Conformation-dependent scFv antibodies specifically recognize the oligomers assembled from various amyloids and show colocalization of amyloid fibrils with oligomers in patients with amyloidoses

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1814, Issue 12, 2011, Pages 1703-1712

  Zhang, Xi ^a   Sun, Xiao Xia ^a   Xue, Di ^a,b   Liu, Dong Ge ^c   Hu, Xiao Yan ^d   Zhao, Min ^a   Yang, Shi Gao ^a   Yang, Yang ^a,b   Xia, Yong Jing ^a   Wang, Ying ^a   Liu, Rui Tian ^a  

^a Tsinghua University   (China)

^b NINGXIA UNIVERSITY   (China)

^c BEIJING HOSPITAL   (China)

^d WASHINGTON UNIVERSITY   (United States)

Author keywords

Amyloid; Amyloidosis; Fibril deposit; Single chain variable fragment antibody

Indexed keywords

ALPHA SYNUCLEIN; AMYLIN; AMYLOID; AMYLOID BETA PROTEIN[1-40]; INSULIN; LYSOZYME; OLIGOMER; PRION PROTEIN; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

AMYLOIDOSIS; ANTIBODY ISOLATION; ANTIBODY SPECIFICITY; ARTICLE; CYTOTOXICITY; HUMAN; LEWY BODY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN LOCALIZATION;

AMYLOID; AMYLOIDOSIS; ANTIGEN-ANTIBODY REACTIONS; DIABETES MELLITUS, TYPE 2; HUMANS; LEWY BODIES; MULTIPROTEIN COMPLEXES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN MULTIMERIZATION; SINGLE-CHAIN ANTIBODIES; TISSUE DISTRIBUTION; TUMOR CELLS, CULTURED;

EID: 80054754517     PISSN: 15709639     EISSN: 18781454     Source Type: Journal    
DOI: 10.1016/j.bbapap.2011.09.005     Document Type: Article

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