-
1
-
-
33746310315
-
Alzheimer's disease
-
Blennow, K.; de Leon, M. J.; Zetterberg, H. Alzheimer's disease Lancet 2006, 368, 387-403
-
(2006)
Lancet
, vol.368
, pp. 387-403
-
-
Blennow, K.1
De Leon, M.J.2
Zetterberg, H.3
-
2
-
-
0026941497
-
The disordered neuronal cytoskeleton in Alzheimer's disease
-
Lee, V. M.; Trojanowski, J. Q. The disordered neuronal cytoskeleton in Alzheimer's disease Curr. Opin. Neurobiol. 1992, 2, 653-656
-
(1992)
Curr. Opin. Neurobiol.
, vol.2
, pp. 653-656
-
-
Lee, V.M.1
Trojanowski, J.Q.2
-
3
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
DOI 10.1126/science.1072994
-
Hardy, J.; Selkoe, D. J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics Science 2002, 297, 353-356 (Pubitemid 34790756)
-
(2002)
Science
, vol.297
, Issue.5580
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
4
-
-
0035829592
-
A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity
-
DOI 10.1038/35102591
-
Weggen, S.; Eriksen, J. L.; Das, P.; Sagi, S. A.; Wang, R.; Pietrzik, C. U.; Findlay, K. A.; Smith, T. E.; Murphy, M. P.; Bulter, T.; Kang, D. E.; Marquez-Sterling, N.; Golde, T. E.; Koo, E. H. A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity Nature 2001, 414, 212-216 (Pubitemid 33051236)
-
(2001)
Nature
, vol.414
, Issue.6860
, pp. 212-216
-
-
Weggen, S.1
Eriksen, J.L.2
Das, P.3
Sagi, S.A.4
Wang, R.5
Pietrzik, C.U.6
Findlay, K.A.7
Smith, T.E.8
Murphy, M.P.9
Bulter, T.10
Kang, D.E.11
Marquez-Sterling, N.12
Golde, T.E.13
Koo, E.H.14
-
5
-
-
34548812551
-
The role of amyloid β peptide 42 in Alzheimer's disease
-
DOI 10.1016/j.pharmthera.2007.06.006, PII S016372580700143X
-
Findeis, M. A. The role of amyloid beta peptide 42 in Alzheimer's disease Pharmacol. Ther. 2007, 116, 266-286 (Pubitemid 47451506)
-
(2007)
Pharmacology and Therapeutics
, vol.116
, Issue.2
, pp. 266-286
-
-
Findeis, M.A.1
-
6
-
-
28644437291
-
The amyloid-β precursor protein: Integrating structure with biological function
-
DOI 10.1038/sj.emboj.7600860
-
Reinhard, C.; Hebert, S. S.; De Strooper, B. The amyloid-beta precursor protein: integrating structure with biological function EMBO J. 2005, 24, 3996-4006 (Pubitemid 41752869)
-
(2005)
EMBO Journal
, vol.24
, Issue.23
, pp. 3996-4006
-
-
Reinhard, C.1
Hebert, S.S.2
De Strooper, B.3
-
7
-
-
85047691727
-
NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo
-
DOI 10.1172/JCI200318162
-
Eriksen, J. L.; Sagi, S. A.; Smith, T. E.; Weggen, S.; Das, P.; McLendon, D. C.; Ozols, V. V.; Jessing, K. W.; Zavitz, K. H.; Koo, E. H.; Golde, T. E. NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo J. Clin. Invest. 2003, 112, 440-449 (Pubitemid 38063773)
-
(2003)
Journal of Clinical Investigation
, vol.112
, Issue.3
, pp. 440-449
-
-
Eriksen, J.L.1
Sagi, S.A.2
Smith, T.E.3
Weggen, S.4
Das, P.5
McLendon, D.C.6
Ozols, V.V.7
Jessing, K.W.8
Zavitz, K.H.9
Koo, E.H.10
Golde, T.E.11
-
8
-
-
33845931855
-
Scaffold of the cyclooxygenase-2 (COX-2) inhibitor carprofen provides Alzheimer γ-secretase modulators
