메뉴 건너뛰기




Volumn 73, Issue 3, 2014, Pages 413-421

DNA methylation, ageing and the influence of early life nutrition

Author keywords

Ageing; Developmental origins of adult disease; DNA methylation; Epigenetics; Nutrition

Indexed keywords

DNA METHYLTRANSFERASE; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; ENDOCRINE DISRUPTOR; FOLIC ACID; HISTONE H2A; HISTONE H3; HISTONE H4; METHYL CPG BINDING PROTEIN 2; REPETITIVE DNA; TRANSCRIPTION FACTOR; HISTONE; RNA;

EID: 84904506813     PISSN: 00296651     EISSN: 14752719     Source Type: Journal    
DOI: 10.1017/S0029665114000081     Document Type: Conference Paper
Times cited : (45)

References (106)
  • 1
    • 77950657253 scopus 로고    scopus 로고
    • Human aging-Associated DNA hypermethylation occurs preferentially at bivalent chromatin Domains
    • Rakyan VKó Down TAó Maslau S et al. (2010) Human aging-Associated DNA hypermethylation occurs preferentially at bivalent chromatin Domains. Genome Res 20ó 434-439
    • (2010) Genome Res , vol.20 , pp. 434-439
    • Rakyan, V.K.1    Down, T.A.2    Maslau, S.3
  • 3
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • Bird A (2002) DNA methylation patterns and epigenetic memory. Genes Dev 16ó 6-21
    • (2002) Genes Dev , vol.16 , pp. 6-21
    • Bird, A.1
  • 4
    • 0026653420 scopus 로고
    • The essentials of DNA methylation
    • Bird A (1992) The essentials of DNA methylation. Cell 70ó 5-8
    • (1992) Cell , vol.70 , pp. 5-8
    • Bird, A.1
  • 5
    • 0035824504 scopus 로고    scopus 로고
    • Molecular biology Methylation talk between histones and DNA
    • Bird A (2001) Molecular biology. Methylation talk between histones and DNA. Science 294ó 2113-2115
    • (2001) Science , vol.294 , pp. 2113-2115
    • Bird, A.1
  • 6
    • 0037423186 scopus 로고    scopus 로고
    • The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation
    • Fuks Fó Hurd PJó Wolf D et al. (2003) The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation. J Biol Chem 278ó 4035-4040
    • (2003) J Biol Chem , vol.278 , pp. 4035-4040
    • Fuks, F.1    Hurd, P.J.2    Wolf, D.3
  • 7
    • 0035234557 scopus 로고    scopus 로고
    • Genomic imprinting: Parental influence on the genome
    • Reik W &Walter J (2001) Genomic imprinting: Parental influence on the genome. Nat Rev Genet 2ó 21-32
    • (2001) Nat Rev Genet , vol.2 , pp. 21-32
    • Reik, W.1    Walter, J.2
  • 8
    • 0031662164 scopus 로고    scopus 로고
    • Transcription of IAP endogenous retroviruses is constrained by cytosine methylation
    • Walsh CPó Chaillet JR &Bestor TH (1998) Transcription of IAP endogenous retroviruses is constrained by cytosine methylation. Nat Genet 20ó 116-117
    • (1998) Nat Genet , vol.20 , pp. 116-117
    • Walsh, C.P.1    Chaillet, J.R.2    Bestor, T.H.3
  • 9
    • 0043093697 scopus 로고    scopus 로고
    • Transposable elements: Targets for early nutritional effects on epigenetic gene regulation
    • Waterland RA &Jirtle RL (2003) Transposable elements: Targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol 23ó 5293-5300
    • (2003) Mol Cell Biol , vol.23 , pp. 5293-5300
    • Waterland, R.A.1    Jirtle, R.L.2
  • 10
    • 0035839126 scopus 로고    scopus 로고
    • Epigenetic reprogramming in mammalian Development
    • Reik Wó Dean W &Walter J (2001) Epigenetic reprogramming in mammalian Development. Science 293ó 1089-1093
    • (2001) Science , vol.293 , pp. 1089-1093
    • Reik, W.1    Dean, W.2    Walter, J.3
  • 11
    • 0037233240 scopus 로고    scopus 로고
    • Mammalian epigenomics: Reprogramming the genome for development and therapy
    • Reik Wó Santos F &Dean W (2003) Mammalian epigenomics: Reprogramming the genome for development and therapy. Theriogenology 59ó 21-32
    • (2003) Theriogenology , vol.59 , pp. 21-32
    • Reik, W.1    Santos, F.2    Dean, W.3
  • 12
    • 0033615717 scopus 로고    scopus 로고
    • DNA methyltransferases DNMT3a and DNMT3b are essential for de novo methylation and mammalian Development
    • Okano Mó Bell DWó Haber DA et al. (1999) DNA methyltransferases DNMT3a and DNMT3b are essential for de novo methylation and mammalian Development. Cell 99ó 247-257
    • (1999) Cell , vol.99 , pp. 247-257
    • Okano, M.1    Bell, D.W.2    Haber, D.A.3
  • 13
    • 0032731355 scopus 로고    scopus 로고
    • Recombinant human DNA (cytosine-5) methyltransferase II Steady-state kinetics reveal allosteric activation by methylated DNA
    • Bacolla Aó Pradhan Só Roberts RJ et al. (1999) Recombinant human DNA (cytosine-5) methyltransferase. II. Steady-state kinetics reveal allosteric activation by methylated DNA. J Biol Chem 274ó 33011-33019
    • (1999) J Biol Chem , vol.274 , pp. 33011-33019
    • Bacolla, A.1    Pradhan, S.2    Roberts, R.J.3
  • 14
    • 0033848849 scopus 로고    scopus 로고
