The bilirubin level is negatively correlated with the incidence of hypertension in normotensive Korean population

Journal of Korean Medical Science

Volumn 24, Issue SUPPL.1, 2009, Pages

  Chin, Ho Jun ^a,b   Song, Young Rim ^c   Kim, Hyo Sang ^a   Park, Minseon ^a   Yoon, Hyung Jin ^d   Na, Ki Young ^a,b   Kim, Yonsu ^a   Chae, Dong Wan ^a,b   Kim, Suhnggwon ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Seoul National University Bundang Hospital   (South Korea)

^c Hallym University College of Medicine   (South Korea)

^d Seoul National University Hospital   (South Korea)

Author keywords

Hyperbilirubinemia; Hypertension; Risk factor

Indexed keywords

BILIRUBIN; HEME; HEME OXYGENASE;

ADULT; ARTICLE; BLOOD; BLOOD PRESSURE; CHEMISTRY; FEMALE; HUMAN; HYPERTENSION; KOREA; MALE; METABOLISM; MIDDLE AGED; PROPORTIONAL HAZARDS MODEL; QUESTIONNAIRE; RISK; SMOKING;

ADULT; BILIRUBIN; BLOOD PRESSURE; FEMALE; HEME; HEME OXYGENASE (DECYCLIZING); HUMANS; HYPERTENSION; KOREA; MALE; MIDDLE AGED; PROPORTIONAL HAZARDS MODELS; QUESTIONNAIRES; RISK; SMOKING;

EID: 62449095700     PISSN: 10118934     EISSN: 15986357     Source Type: Journal    
DOI: 10.3346/jkms.2009.24.S1.S50     Document Type: Article

References (33)

