Vascular calcification in chronic kidney disease

Clinical Science

Volumn 119, Issue 3, 2010, Pages 111-121

  Covic, Adrian ^a   Kanbay, Mehmet ^b   Voroneanu, Luminita ^a   Turgut, Faruk ^b   Serban, Dragomir N ^c   Serban, Ionela Lacramioara ^c   Goldsmith, David J ^d  

^a C I PARHON NATIONAL INSTITUTE OF ENDOCRINOLOGY   (Romania)

^b FATIH UNIVERSITY MEDICAL SCHOOL   (Turkey)

^c GRIGORE T POPA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^d GUY S HOSPITAL   (United Kingdom)

Author keywords

Arterial stiffness; Calcimimetic; Haemodialysis; Hyperphosphataemia; Non calcium phosphate binder; Vitamin D

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; CALCIMIMETIC AGENT; CALCITRIOL; CALCIUM; CALCIUM ACETATE; CALCIUM CARBONATE; CINACALCET; DOXERCALCIFEROL; ETIDRONIC ACID; FETUIN A; FIBROBLAST GROWTH FACTOR 23; INDICAN; LANTHANUM; MATRIX PROTEIN; OSTEOPROTEGERIN; PAMIDRONIC ACID; PARATHYROID HORMONE; PARICALCITOL; PHOSPHATE; PHOSPHATE BINDING AGENT; PYROPHOSPHATE; SEVELAMER; VITAMIN D; VITAMIN D RECEPTOR; VITAMIN K GROUP;

ABDOMINAL RADIOGRAPHY; ARTERIAL STIFFNESS; ARTERY CALCIFICATION; BLOOD VESSEL CALCIFICATION; BONE METABOLISM; CALCIFICATION; CALCIUM METABOLISM; CARDIOVASCULAR RISK; CARTILAGE CELL; CHRONIC KIDNEY DISEASE; COMPUTER ASSISTED TOMOGRAPHY; CORONARY ARTERY BLOOD FLOW; ELECTRON BEAM TOMOGRAPHY; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE ISCHEMIA; HUMAN; MORBIDITY; MORTALITY; MULTIDETECTOR COMPUTED TOMOGRAPHY; NONHUMAN; OSTEOBLAST; OUTCOME ASSESSMENT; PATHOGENESIS; PHOSPHATE METABOLISM; PRIORITY JOURNAL; REVIEW; SMOOTH MUSCLE FIBER; ULTRASOUND; URINARY EXCRETION;

CALCINOSIS; CALCIUM; HUMANS; PHOSPHATES; RENAL INSUFFICIENCY, CHRONIC; VASCULAR DISEASES; VITAMIN D DEFICIENCY;

EID: 77954904199     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20090631     Document Type: Review

References (102)

