-
1
-
-
3142514201
-
Protein aggregation and neurodegenerative disease
-
Ross C.A., and Poirier M.A. Protein aggregation and neurodegenerative disease. Nat. Med. 10 (2004) S10-S17
-
(2004)
Nat. Med.
, vol.10
-
-
Ross, C.A.1
Poirier, M.A.2
-
2
-
-
4344580888
-
Strategies for disease modification in Alzheimer's disease
-
Citron M. Strategies for disease modification in Alzheimer's disease. Nat. Rev. Neurosci. 5 (2004) 677-685
-
(2004)
Nat. Rev. Neurosci.
, vol.5
, pp. 677-685
-
-
Citron, M.1
-
3
-
-
0037264120
-
Unfolding the role of protein misfolding in neurodegenerative diseases
-
Soto C. Unfolding the role of protein misfolding in neurodegenerative diseases. Nat. Rev. Neurosci. 4 (2003) 49-60
-
(2003)
Nat. Rev. Neurosci.
, vol.4
, pp. 49-60
-
-
Soto, C.1
-
5
-
-
0035411641
-
Beta-amyloid aggregation inhibitors for the treatment of Alzheimer's disease: dream or reality?
-
Talaga P. Beta-amyloid aggregation inhibitors for the treatment of Alzheimer's disease: dream or reality?. Mini Rev. Med. Chem. 1 (2001) 175-186
-
(2001)
Mini Rev. Med. Chem.
, vol.1
, pp. 175-186
-
-
Talaga, P.1
-
6
-
-
0035983921
-
The challenge of inhibiting Abeta polymerization
-
LeVine H. The challenge of inhibiting Abeta polymerization. Curr. Med. Chem. 9 (2002) 1121-1133
-
(2002)
Curr. Med. Chem.
, vol.9
, pp. 1121-1133
-
-
LeVine, H.1
-
7
-
-
18644384035
-
Potent and selective structure-based dibenzofuran inhibitors of transthyretin amyloidogenesis: kinetic stabilization of the native state
-
Petrassi H.M., Johnson S.M., Purkey H.E., Chiang K.P., Walkup T., Jiang X., et al. Potent and selective structure-based dibenzofuran inhibitors of transthyretin amyloidogenesis: kinetic stabilization of the native state. J. Am. Chem. Soc. 127 (2005) 6662-6671
-
(2005)
J. Am. Chem. Soc.
, vol.127
, pp. 6662-6671
-
-
Petrassi, H.M.1
Johnson, S.M.2
Purkey, H.E.3
Chiang, K.P.4
Walkup, T.5
Jiang, X.6
-
8
-
-
0141632823
-
New inhibitors of scrapie-associated prion protein formation in a library of 2000 drugs and natural products
-
Kocisko D.A., Baron G.S., Rubenstein R., Chen J., Kuizon S., and Caughey B. New inhibitors of scrapie-associated prion protein formation in a library of 2000 drugs and natural products. J. Virol. 77 (2003) 10288-10294
-
(2003)
J. Virol.
, vol.77
, pp. 10288-10294
-
-
Kocisko, D.A.1
Baron, G.S.2
Rubenstein, R.3
Chen, J.4
Kuizon, S.5
Caughey, B.6
-
9
-
-
0034807861
-
Amyloid fibril formation in microwell plates for screening of inhibitors
-
Lin Y.M., Raffen R., Zhou Y., Cassidy C.S., Flavin M.T., and Stevens F.J. Amyloid fibril formation in microwell plates for screening of inhibitors. Amyloid 8 (2001) 182-193
-
(2001)
Amyloid
, vol.8
, pp. 182-193
-
-
Lin, Y.M.1
Raffen, R.2
Zhou, Y.3
Cassidy, C.S.4
Flavin, M.T.5
Stevens, F.J.6
-
10
-
-
33749043758
-
Peptide model systems for amyloid fiber formation: design strategies and validation methods
-
Esteras-Chopo A., Pastor M.T., and López de la Paz M. Peptide model systems for amyloid fiber formation: design strategies and validation methods. Methods Mol. Biol. 340 (2006) 253-276
-
(2006)
Methods Mol. Biol.