-
DOI 10.1021/jm0610200
-
Narlawar, R.; Perez Revuelta, B. I.; Haass, C.; Steiner, H.; Schmidt, B.; Baumann, K. Scaffold of the cyclooxygenase-2 (COX-2) inhibitor carprofen provides Alzheimer gamma-secretase modulators J. Med. Chem. 2006, 49, 7588-7591 (Pubitemid 46033648)
-
(2006)
Journal of Medicinal Chemistry
, vol.49
, Issue.26
, pp. 7588-7591
-
-
Narlawar, R.1
Revuelta, B.I.P.2
Haass, C.3
Steiner, H.4
Schmidt, B.5
Baumann, K.6
-
9
-
-
36349011989
-
1-(3′,4′-Dichloro-2-fluoro[1,1′-biphenyl]-4-yl) -cyclopropanecarboxylic acid (CHF5074), a novel γ-secretase modulator, reduces brain β-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity
-
DOI 10.1124/jpet.107.129007
-
Imbimbo, B. P.; Del Giudice, E.; Colavito, D.; D'Arrigo, A.; Dalle Carbonare, M.; Villetti, G.; Facchinetti, F.; Volta, R.; Pietrini, V.; Baroc, M. F.; Serneels, L.; De Strooper, B.; Leon, A. 1-(3′,4-Dichloro-2-fluoro[1, 1-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity J. Pharmacol. Exp. Ther. 2007, 323, 822-830 (Pubitemid 350146064)
-
(2007)
Journal of Pharmacology and Experimental Therapeutics
, vol.323
, Issue.3
, pp. 822-830
-
-
Imbimbo, B.P.1
Del Giudice, E.2
Colavito, D.3
D'Arrigo, A.4
Dalle Carbonare, M.5
Villetti, G.6
Facchinetti, F.7
Volta, R.8
Pietrini, V.9
Baroc, M.F.10
Serneels, L.11
De Strooper, B.12
Leon, A.13
-
10
-
-
33644804185
-
42 inhibitor and potential Alzheimer's disease modifying agent
-
DOI 10.1016/j.bmcl.2006.01.033, PII S0960894X06000825
-
Stock, N.; Munoz, B.; Wrigley, J. D.; Shearman, M. S.; Beher, D.; Peachey, J.; Williamson, T. L.; Bain, G.; Chen, W.; Jiang, X.; St-Jacques, R.; Prasit, P. The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent Bioorg. Med. Chem. Lett. 2006, 16, 2219-2223 (Pubitemid 43351082)
-
(2006)
Bioorganic and Medicinal Chemistry Letters
, vol.16
, Issue.8
, pp. 2219-2223
-
-
Stock, N.1
Munoz, B.2
Wrigley, J.D.J.3
Shearman, M.S.4
Beher, D.5
Peachey, J.6
Williamson, T.L.7
Bain, G.8
Chen, W.9
Jiang, X.10
St-Jacques, R.11
Prasit, P.12
-
11
-
-
24744448213
-
1-42 secretion
-
DOI 10.1021/jm0502541
-
Peretto, I.; Radaelli, S.; Parini, C.; Zandi, M.; Raveglia, L. F.; Dondio, G.; Fontanella, L.; Misiano, P.; Bigogno, C.; Rizzi, A.; Riccardi, B.; Biscaioli, M.; Marchetti, S.; Puccini, P.; Catinella, S.; Rondelli, I.; Cenacchi, V.; Bolzoni, P. T.; Caruso, P.; Villetti, G.; Facchinetti, F.; Del Giudice, E.; Moretto, N.; Imbimbo, B. P. Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(B)(42) secretion J. Med. Chem. 2005, 48, 5705-5720 (Pubitemid 41298345)
-
(2005)
Journal of Medicinal Chemistry
, vol.48
, Issue.18
, pp. 5705-5720
-
-
Peretto, I.1
Radaelli, S.2
Parini, C.3
Zandi, M.4
Raveglia, L.F.5
Dondio, G.6
Fontanella, L.7
Misiano, P.8
Bigogno, C.9
Rizzi, A.10
Riccardi, B.11
Biscaioli, M.12
Marchetti, S.13
Puccini, P.14
Catinella, S.15
Rondelli, I.16
Cenacchi, V.17
Bolzoni, P.T.18
Caruso, P.19
Villetti, G.20
Facchinetti, F.21
Del Giudice, E.22
Moretto, N.23
Imbimbo, B.P.24
more..