1. Moe, S. M. and Chen, N. X. (2008) Mechanisms of vascular calcification in chronic kidney disease. J. Am. Soc. Nephrol. 19, 213-216
2. Goldsmith, D., Covic, A., Sambrook, P. and Ackrill, P. (1997) Vascular calcification in long-term haemodialysis patients in a single unit: a retrospective analysis. Nephron 77, 37-43 (Pubitemid 27395339)
3. Shroff, R. C. and Shanahan, C. M. (2007) The vascular biology of calcification. Semin. Dial. 20, 103-109
4. Chertow, G. M., Raggi, P., Chasan-Taber S. Bommer, J., Holzer, H. and Burke, S.K. (2004) Determinants of progressive vascular calcification in haemodialysis patients. Nephrol. Dial. Transplant. 19, 1489-1496
5. Nitta, K., Akiba, T., Uchida, K., Otsubo, S., Otsubo, Y., Takei, T., Ogawa, T., Yumura, W., Kabaya, T. and Nihei, H. (2004) Left ventricular hypertrophy is associated with arterial stiffness and vascular calcification in hemodialysis patients. Hypertens. Res. 27, 47-52
6. London, G. M., Guérin, A. P., Marchais, S. J., Métivier, F., Pannier, B. and Adda, H. (2003) Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality. Nephrol. Dial. Transplant. 18, 1731-1740
7. Floege, J., Raggi, P., Block, G. A., Torres, P. A., Csiky, B., Naso, A., Nossuli, K., Moustafa, M., Goodman, W. G., Nicole Lopez, L. et al. (2010) Study design and subject baseline characteristics in the ADVANCE Study: effects of cinacalcet on vascular calcification in haemodialysis patients. Nephrol. Dial, Transplant., doi:10.1093/ndt/gfp762
8. Kalantar-Zadeh, K., Block, G., Humphreys, M. H. and Kopple, J. D. (2003) Reverse epidemiology of cardiovascular risk factors in maintenance dialysis patients. Kidney Int. 63, 793-808 (Pubitemid 36315558)
9. Guérin, A., London, G., Marchais, S. and Metivier, F. (2000) Arterial stiffening and vascular calcifications in end-stage renal disease. Nephrol. Dial. Transplant. 15, 1014-1021
10. Shanahan, C., Cary, N., Salisbury, J., Proudfoot, D., Weissberg, P. and Edmonds, M. (1999) Medial localization of mineralization-regulating proteins in association with Mönckeberg's sclerosis: evidence for smooth muscle cell-mediated vascular calcification. Circulation 100, 2168-2176
11. Shioi, A., Taniwaki, H., Jono, S., Okuno, Y., Koyama, H., Mori, K. and Nishizawa, Y. (2001) Mönckeberg's medial sclerosis and inorganic phosphate in uremia. Am. J. Kidney Dis. 38, S47-S49
12. Wexler, L., Brundage, B., Crouse, J., Detrano, R., Fuster, V., Maddahi, J., Rumberger, J., Stanford, W., White, R. and Taubert, K. (1996) Coronary artery calcification: pathophysiology, epidemiology, imaging methods, and clinical implications. A statement for health professionals from the American Heart Association. Circulation 94, 1175-1192
13. London, G., Marchais, S., Guerin, A., Metivier, F. and Adda, H. (2002) Arterial structure and function in end-stage renal disease. Nephrol. Dial. Transplant. 17, 1713-1724
14. Dhore, C. R., Cleutjens, J. P., Lutgens, E., Cleutjens, K. B., Geusens, P. P., Kitslaar, P. J., Tordoir, J. H., Spronk, H. M., Vermeer, C. and Daemen, M. J. (2001) Differential expression of bone matrix regulatory proteins in human atherosclerotic plaques. Arterioscler. Thromb. Vasc. Biol. 21, 1998-2003
15. Chillon, J. M., Mozar, A., Six, I., Maizel, J., Bugnicourt, J. M., Kamel, S., Slama, M., Brazier, M. and Massy, Z. A. (2009) Pathophysiological mechanisms and consequences of cardiovascular calcifications: role of uremic toxicity. Ann. Pharm. Fr. 67, 234-240
16. Shroff, R. C., McNair, R., Figg, N., Skepper, J. N., Schurgers, L., Gupta, A., Hiorns, M., Donald, A. E., Deanfield, J., Rees, L. and Shanahan, C.M. (2008) Dialysis accelerates medial vascular calcification in part by triggering smooth muscle cell apoptosis. Circulation 118, 1748-1757