, vol.340
, pp. 253-276
-
-
Esteras-Chopo, A.1
Pastor, M.T.2
López de la Paz, M.3
-
11
-
-
0034682788
-
Inhibition of toxicity in the beta-amyloid peptide fragment β(25-35) using N-methylated derivatives-a general strategy to prevent amyloid formation
-
Hughes E., Burke R.M., and Doig A.J. Inhibition of toxicity in the beta-amyloid peptide fragment β(25-35) using N-methylated derivatives-a general strategy to prevent amyloid formation. J. Biol. Chem. 275 (2000) 25109-25115
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 25109-25115
-
-
Hughes, E.1
Burke, R.M.2
Doig, A.J.3
-
12
-
-
0036300750
-
Structure-based design and study of non-amyloidogenic, double N-methylated IAPP amyloid core sequences as inhibitors of IAPP amyloid formation and cytotoxicity
-
Kapurniotu A., Schmauder A., and Tenidis K. Structure-based design and study of non-amyloidogenic, double N-methylated IAPP amyloid core sequences as inhibitors of IAPP amyloid formation and cytotoxicity. J. Mol. Biol. 315 (2002) 339-350
-
(2002)
J. Mol. Biol.
, vol.315
, pp. 339-350
-
-
Kapurniotu, A.1
Schmauder, A.2
Tenidis, K.3
-
13
-
-
0033603003
-
Modified-peptide inhibitors of amyloid beta-peptide polymerization
-
Findeis M.A., Musso G.M., Arico-Muendel C.C., Benjamin H.W., Hundal A.M., Lee J.J., et al. Modified-peptide inhibitors of amyloid beta-peptide polymerization. Biochemistry 38 (1999) 6791-6800
-
(1999)
Biochemistry
, vol.38
, pp. 6791-6800
-
-
Findeis, M.A.1
Musso, G.M.2
Arico-Muendel, C.C.3
Benjamin, H.W.4
Hundal, A.M.5
Lee, J.J.6
-
14
-
-
0030600371
-
Inhibition of Alzheimer's amyloidosis by peptides that prevent beta-sheet conformation
-
Soto C., Kindy M.S., Baumann M., and Frangione B. Inhibition of Alzheimer's amyloidosis by peptides that prevent beta-sheet conformation. Biochem. Biophys. Res. Commun. 226 (1996) 672-680
-
(1996)
Biochem. Biophys. Res. Commun.
, vol.226
, pp. 672-680
-
-
Soto, C.1
Kindy, M.S.2
Baumann, M.3
Frangione, B.4
-
15
-
-
4544388592
-
Inhibition of amyloid fibril formation by peptide analogues modified with alpha-aminoisobutyric acid
-
Gilead S., and Gazit E. Inhibition of amyloid fibril formation by peptide analogues modified with alpha-aminoisobutyric acid. Angew. Chem., Int. Ed. Engl. 43 (2004) 4041-4044
-
(2004)
Angew. Chem., Int. Ed. Engl.
, vol.43
, pp. 4041-4044
-
-
Gilead, S.1
Gazit, E.2
-
16
-
-
33646130171
-
Inhibition of insulin fibrillogenesis with targeted peptides
-
Gibson T.J., and Murphy R.M. Inhibition of insulin fibrillogenesis with targeted peptides. Protein Sci. 15 (2006) 1133-1141
-
(2006)
Protein Sci.
