (2001) (Pubitemid 32938752)
37. A. K. Singh, M. T. Wilson, S. Hong, D. Olivares-Villagómez, C. Du, A. K. Stanic, S. Joyce, S. Sriram, Y. Koezuka, L. Van Kaer: Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis. J Exp Med 194, 1801-1811 (2001) (Pubitemid 34028659)
38. S. Hong, M. T. Wilson, I. Serizawa, L. Wu, N. Singh, O. V. Naidenko, T. Miura, T. Haba, D. C. Scherer, J. Wei, M. Kronenberg, Y. Koezuka, L. Van Kaer: The natural killer Tcell ligand alpha-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice. Nat Med 7, 1052-1056 (2001) (Pubitemid 32937387)
39. S. Sharif, G. A. Arreaza, P. Zucker, Q. S. Mi, J. Sondhi, O. V. Naidenko, M. Kronenberg, Y. Koezuka, T. L. Delovitch, J. M. Gombert, M. Leite-De-Moraes, C. Gouarin, R. Zhu, A. Hameg, T. Nakayama, M. Taniguchi, F. Lepault, A. Lehuen, J. F. Bach, A. Herbelin: Activation of natural killer T cells by alpha-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes. Nat Med 7, 1057-1062 (2001) (Pubitemid 32937388)
40. S. Kojo, Y. Adachi, H. Keino, M. Taniguchi & T. Sumida: Dysfunction of T cell receptor aV24aJ18+, BV11+ double-negative regulatory natural killer T cells in autoimmune diseases. Arthritis Rheum 44, 1127-1138 (2001) (Pubitemid 32433619)
41. S. Kaieda, C. Tomi, S. Oki, T. Yamamura & S. Miyake: Activation of invariant natural killer T cells by synthetic glycolipid ligands suppresses autoantibody-induced arthritis. Arthritis Rheum 56, 1836-1845 (2007) (Pubitemid 47110383)
42. S. B. Wilson, S. C. Kent, K. T. Patton, T. Orban, R. A. Jackson, M. Exley, S. A. Porcelli, D. A. Schatz, M. A. Atkinson, S. P. Balk: Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes. Nature 391, 177-181 (1998) (Pubitemid 28092476)
43. S. B. Wilson, S. C. Kent, H. F. Horton, A. A. Hill, P. L. Bollyky, D. A. Hafler, J. L. Strominger, M. C. Byrne: Multiple differences in gene expression in regulatory Valpha 24Jalpha Q T cells from identical twins discordant for type I diabetes. Proc Natl Acad Sci U S A 97, 7411-7416 (2000) (Pubitemid 30431477)
44. A. Kukreja, G. Cost, J. Marker, C. Zhang, Z. Sun, K. Lin-Su, S. Ten, M. Sanz, M. Exley, B. Wilson, S. Porcelli, N. Maclaren: Multiple immuno-regulatory defects in type-1 diabetes. J Clin Invest 109, 131-140 (2002) (Pubitemid 34052549)
45. Z. Illes, T. Kondo, J. Newcombe, N. Oka, T. Tabira, T. Yamamura: Differential expression of NK T cell V alpha 24J alpha Q invariant TCR chain in the lesions of multiple sclerosis and chronic inflammatory demyelinating polyneuropathy. J Immunol 164, 4375-4381 (2000) (Pubitemid 30215101)
46. R. Gausling, C. Trollmo & D. A. Hafler: Decreases in interleukin-4 secretion by invariant CD4 (-) CD8 (-) V alpha 24J alpha Q T cells in peripheral blood of patients with relapsing-remitting multiple sclerosis. Clin Immunol 98, 11-17 (2001)
47. H. J. van der Vliet, B. M. von Blomberg, N. Nishi, M. Reijm, A. E. Voskuyl, A. A. van Bodegraven, C. H. Polman, T. Rustemeyer, P. Lips, A. J. van den Eertwegh, G. Giaccone, R. J. Scheper, H. M. Pinedo: Circulating V (alpha24+) Vbeta11+ NKT cell numbers are decreased in a wide variety of diseases that are characterized by autoreactive tissue damage. Clin Immunol 100, 144-148 (2001)