17. Eknoyan, G., Levin, A. and Levin, N. W. (2003) Bone metabolism and disease in chronic kidney disease. Am. J. Kidney Dis. 42, S1-S201
18. Goodman, W. G., London, G., Amann, K., Block, G. A., Giachelli, C., Hruska, K. A., Ketteler, M., Levin, A., Massy, Z., McCarron, D. A. et al. (2004) Vascular calcification in chronic kidney disease. Am. J. Kidney Dis. 43, 572-579
19. Raggi, P., Boulay, A., Chasan-Taber, S., Amin, N., Dillon, M., Burke, S. and Chertow, G.M. (2002) Cardiac calcification in adult hemodialysis patients. A link between end-stage renal disease and cardiovascular disease? J. Am. Coll. Cardiol. 39, 695-701
20. Kanbay, M., Goldsmith, D., Akcay, A. and Covic, A. (2009) Phosphate: the silent stealthy cardiorenal culprit in all stages of chronic kidney disease: a systematic review. Blood Purif. 27, 220-230
21. Kestenbaum, B., Sampson, J. N., Rudser, K. D., Patterson, D. J., Seliger, S. L., Young, B., Sherrard, D. J. and Andress, D. L. (2005) Serum phosphate levels and mortality risk among people with chronic kidney disease. J. Am. Soc. Nephrol. 16, 520-528
22. Yang, H., Curinga, G. and Giachelli, C. (2004) Elevated extracellular calcium levels induce smooth muscle cell matrix mineralization in vitro. Kidney Int. 66, 2293-2299
23. Reynolds, J. L., Joannides, A. J., Skepper, J. N., McNair, R., Schurgers, L. J., Proudfoot, D., Jahnen-Dechent, W., Weissberg, P. L. and Shanahan, C. M. (2004) Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD. J. Am. Soc. Nephrol. 15, 2857-2867
24. Shioi, A. and Nishizawa, Y. (2009) Roles of hyperphosphatemia in vascular calcification. Clin. Calcium 19, 180-185
25. Jono, S., McKee, M., Murry, C., Shioi, A., Nishizawa, Y., Mori, K., Morii, H. and Giachelli, C. M. (2000) Phosphate regulation of vascular smooth muscle cell calcification. Circ. Res. 87, E10-E17
26. El-Abbadi, M. M., Pai, A. S., Leaf, E. M., Yang, H. Y., Bartley, B. A., Quan, K. K., Ingalls, C. M., Liao, H. W. and Giachelli, C. M. (2009) Phosphate feeding induces arterial medial calcification in uremic mice: role of serum phosphorus, fibroblast growth factor-23, and osteopontin. Kidney Int. 75, 1297-1307
27. Jean, G., Bresson, E., Terrat, J. C., Vanel, T., Hurot, J. M., Lorriaux, C., Mayor, B. and Chazot, C. (2009) Peripheral vascular calcification in long-haemodialysis patients: associated factors and survival consequences. Nephrol. Dial. Transplant. 24, 948-955
28. Levin, A., Bakris, G., Molitch, M., Smulders, M., Tian, J., Williams, L. A. and Andress, D. L. (2007) Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease. Kidney Int. 71, 31-38 (Pubitemid 44967731)
29. Holick, M. (2007) Vitamin D deficiency. N. Engl. J. Med. 357, 266-281
30. Barreto, D. V., Barreto, F. C., Liabeuf, S., Temmar, M., Boitte, F., Choukroun, G., Fournier, A. and Massy, Z. A. (2009) Vitamin D affects survival independently of vascular calcification in chronic kidney disease. Clin. J. Am. Soc. Nephrol. 4, 1128-1135
31. Schleithoff, S., Zittermann, A., Tenderich, G., Berthold, H., Stehle, P. and Koerfer, R. (2006) Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial. Am. J. Clin. Nutr. 83, 754-759
32. Li, Y., Kong, J., Wei, M., Chen, Z., Liu, S. and Cao, L. (2002) 1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system. J. Clin. Invest. 110, 229-238
33. Henley, C., Colloton, M., Cattley, R. C., Shatzen, E., Towler, D. A., Lacey, D. and Martin, D. (2005) 1,25-Dihydroxyvitamin D3 but not cinacalcet HCl (Sensipar/Mimpara) treatment mediates aortic calcification in a rat model of secondary hyperparathyroidism. Nephrol. Dial. Transplant. 20, 1370-1377
