Decreasing oxidative stress and neuroinflammation with a multifunctional peptide rescues memory deficits in mice with Alzheimer disease

Free Radical Biology and Medicine

Volumn 74, Issue , 2014, Pages 50-63

  Zhou, Wei Wei ^a   Lu, Shuai ^a   Su, Ya Jing ^a,b   Xue, Di ^b   Yu, Xiao Lin ^a   Wang, Shao Wei ^a   Zhang, He ^a   Xu, Peng Xin ^a,b   Xie, Xi Xiu ^a   Liu, Rui Tian ^a  

^a INSTITUTE OF PROCESS ENGINEERING   (China)

^b NINGXIA UNIVERSITY   (China)

Author keywords

Alzheimer disease; Free radicals; Inflammation; Oxidative stress; Peptide; Amyloid

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; AMYLOID BETA PROTEIN[25-35]; COPPER ZINC SUPEROXIDE DISMUTASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HEPTAPEPTIDE; INTERLEUKIN 1BETA; MANGANESE SUPEROXIDE DISMUTASE; NEUROPROTECTIVE AGENT; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ZW1 PEPTIDE; AMYLOID BETA-PROTEIN (1-42); AUTACOID; OLIGOPEPTIDE; PEPTIDE FRAGMENT; PEPTIDE LIBRARY; SERYL-METHIONYL-SERYL-ALANYL-ARGINYL-GLUTAMINYL-LEUCINE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; BRAIN TISSUE; CELL VIABILITY; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DRUG BINDING SITE; DRUG EFFECT; ENZYME ACTIVITY; FEMALE; GLIOSIS; HUMAN; HUMAN CELL; LIPID PEROXIDATION; MEMORY DISORDER; MICROGLIA; MOLECULAR DYNAMICS; MORRIS WATER MAZE TEST; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEUROBLASTOMA CELL; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; SPATIAL MEMORY; UPREGULATION; AMINO ACID SEQUENCE; ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; C57BL MOUSE; CHEMISTRY; CONVALESCENCE; DISEASE MODEL; DRUG EFFECTS; MEMORY DISORDERS; METABOLISM; MOLECULAR GENETICS; PATHOLOGY; PEPTIDE LIBRARY; PSYCHOLOGY; TRANSGENIC MOUSE; TUMOR CELL LINE;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PEPTIDES; ANIMALS; APOPTOSIS; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; FEMALE; GLUTATHIONE DISULFIDE; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; MEMORY DISORDERS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROGLIA; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; OXIDATIVE STRESS; PEPTIDE FRAGMENTS; PEPTIDE LIBRARY; REACTIVE OXYGEN SPECIES; RECOVERY OF FUNCTION; SPATIAL MEMORY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84904349778     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.06.013     Document Type: Article

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