, vol.15
, pp. 1133-1141
-
-
Gibson, T.J.1
Murphy, R.M.2
-
17
-
-
0035800087
-
Structure-function relationships for inhibitors of beta-amyloid toxicity containing the recognition sequence KLVFF
-
Lowe T.L., Strzelec A., Kiessling L.L., and Murphy R.M. Structure-function relationships for inhibitors of beta-amyloid toxicity containing the recognition sequence KLVFF. Biochemistry 40 (2001) 7882-7889
-
(2001)
Biochemistry
, vol.40
, pp. 7882-7889
-
-
Lowe, T.L.1
Strzelec, A.2
Kiessling, L.L.3
Murphy, R.M.4
-
18
-
-
0036615884
-
Reduction of amyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with a beta-sheet breaker peptide
-
Permanne B., Adessi C., Saborio G.P., Fraga S., Frossard M.J., Van Dorpe J., et al. Reduction of amyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with a beta-sheet breaker peptide. FASEB J. 16 (2002) 860-862
-
(2002)
FASEB J.
, vol.16
, pp. 860-862
-
-
Permanne, B.1
Adessi, C.2
Saborio, G.P.3
Fraga, S.4
Frossard, M.J.5
Van Dorpe, J.6
-
19
-
-
0038529679
-
Pharmacological profiles of peptide drug candidates for the treatment of Alzheimer's disease
-
Adessi C., Frossard M.J., Boissard C., Fraga S., Bieler S., Ruckle T., et al. Pharmacological profiles of peptide drug candidates for the treatment of Alzheimer's disease. J. Biol. Chem. 278 (2003) 13905-13911
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 13905-13911
-
-
Adessi, C.1
Frossard, M.J.2
Boissard, C.3
Fraga, S.4
Bieler, S.5
Ruckle, T.6
-
20
-
-
40949123338
-
-
Soto-Jara, C., Baumann, M. H. & Frangione, B. (2002). Peptides and pharmaceutical compositions thereof for treatment of disorders or diseases associated with abnormal protein folding into amyloid or amyloid-like deposits. US Patent 6462171.
-
Soto-Jara, C., Baumann, M. H. & Frangione, B. (2002). Peptides and pharmaceutical compositions thereof for treatment of disorders or diseases associated with abnormal protein folding into amyloid or amyloid-like deposits. US Patent 6462171.
-
-
-
-
21
-
-
6044240725
-
Beta-sheet breaker peptide prevents Abeta-induced spatial memory impairments with partial reduction of amyloid deposits
-
Chacon M.A., Barria M.I., Soto C., and Inestrosa N.C. Beta-sheet breaker peptide prevents Abeta-induced spatial memory impairments with partial reduction of amyloid deposits. Mol. Psychiatry 9 (2004) 953-961
-
(2004)
Mol. Psychiatry
, vol.9
, pp. 953-961
-
-
Chacon, M.A.1
Barria, M.I.2
Soto, C.3
Inestrosa, N.C.4
-
22
-
-
40949094578
-
-
Axonyx Announces Milestone Payment from Serono after Initiation of Clinical Trial in Alzheimer's. Press release (April 14, 2003): http://findarticles.com/p/articles/mi_m0EIN/is_2003_April_24/ai_10054655 1
-
Axonyx Announces Milestone Payment from Serono after Initiation of Clinical Trial in Alzheimer's. Press release (April 14, 2003): http://findarticles.com/p/articles/mi_m0EIN/is_2003_April_24/ai_10054655 1
-
-
-
-
23
-
-
0030953792
-
Controlling amyloid beta-peptide fibril formation with protease-stable ligands
-
Tjernberg L.O., Lilliehook C., Callaway D.J., Naslund J., Hahne S., Thyberg J., et al. Controlling amyloid beta-peptide fibril formation with protease-stable ligands. J. Biol. Chem. 272 (1997) 12601-12605
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 12601-12605
-
-
Tjernberg, L.O.1
Lilliehook, C.2
Callaway, D.J.3
Naslund, J.4
Hahne, S.5
Thyberg, J.6
-
24
-
-
0042818327
-
Stereoselective interactions of peptide inhibitors with the beta-amyloid peptide
-