34. Mathew, S., Lund, R., Chaudhary, L., Geurs, T. and Hruska, K. (2008) Vitamin D receptor activators can protect against vascular calcification. J. Am. Soc. Nephrol. 19, 1509-1519
35. Shroff, R. C., Donald, A. E., Hiorns, M. P., Watson, A., Feather, S., Milford, D., Ellins, E. A., Storry, C., Ridout, D., Deanfield, J. and Rees, L. (2007) Mineral metabolism and vascular damage in children on dialysis. J. Am. Soc. Nephrol. 18, 2996-3003
36. Shimada, T., Kakitani, M., Yamazaki, Y., Hasegawa, H., Takeuchi, Y., Fujita, T., Fukumoto, S., Tomizuka, K. and Yamashita, T. (2004) Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J. Clin. Invest. 113, 561-568
37. Gutiérrez, O. M., Mannstadt, M., Isakova, T., Rauh-Hain, J. A., Tamez, H., Shah, A., Smith, K., Lee, H., Thadhani, R., Jüppner, H. and Wolf, M. (2008) Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis. N. Engl. J. Med. 359, 584-592
38. Roos, M., Lutz, J., Salmhofer, H., Luppa, P., Knauss, A., Braun, S., Martinof, S., Schömig, A., Heemann, U., Kastrati, A. and Hausleiter, J. (2008) Relation between plasma fibroblast growth factor-23, serum fetuin-A levels and coronary artery calcification evaluated by multislice computed tomography in patients with normal kidney function. Clin. Endocrinol. 68, 660-665
39. Perwad, F., Zhang, M., Tenenhouse, H. and Portale, A. (2007) Fibroblast growth factor 23 impairs phosphorus and vitamin D metabolism in vivo and suppresses 25-hydroxyvitamin D-1α-hydroxylase expression in vitro. Am. J. Physiol. Renal Physiol. 293, F1577-F1583
40. Sitara, D., Kim, S., Razzaque, M. S., Bergwitz, C., Taguchi, T., Schüler, C., Erben, R. G. and Lanske, B. (2008) Genetic evidence of serum phosphate-independent functions of FGF-23 on bone. PLoS Genet. 4, e1000154
41. Memon, F. (2008) Does Fgf23 - klotho activity influence vascular and soft tissue calcification through regulating mineral ion metabolism? Kidney Int. 74, 566-570
42. Sitara, D., Razzaque, M. S., St-Arnaud, R., Huang, W., Taguchi, T., Erben, R. G. and Lanske, B. (2006) Genetic ablation of vitamin D activation pathway reverses biochemical and skeletal anomalies in Fgf-23-null animals. Am. J. Pathol. 169, 2161-2170
43. Shimada T, Hasegawa H, Yamazaki Y Muto T, Hino R, Takeuchi Y, Fujita T, Nakahara K, Fukumoto S and Yamashita, T. (2004) FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis. J. Bone Miner. Res. 19, 429-435
44. Cozzolino, M., Mazzaferro, S., Pugliese, F. and Brancaccio, D. (2007) Vascular calcification and uremia: what do we know? Am. J. Nephrol. 28, 339-346
45. Niwa, T., Takeda, N., Tatematsu, A. and Maeda, K. (1998) Accumulation of indoxyl sulfate, an inhibitor of drug-binding, in uremic serum as demonstrated by internal-surface reversed-phase liquid chromatography. Clin. Chem. 34, 2264-2267
46. Barreto, F. C., Barreto, D. V., Liabeuf, S., Meert, N., Glorieux, G., Temmar, M., Choukroun, G., Vanholder, R. and Massy, Z. A. (2009) Serum indoxyl sulfate is associated with vascular disease and mortality in chronic kidney disease patients. Clin. J. Am. Soc. Nephrol. 4, 1551-1558
47. Yamamoto, H., Tsuruoka, S., Ioka, T., Ando, H., Ito, C., Akimoto, T., Fujimura, A., Asano, Y. and Kusano, E. (2006) Indoxyl sulfate stimulates proliferation of rat vascular smooth muscle cells. Kidney Int. 69, 1780-1785 (Pubitemid 43739205)
48. Adijiang, A., Goto, S., Uramoto, S., Nishijima, F. and Niwa, T. (2008) Indoxyl sulphate promotes aortic calcification with expression of osteoblast-specific proteins in hypertensive rats. Nephrol. Dial. Transplant. 23, 1892-1901