-
12
-
-
0242609178
-
Nonsteroidal Anti-Inflammatory Drugs and Peroxisome Proliferator- Activated Receptor-γ Agonists Modulate Immunostimulated Processing of Amyloid Precursor Protein through Regulation of β-Secretase
-
Sastre, M.; Dewachter, I.; Landreth, G. E.; Willson, T. M.; Klockgether, T.; van Leuven, F.; Heneka, M. T. Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase J. Neurosci. 2003, 23, 9796-9804 (Pubitemid 37371592)
-
(2003)
Journal of Neuroscience
, vol.23
, Issue.30
, pp. 9796-9804
-
-
Sastre, M.1
Dewachter, I.2
Landreth, G.E.3
Wilson, T.M.4
Klockgether, T.5
Van Leuven, F.6
Heneka, M.T.7
-
13
-
-
31044445398
-
Nonsteroidal anti-inflammatory drugs repress β-secretase gene promoter activity by the activation of PPARγ
-
DOI 10.1073/pnas.0503839103
-
Sastre, M.; Dewachter, I.; Rossner, S.; Bogdanovic, N.; Rosen, E.; Borghgraef, P.; Evert, B. O.; Dumitrescu-Ozimek, L.; Thal, D. R.; Landreth, G.; Walter, J.; Klockgether, T.; van Leuven, F.; Heneka, M. T. Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma Proc. Natl. Acad. Sci. U.S.A 2006, 103, 443-448 (Pubitemid 43122420)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.2
, pp. 443-448
-
-
Sastre, M.1
Dewachter, I.2
Rossner, S.3
Bogdanovic, N.4
Rosen, E.5
Borghgraef, P.6
Evert, B.O.7
Dumitrescu-Ozimek, L.8
Thal, D.R.9
Landreth, G.10
Walter, J.11
Klockgether, T.12
Van Leuven, F.13
Heneka, M.T.14
-
14
-
-
0242414463
-
42 by Inhibiting Rho
-
DOI 10.1126/science.1090154
-
Zhou, Y.; Su, Y.; Li, B.; Liu, F.; Ryder, J. W.; Wu, X.; Gonzalez-DeWhitt, P. A.; Gelfanova, V.; Hale, J. E.; May, P. C.; Paul, S. M.; Ni, B. Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho Science 2003, 302, 1215-1217 (Pubitemid 37421027)
-
(2003)
Science
, vol.302
, Issue.5648
, pp. 1215-1217
-
-
Zhou, Y.1
Su, Y.2
Li, B.3
Liu, F.4
Ryder, J.W.5
Wu, X.6
Gonzalez-DeWhitt, P.A.7
Gelfanova, V.8
Hale, J.E.9
May, P.C.10
Paul, S.H.11
Ni, B.12
-
15
-
-
2942599707
-
Native state stabilization by NSAIDs inhibits transthyretin amyloidogenesis from the most common familial disease variants
-
DOI 10.1038/labinvest.3700059
-
Miller, S. R.; Sekijima, Y.; Kelly, J. W. Native state stabilization by NSAIDs inhibits transthyretin amyloidogenesis from the most common familial disease variants Lab. Invest. 2004, 84, 545-552 (Pubitemid 38858463)
-
(2004)
Laboratory Investigation
, vol.84
, Issue.5
, pp. 545-552
-
-
Miller, S.R.1
Sekijima, Y.2
Kelly, J.W.3
-
16
-
-
70349913875
-
Selective modulation of amyloid-beta peptide degradation by flurbiprofen, fenofibrate, and related compounds regulates Abeta levels
-
Abdul-Hay, S. O.; Edirisinghe, P.; Thatcher, G. R. Selective modulation of amyloid-beta peptide degradation by flurbiprofen, fenofibrate, and related compounds regulates Abeta levels J. Neurochem. 2009, 111, 683-695
-
(2009)
J. Neurochem.
, vol.111
, pp. 683-695
-
-
Abdul-Hay, S.O.1
Edirisinghe, P.2
Thatcher, G.R.3
-
17
-
-
77951060145
-
Proteases and proteolysis in Alzheimer disease: A multifactorial view on the disease process
-
De Strooper, B. Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process Physiol. Rev. 2010, 90, 465-494
-
(2010)
Physiol. Rev.
, vol.90
, pp. 465-494
-
-
De Strooper, B.1
-
18
-
-
77952515576
-
An overview of APP processing enzymes and products
-
Chow, V. W.; Mattson, M. P.; Wong, P. C.; Gleichmann, M. An overview of APP processing enzymes and products Neuromol. Med. 2010, 12, 1-12
-
(2010)
Neuromol. Med.