    • Histone acetylation and an epigenetic code
    • Turner BM (2000) Histone acetylation and an epigenetic code. Bioessays 22ó 836-845
    • (2000) Bioessays , vol.22 , pp. 836-845
    • Turner, B.M.1
  • 15
    • 34249290027 scopus 로고    scopus 로고
    • A methylation rendezvous: Reader meets writers
    • Brenner C &Fuks F (2007) A methylation rendezvous: Reader meets writers. Dev Cell 12ó 843-844
    • (2007) Dev Cell , vol.12 , pp. 843-844
    • Brenner, C.1    Fuks, F.2
  • 16
    • 0035815360 scopus 로고    scopus 로고
    • Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly
    • Nakayama Jó Rice JCó Strahl BD et al. (2001) Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly. Science 292ó 110-113
    • (2001) Science , vol.292 , pp. 110-113
    • Nakayama, J.1    Rice, J.C.2    Strahl, B.D.3
  • 17
    • 0033592999 scopus 로고    scopus 로고
    • Methylation of histone H3 at lysine 4 is highly conserved and correlates with transcriptionally active nuclei in Tetrahymena
    • Strahl BDó Ohba Ró Cook RG et al. (1999) Methylation of histone H3 at lysine 4 is highly conserved and correlates with transcriptionally active nuclei in Tetrahymena. Proc Natl Acad Sci USA 96ó 14967-14972
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 14967-14972
    • Strahl, B.D.1    Ohba, R.2    Cook, R.G.3
  • 18
    • 0035282573 scopus 로고    scopus 로고
    • Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
    • Lachner Mó OCarroll Dó Rea S et al. (2001) Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 410ó 116-120
    • (2001) Nature , vol.410 , pp. 116-120
    • Lachner, M.1    O'Carroll, D.2    Rea, S.3
  • 19
    • 0033988813 scopus 로고    scopus 로고
    • DNA methyltransferase Dnmt1 associates with histone deacetylase activity
    • Fuks Fó Burgers WAó Brehm A et al. (2000) DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nat Genet 24ó 88-91
    • (2000) Nat Genet , vol.24 , pp. 88-91
    • Fuks, F.1    Burgers, W.A.2    Brehm, A.3
  • 20
    • 0033945861 scopus 로고    scopus 로고
    • DNMT1 binds HDAC2 and a new co-repressoró DMAP1ó to form a complex at replication foci
    • Rountree MRó Bachman KE &Baylin SB (2000) DNMT1 binds HDAC2 and a new co-repressoró DMAP1ó to form a complex at replication foci. Nat Genet 25ó 269-277
    • (2000) Nat Genet , vol.25 , pp. 269-277
    • Rountree, M.R.1    Bachman, K.E.2    Baylin, S.B.3
  • 21
    • 32844459336 scopus 로고    scopus 로고
    • The Polycomb group protein EZH2 directly controls DNA methylation
    • Vire Eó Brenner Có Deplus R et al. (2006) The Polycomb group protein EZH2 directly controls DNA methylation. Nature 439ó 871-874
    • (2006) Nature , vol.439 , pp. 871-874
    • Vire, E.1    Brenner, C.2    Deplus, R.3
  • 22
    • 0032443019 scopus 로고    scopus 로고
    • Folic acidó homocysteine and one-carbon metabolism: A review of the essential biochemistry
    • Scott JM &Weir DG (1998) Folic acidó homocysteine and one-carbon metabolism: A review of the essential biochemistry. J Cardiovasc Risk 5ó 223-227
    • (1998) J Cardiovasc Risk , vol.5 , pp. 223-227
    • Scott, J.M.1    Weir, D.G.2
  • 23
    • 45449114804 scopus 로고    scopus 로고
    • The colorful history of active DNA demethylation
    • Ooi SK &Bestor TH (2008) The colorful history of active DNA demethylation. Cell 133ó 1145-1148
    • (2008) Cell , vol.133 , pp. 1145-1148
    • Ooi, S.K.1    Bestor, T.H.2
  • 24
    • 33847614418 scopus 로고    scopus 로고
    • Covalent modification of DNA regulates memory formation
    • Miller CA &Sweatt JD (2007) Covalent modification of DNA regulates memory formation. Neuron 53ó 857-869
    • (2007) Neuron , vol.53 , pp. 857-869
    • Miller, C.A.1    Sweatt, J.D.2
  • 25
    • 33646058925 scopus 로고    scopus 로고
    • Rapid demethylation of the IFN-gamma gene occurs in memory but not naive CD8T cells
    • Kersh ENó Fitzpatrick DRó Murali-Krishna K et al. (2006) Rapid demethylation of the IFN-gamma gene occurs in memory but not naive CD8T cells. J Immunol 176ó 4083-4093
    • (2006) J Immunol , vol.176 , pp. 4083-4093
    • Kersh, E.N.1    Fitzpatrick, D.R.2    Murali-Krishna, K.3
  • 26
    • 66149146320 scopus 로고    scopus 로고
    • Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian Dna by mll partner tet1
    • Tahiliani Mó Koh KPó Shen Y et al. (2009) Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324ó 930-935
    • (2009) Science , vol.324 , pp. 930-935
    • Tahiliani, M.1    Koh, K.P.2    Shen, Y.3
  • 27
    • 77956189495 scopus 로고    scopus 로고
    • Role of Tet proteins in 5mC to 5hmC conversion ES-cell selfrenewal and inner cell mass specification
    • Ito Só DAlessio ACó Taranova OV et al. (2010) Role of Tet proteins in 5mC to 5hmC conversionó ES-cell selfrenewal and inner cell mass specification. Nature 466ó 1129-1133
    • (2010) Nature , vol.466 , pp. 1129-1133
