A genome scan for loci influencing anti-atherogenic serum bilirubin levels

European Journal of Human Genetics

Volumn 10, Issue 9, 2002, Pages 539-546

  Kronenberg, Florian ^a,b   Coon, Hilary ^a,c   Gutin, Alexader ^a,b   Abkevich, Victor ^a,b   Samuels, Mark E ^a,b,d   Ballinger, Dennis G ^a,b,e   Hopkins, Paul N ^a   Hunt, Steven C ^a  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF INNSBRUCK   (Austria)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^d Xenon Genetics Inc   (Canada)

^e Ingenuity Systems Inc   (United States)

Author keywords

Antioxidants; Atherosclerosis; Bilirubin; Coronary artery disease; Genetics; Linkage analysis

Indexed keywords

BILIRUBIN; GLYCOSYLTRANSFERASE;

ADULT; ARTICLE; ATHEROGENESIS; BILIRUBIN BLOOD LEVEL; CHROMOSOME 10Q; CHROMOSOME 18Q; CHROMOSOME 2Q; CHROMOSOME 9Q; CHROMOSOME POLYMORPHISM; CONTROLLED STUDY; CORONARY ARTERY DISEASE; FEMALE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC MODEL; GENOME ANALYSIS; GENOTYPE; GILBERT DISEASE; HUMAN; HYPERBILIRUBINEMIA; LINKAGE ANALYSIS; MAJOR CLINICAL STUDY; MALE; MARKER GENE; NONPARAMETRIC TEST; PEDIGREE ANALYSIS; POPULATION GENETICS; PRIORITY JOURNAL; PROMOTER REGION; SCORING SYSTEM; SEGREGATION ANALYSIS;

ADULT; ARTERIOSCLEROSIS; BILIRUBIN; BIOLOGICAL MARKERS; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 2; CORONARY DISEASE; FEMALE; GENETIC MARKERS; GENOTYPE; HUMANS; IMMUNITY, NATURAL; LINKAGE (GENETICS); MALE; MODELS, GENETIC; PEDIGREE; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); STATISTICS, NONPARAMETRIC;

EID: 0036713314     PISSN: 10184813     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ejhg.5200842     Document Type: Article

References (55)

1. Association of serum bilirubin concentration with risk of coronary artery disease
2. Bilirubin is an antioxidant of possible physiological importance
3. Antioxidant activity of albumin-bound bilirubin
4. Free and albumin-bound bilirubin are efficient co-antioxidants for alpha-tocopherol, inhibiting plasma and low density lipoprotein lipid peroxidation
5. Characterization of bilirubin inhibitory properties in free radical oxidation reactions
6. Antioxidation of human low density lipoprotein by unconjugated and conjugated bilirubins
7. Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury
8. Albumin-bound bilirubins protect human ventricular myocytes against oxyradical damage
9. Heme oxygenase-carbon monoxide signalling pathway in atherosclerosis: Anti-atherogenic actions of bilirubin and carbon monoxide?
10. Regulation of scavenger receptor expression in smooth muscle cells by protein kinase C: A role for oxidative stress
11. Bilirubin inhibits protein kinase C activity and protein kinase C-mediated phosphorylation of endogenous substrates in human skin fibroblasts
12. Association of low serum concentration of bilirubin with increased risk of coronary artery disease
13. Evidence for a major gene elevating serum bilirubin concentration in Utah pedigrees
14. Association of plasma bilirubin with coronary heart disease and segregation of bilirubin as a major gene trait: The NHLBI Family Heart Study
15. Serum bilirubin and risk of ischemic heart disease in middle-aged British men
16. Higher serum bilirubin is associated with decreased risk for early familial coronary artery disease
17. Relationship between bilirubin, apolipoprotein B, and coronary artery disease
18. Total serum bilirubin and risk of cardiovascular disease in the Framingham offspring study
19. Serum bilirubin distribution and its relation to cardiovascular risk in children and young adults
20. Evidence of linkage of familial hypoalphalipoproteinernia to a novel locus on chromosome I1q23
21. Health family trees: A tool for finding and helping young family members of coronary and cancer prone pedigrees in Texas and Utah
22. Liver Function
23. PedCheck: A program for identification of genotype incompatibilities in linkage analysis
24. Construction of multilocus genetic linkage maps in humans
25. Pedigree analysis package, rev. 4
26. Linkage analysis in the presence of errors I: Complex-valued recombination fractions and complex phenotypes
27. Multilocus linkage analysis by blocked Gibbs sampling
28. A new nonparametric linkage statistic for mapping both qualitative and quantitative trait loci
29. Parametric and nonparametric linkage analysis: A unified multipoint approach
30. A major predisposition locus for severe obesity, at 4p15-p14
31. Association of smoking and low serum bilirubin antioxidant concentrations
32. Comparison of laboratory parameters as risk factors for the presence and the extent of coronary or carotid atherosclerosis: The significance of apolipoprotein B to apolipoprotein all ratio
33. Serum bilirubin and 10-year mortality risk in a Belgian population
34. Contributions of NO synthase and heme oxygenase to cGMP formation by cytokine and hermin treated brain capillary endothelial cells
35. Induction of the antioxidant stress proteins heme oxygenase-1 and MSP23 by stress agents and oxidised LDL in cultured vascular smooth muscle cells
36. The interaction between ruptured erythrocytes and low-density lipoproteins
37. A beneficial role of bile pigments as an endogenous tissue protector: Anticomplement effects of biliverdin and conjugated bilirubin
38. Heme oxygenase: A novel target for the modulation of the inflammatory response
39. Chromosomal mapping of a human phenol UDP-glucuronosyltransferase, GNT1
40. Sequence of exons and the flanking regions of human bilirubin-UDP-glucuronosyltransferase gene complex and identification of a genetic mutation in a patient with Crigler-Naijar syndrome, type I
41. Identification of a genetic alteration in the code for bilirubin UDP-glucuronosyl-transferase in the UGT1 gene complex of a Crigler-Najjar type I patient
42. Cosegregation of intragenic markers with a novel mutation that causes Crigler-Najjar syndrome type I: Implication in carrier detection and prenatal diagnosis
43. A mutation in bilirubin uridine 5′-diphosphate-glucuronosyltransferase isoform 1 causing Crigler-Najjar syndrome type II
44. Identification of an A-to-G missense mutation in exon 2 of the UGT1 gene complex that causes Crigler-Najjar syndrome type 2
45. Population studies on Gilbert's syndrome
46. Does Gilbert's disease exist?
47. Die Prävalenz des Gilbert-Syndroms in Deutschland
48. Genetic defects of the UDP-glucuronosyltransferase-1 (UGT1) gene that cause familial non-haemolytic unconjugated hyperbilirubinaemias
49. The genetic basis of the reduced expression of bilirubin UDP- glucuronosyltransferase 1 in Gilbert's syndrome
50. Genetic variation in bilirubin UPD-glucuronosyltransferase gene promoter and Gilbert's syndrome
51. (TA)8 allele in the UGT1A1 gene promoter of a Caucasian with Gilbert's syndrome
52. Gilbert syndrome and ischemic heart disease: A protective effect of elevated bilirubin levels
53. Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis
54. Identification of a common variant in the lipoprotein lipase gene in a large Utah kindred ascertained for coronary heart disease: The -93G/D9N variant predisposes to low HDL-C/high triglycerides
55. Normal variation in leptin levels in associated with polymorphisms in the proopiomelanocortin gene, POMC