49. Dou, L., Jourde-Chiche, N., Faure, V., Cerini, C., Berland, Y., Dignat-George, F. and Brunet, P. (2007) The uremic solute indoxyl sulfate induces oxidative stress in endothelial cells. J. Thromb. Haemostasis 5, 1302-1308 (Pubitemid 46902134)
50. Ketteler, M., Vermeer, C., Wanner, C., Westenfeld, R., Jahnen-Dechent, W. and Floege, J. (2002) Novel insights into uremic vascular calcification: role of matrix Gla protein and α-2-Heremans Schmid glycoprotein/fetuin. Blood Purif. 20, 473-476
51. Ketteler, M., Wanner, C., Metzger, T., Bongartz, P., Westenfeld, R., Gladziwa, U., Schurgers, L. J., Vermeer, C., Jahnen-Dechent, W. and Floege, J. (2003) Deficiencies of calcium-regulatory proteins in dialysis patients: a novel concept of cardiovascular calcification in uremia. Kidney Int. Suppl. 84, S84-S87
52. Schafer, C., Heiss, A., Schwarz, A., Westenfeld, R., Ketteler, M., Floege, J., Muller-Esterl, W., Schinke, T. and Jahnen-Dechent, W. (2003) The serum protein α2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification. J. Clin. Invest, 112, 357-366
53. Reynolds, J. L. (2005) Multifunctional roles for serum protein fetuin-A in inhibition of human vascular smooth muscle cell calcification. J. Am. Soc. Nephrol. 16, 2920-2930
54. Price, P. and Williamson, M. (1985) Primary structure of bovine matrix Gla protein, a new vitamin K-dependent bone protein. J. Biol. Chem. 260, 14971-14975
55. Cancela, L., Hsieh, C. L., Francke, U. and Price, P. A, (1990) Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene. J. Biol. Chem. 265, 15040-15048
56. Luo, G., Ducy, P., McKee, M., Pinero, G., Loyer, E., Behringer, R. and Karsenty, G. (1997) Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature 386, 78-81 (Pubitemid 27130923)
57. Boström, K., Tsao, D., Shen, S., Wang, Y. and Demer, L. (2001) Matrix GLA protein modulates differentiation induced by bone morphogenetic protein-2 in C3H10T1/2 cells. J. Biol. Chem. 276, 14044-14052
58. Parker, B., Ix, J., Cranenburg, E., Vermeer, C., Whooley, M. and Schurgers, L. (2009) Association of kidney function and uncarboxylated matrix Gla protein: data from the Heart and Soul Study. Nephrol. Dial. Transplant. 24, 2095-2101
59. Morena, M., Dupuy, A. M., Jaussent, I., Vernhet, H., Gahide, G., Klouche, K., Bargnoux, A. S., Delcourt, C., Canaud, B. and Cristol, J. P. (2009) A cut-off value of plasma osteoprotegerin level may predict the presence of coronary artery calcifications in chronic kidney disease patients. Nephrol. Dial. Transplant. 24, 3389-3397
60. -/- mice. Arterioscler. Thromb. Vasc. Biol. 26, 2117-2124
61. Schoppet, M., Sattler, A. M., Schaefer, J. R., Herzum, M., Maisch, B. and Hofbauer, L. C. (2003) Increased osteoprotegerin serum levels in men with coronary artery disease. J. Clin. Endocrinol. Metab. 88, 1024-1028
62. Shiraki, M., Shiraki, Y., Aoki, C. and Miura, M. (2000) Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis. J. Bone Miner. Res. 15, 515-521
63. Iwamoto, J., Sato, Y., Takeda, T. and Matsumoto, H. (2009) High-dose vitamin K supplementation reduces fracture incidence in postmenopausal women: a review of the literature. Nutr. Res. 29, 221-228
64. Geleijnse, J. M., Vermeer, C., Grobbee, D. E., Schurgers, L. J., Knapen, M. H., van der Meer, I. M., Hofman, A. and Witteman, J. C. (2004) Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J. Nutr. 134, 3100-3105 (Pubitemid 39470091)
65. Schurgers, L. J., Teunissen, K. J., Hamulyák, K., Knapen, M. H., Vik, H. and Vermeer, C. (2007) Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood 109, 3279-3283 (Pubitemid 46572513)