    • Ito, S.1    D'Alessio, A.C.2    Taranova, O.V.3
  • 28
    • 0033580326 scopus 로고    scopus 로고
    • A mammalian protein with specific demethylase activity for mCpG DNA
    • Bhattacharya SKó Ramchandani Só Cervoni N et al. (1999) A mammalian protein with specific demethylase activity for mCpG DNA. Nature 397ó 579-583
    • (1999) Nature , vol.397 , pp. 579-583
    • Bhattacharya, S.K.1    Ramchandani, S.2    Cervoni, N.3
  • 29
    • 0034326849 scopus 로고    scopus 로고
    • 5-Methylcytosine DNA glycosylase activity is also present in the human MBD4 (G/T mismatch glycosylase) and in a related avian sequence
    • Zhu Bó Zheng Yó Angliker H et al. (2000) 5-Methylcytosine DNA glycosylase activity is also present in the human MBD4 (G/T mismatch glycosylase) and in a related avian sequence. Nucleic Acids Res 28ó 4157-4165
    • (2000) Nucleic Acids Res , vol.28 , pp. 4157-4165
    • Zhu, B.1    Zheng, Y.2    Angliker, H.3
  • 30
    • 33846933274 scopus 로고    scopus 로고
    • Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation
    • Barreto Gó Schafer Aó Marhold J et al. (2007) Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. Nature 445ó 671-675
    • (2007) Nature , vol.445 , pp. 671-675
    • Barreto, G.1    Schafer, A.2    Marhold, J.3
  • 31
    • 0027310491 scopus 로고
    • Nuclear extracts of chicken embryos promote an active demethylation of DNA by excision repair of 5-methyldeoxycytidine
    • Jost JP (1993) Nuclear extracts of chicken embryos promote an active demethylation of DNA by excision repair of 5-methyldeoxycytidine. Proc Natl Acad Sci USA 90ó 4684-4688
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 4684-4688
    • Jost, J.P.1
  • 32
    • 17944397700 scopus 로고
    • Nucleotide composition of DNA and RNA from somatic tissues of humpback and its changes during spawning
    • Berdyshev GDó Korotaev GKó Boiarskikh GV et al. (1967) Nucleotide composition of DNA and RNA from somatic tissues of humpback and its changes during spawning. Biokhimiia 32ó 988-993
    • (1967) Biokhimiia , vol.32 , pp. 988-993
    • Berdyshev, G.D.1    Korotaev, G.K.2    Boiarskikh, G.V.3
  • 33
    • 60849100524 scopus 로고    scopus 로고
    • Decline in genomic DNA methylation through aging in a cohort of elderly subjects
    • Bollati Vó Schwartz Jó Wright R et al. (2009) Decline in genomic DNA methylation through aging in a cohort of elderly subjects. Mech Ageing Dev 130ó 234-239
    • (2009) Mech Ageing Dev , vol.130 , pp. 234-239
    • Bollati, V.1    Schwartz, J.2    Wright, R.3
  • 34
    • 0024552485 scopus 로고
    • Human lymphocytes aged in vivo have reduced levels of methylation in transcriptionally active and inactive DNA
    • Drinkwater RDó Blake TJó Morley AA et al. (1989) Human lymphocytes aged in vivo have reduced levels of methylation in transcriptionally active and inactive DNA. Mutat Res 219ó 29-37
    • (1989) Mutat Res , vol.219 , pp. 29-37
    • Drinkwater, R.D.1    Blake, T.J.2    Morley, A.A.3
  • 36
    • 0141839825 scopus 로고    scopus 로고
    • Transcriptional control of the DNA methyltransferases is altered in aging and neoplastically-Transformed human fibroblasts
    • Casillas MA Jró Lopatina Nó Andrews LG et al. (2003) Transcriptional control of the DNA methyltransferases is altered in aging and neoplastically-Transformed human fibroblasts. Mol Cell Biochem 252ó 33-43
    • (2003) Mol Cell Biochem , vol.252 , pp. 33-43
    • Casillas Jr., M.A.1    Lopatina, N.2    Andrews, L.G.3
  • 37
    • 0028001087 scopus 로고
    • Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon
    • Issa JPó Ottaviano YLó Celano P et al. (1994) Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat Genet 7ó 536-540
    • (1994) Nat Genet , vol.7 , pp. 536-540
    • Issa, J.P.1    Ottaviano, Y.L.2    Celano, P.3
  • 38
    • 0033913645 scopus 로고    scopus 로고
    • Agingó methylation and cancer
    • Ahuja N &Issa JP (2000) Agingó methylation and cancer. Histol Histopathol 15ó 835-842
    • (2000) Histol Histopathol , vol.15 , pp. 835-842
    • Ahuja, N.1    Issa, J.P.2
  • 39
    • 0038476350 scopus 로고    scopus 로고
    • Profile of aberrant CpG island methylation along the multistep pathway of gastric carcinogenesis
    • Kang GHó Lee Só Kim JS et al. (2003) Profile of aberrant CpG island methylation along the multistep pathway of gastric carcinogenesis. Lab Investig J Techn Methods Pathol 83ó 635-641
    • (2003) Lab Investig J Techn Methods Pathol , vol.83 , pp. 635-641
    • Kang, G.H.1    Lee, S.2    Kim, J.S.3
  • 40
    • 84865388989 scopus 로고    scopus 로고
    • Clustered DNA methylation changes in polycomb target genes in earlystage liver cancer
    • Chen YLó Ko CJó Lin PY et al. (2012) Clustered DNA methylation changes in polycomb target genes in earlystage liver cancer. Biochem Biophys Res Commun 425ó 290-296