, vol.12
, pp. 1-12
-
-
Chow, V.W.1
Mattson, M.P.2
Wong, P.C.3
Gleichmann, M.4
-
19
-
-
0028896679
-
Nonsteroidal anti-inflammatory drugs in Alzheimer's disease
-
Rich, J. B.; Rasmusson, D. X.; Folstein, M. F.; Carson, K. A.; Kawas, C.; Brandt, J. Nonsteroidal anti-inflammatory drugs in Alzheimer's disease Neurology 1995, 45, 51-55
-
(1995)
Neurology
, vol.45
, pp. 51-55
-
-
Rich, J.B.1
Rasmusson, D.X.2
Folstein, M.F.3
Carson, K.A.4
Kawas, C.5
Brandt, J.6
-
20
-
-
0030897133
-
Risk of Alzheimer's disease and duration of NSAID use
-
Stewart, W. F.; Kawas, C.; Corrada, M.; Metter, E. J. Risk of Alzheimer's disease and duration of NSAID use Neurology 1997, 48, 626-632 (Pubitemid 27120096)
-
(1997)
Neurology
, vol.48
, Issue.3
, pp. 626-632
-
-
Stewart, W.F.1
Kawas, C.2
Corrada, M.3
Metter, E.J.4
-
21
-
-
0035936004
-
Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease
-
DOI 10.1056/NEJMoa010178
-
in t' Veld, B. A.; Ruitenberg, A.; Hofman, A.; Launer, L. J.; van Duijn, C. M.; Stijnen, T.; Breteler, M. M.; Stricker, B. H. Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease N. Engl. J. Med. 2001, 345, 1515-1521 (Pubitemid 33144916)
-
(2001)
New England Journal of Medicine
, vol.345
, Issue.21
, pp. 1515-1521
-
-
In 'T Veld, B.A.1
Ruitenberg, A.2
Hofman, A.3
Launer, L.J.4
Van Duijn, C.M.5
Stijnen, T.6
Breteler, M.M.B.7
Stricker, B.H.C.8
-
22
-
-
43249122280
-
Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: A randomised phase II trial
-
Wilcock, G. K.; Black, S. E.; Hendrix, S. B.; Zavitz, K. H.; Swabb, E. A.; Laughlin, M. A. Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial Lancet Neurol. 2008, 7, 483-493
-
(2008)
Lancet Neurol.
, vol.7
, pp. 483-493
-
-
Wilcock, G.K.1
Black, S.E.2
Hendrix, S.B.3
Zavitz, K.H.4
Swabb, E.A.5
Laughlin, M.A.6
-
23
-
-
77956290821
-
Tarenflurbil in patients with mild Alzheimer's disease
-
Marder, K. Tarenflurbil in patients with mild Alzheimer's disease Curr. Neurol. Neurosci. Rep. 2010, 10, 336-337
-
(2010)
Curr. Neurol. Neurosci. Rep.
, vol.10
, pp. 336-337
-
-
Marder, K.1
-
24
-
-
77954512014
-
CHF5074, a novel gamma-secretase modulator, restores hippocampal neurogenesis potential and reverses contextual memory deficit in a transgenic mouse model of Alzheimer's disease
-
Imbimbo, B. P.; Giardino, L.; Sivilia, S.; Giuliani, A.; Gusciglio, M.; Pietrini, V.; Del Giudice, E.; D'Arrigo, A.; Leon, A.; Villetti, G.; Calza, L. CHF5074, a novel gamma-secretase modulator, restores hippocampal neurogenesis potential and reverses contextual memory deficit in a transgenic mouse model of Alzheimer's disease J. Alzheimer's Dis. 2010, 20, 159-173
-
(2010)
J. Alzheimer's Dis.
, vol.20
, pp. 159-173
-
-
Imbimbo, B.P.1
Giardino, L.2
Sivilia, S.3
Giuliani, A.4
Gusciglio, M.5
Pietrini, V.6
Del Giudice, E.7
D'arrigo, A.8
Leon, A.9
Villetti, G.10
Calza, L.11
-
25
-
-
0024844763
-
Endothelium-derived relaxing factor (nitric oxide) has protective actions in the stomach
-
DOI 10.1016/0024-3205(89)90540-7
-
MacNaughton, W. K.; Cirino, G.; Wallace, J. L. Endothelium-derived relaxing factor (nitric oxide) has protective actions in the stomach Life Sci. 1989, 45, 1869-1876 (Pubitemid 19284677)
-
(1989)
Life Sciences
, vol.45
, Issue.20
, pp. 1869-1876
-
-
MacNaughton, W.K.1
Cirino, G.2
Wallace, J.L.3
-
26
-
-
0038393248
-
Nitric oxide-donating non-steroidal anti-inflammatory drugs: The case of nitroderivatives of aspirin
-
DOI 10.1016/S0223-5234(03)00055-2
-
Chiroli, V.; Benedini, F.; Ongini, E.; Del Soldato, P. Nitric oxide-donating non-steroidal anti-inflammatory drugs: the case of nitroderivatives of aspirin Eur. J. Med. Chem. 2003, 38, 441-446 (Pubitemid 36577196)
-
(2003)
European Journal of Medicinal Chemistry
, vol.38
, Issue.4
, pp. 441-446
-
-
Chiroli, V.1
Benedini, F.2
Ongini, E.3
Del Soldato, P.4
-
27
-
-
17844377296
-
Transgenic AD model mice, effects of potential anti-AD treatments on inflammation and pathology
-
DOI 10.1016/j.brainresrev.2004.12.026, Glial-Neuron Crosstalk in Neuroinflamation, Neurodegeneration and Neuroprotection
-
van Groen, T.; Kadish, I. Transgenic AD model mice, effects of potential anti-AD treatments on inflammation and pathology Brain Res. Brain Res. Rev. 2005, 48, 370-378 (Pubitemid 40585768)
-
(2005)
Brain Research Reviews
, vol.48
, Issue.2
, pp. 370-378
-
-
Van Groen, T.1
Kadish, I.2
-
28
-
-
70349915914
-
NO-flurbiprofen reduces amyloid-beta, is neuroprotective in cell culture, and enhances cognition in response to cholinergic blockade
-
Abdul-Hay, S. O.; Luo, J.; Ashghodom, R. T.; Thatcher, G. R. NO-flurbiprofen reduces amyloid-beta, is neuroprotective in cell culture, and enhances cognition in response to cholinergic blockade J. Neurochem. 2009, 111, 766-776
-
(2009)