48. S. H. Yang, J. Z. Jin, S. H. Lee, H. Park, C. H. Kim, D. S. Lee, S. Kim, N. H. Chung, Y. S. Kim: Role of NKT cells in allogeneic islet graft survival. Clin Immunol 124, 258-266 (2007) (Pubitemid 47247615)
49. Y. Ikehara, Y. Yasunami, S. Kodama, T. Maki, M. Nakano, T. Nakayama, M. Taniguchi, S. Ikeda: CD4 (+) Valpha14 natural killer T cells are essential for acceptance of rat islet xenografts in mice. J Clin Invest 105, 1761-1767 (2000) (Pubitemid 30421757)
50. K. I. Seino, K. Fukao, K. Muramoto, K. Yanagisawa, Y. Takada, S. Kakuta, Y. Iwakura, L. Van Kaer, K. Takeda, T. Nakayama, M. Taniguchi, H. Bashuda, H. Yagita, K. Okumura: Requirement for natural killer T (NKT) cells in the induction of allograft tolerance. Proc Natl Acad Sci U S A 98, 2577-2581 (2001) (Pubitemid 32209524)
51. T. Yoshimoto, A. Bendelac, J. Hu-Li & W. E. Paul: Defective IgE production by SJL mice is linked to the absence of CD4+NK1.1.+ T cells that promptly produce interleukin 4. Proc Natl Acad Sci USA 92, 11931-11934 (1995) (Pubitemid 26014224)
52. G. Gigli, S. Caielli, D. Cutuli & M. Falcone: Innate immunity modulates autoimmunity: type 1 interferon-beta treatment in multiple sclerosis promotes growth and function of regulatory invariant natural killer T cells through dendritic cell maturation. Immunology 122, 409-417 (2007) (Pubitemid 47556478)
53. R. Furlan, A. Bergami, D. Cantarella, E. Brambilla, M. Taniguchi, P. Dellabona, G. Casorati, G. R. Martino: Activation of invariant NKT cells by alphaGalCer administration protects mice from MOG35-55-induced EAE: critical roles for administration route and IFNgamma. Eur J Immunol 33, 1830-1838 (2003) (Pubitemid 37120854)
54. J. M. Gombert, A. Herbelin, E. Tancrède-Bohin, M. Dy, C. Carnaud, J. F. Bach: Early quantitative and functional deficiency of NK1+-like thymocytes in the NOD mouse. Eur J Immunol 26, 2989-2998 (1996) (Pubitemid 26411504)
55. A. G. Baxter, S. J. Kinder, K. J. Hammond, R. Scollay & D. I. Godfrey: Association between alphabetaTCR+CD4-CD8-T-cell deficiency and IDDM in NOD/Lt mice. Diabetes 46, 572-582 (1997) (Pubitemid 27143372)
56. N. N. Iwakoshi, D. L. Greiner, A. A. Rossini & J. P. Mordes: Diabetes prone BB rats are severely deficient in natural killer T cells. Autoimmunity 31, 1-14 (1999) (Pubitemid 32454566)
57. P. T. Lee, A. Putnam, K. Benlagha, L. Teyton, P. A. Gottlieb, A. Bendelac: Testing the NKT cell hypothesis of human IDDM pathogenesis. J Clin Invest. 110, 793-800 (2002)
58. M. A. Jordan, J. M. Fletcher, D. Pellicci & A. G. Baxter: Slamf1, the NKT cell control gene Nkt1. J Immunol 178, 1618-1627 (2007) (Pubitemid 46154633)
59. M. Falcone, F. Facciotti, N. Ghidoli, P. Monti, S. Olivieri, L. Zaccagnino, E. Bonifacio, G. Casorati, F. Sanvito, N. Sarvetnick: Up-regulation of CD1d expression restores the immunoregulatory function of NKT cells and prevents autoimmune diabetes in nonobese diabetic mice. J Immunol 172, 5908-5916 (2004) (Pubitemid 38621189)
60. M. A. Mieza, T. Itoh, J. Q. Cui, Y. Makino, T. Kawano, K. Tsuchida, T. Koike, T. Shirai, H. Yagita, A. Matsuzawa, H. Koseki, M. Taniguchi: Selective reduction of V alpha 14+ NK T cells associated with disease development in autoimmuneprone mice. J Immunol 156, 4035-4040 (1996) (Pubitemid 26137692)