    • (2012) Biochem Biophys Res Commun , vol.425 , pp. 290-296
    • Chen, Y.L.1    Ko, C.J.2    Lin, P.Y.3
  • 41
    • 77956913463 scopus 로고    scopus 로고
    • Personalized epigenomic signatures that are stable over time and covary with body mass index
    • Feinberg APó Irizarry RAó Fradin D et al. (2010) Personalized epigenomic signatures that are stable over time and covary with body mass index. Sci Transl Med 2ó 49ra67
    • (2010) Sci Transl Med , vol.2 , pp. 49-67
    • Feinberg, A.P.1    Irizarry, R.A.2    Fradin, D.3
  • 42
    • 45849127657 scopus 로고    scopus 로고
    • Intra-individual change over time in DNA methylation with familial clustering
    • Bjornsson HTó Sigurdsson MIó Fallin MD et al. (2008) Intra-individual change over time in DNA methylation with familial clustering. J Am Med Assoc 299ó 2877-2883
    • (2008) J Am Med Assoc , vol.299 , pp. 2877-2883
    • Bjornsson, H.T.1    Sigurdsson, M.I.2    Fallin, M.D.3
  • 43
    • 79952104806 scopus 로고    scopus 로고
    • A twin approach to unraveling epigenetics
    • Bell JT &Spector TD (2011) A twin approach to unraveling epigenetics. Trends Genet 27ó 116-125
    • (2011) Trends Genet , vol.27 , pp. 116-125
    • Bell, J.T.1    Spector, T.D.2
  • 44
    • 23044514669 scopus 로고    scopus 로고
    • Epigenetic differences arise during the lifetime of monozygotic twins
    • Fraga MFó Ballestar Eó Paz MF et al. (2005) Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci USA 102ó 10604-10609
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 10604-10609
    • Fraga, M.F.1    Ballestar, E.2    Paz, M.F.3
  • 45
    • 77956642106 scopus 로고    scopus 로고
    • Variationó patternsó and temporal stability of DNA methylation: Considerations for epigenetic epidemiology
    • Talens RPó Boomsma DIó Tobi EW et al. (2010) Variationó patternsó and temporal stability of DNA methylation: Considerations for epigenetic epidemiology. FASEB J 24ó 3135-3144
    • (2010) FASEB J , vol.24 , pp. 3135-3144
    • Talens, R.P.1    Boomsma, D.I.2    Tobi, E.W.3
  • 47
    • 79959997358 scopus 로고    scopus 로고
    • Epigenetic discordance at imprinting control regions in twins
    • Ollikainen M &Craig JM (2011) Epigenetic discordance at imprinting control regions in twins. Epigenomics 3ó 295-306
    • (2011) Epigenomics , vol.3 , pp. 295-306
    • Ollikainen, M.1    Craig, J.M.2
  • 48
    • 84864610761 scopus 로고    scopus 로고
    • Neonatal DNA methylation profile in human twins is specified by a complex interplay between intrauterine environmental and genetic factorsó subject to tissue-specific influence
    • Gordon Ló Joo JEó Powell JE et al. (2012) Neonatal DNA methylation profile in human twins is specified by a complex interplay between intrauterine environmental and genetic factorsó subject to tissue-specific influence. Genome Res 22ó 1395-1406
    • (2012) Genome Res , vol.22 , pp. 1395-1406
    • Gordon, L.1    Joo, J.E.2    Powell, J.E.3
  • 49
    • 67149099680 scopus 로고    scopus 로고
    • Histone H4 lysine 16 acetylation regulates cellular lifespan
    • Dang Wó Steffen KKó Perry R et al. (2009) Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature 459ó 802-807
    • (2009) Nature , vol.459 , pp. 802-807
    • Dang, W.1    Steffen, K.K.2    Perry, R.3
  • 50
    • 32444434989 scopus 로고    scopus 로고
    • Histone H4-K16 acetylation controls chromatin structure and protein interactions
    • Shogren-Knaak Mó Ishii Hó Sun JM et al. (2006) Histone H4-K16 acetylation controls chromatin structure and protein interactions. Science 311ó 844-847
    • (2006) Science , vol.311 , pp. 844-847
    • Shogren-Knaak, M.1    Ishii, H.2    Sun, J.M.3
  • 51
    • 0023874975 scopus 로고
    • Differential acetylation of core histones in rat cerebral cortex neurons during development and aging
    • Pina Bó Martinez P &Suau P (1988) Differential acetylation of core histones in rat cerebral cortex neurons during development and aging. Eur J Biochem/FEBS 174ó 311-315
    • (1988) Eur J Biochem/FEBS , vol.174 , pp. 311-315
    • Pina, B.1    Martinez, P.2    Suau, P.3
  • 52
    • 77957814604 scopus 로고    scopus 로고
    • Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres
    • OSullivan RJó Kubicek Só Schreiber SL et al. (2010) Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres. Nat Struc Mol Biol 17ó 1218-1225
    • (2010) Nat Struc Mol Biol , vol.17 , pp. 1218-1225
    • O'Sullivan, R.J.1    Kubicek, S.2    Schreiber, S.L.3
  • 53
    • 65249093055 scopus 로고    scopus 로고
    • Polycomb protein Ezh2 regulates pancreatic β-cell Ink4a/Arf expression and regeneration in Diabetes mellitus
    • Chen Hó Gu Xó Su IH et al. (2009) Polycomb protein Ezh2 regulates pancreatic β-cell Ink4a/Arf expression and regeneration in Diabetes mellitUS Genes Dev 23ó 975-985