J. Neurochem.
, vol.111
, pp. 766-776
-
-
Abdul-Hay, S.O.1
Luo, J.2
Ashghodom, R.T.3
Thatcher, G.R.4
-
29
-
-
7244223227
-
Comparison between flurbiprofen and its nitric oxide-releasing derivatives HCT-1026 and NCX-2216 on Aβ(1-42)-induced brain inflammation and neuronal damage in the rat
-
Prosperi, C.; Scali, C.; Barba, M.; Bellucci, A.; Giovannini, M. G.; Pepeu, G.; Casamenti, F. Comparison between flurbiprofen and its nitric oxide-releasing derivatives HCT-1026 and NCX-2216 on Abeta(1-42)-induced brain inflammation and neuronal damage in the rat Int. J. Immunopathol. Pharmacol. 2004, 17, 317-330 (Pubitemid 39481675)
-
(2004)
International Journal of Immunopathology and Pharmacology
, vol.17
, Issue.3
, pp. 317-330
-
-
Prosperi, C.1
Scali, C.2
Barba, M.3
Bellucci, A.4
Giovannini, M.G.5
Pepeu, G.6
Casamenti, F.7
-
30
-
-
34047202594
-
1-42 lowering agents
-
DOI 10.1016/j.phrs.2006.12.010, PII S104366180700014X
-
Imbimbo, B. P.; Del Giudice, E.; Cenacchi, V.; Volta, R.; Villetti, G.; Facchinetti, F.; Riccardi, B.; Puccini, P.; Moretto, N.; Grassi, F.; Ottonello, S.; Leon, A. In vitro and in vivo profiling of CHF5022 and CHF5074 Two beta-amyloid1-42 lowering agents Pharmacol. Res. 2007, 55, 318-328 (Pubitemid 46533934)
-
(2007)
Pharmacological Research
, vol.55
, Issue.4
, pp. 318-328
-
-
Imbimbo, B.P.1
Del Giudice, E.2
Cenacchi, V.3
Volta, R.4
Villetti, G.5
Facchinetti, F.6
Riccardi, B.7
Puccini, P.8
Moretto, N.9
Grassi, F.10
Ottonello, S.11
Leon, A.12
-
31
-
-
54349129548
-
Anti-inflammatory, antiproliferative, and cytoprotective activity of NO chimera nitrates of use in cancer chemoprevention
-
Hagos, G. K.; Abdul-Hay, S. O.; Sohn, J.; Edirisinghe, P. D.; Chandrasena, R. E.; Wang, Z.; Li, Q.; Thatcher, G. R. J. Anti-inflammatory, antiproliferative, and cytoprotective activity of NO chimera nitrates of use in cancer chemoprevention Mol. Pharmacol. 2008, 74, 1381-1391
-
(2008)
Mol. Pharmacol.