61. D. Zeng, M. K. Lee, J. Tung, A. Brendolan & S. Strober: Cutting edge: a role for CD1 in the pathogenesis of lupus in NZB/NZW mice. J Immunol 164, 5000-5004 (2000) (Pubitemid 30305168)
62. A. W. Jahng, I. Maricic, B. Pedersen, N. Burdin, O. Naidenko, M. Kronenberg, Y. Koezuka, V Kumar: Activation of natural killer T cells potentiates or prevents experimental autoimmune encephalomyelitis. J Exp Med 194, 1789-1799 (2001) (Pubitemid 34028658)
63. Y. G. Chen, C. M. Choisy-Rossi, T. M. Holl, H. D. Chapman, G. S. Besra, S. A. Porcelli, D. J. Shaffer, D. Roopenian, S. B. Wilson, D. V. Serreze: Activated NKT cells inhibit autoimmune diabetes through tolerogenic recruitment of dendritic cells to pancreatic lymph nodes. J Immunol 174, 1196-1204 (2005)
64. Q. S. Mi, D. Ly, P. Zucker, M. McGarry & T. L. Delovitch: Interleukin-4 but not interleukin-10 protects against spontaneous and recurrent type 1 diabetes by activated CD1d-restricted invariant natural killer T-cells. Diabetes 53, 1303-1310 (2004) (Pubitemid 38569017)
65. L. Beaudoin, V. Laloux, J. Novak, B. Lucas & A. Lehuen: NKT cells inhibit the onset of diabetes by impairing the development of pathogenic T cells specific for pancreatic beta cells. Immunity 17, 725-736 (2002) (Pubitemid 35477792)
66. J. Novak, L. Beaudoin, T. Griseri & A. Lehuen: Inhibition of T cell differentiation into effectors by NKT cells requires cell contacts. J Immunol 174, 1954-1961 (2005) (Pubitemid 40223936)
67. S. Fujii, K. Shimizu, H. Hemmi & R. M. Steinman: Innate Valpha14 (+) natural killer T cells mature dendritic cells, leading to strong adaptive immunity. Immunol Rev 220, 183-198 (2007) (Pubitemid 350045564)
68. M. S. Vincent, J. E. Gumperz, M. B. Brenner: CD1-dependent dendritic cell instruction. Nat Immunol 3, 1163-1168 (2002)
69. Y. N. Naumov, K. S. Bahjat, R. Gausling, R. Abraham, M. A. Exley, Y. Koezuka, S. B. Balk, J. L. Strominger, M. Clare-Salzer, S. B. Wilson: Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets. Proc Natl Acad Sci U S A 98, 13838-13843 (2001) (Pubitemid 33115985)
70. V. Saxena, J. K. Ondr, A. F. Magnusen, D. H. Munn & J. D. Katz: The countervailing actions of myeloid and plasmacytoid dendritic cells control autoimmune diabetes in the nonobese diabetic mouse. J Immunol 179, 5041-5053 (2007)
71. S. Kojo, K. Seino, M. Harada, H. Watarai, H. Wakao, T. Uchida, T. Nakayama, M. Taniguchi: Induction of regulatory properties in dendritic cells by Valpha14 NKT cells. J Immunol 175, 3648-3655 (2005) (Pubitemid 41292024)
72. S. Caielli, C. Conforti-Andreoni, C. Di Pietro, V. Usuelli, E. Badami, M. L. Malosio, M. Falcone: On/off TLR signaling decides proinflammatory or tolerogenic dendritic cell maturation upon CD1d-mediated interaction with invariant NKT cells. J Immunol 185, 7317-7329 (2010)
73. V. Cerundolo, J. D. Silk, S. H. Masri & M. Salio: Harnessing invariant NKT cells in vaccination strategies. Nat Rev Immunol 9, 28-38 (2009)
74. S. Fujii, K. Shimizu, C. Smith, L. Bonifaz & R. M. Steinman: Activation of natural killer T cells by alphagalactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8 T cell immunity to a coadministered protein. J Exp Med 198, 267-279 (2003) (Pubitemid 36987852)