    • (2009) Genes Dev , vol.23 , pp. 975-985
    • Chen, H.1    Gu, X.2    Su, I.H.3
  • 54
    • 0037131426 scopus 로고    scopus 로고
    • Postsynthetic trimethylation of histone H4 at lysine 20 in mammalian tissues is associated with aging
    • Sarg Bó Koutzamani Eó Helliger W et al. (2002) Postsynthetic trimethylation of histone H4 at lysine 20 in mammalian tissues is associated with aging. J Biol Chem 277ó 39195-39201
    • (2002) J Biol Chem , vol.277 , pp. 39195-39201
    • Sarg, B.1    Koutzamani, E.2    Helliger, W.3
  • 55
    • 9944228800 scopus 로고    scopus 로고
    • Distinct dynamics and distribution of histone methyl-lysine derivatives in mouse development
    • Biron VLó McManus KJó Hu N et al. (2004) Distinct dynamics and distribution of histone methyl-lysine derivatives in mouse development. Dev Biol 276ó 337-351
    • (2004) Dev Biol , vol.276 , pp. 337-351
    • Biron, V.L.1    McManus, K.J.2    Hu, N.3
  • 56
    • 0030759780 scopus 로고    scopus 로고
    • The heterochromatin loss model of aging
    • Villeponteau B (1997) The heterochromatin loss model of aging. Exp Gerontol 32ó 383-394
    • (1997) Exp Gerontol , vol.32 , pp. 383-394
    • Villeponteau, B.1
  • 57
    • 19944427674 scopus 로고    scopus 로고
    • Formation of macroh2a-containing senescence-Associated heterochromatin foci and senescence driven by asf1a and hira
    • Zhang Ró Poustovoitov MVó Ye X et al. (2005) Formation of MacroH2A-containing senescence-Associated heterochromatin foci and senescence driven by ASF1a and HIRA. Dev Cell 8ó 19-30
    • (2005) Dev Cell , vol.8 , pp. 19-30
    • Zhang, R.1    Poustovoitov, M.V.2    Ye, X.3
  • 58
    • 33745016642 scopus 로고    scopus 로고
    • Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging
    • Shumaker DKó Dechat Tó Kohlmaier A et al. (2006) Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging. Proc Natl Acad Sci USA 103ó 8703-8708
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 8703-8708
    • Shumaker, D.K.1    Dechat, T.2    Kohlmaier, A.3
  • 59
    • 0033214237 scopus 로고    scopus 로고
    • The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
    • Kaeberlein Mó McVey M &Guarente L (1999) The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 13ó 2570-2580
    • (1999) Genes Dev , vol.13 , pp. 2570-2580
    • Kaeberlein, M.1    McVey, M.2    Guarente, L.3
  • 60
    • 33748948208 scopus 로고    scopus 로고
    • DeltaNp63alpha overexpression induces downregulation of Sirt1 and an accelerated aging phenotype in the mouse
    • Sommer Mó Poliak Nó Upadhyay S et al. (2006) DeltaNp63alpha overexpression induces downregulation of Sirt1 and an accelerated aging phenotype in the mouse. Cell Cycle 5ó 2005-2011
    • (2006) Cell Cycle , vol.5 , pp. 2005-2011
    • Sommer, M.1    Poliak, N.2    Upadhyay, S.3
  • 61
    • 3943054839 scopus 로고    scopus 로고
    • The Sir2 family of protein Deacetylases
    • Blander G &Guarente L (2004) The Sir2 family of protein Deacetylases. Annu Rev Biochem 73ó 417-435
    • (2004) Annu Rev Biochem , vol.73 , pp. 417-435
    • Blander, G.1    Guarente, L.2
  • 62
    • 79959836522 scopus 로고    scopus 로고
    • Chromatin structure as a mediator of aging
    • Feser J &Tyler J (2011) Chromatin structure as a mediator of aging. FEBS Lett 585ó 2041-2048
    • (2011) FEBS Lett , vol.585 , pp. 2041-2048
    • Feser, J.1    Tyler, J.2
  • 63
    • 0020699979 scopus 로고
    • Hypomethylation Distinguishes genes of some human cancers from their normal counterparts
    • Feinberg AP &Vogelstein B (1983) Hypomethylation Distinguishes genes of some human cancers from their normal counterparts. Nature 301ó 89-92
    • (1983) Nature , vol.301 , pp. 89-92
    • Feinberg, A.P.1    Vogelstein, B.2
  • 64
    • 1042278765 scopus 로고    scopus 로고
    • The history of cancer epigenetics
    • Feinberg AP &Tycko B (2004) The history of cancer epigenetics. Nat Rev Cancer 4ó 143-153
    • (2004) Nat Rev Cancer , vol.4 , pp. 143-153
    • Feinberg, A.P.1    Tycko, B.2
  • 65
    • 4143140030 scopus 로고    scopus 로고
    • A mouse skin multistage carcinogenesis model reflects the aberrant DNA methylation patterns of human tumors
    • Fraga MFó Herranz Mó Espada J et al. (2004) A mouse skin multistage carcinogenesis model reflects the aberrant DNA methylation patterns of human tumors. Cancer Res 64ó 5527-5534
    • (2004) Cancer Res , vol.64 , pp. 5527-5534
    • Fraga, M.F.1    Herranz, M.2    Espada, J.3
  • 66
    • 0242584454 scopus 로고    scopus 로고
    • Chromosomal instability and tumors promoted by DNA hypomethylation
    • Eden Aó Gaudet Fó Waghmare A et al. (2003) Chromosomal instability and tumors promoted by DNA hypomethylation. Science 300ó 455
    • (2003) Science , vol.300 , pp. 455
    • Eden, A.1    Gaudet, F.2    Waghmare, A.3