66. Meyer, J. L. (1984) Can biological calcification occurs in the presence of pyrophosphate? Arch. Biochem. Biophys. 231, 1-8
67. Rutsch, F., Vaingankar, S., Johnson, K., Goldfine, I., Maddux, B., Schauerte, P., Kalhoff, H., Sano, K., Boisvert, W. A., Superti-Furga, A. and Terkeltaub, R. (2001) PC-1 nucleoside triphosphate pyrophosphohydrolase deficiency in idiopathic infantile arterial calcification. Am. J. Pathol. 158, 543-554
68. Lomashvili, K. A., Cobbs, S., Hennigar, R. A., Hardcastle, K. I. and O'Neill, W. C. (2004) Phosphate-induced vascular calcification: role of pyrophosphate and osteopontin. J. Am. Soc. Nephrol. 15, 1392-1401
69. Lomashvili, K. A., Garg, P., Narisawa, S., Millan, J. L. and O'Neill, W. C. (2008) Renal failure upregulates smooth muscle alkaline phosphatase and increases pyrophosphate hydrolysis: potential mechanism for uremic vascular calcification. Kidney Int. 73, 1024-1030 (Pubitemid 351543906)
70. O'Neill, W. C., Sigrist, M. K. and McIntyre, C. W. (2010) Plasma pyrophosphate and vascular calcification in chronic kidney disease. Nephrol. Dial. Transplant. 25, 187-191
71. Salazar, H. and Raggi, P. (2002) Usefulness of electron-beam computed tomography. Am. J. Cardiol. 89, 17B-22B
72. Chertow, G. M., Raggi, P., Chasan-Taber, S., Bommer, J., Holzer, H. and Burke, S. K. (2004) Determinants of progressive vascular calcification in haemodialysis patients. Nephrol. Dial. Transplant. 19, 1489-1496
73. Sharples, E., Pereira, D., Summers, S., Cunningham, J., Rubens, M., Goldsmith, D. and Yaqoob, M. M. (2004) Coronary artery calcification measured with electron-beam computerized tomography correlates poorly with coronary artery angiography in dialysis patients. Am. J. Kidney Dis. 43, 313-319
74. Haydar, A., Hujairi, N., Covic, A., Pereira, D., Rubens, M. and Goldsmith, D. (2004) Coronary artery calcification is related to coronary atherosclerosis in chronic renal disease patients: a study comparing EBCT-generated coronary artery calcium scores and coronary angiography. Nephrol. Dial. Transplant. 19, 2307-2312
75. Moe, S. N., O'Neill, K. D.,Fineberg, N, Persohn, S, Ahmed, S, Garrett, P, Meyer and C.A. (2003) Assessment of vascular calcification in ESRD patients using spiral CT. Nephrol. Dial. Transplant. 18, 1152-1158
76. Taniwaki, H., Ishimura, E., Tabata, T., Tsujimoto, Y., Shioi, A., Shoji, T., Inaba, M., Inoue, T. and Nishizawa, Y. (2005) Aortic calcification in haemodialysis patients with diabetes mellitus. Nephrol. Dial. Transplant. 20, 2472-2478
77. Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBDWork Group (2009) KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD). Kidney Int. Suppl. 113, S1-S130
78. Kauppila, L. I., Polak, J. F., Cupples, L. A., Hannan, M. T., Kiel, D. P. and Wilson, P.W. (1997) New indices to classify location, severity and progression of calcific lesions in the abdominal aorta: a 25-years follow-up study. Atherosclerosis 132, 245-250
79. Leskinen, Y., Paana, T., Saha, H., Groundstroem, K., Lehtimäki, T., Kilpinen, S., Huhtala, H. and Airaksinen, J. (2009) Valvular calcification and its relationship to atherosclerosis in chronic kidney disease. J. Heart Valve Dis. 18, 429-438
80. Sigrist, M., Taal, M., Bungay, P. and McIntyre, C. (2007) Progressive vascular calcification over 2 years is associated with arterial stiffening and increased mortality in patients with stages 4 and 5 chronic kidney disease. Clin. J. Am. Soc. Nephrol. 2, 1241-1248