Chalifour R.J., McLaughlin R.W., Lavoie L., Morissette C., Tremblay N., Boule M., et al. Stereoselective interactions of peptide inhibitors with the beta-amyloid peptide. J. Biol. Chem. 278 (2003) 34874-34881
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 34874-34881
-
-
Chalifour, R.J.1
McLaughlin, R.W.2
Lavoie, L.3
Morissette, C.4
Tremblay, N.5
Boule, M.6
-
25
-
-
0041467577
-
Selection of d-amino-acid peptides that bind to Alzheimer's disease amyloid peptide abeta1-42 by mirror image phage display
-
Wiesehan K., Buder K., Linke R.P., Patt S., Stoldt M., Unger E., et al. Selection of d-amino-acid peptides that bind to Alzheimer's disease amyloid peptide abeta1-42 by mirror image phage display. ChemBioChem 4 (2003) 748-753
-
(2003)
ChemBioChem
, vol.4
, pp. 748-753
-
-
Wiesehan, K.1
Buder, K.2
Linke, R.P.3
Patt, S.4
Stoldt, M.5
Unger, E.6
-
26
-
-
0031445940
-
Mechanism and prevention of neurotoxicity caused by beta-amyloid peptides: relation to Alzheimer's disease
-
Blanchard B.J., Konopka G., Russell M., and Ingram V.M. Mechanism and prevention of neurotoxicity caused by beta-amyloid peptides: relation to Alzheimer's disease. Brain Res. 776 (1997) 40-50
-
(1997)
Brain Res.
, vol.776
, pp. 40-50
-
-
Blanchard, B.J.1
Konopka, G.2
Russell, M.3
Ingram, V.M.4
-
27
-
-
0033135179
-
Stereochemical specificity of Alzheimer's disease beta-peptide assembly
-
Esler W.P., Stimson E.R., Fishman J.B., Ghilardi J.R., Vinters H.V., Mantyh P.W., and Maggio J.E. Stereochemical specificity of Alzheimer's disease beta-peptide assembly. Biopolymers 49 (1999) 505-514
-
(1999)
Biopolymers
, vol.49
, pp. 505-514
-
-
Esler, W.P.1
Stimson, E.R.2
Fishman, J.B.3
Ghilardi, J.R.4
Vinters, H.V.5
Mantyh, P.W.6
Maggio, J.E.7
-
28
-
-
11844298976
-
Stereospecific amyloid-like fibril formation by a peptide fragment of beta2-microglobulin
-
Wadai H., Yamaguchi K., Takahashi S., Kanno T., Kawai T., Naiki H., and Goto Y. Stereospecific amyloid-like fibril formation by a peptide fragment of beta2-microglobulin. Biochemistry 44 (2005) 157-164
-
(2005)
Biochemistry
, vol.44
, pp. 157-164
-
-
Wadai, H.1
Yamaguchi, K.2
Takahashi, S.3
Kanno, T.4
Kawai, T.5
Naiki, H.6
Goto, Y.7
-
31
-
-
2442553006
-
Short amino acid stretches can mediate amyloid formation in globular proteins: the Src homology 3 (SH3) case
-
Ventura S., Zurdo J., Narayanan S., Parreno M., Mangues R., Reif B., et al. Short amino acid stretches can mediate amyloid formation in globular proteins: the Src homology 3 (SH3) case. Proc. Natl Acad. Sci. USA 101 (2004) 7258-7263
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 7258-7263
-
-
Ventura, S.1
Zurdo, J.2
Narayanan, S.3
Parreno, M.4
Mangues, R.5
Reif, B.6
-
32
-
-
3242735504
-
An amyloid-forming segment of beta2-microglobulin suggests a molecular model for the fibril
-
Ivanova M.I., Sawaya M.R., Gingery M., Attinger A., and Eisenberg D. An amyloid-forming segment of beta2-microglobulin suggests a molecular model for the fibril. Proc. Natl Acad. Sci. USA 101 (2004) 10584-10589
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 10584-10589
-
-
Ivanova, M.I.1
Sawaya, M.R.2
Gingery, M.3
Attinger, A.4
Eisenberg, D.5
-
33
-
-
37349043948
-
Amyloid toxicity is independent of polypeptide sequence, length and chirality
-
Pastor M.T., Kummerer N., Schubert V., Esteras-Chopo A., Dotti C.G., López de la Paz M., and Serrano L. Amyloid toxicity is independent of polypeptide sequence, length and chirality. J. Mol. Biol. 375 (2008) 695-707
-
(2008)