  • 67
    • 40849139208 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • Esteller M (2008) Epigenetics in cancer. N Engl J Med 358ó 1148-1159
    • (2008) N Engl J Med , vol.358 , pp. 1148-1159
    • Esteller, M.1
  • 68
    • 0035870248 scopus 로고    scopus 로고
    • A gene hypermethylation profile of human cancer
    • Esteller Mó Corn PGó Baylin SB et al. (2001) A gene hypermethylation profile of human cancer. Cancer Res 61ó 3225-3229
    • (2001) Cancer Res , vol.61 , pp. 3225-3229
    • Esteller, M.1    Corn, P.G.2    Baylin, S.B.3
  • 69
    • 77952248685 scopus 로고    scopus 로고
    • DNA methylation profiling in Doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response
    • Dejeux Eó Ronneberg JAó Solvang H et al. (2010) DNA methylation profiling in Doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response. Mol Cancer 9ó 68
    • (2010) Mol Cancer , vol.9 , pp. 68
    • Dejeux, E.1    Ronneberg, J.A.2    Solvang, H.3
  • 70
    • 73449144780 scopus 로고    scopus 로고
    • Targeting of EZH2 to a defined genomic site is sufficient for recruitment of Dnmt3a but not de novo DNA methylation
    • Rush Mó Appanah Ró Lee S et al. (2009) Targeting of EZH2 to a defined genomic site is sufficient for recruitment of Dnmt3a but not de novo DNA methylation. Epigenetics 4ó 404-414
    • (2009) Epigenetics , vol.4 , pp. 404-414
    • Rush, M.1    Appanah, R.2    Lee, S.3
  • 71
    • 33846569960 scopus 로고    scopus 로고
    • A stem celllike chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing
    • Ohm JEó McGarvey KMó Yu X et al. (2007) A stem celllike chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet 39ó 237-242
    • (2007) Nat Genet , vol.39 , pp. 237-242
    • Ohm, J.E.1    McGarvey, K.M.2    Yu, X.3
  • 72
    • 34447543913 scopus 로고    scopus 로고
    • Cellular senescence in cancer and aging
    • Collado Mó Blasco MA &Serrano M (2007) Cellular senescence in cancer and aging. Cell 130ó 223-233
    • (2007) Cell , vol.130 , pp. 223-233
    • Collado, M.1    Blasco, M.A.2    Serrano, M.3
  • 73
    • 34548153747 scopus 로고    scopus 로고
    • How stem cells age and why this makes us grow old
    • Sharpless NE &DePinho RA (2007) How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol 8ó 703-713
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 703-713
    • Sharpless, N.E.1    De Pinho, R.A.2
  • 74
    • 33749172559 scopus 로고    scopus 로고
    • Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
    • Janzen Vó Forkert Ró Fleming HE et al. (2006) Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature 443ó 421-426
    • (2006) Nature , vol.443 , pp. 421-426
    • Janzen, V.1    Forkert, R.2    Fleming, H.E.3
  • 75
    • 33947134834 scopus 로고    scopus 로고
    • The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
    • Bracken APó Kleine-Kohlbrecher Dó Dietrich N et al. (2007) The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev 21ó 525-530
    • (2007) Genes Dev , vol.21 , pp. 525-530
    • Bracken, A.P.1    Kleine-Kohlbrecher, D.2    Dietrich, N.3
  • 76
    • 70350500219 scopus 로고    scopus 로고
    • Polycomb group proteins: Navigators of lineage pathways led astray in cancer
    • Bracken AP &Helin K (2009) Polycomb group proteins: Navigators of lineage pathways led astray in cancer. Nat Rev Cancer 9ó 773-784
    • (2009) Nat Rev Cancer , vol.9 , pp. 773-784
    • Bracken, A.P.1    Helin, K.2
  • 77
    • 33745752370 scopus 로고    scopus 로고
    • Epigenetics and twins: Three variations on the theme
    • Petronis A (2006) Epigenetics and twins: Three variations on the theme. Trends Genet 22ó 347-350
    • (2006) Trends Genet , vol.22 , pp. 347-350
    • Petronis, A.1
  • 78
    • 33745532801 scopus 로고    scopus 로고
    • Increased cell-To-cell variation in gene expression in ageing mouse heart
    • Bahar Ró Hartmann CHó Rodriguez KA et al. (2006) Increased cell-To-cell variation in gene expression in ageing mouse heart. Nature 441ó 1011-1014
    • (2006) Nature , vol.441 , pp. 1011-1014
    • Bahar, R.1    Hartmann, C.H.2    Rodriguez, K.A.3
  • 81
    • 54949122508 scopus 로고    scopus 로고
    • Epigenetic integration of environmental and genomic signals in honey bees
    • Maleszka R (2008) Epigenetic integration of environmental and genomic signals in honey bees. Epigenetics 3ó 188-192
    • (2008) Epigenetics , vol.3 , pp. 188-192
    • Maleszka, R.1
  • 82
    • 41349085806 scopus 로고    scopus 로고
    • Nutritional control of reproductive status in honeybees via DNA methylation
    • Kucharski Ró Maleszka Jó Foret S et al. (2008) Nutritional control of reproductive status in honeybees via DNA methylation. Science 319ó 1827-1830
    • (2008) Science , vol.319 , pp. 1827-1830
    • Kucharski, R.1    Maleszka, J.2    Foret, S.3
  • 83
    • 0031873353 scopus 로고    scopus 로고
    • Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice
    • Wolff GLó Kodell RLó Moore SR et al. (1998) Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice. FASEB J 12ó 949-957
    • (1998) FASEB J , vol.12 , pp. 949-957
    • Wolff, G.L.1    Kodell, R.L.2    Moore, S.R.3
  • 84
    • 20444411948 scopus 로고    scopus 로고
    • Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring
    • Lillycrop KAó Phillips ESó Jackson AA et al. (2005) Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr 135ó 1382-1386
    • (2005) J Nutr , vol.135 , pp. 1382-1386
    • Lillycrop, K.A.1    Phillips, E.S.2    Jackson, A.A.3
  • 85
    • 34247514180 scopus 로고    scopus 로고
    • Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and changes in histone modifications
    • Lillycrop KAó Slater-Jefferies JLó Hanson MA et al. (2007) Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and changes in histone modifications. Br J Nutr 97ó 1064-1073
    • (2007) Br J Nutr , vol.97 , pp. 1064-1073
    • Lillycrop, K.A.1    Slater-Jefferies, J.L.2    Hanson, M.A.3
  • 86
    • 50049108528 scopus 로고    scopus 로고
    • Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPARa promoter of the offspring
    • Lillycrop KAó Phillips ESó Torrens C et al. (2008) Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPARa promoter of the offspring. Br J Nutr 100ó 278-282
    • (2008) Br J Nutr , vol.100 , pp. 278-282
    • Lillycrop, K.A.1    Phillips, E.S.2    Torrens, C.3
  • 87
    • 34547924466 scopus 로고    scopus 로고
    • Metabolic plasticity during mammalian Development is directionally dependent on early nutritional status
    • Gluckman PDó Lillycrop KAó Vickers MH et al. (2007) Metabolic plasticity during mammalian Development is directionally dependent on early nutritional statUS Proc Natl Acad Sci USA 104ó 12796-12800
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 12796-12800
    • Gluckman, P.D.1    Lillycrop, K.A.2    Vickers, M.H.3
  • 88
    • 78650446334 scopus 로고    scopus 로고
    • Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals
    • Carone BRó Fauquier Ló Habib N et al. (2010) Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals. Cell 143ó 1084-1096
    • (2010) Cell , vol.143 , pp. 1084-1096
    • Carone, B.R.1    Fauquier, L.2    Habib, N.3
  • 89
    • 77958596171 scopus 로고    scopus 로고
    • Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring
    • Ng SFó Lin RCó Laybutt DR et al. (2010) Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring. Nature 467ó 963-966
    • (2010) Nature , vol.467 , pp. 963-966
    • Ng, S.F.1    Lin, R.C.2    Laybutt, D.R.3
  • 90
    • 70349999407 scopus 로고    scopus 로고
    • DNA methylation Differences after exposure to prenatal famine are common and timing- And sex-specific
    • Tobi EWó Lumey LHó Talens RP et al. (2009) DNA methylation Differences after exposure to prenatal famine are common and timing- And sex-specific. Hum Mol Genet 18ó 4046-4053
    • (2009) Hum Mol Genet , vol.18 , pp. 4046-4053
    • Tobi, E.W.1    Lumey, L.H.2    Talens, R.P.3
  • 91
    • 55949137722 scopus 로고    scopus 로고
    • Persistent epigenetic differences associated with prenatal exposure to famine in humans
    • Heijmans BTó Tobi EWó Stein AD et al. (2008) Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc Natl Acad Sci USA 105ó 17046-17049
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 17046-17049
    • Heijmans, B.T.1    Tobi, E.W.2    Stein, A.D.3
  • 92
    • 70649097099 scopus 로고    scopus 로고
    • Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child
    • Steegers-Theunissen RPó Obermann-Borst SAó Kremer D et al. (2009) Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child. PLoS ONE 4ó e7845
    • (2009) PLoS ONE , vol.4
    • Steegers-Theunissen, R.P.1    Obermann-Borst, S.A.2    Kremer, D.3
  • 93
    • 79957834770 scopus 로고    scopus 로고
    • Epigenetic gene promoter methylation at birth is associated with childs later adiposity
    • Godfrey KMó Sheppard Aó Gluckman PD et al. (2011) Epigenetic gene promoter methylation at birth is associated with childs later adiposity. Diabetes 60ó 1528-1534
    • (2011) Diabetes , vol.60 , pp. 1528-1534
    • Godfrey, K.M.1    Sheppard, A.2    Gluckman, P.D.3
  • 94
    • 70350674919 scopus 로고    scopus 로고
    • Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: An epigenetic model of obesity and the metabolic syndrome
    • Plagemann Aó Harder Tó Brunn M et al. (2009) Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: An epigenetic model of obesity and the metabolic syndrome. J Physiol 587ó 4963-4976
    • (2009) J Physiol , vol.587 , pp. 4963-4976
    • Plagemann, A.1    Harder, T.2    Brunn, M.3
  • 95
    • 66749093541 scopus 로고    scopus 로고
