Decreased oxidation susceptibility of plasma low density lipoproteins in patients with Gilbert's syndrome

Journal of Gastroenterology and Hepatology (Australia)

Volumn 23, Issue 10, 2008, Pages 1556-1560

  Yesilova, Zeki ^a,b   Serdar, Muhittin ^b   Ercin, C Nuri ^b   Gunay, Alp ^c   Kilciler, Guldem ^b   Hasimi, Adnan ^b   Uygun, Ahmet ^b   Kurt, Ismail ^b   Erbil, M Kemal ^b   Dagalp, Kemal ^b  

^a GULHANE SCHOOL OF MEDICINE   (Turkey)

^b Gulhane Military Academic Hospital   (Japan)

^c Golcuk Army Hospital   (Turkey)

Author keywords

Bilirubin; Gilbert's syndrome; Low density lipoprotein (LDL) oxidation

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; APOLIPOPROTEIN A; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CHOLESTEROL; GAMMA GLUTAMYLTRANSFERASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRIACYLGLYCEROL;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORONARY ARTERY DILATATION; ENZYME ACTIVITY; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GILBERT DISEASE; HUMAN; LIPOPROTEIN BLOOD LEVEL; MALE; OXIDATION; PATHOGENESIS; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 53349127896     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2008.05388.x     Document Type: Article

References (28)

1. Bosma PJ. Inherited disorders of bilirubin metabolism. J. Hepatol. 2003 38 : 107 17.
2. Peters WHM, te Morsche RHM, Roelofs HMJ. Combined polymorphisms in UDP-glucuronosyltransferases 1A1 and 1A6: implications for patients with Gilbert's syndrome. J. Hepatol. 2003 38 : 3 8.
3. Gullu H, Erdogan D, Tok D et al. High serum bilirubin concentrations preserve coronary flow reserve and coronary microvascular functions. Arterioscler. Thromb. Vasc. Biol. 2005 11 : 2289 9.
4. Ross R. Atherosclerosis-an inflamatory disease. N. Engl. J Med. 1999 340 : 115 26.
5. Mylonas C, Kouretas D. Lipid peroxidation and tissue damage. In Vivo 1999 13 : 295 309.
6. Vitek L, Jirsa M Brodanova M et al. Gilbert syndrome and ischemic heart disease: a protective effect of elevated bilirubin concentrations, Atherosclerosis 2002 160 : 449 56.
7. Danzong Y. Appropriate excitation/emission wavelengths for flourometric determination of thiobarbituric acid reactive substances. Clin. Chem. 1995 41 : 329 30.
8. Cao G, Alessio HM, Cutler RG. Oxygen-radical absorbance capacity assay for antioxidants. Free Radic. Biol. Med. 1993 14 : 303 11.
9. Schwertner HA, Jackson WG, Tolan G. Association of low serum concentration of bilirubin with increased risk of coronary artery disease. Clin. Chem. 1994 40 : 18 23.
10. Hopkins PN, Wu LL, Hunt SC, James BC, Vincent GM, Williams RR. Higher serum bilirubin is associated with decreased risk for early familial coronary artery disease. Arterioscler. Thromb. Vasc. Biol. 1996 16 : 250 5.
11. Breimer LH, Wannamethee G, Ebraim S, Shaper AG. Serum bilirubin and risk of ischemic heart disease in middle-aged British men. Clin. Chem. 1995 41 : 1504 8.
12. Wu TW, Fung KP, Yang CC. Unconjugated bilirubin inhibits the oxidation of human low-density lipoprotein better than trolox. Life Sci. 1994 54 : 477 81.
13. Yamaguchi T, Terakado M, Horio F, Aoki K, Tanaka M, Nakajima H. Role of bilirubin as an antioxidant in an ischemia-reperfusion of rat liver and induction of heme oxygenase. Biochem. Biophys. Res. Commun. 1996 223 : 129 31.
14. Nakagami T, Toyomura K, Kinoshita T, Morisawa S. A beneficial role of bile pigments as an endogenous tissue protector: anti-complement effects of biliverdin and conjugated bilirubin. Biochim. Biophys. Acta 1993 1158 : 189 93.
15. Hulea SA, Wasowicz E, Kummerow FA. Inhibition of metal-catalyzed oxidation of low-density lipoprotein by free and albumin-bound bilirubin. Biochim. Biophys. Acta 1995 1259 : 29 38.
16. Mayer M. Association of serum bilirubin concentration with risk of coronary artery disease. Clin. Chem. 2000 46 : 1723 7.
17. Wu TW, Fung KP, Wu J, Yang CC, Weisel RD. Antioxidation of human low density lipoprotein by unconjugated and conjugated bilirubins. Biochem. Pharmacol. 1996 51 : 859 62.
18. Wu TW, Fung KP, Yang CC. Unconjugated bilirubin inhibits the oxidation of human low density lipoprotein better than Trolox. Life Sci. 1994 54 : 477 81.
19. Breimer LH, Wannamethee G, Ebrahim S, Shaper AG. Serum bilirubin and risk of ischemic heart disease in middle-aged British men. Clin. Chem. 1995 41 : 1504 8.
20. Clark JE, Foresti R, Sarathchandra P, Kaur H, Green CJ, Motterlini R. Heme oxygenase-1-derived bilirubin ameliorates postischemic myocardial dysfunction. Am. J. Physiol. Heart Circ. Physiol. 2000 278 : H643.
21. Sharma HS, Manlik N, Gho BC, Das DK, Verdouw PD. Coordinated expression of heme oxygenase-1 and ubiquitin in the porcine heart subjected to ischemia and reperfusion. Mol. Cell Biochem. 1996 157 : 111 16.
22. Raju VS, Maines MD. Renal ischemia/reperfusion up-regulates heme oxygenase-l (H5P32): expression and increases cGMP in rat. J. Pharmacol. Exp. Ther. 1996 277 (3 1814 22.
23. Ishizaka N, de Leon H, Laursen JB et al. Angiotensin II-induced hypertension increases heme oxygenase-1 expression in rat aorta. Circulation 1997 96 : 1923 9.
24. Hanckock WW, Buelow R, Sayegh MH, Turka LA. Antibody induced transplant arteriosclerosis is prevented by graft expression of antioxidant and antiapoptotic genes. Nat. Med. 1998 4 : 1392 6.
25. Siow RC, Sato H, Mann GE. Heme oxygenase-carbon monoxide signalling pathway in atherosclerosis: anti-atherogenic actions of bilirubin and carbon monoxide? Cardiovasc. Res. 1999 41 : 385 94.
26. Platt JL, Nath KA. Heme oxygenase: protective gene or Trojan horse. Nat. Med. 1998 4 : 1364 5.
27. Willis D, Moore AR, Frederik R, Willoughby DA. Heme oxygenase: a novel target for the modulation of the inflammatory response. Nat. Med. 1996 2 : 87 90.
28. Pflueger A, Croatt AJ, Peterson TE et al. The hyperbilirubinemic Gunn rat is resistant to the pressor effects of angiotensin II. Am. J. Physiol. Renal Physiol. 2005 288 : 552 8.