J. Mol. Biol.
, vol.375
, pp. 695-707
-
-
Pastor, M.T.1
Kummerer, N.2
Schubert, V.3
Esteras-Chopo, A.4
Dotti, C.G.5
López de la Paz, M.6
Serrano, L.7
-
34
-
-
0037059063
-
De novo designed peptide-based amyloid fibrils
-
López de la Paz M., Goldie K., Zurdo J., Lacroix E., Dobson C.M., Hoenger A., and Serrano L. De novo designed peptide-based amyloid fibrils. Proc. Natl Acad. Sci. USA 99 (2002) 16052-16057
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 16052-16057
-
-
López de la Paz, M.1
Goldie, K.2
Zurdo, J.3
Lacroix, E.4
Dobson, C.M.5
Hoenger, A.6
Serrano, L.7
-
35
-
-
3843148352
-
Prefibrillar amyloid protein aggregates share common features of cytotoxicity
-
Bucciantini M., Calloni G., Chiti F., Formigli L., Nosi D., Dobson C.M., and Stefani M. Prefibrillar amyloid protein aggregates share common features of cytotoxicity. J. Biol. Chem. 279 (2004) 31374-31382
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 31374-31382
-
-
Bucciantini, M.1
Calloni, G.2
Chiti, F.3
Formigli, L.4
Nosi, D.5
Dobson, C.M.6
Stefani, M.7
-
36
-
-
16644379264
-
Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function
-
Cleary J.P., Walsh D.M., Hofmeister J.J., Shankar G.M., Kuskowski M.A., Selkoe D.J., and Ashe K.H. Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function. Nat. Neurosci. 8 (2005) 79-84
-
(2005)
Nat. Neurosci.
, vol.8
, pp. 79-84
-
-
Cleary, J.P.1
Walsh, D.M.2
Hofmeister, J.J.3
Shankar, G.M.4
Kuskowski, M.A.5
Selkoe, D.J.6
Ashe, K.H.7
-
37
-
-
0242668337
-
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
-
Kayed R., Head E., Thompson J.L., McIntire T.M., Milton S.C., Cotman C.W., and Glabe C.G. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 300 (2003) 486-489
-
(2003)
Science
, vol.300
, pp. 486-489
-
-
Kayed, R.1
Head, E.2
Thompson, J.L.3
McIntire, T.M.4
Milton, S.C.5
Cotman, C.W.6
Glabe, C.G.7
-
38
-
-
0037041426
-
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
-
Walsh D.M., Klyubin I., Fadeeva J.V., Cullen W.K., Anwyl R., Wolfe M.S., et al. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416 (2002) 535-539
-
(2002)
Nature
, vol.416
, pp. 535-539
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
Cullen, W.K.4
Anwyl, R.5
Wolfe, M.S.6
-
39
-
-
0035961291
-
Pathogenesis, diagnosis and treatment of systemic amyloidosis
-
discussion 210-1
-
Pepys M.B. Pathogenesis, diagnosis and treatment of systemic amyloidosis. Philos. Trans. R. Soc. London, Ser. B 356 (2001) 203-210 discussion 210-1
-
(2001)
Philos. Trans. R. Soc. London, Ser. B
, vol.356
, pp. 203-210
-
-
Pepys, M.B.1
-
40
-
-
0027946254
-
Helix stop and start signals in peptides and proteins. The capping box does not necessarily prevent helix elongation
-
Jimenez M.A., Munoz V., Rico M., and Serrano L. Helix stop and start signals in peptides and proteins. The capping box does not necessarily prevent helix elongation. J. Mol. Biol. 242 (1994) 487-496
-
(1994)