, vol.74
, pp. 1381-1391
-
-
Hagos, G.K.1
Abdul-Hay, S.O.2
Sohn, J.3
Edirisinghe, P.D.4
Chandrasena, R.E.5
Wang, Z.6
Li, Q.7
Thatcher, G.R.J.8
-
32
-
-
0034949092
-
Flurbiprofen enantiomers inhibit inducible nitric oxide synthase expression in RAW 264.7 macrophages
-
DOI 10.1023/A:1011020132140
-
Hinz, B.; Brune, K.; Rau, T.; Pahl, A. Flurbiprofen enantiomers inhibit inducible nitric oxide synthase expression in RAW 264.7 macrophages Pharm. Res. 2001, 18, 151-156 (Pubitemid 32592593)
-
(2001)
Pharmaceutical Research
, vol.18
, Issue.2
, pp. 151-156
-
-
Hinz, B.1
Brune, K.2
Rau, T.3
Pahl, A.4
-
33
-
-
0035220745
-
Inhibition of NF-kappaB and AP-1 activation by R - And S -flurbiprofen
-
Tegeder, I.; Niederberger, E.; Israr, E.; Guhring, H.; Brune, K.; Euchenhofer, C.; Grosch, S.; Geisslinger, G. Inhibition of NF-kappaB and AP-1 activation by R-and S -flurbiprofen FASEB J 2001, 15, 2-4
-
(2001)
FASEB J
, vol.15
, pp. 2-4
-
-
Tegeder, I.1
Niederberger, E.2
Israr, E.3
Guhring, H.4
Brune, K.5
Euchenhofer, C.6
Grosch, S.7
Geisslinger, G.8
-
34
-
-
4644231576
-
Nitrates and no release: Contemporary aspects in biological and medicinal chemistry
-
DOI 10.1016/j.freeradbiomed.2004.06.013, PII S0891584904004654
-
Thatcher, G. R. J.; Nicolescu, A. C.; Bennett, B. M.; Toader, V. Nitrates and NO release: contemporary aspects in biological and medicinal chemistry Free Radical Biol. Med. 2004, 37, 1122-1143 (Pubitemid 39302540)
-
(2004)
Free Radical Biology and Medicine
, vol.37
, Issue.8
, pp. 1122-1143
-
-
Thatcher, G.R.J.1
Nicolescu, A.C.2
Bennett, B.M.3
Toader, V.4
-
35
-
-
0347717736
-
Modulation of β-amyloid metabolism by non-steroidal anti-inflammatory drugs in neuronal cell cultures
-
Gasparini, L.; Rusconi, L.; Xu, H.; del Soldato, P.; Ongini, E. Modulation of beta-amyloid metabolism by non-steroidal anti-inflammatory drugs in neuronal cell cultures J. Neurochem. 2004, 88, 337-348 (Pubitemid 38084550)
-
(2004)
Journal of Neurochemistry
, vol.88
, Issue.2
, pp. 337-348
-
-
Gasparini, L.1
Rusconi, L.2
Xu, H.3
Del Soldato, P.4
Ongini, E.5
-
36
-
-
67650604641
-
CHF5074, a novel gamma-secretase modulator, attenuates brain beta-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease
-
Imbimbo, B.; Hutter-Paier, B.; Villetti, G.; Facchinetti, F.; Cenacchi, V.; Volta, R.; Lanzillotta, A.; Pizzi, M.; Windisch, M. CHF5074, a novel gamma-secretase modulator, attenuates brain beta-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease Br. J. Pharmacol. 2009, 156 (6) 982-993
-
(2009)
Br. J. Pharmacol.
, vol.156
, Issue.6
, pp. 982-993
-
-
Imbimbo, B.1
Hutter-Paier, B.2
Villetti, G.3
Facchinetti, F.4
Cenacchi, V.5
Volta, R.6
Lanzillotta, A.7
Pizzi, M.8
Windisch, M.9
-
37
-
-
58149147147
-
The nitrosylated flurbiprofen derivative HCT1026 inhibits cytokine-induced signalling through a novel mechanism of action
-
Idris, A. I.; Ralston, S. H.; van't Hof, R. J. The nitrosylated flurbiprofen derivative HCT1026 inhibits cytokine-induced signalling through a novel mechanism of action Eur. J. Pharmacol. 2009, 602, 215-222
-
(2009)
Eur. J. Pharmacol.