    • Folic acid Supplementation During the juvenile-pubertal period in rats modifies the phenotype and epigenotype induced by prenatal nutrition
    • Burdge GCó Lillycrop KAó Phillips ES et al. (2009) Folic acid Supplementation During the juvenile-pubertal period in rats modifies the phenotype and epigenotype induced by prenatal nutrition. J Nutr 139ó 1054-1060
    • (2009) J Nutr , vol.139 , pp. 1054-1060
    • Burdge, G.C.1    Lillycrop, K.A.2    Phillips, E.S.3
  • 96
    • 79551558477 scopus 로고    scopus 로고
    • Effect of maternal and postweaning folic acid supplementation on mammary tumor risk in the offspring
    • Ly Aó Lee Hó Chen J et al. (2011) Effect of maternal and postweaning folic acid supplementation on mammary tumor risk in the offspring. Cancer Res 71ó 988-997
    • (2011) Cancer Res , vol.71 , pp. 988-997
    • Ly, A.1    Lee, H.2    Chen, J.3
  • 97
    • 33144488275 scopus 로고    scopus 로고
    • Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus
    • Waterland RAó Lin JRó Smith CA et al. (2006) Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locUS Hum Mol Genet 15ó 705-716
    • (2006) Hum Mol Genet , vol.15 , pp. 705-716
    • Waterland, R.A.1    Lin, J.R.2    Smith, C.A.3
  • 98
    • 0027256637 scopus 로고
    • Reversibility of changes in nucleic acid methylation and gene expression induced in rat liver by severe dietary methyl deficiency
    • Christman JKó Sheikhnejad Gó Dizik M et al. (1993) Reversibility of changes in nucleic acid methylation and gene expression induced in rat liver by severe dietary methyl deficiency. Carcinogenesis 14ó 551-557
    • (1993) Carcinogenesis , vol.14 , pp. 551-557
    • Christman, J.K.1    Sheikhnejad, G.2    Dizik, M.3
  • 99
    • 34447114447 scopus 로고    scopus 로고
    • Older age and dietary folate are determinants of genomic and p16-specific DNA methylation in mouse colon
    • Keyes MKó Jang Hó Mason JB et al. (2007) Older age and dietary folate are determinants of genomic and p16-specific DNA methylation in mouse colon. J Nutr 137ó 1713-1717
    • (2007) J Nutr , vol.137 , pp. 1713-1717
    • Keyes, M.K.1    Jang, H.2    Mason, J.B.3
  • 100
    • 84879302084 scopus 로고    scopus 로고
    • Maternal fat intake in rats alters 20:4n-6 and 22:6n-3 status and the epigenetic regulation of FADS2 in offspring liver
    • Hoile SPó Irvine NAó Kelsall CJ et al. (2013) Maternal fat intake in rats alters 20:4n-6 and 22:6n-3 status and the epigenetic regulation of FADS2 in offspring liver. J Nutr Biochem 24ó 1213-1220
    • (2013) J Nutr Biochem , vol.24 , pp. 1213-1220
    • Hoile, S.P.1    Irvine, N.A.2    Kelsall, C.J.3
  • 101
    • 70449864788 scopus 로고    scopus 로고
    • Effects of caloric restriction on cardiovascular aging in non-human primates and humans
    • ix-x.
    • Cruzen C &Colman RJ (2009) Effects of caloric restriction on cardiovascular aging in non-human primates and humans. Clin Geriatr Med 25ó 733-743ó ix-x.
    • (2009) Clin Geriatr Med , vol.25 , pp. 733-743
    • Cruzen, C.1    Colman, R.J.2
  • 102
    • 34447316421 scopus 로고    scopus 로고
    • Caloric restriction in humans
    • Holloszy JO &Fontana L (2007) Caloric restriction in humans. Exp Gerontol 42ó 709-712
    • (2007) Exp Gerontol , vol.42 , pp. 709-712
    • Holloszy, J.O.1    Fontana, L.2
  • 103
    • 13944253348 scopus 로고    scopus 로고
    • Calorie restriction - The SIR2 connection
    • Guarente L &Picard F (2005) Calorie restriction - The SIR2 connection. Cell 120ó 473-482
    • (2005) Cell , vol.120 , pp. 473-482
    • Guarente, L.1    Picard, F.2
  • 104
    • 0027745794 scopus 로고
    • Effects of caloric restriction in animals on cellular functionó oncogene expressionó and DNA methylation in vitro
    • Hass BSó Hart RWó Lu MH et al. (1993) Effects of caloric restriction in animals on cellular functionó oncogene expressionó and DNA methylation in vitro. Mutat Res 295ó 281-289
    • (1993) Mutat Res , vol.295 , pp. 281-289
    • Hass, B.S.1    Hart, R.W.2    Lu, M.H.3
  • 105
    • 79954838543 scopus 로고    scopus 로고
    • Caloric restriction attenuates age-related changes of DNA methyltransferase 3a in mouse hippocampus
    • Chouliaras Ló van Den Hove DLó Kenis G et al. (2011) Caloric restriction attenuates age-related changes of DNA methyltransferase 3a in mouse hippocampUS Brainó Behav Immun 25ó 616-623
    • (2011) Brainó Behav Immun , vol.25 , pp. 616-623
    • Chouliaras, L.1    Van Den Hove, D.L.2    Kenis, G.3
  • 106
    • 77952305618 scopus 로고    scopus 로고
    • Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression
    • Li Yó Liu L &Tollefsbol TO (2010) Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression. FASEB J 24ó 1442-1453
    • (2010) FASEB J , vol.24 , pp. 1442-1453
    • Li, Y.1    Liu, L.2    Tollefsbol, T.O.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.