J. Mol. Biol.
, vol.242
, pp. 487-496
-
-
Jimenez, M.A.1
Munoz, V.2
Rico, M.3
Serrano, L.4
-
41
-
-
0037154249
-
Combinatorial approaches: a new tool to search for highly structured beta-hairpin peptides
-
Pastor M.T., López de la Paz M., Lacroix E., Serrano L., and Perez-Paya E. Combinatorial approaches: a new tool to search for highly structured beta-hairpin peptides. Proc. Natl Acad. Sci. USA 99 (2002) 614-619
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 614-619
-
-
Pastor, M.T.1
López de la Paz, M.2
Lacroix, E.3
Serrano, L.4
Perez-Paya, E.5
-
42
-
-
20444440728
-
Structure of the cross-beta spine of amyloid-like fibrils
-
Nelson R., Sawaya M.R., Balbirnie M., Madsen A.O., Riekel C., Grothe R., and Eisenberg D. Structure of the cross-beta spine of amyloid-like fibrils. Nature 435 (2005) 773-778
-
(2005)
Nature
, vol.435
, pp. 773-778
-
-
Nelson, R.1
Sawaya, M.R.2
Balbirnie, M.3
Madsen, A.O.4
Riekel, C.5
Grothe, R.6
Eisenberg, D.7
-
43
-
-
5044235541
-
Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins
-
Fernandez-Escamilla A.M., Rousseau F., Schymkowitz J., and Serrano L. Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins. Nat. Biotechnol. 22 (2004) 1302-1306
-
(2004)
Nat. Biotechnol.
, vol.22
, pp. 1302-1306
-
-
Fernandez-Escamilla, A.M.1
Rousseau, F.2
Schymkowitz, J.3
Serrano, L.4
-
44
-
-
20444403757
-
Prediction of "aggregation-prone" and "aggregation-susceptible" regions in proteins associated with neurodegenerative diseases
-
Pawar A.P., Dubay K.F., Zurdo J., Chiti F., Vendruscolo M., and Dobson C.M. Prediction of "aggregation-prone" and "aggregation-susceptible" regions in proteins associated with neurodegenerative diseases. J. Mol. Biol. 350 (2005) 379-392
-
(2005)
J. Mol. Biol.
, vol.350
, pp. 379-392
-
-
Pawar, A.P.1
Dubay, K.F.2
Zurdo, J.3
Chiti, F.4
Vendruscolo, M.5
Dobson, C.M.6
-
45
-
-
33645238380
-
The 3D profile method for identifying fibril-forming segments of proteins
-
Thompson M.J., Sievers S.A., Karanicolas J., Ivanova M.I., Baker D., and Eisenberg D. The 3D profile method for identifying fibril-forming segments of proteins. Proc. Natl Acad. Sci. USA 103 (2006) 4074-4078
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 4074-4078
-
-
Thompson, M.J.1
Sievers, S.A.2
Karanicolas, J.3
Ivanova, M.I.4
Baker, D.5
Eisenberg, D.6
-
46
-
-
34249290108
-
Atomic structures of amyloid cross-beta spines reveal varied steric zippers
-
Sawaya M.R., Sambashivan S., Nelson R., Ivanova M.I., Sievers S.A., Apostol M.I., et al. Atomic structures of amyloid cross-beta spines reveal varied steric zippers. Nature 447 (2007) 453-457
-
(2007)
Nature
, vol.447
, pp. 453-457
-
-
Sawaya, M.R.1
Sambashivan, S.2
Nelson, R.3
Ivanova, M.I.4
Sievers, S.A.5
Apostol, M.I.6
-
47
-
-
24044507958
-
Multiple assembly pathways underlie amyloid-beta fibril polymorphisms
-
Goldsbury C., Frey P., Olivieri V., Aebi U., and Muller S.A. Multiple assembly pathways underlie amyloid-beta fibril polymorphisms. J. Mol. Biol. 352 (2005) 282-298
-
(2005)
J. Mol. Biol.
, vol.352
, pp. 282-298
-
-
Goldsbury, C.1
Frey, P.2
Olivieri, V.3
Aebi, U.4
Muller, S.A.5
|