, vol.602
, pp. 215-222
-
-
Idris, A.I.1
Ralston, S.H.2
Van't Hof, R.J.3
-
38
-
-
2142757264
-
Gastric Tolerability and Prolonged Prostaglandin Inhibition in the Brain with a Nitric Oxide-Releasing Flurbiprofen Derivative, NCX-2216 [3-[4-(2-Fluoro-±-methyl-[1,1′-biphenyl]-4-acetyloxy) -3-methoxyphenyl]-2-propenoic acid 4-nitrooxy butyl ester]
-
DOI 10.1124/jpet.103.063453
-
Wallace, J. L.; Muscara, M. N.; de Nucci, G.; Zamuner, S.; Cirino, G.; del Soldato, P.; Ongini, E. Gastric tolerability and prolonged prostaglandin inhibition in the brain with a nitric oxide-releasing flurbiprofen derivative, NCX-2216 [3-[4-(2-fluoro-alpha-methyl-[1,1-biphenyl]-4-acetyloxy)-3- methoxyphenyl]-2-propenoic acid 4-nitrooxy butyl ester] J. Pharmacol. Exp. Ther. 2004, 309, 626-633 (Pubitemid 38542616)
-
(2004)
Journal of Pharmacology and Experimental Therapeutics
, vol.309
, Issue.2
, pp. 626-633
-
-
Wallace, J.L.1
Muscara, M.N.2
De Nucci, G.3
Zamuner, S.4
Cirino, G.5
Del Soldato, P.6
Ongini, E.7
-
39
-
-
33645867681
-
In vitro metabolism of (nitrooxy)butyl ester nitric oxide-releasing compounds: Comparison with glyceryl trinitrate
-
Govoni, M.; Casagrande, S.; Maucci, R.; Chiroli, V.; Tocchetti, P. In vitro metabolism of (nitrooxy)butyl ester nitric oxide-releasing compounds: comparison with glyceryl trinitrate J. Pharmacol. Exp. Ther. 2006, 317, 752-761
-
(2006)
J. Pharmacol. Exp. Ther.
, vol.317
, pp. 752-761
-
-
Govoni, M.1
Casagrande, S.2
Maucci, R.3
Chiroli, V.4
Tocchetti, P.5
-
40
-
-
0034945019
-
NO-flurbiprofen attenuates excitotoxin-induced brain inflammation, and releases nitric oxide in the brain
-
Prosperi, C.; Scali, C.; Pepeu, G.; Casamenti, F. NO-flurbiprofen attenuates excitotoxin-induced brain inflammation, and releases nitric oxide in the brain Jpn J. Pharmacol. 2001, 86, 230-235
-
(2001)
Jpn J. Pharmacol.
, vol.86
, pp. 230-235
-
-
Prosperi, C.1
Scali, C.2
Pepeu, G.3
Casamenti, F.4
-
41
-
-
21044458540
-
Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Aβ42 production
-
DOI 10.1038/nm1235
-
Kukar, T.; Murphy, M. P.; Eriksen, J. L.; Sagi, S. A.; Weggen, S.; Smith, T. E.; Ladd, T.; Khan, M. A.; Kache, R.; Beard, J.; Dodson, M.; Merit, S.; Ozols, V. V.; Anastasiadis, P. Z.; Das, P.; Fauq, A.; Koo, E. H.; Golde, T. E. Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production Nature Med. 2005, 11, 545-550 (Pubitemid 40685978)
-
(2005)
Nature Medicine
, vol.11
, Issue.5
, pp. 545-550
-
-
Kukar, T.1
Murphy, M.P.2
Eriksen, J.L.3
Sagi, S.A.4
Weggen, S.5
Smith, T.E.6
Ladd, T.7
Khan, M.A.8
Kache, R.9
Beard, J.10
Dodson, M.11
Merit, S.12
Ozols, V.V.13
Anastasiadis, P.Z.14
Das, P.15
Fauq, A.16
Koo, E.H.17
Golde, T.E.18
-
42
-
-
45149105232
-
Substrate-targeting gamma-secretase modulators
-
Kukar, T. L.; Ladd, T. B.; Bann, M. A.; Fraering, P. C.; Narlawar, R.; Maharvi, G. M.; Healy, B.; Chapman, R.; Welzel, A. T.; Price, R. W.; Moore, B.; Rangachari, V.; Cusack, B.; Eriksen, J.; Jansen-West, K.; Verbeeck, C.; Yager, D.; Eckman, C.; Ye, W.; Sagi, S.; Cottrell, B. A.; Torpey, J.; Rosenberry, T. L.; Fauq, A.; Wolfe, M. S.; Schmidt, B.; Walsh, D. M.; Koo, E. H.; Golde, T. E. Substrate-targeting gamma-secretase modulators Nature 2008, 453, 925-929
-
(2008)
Nature
, vol.453
, pp. 925-929
-
-
Kukar, T.L.1
Ladd, T.B.2
Bann, M.A.3
Fraering, P.C.4
Narlawar, R.5
Maharvi, G.M.6
Healy, B.7
Chapman, R.8
Welzel, A.T.9
Price, R.W.10
Moore, B.11
Rangachari, V.12
Cusack, B.13
Eriksen, J.14
Jansen-West, K.15
Verbeeck, C.16
Yager, D.17
Eckman, C.18
Ye, W.19
Sagi, S.20
Cottrell, B.A.21
Torpey, J.22
Rosenberry, T.L.23
Fauq, A.24
Wolfe, M.S.25
Schmidt, B.26
Walsh, D.M.27
Koo, E.H.28
Golde, T.E.29
more..