1. Kirkby KA, Adin CA. Products of heme oxygenase and their potential therapeutic applications. Am J Physiol Renal Physiol 2006; 290: F563-71.
2. Goodman AI, Quan S, Yang L, Synghal A, Abraham NG. Functional expression of human heme oxygenase-1 gene in renal structure of spontaneously hypertensive rats. Exp Biol Med 2003; 228: 454-8.
3. Sabaawy HE, Zhang F, Nguyen X, ElHosseiny A, Nasjletti A, Schwartzman M, Dennery P, Kappas A, Abraham NG. Human heme oxygenase-1 gene transfer lowers blood pressure and promotes growth in spontaneously hypertensive rats. Hypertension 2001; 38: 210-5.
4. Ndisang JF, Zhao W, Wang R. Selective regulation of blood pressure by heme oxygenase-1 in hypertension. Hypertension 2002; 40: 315-21.
5. Botros FT, Schwartzman ML, Stier CT Jr, Goodman AI, Abraham NG. Increase in heme oxygenase-1 levels ameliorates renovascular hypertension. Kidney Int 2005; 68: 2745-55.
6. Pradhan A, Umezu M, Fukagawa M. Heme-oxygenase upregulation ameliorates angiotensin II- induced tubulointerstitial injury and saltsensitive hypertension. Am J Nephrol 2006; 26: 552-61.
7. Vera T, Kelsen S, Yanes LL, Reckelhoff JF, Stec DE. HO-1 induction lowers blood pressure and superoxide production in the renal medulla of angiotensin II hypertensive mice. Am J Physiol Regul Integr Comp Physiol 2007; 292: R1472-8.
8. Johnson RA, Lavesa M, DeSeyn K, Scholer MJ, Nasjletti A. Heme oxygenase substrates acutely lower blood pressure in hypertensive rats. Am J Physiol 1996; 271: H1132-8.
9. Johnson RA, Lavesa M, Askari B, Abraham NG, Nasjletti. A heme oxygenase product, presumably carbon monoxide, mediates a vasodepressor function in rats. Hypertension 1995; 25: 166-9.
10. Wiesel P, Patel AP, Carvajal IM, Wang ZY, Pellacani A, Maemura K, DiFonzo N, Rennke HG, Layne MD, Yet SF, Lee ME, Perrella MA. Exacerbation of chronic renovascular hypertension and acute renal failure in heme oxygenase-1 deficient mice. Circ Res 2001; 88: 1088-94.
11. Motterlini R, Gonzales A, Foresti R, Clark JE, Green CG, Winslow RM. Heme oxygenase-1- derived carbon monoxide contributes to the suppression of acute hypertensive responses in vivo. Circ Res 1998; 83: 568-77.
12. Kitiyakara C, Wilcox CS. Antioxidants for hypertension. Curr Opin Nephrol Hypertens 1998; 7: 531-8.
13. Reckelhoff JF, Romero JC. Role of oxidative stress in angiotensininduced hypertension. Am J Physiol Regul Integr Comp Physiol 2003; 284: R893-912.
14. Stocker R, Yamamoto Y, McDonagh AF, Glazer AN, Ames BN. Bilirubin is an antioxidant of possible physiological importance. Science 1989; 235: 1043-6.
15. Pflueger A, Croatt AJ, Peterson TE, Smith LA, d'Uscio LV, Katusic ZS, Nath KA. The hyperbilirubinemic Gunn rats is resistant to the pressor effects of angiotensin II. Am J Physiol Renal Physiol 2005; 288: F552-8.
16. Lanone S, Bloc S, Foresti R, Almolki A, Taille C, Callebert J, Conti M, Goven D, Aubier M, Dureuil B, El-Benna J, Motterlini R, Boczkowski J. Bilirubin decreases nos2 expression via inhibition of NAD (P)H oxidase: implications for protection against endotoxic shock in rats. FASEB J 2005; 19: 1890-2.
17. Sano K, Nakamura H, Matsuo T. Mode of inhibitory action of bilirubin on protein kinase C. Pediatr Res 1985; 19: 587-90.
18. Rajagopalan S, Kurz S, Munzel T, Tarpey M, Freeman BA, Griendling KK, Harrison DG. Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/ NADPH oxidase activation. Contribution to alterations of vascular tone. J Clin Invest 1996; 97: 1916-23.
19. Novotny L, Vitek L. Inverse relationship between serum bilirubin and atherosclerosis in Men: A meta-analysis of published studies. Exp Biol Med (Maywood) 2003; 228: 568-71.
20. Papadakis JA. Ganotakis ES, Jagroop IA, Jagroop IA, Mikhailidis DP, Winder AF. Effect of hypertension and its treatment on lipid, lipoprotein(a), fibrinogen, and bilirubin levels in patients referred for dyslipidemia. Am J Hypertens 1999; 12: 673-81.
21. Van Hoydonck PG, Temme EH, Schouten EG. Serum bilirubin concentration in a Belgian population: the association with smoking status and type of cigarettes. Int J Epidemiol 2001; 30: 1465-72.
22. White GL Jr, Nelson JA, Pedersen DM, Ash KO. Fasting and gender (and altitude?) influence reference intervals for serum bilirubin in healthy adults. Clin Chem 1981; 27: 1140-2.
23. Zucker SD, Horn PS, Sherman KE. Serum Bilirubin Levels in the U. S. Population: Gender Effect and Inverse Correlation With Colorectal Cancer. Hepatology 2004; 40: 827-35.
24. Suzuki H, Swei A, Zweifach BW, Schmid-Schonbein GW. In vivo evidence for microvascular oxidative stress in spontaneously hypertensive rats. Hydroethidine microfluorography. Hypertension 1995; 25: 1083-9.
25. Nicod L, Rodriguez S, Letang JM, Viollon-Abadie C, Jacqueson A, Berthelot A, Richert L. Antioxidant status, lipid peroxidation, mixed function oxidase and UDP-glucuronyl transferase activities in livers from control and DOCA-salt hypertensive male Sprague Dawley rats. Mol Cell Biochem 2000; 203: 33-9.
26. Swei A, Lacy F, DeLano FA, Schmid-Schonbein GW. Oxidative stress in the Dahl hypertensive rat. Hypertension 1997; 30: 1628-33.
27. Laursen JB, Rajagopalan S, Galis Z, Tarpey M, Freeman BA, Harrison DG. Role of superoxide in angiotensin II-induced but not catecholamine-induced hypertension. Circulation 1997; 95: 588-93.
28. Kumar KV, Das UN. Are free radicals involved in the pathobiology of human essential hypertension? Free Radic Res Commun 1993; 19: 59-66.
29. Frei B, Forte TM, Ames BN, Cross CE. Gas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma. Biochem J 1991; 277: 133-8.
30. Villard PH, Herber R, Seree EM, Attolini L, Magdalou J, Lacarelle B. Effect of cigarette smoke on UDP-glucuronyltransferase activity and cytochrome P450 content in liver, lung and kidney microsomes in mice. Pharmacol Toxicol 1998; 2: 74-9.
31. Rhee MY, Na SH, Kim YK, Lee MM, Kim HY. Acute effects of cigarettes smoking on arterial Stiffness and blood pressure in male smokers with hypertension. Am J Hypertens 2007; 20: 637-41.
32. Toth B, Yokoyama Y, Kuebler JF, Schwacha MG, Rue LW, Bland KI, Chaudry IH. Sex differences in hepatic heme oxygenase expression and activity following trauma and hemorrhagic shock. Arch Surg 2003; 138: 1375-82.
33. Hong JS, Yi SW, Kang HC, Jee SH, Kang HG, Bayasgalan G, Ohrr H. Age at menopause and cause-specific mortality in South Korean Women: Kangwha Cohort Study. Maturitas 2007; 56: 411-9.