-
43
-
-
38149013121
-
Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation
-
Page, R. M.; Baumann, K.; Tomioka, M.; Perez-Revuelta, B. I.; Fukumori, A.; Jacobsen, H.; Flohr, A.; Luebbers, T.; Ozmen, L.; Steiner, H.; Haass, C. Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation J. Biol. Chem. 2008, 283, 677-683
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 677-683
-
-
Page, R.M.1
Baumann, K.2
Tomioka, M.3
Perez-Revuelta, B.I.4
Fukumori, A.5
Jacobsen, H.6
Flohr, A.7
Luebbers, T.8
Ozmen, L.9
Steiner, H.10
Haass, C.11
-
44
-
-
0038719688
-
Sulindac sulfide is a noncompetitive γ-secretase inhibitor that preferentially reduces Aβ42 generation
-
DOI 10.1074/jbc.M301619200
-
Takahashi, Y.; Hayashi, I.; Tominari, Y.; Rikimaru, K.; Morohashi, Y.; Kan, T.; Natsugari, H.; Fukuyama, T.; Tomita, T.; Iwatsubo, T. Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation J. Biol. Chem. 2003, 278, 18664-18670 (Pubitemid 36799494)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.20
, pp. 18664-18670
-
-
Takahashi, Y.1
Hayashi, I.2
Tominari, Y.3
Rikimaru, K.4
Morohashi, Y.5
Kan, T.6
Natsugari, H.7
Fukuyama, T.8
Tomita, T.9
Iwatsubo, T.10
-
45
-
-
24744448213
-
1-42 secretion
-
DOI 10.1021/jm0502541
-
Peretto, I.; Radaelli, S.; Parini, C.; Zandi, M.; Raveglia, L. F.; Dondio, G.; Fontanella, L.; Misiano, P.; Bigogno, C.; Rizzi, A.; Riccardi, B.; Biscaioli, M.; Marchetti, S.; Puccini, P.; Catinella, S.; Rondelli, I.; Cenacchi, V.; Bolzoni, P. T.; Caruso, P.; Villetti, G.; Facchinetti, F.; DelGiudice, E.; Moretto, N.; Imbimbo, B. P. Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid1-42 secretion J. Med. Chem. 2005, 48, 5705-5720 (Pubitemid 41298345)
-
(2005)
Journal of Medicinal Chemistry
, vol.48
, Issue.18
, pp. 5705-5720
-
-
Peretto, I.1
Radaelli, S.2
Parini, C.3
Zandi, M.4
Raveglia, L.F.5
Dondio, G.6
Fontanella, L.7
Misiano, P.8
Bigogno, C.9
Rizzi, A.10
Riccardi, B.11
Biscaioli, M.12
Marchetti, S.13
Puccini, P.14
Catinella, S.15
Rondelli, I.16
Cenacchi, V.17
Bolzoni, P.T.18
Caruso, P.19
Villetti, G.20
Facchinetti, F.21
Del Giudice, E.22
Moretto, N.23
Imbimbo, B.P.24
more..
-
46
-
-
0001090596
-
Preparation of benzylic ±,±-difluoronitriles, -tetrazoles, and -sulfonates via electrophilic fluorination
-
Kotoris, C. C.; Chen, M.-J.; Taylor, S. D. Preparation of benzylic I±-difluoronitriles, -tetrazoles, and -sulfonates via electrophilic fluorination J. Org. Chem. 1998, 63, 8052-8057 (Pubitemid 128723057)
-
(1998)
Journal of Organic Chemistry
, vol.63
, Issue.22
, pp. 8052-8057
-
-
Kotoris, C.C.1
Chen, M.-J.2
Taylor, S.D.3
-
47
-
-
33748741715
-
A novel general method for preparation of ±-fluoro-±- arylcarboxylic acid. Direct fluorination of silyl ketene acetals with Selectfluor
-
DOI 10.1016/j.tetlet.2006.08.057, PII S0040403906016625
-
Zhang, F.; Song, J. Z. A novel general method for preparation of [alpha]-fluoro-[alpha]-arylcarboxylic acid. Direct fluorination of silyl ketene acetals with Selectfluor Tetrahedron Lett. 2006, 47, 7641-7644 (Pubitemid 44402529)
-
(2006)
Tetrahedron Letters
, vol.47
, Issue.43
, pp. 7641-7644
-
-
Zhang, F.1
Song, J.Z.2
|