81. Toussaint, N., Lau, K., Strauss, B., Polkinghorne, K. and Kerr, P. (2009) Relationship between vascular calcification, arterial stiffness and bone mineral density in a cross-sectional study of prevalent Australian haemodialysis patients. Nephrology 14, 105-112
82. Haydar, A., Covic, A., Colhoun, H., Rubens, M. and Goldsmith, D. (2004) Coronary artery calcification and aortic pulse wave velocity in chronic kidney disease patients. Kidney Int. 65, 1790-1794 (Pubitemid 38591027)
83. Toussaint, N., Lau, K., Strauss, B., Polkinghorne, K. and Kerr, P. (2008) Associations between vascular calcification, arterial stiffness and bone mineral density in chronic kidney disease. Nephrol. Dial. Transplant. 23, 586-593
84. van Popele, N. M., Grobbee, D. E., Bots, M. L., Asmar, R., Topouchian, J., Reneman, R. S., Hoeks, A. P., van der Kuip, D. A., Hofman, A. and Witteman, J. C. (2001) Association between arterial stiffness and atherosclerosis: the Rotterdam Study. Stroke 32, 454-460 (Pubitemid 32155234)
85. London, G. M., Guérin, A. P., Verbeke, F. H., Pannier, B., Boutouyrie, P., Marchais, S. J. and Mëtivier, F. (2007) Mineral metabolism and arterial functions in end-stage renal disease: potential role of 25-hydroxyvitamin D deficiency. J. Am. Soc. Nephrol. 18, 613-620
86. Chertow, G. M., Burke, S. K., Dillon, M. A. and Slatopolsky, E. (1999) Long-term effects of sevelamer hydrochloride on the calcium x phosphate product and lipid profile of hemodialysis patients. Nephrol. Dial. Transplant. 14, 2907-2914
87. Chertow, G. M., Burke, S. K. and Raggi, P. (2002) Sevelamer attenuates the progression of coronary and aortic calcification in hemodialysis patients. Kidney Int. 62, 245-252 (Pubitemid 34754068)
88. Cozzolino, M., Staniforth, M. E., Liapis, H., Finch, J., Burke, S. K., Dusso, A. S. and Slatopolsky, E. (2003) Sevelamer hydrochloride attenuates kidney and cardiovascular calcifications in long-term experimental uremia. Kidney Int. 64, 1653-1661
89. Block, G. A., Spiegel, D. M., Ehrlich, J., Mehta, R., Lindbergh, J., Dreisbach, A. and Raggi, P. (2005) Effects of sevelamer and calcium on coronary artery calcification in patients new to hemodialysis. Kidney Int. 68, 1815-1824 (Pubitemid 43169927)
90. Proudfoot, D., Davies, J. D., Skepper, J. N., Weissberg, P. L. and Shanahan, C. M. (2002) Acetylated low-density lipoprotein stimulates human vascular smooth muscle cell calcification by promoting osteoblastic differentiation and inhibiting phagocytosis. Circulation 106, 3044-3050
91. Qunibi, W., Moustafa, M., Muenz, L. R., He, D. Y., Kessler, P. D., Diaz-Buxo, J. A. and and Budoff, M. (2008) A 1-year randomized trial of calcium acetate versus sevelamer on progression of coronary artery calcification in hemodialysis patients with comparable lipid control: the Calcium Acetate Renagel Evaluation-2 (CARE-2) study. Am. J. Kidney Dis. 51, 952-965
92. Cardús, A., Panizo, S., Parisi, E., Fernandez, E. and Valdivielso, J. M. (2007) Differential effects of vitamin D analogs on vascular calcification. J. Bone Miner. Res. 22, 860-866
93. Hirata, M., Katsumata, K., Endo, K., Fukushima, N., Ohkawa, H. and Fukagawa, M. (2003) In subtotally nephrectomized rats 22-oxacalcitriol suppresses parathyroid hormone with less risk of cardiovascular calcification or deterioration of residual renal function than 1,25(OH)2 vitamin D3. Nephrol. Dial. Transplant. 18, 1770-1776
94. Noonan, W., Koch, K., Nakane, M., Ma, J., Dixon, D., Bolin, A. and Reinhart, G. (2008) Differential effects of vitamin D receptor activators on aortic calcification and pulse wave velocity in uraemic rats. Nephrol. Dial. Transplant. 23, 3824-3830
95. Mathew, S., Lund, R. J., Chaudhary, L. R., Geurs, T. and Hruska, K. A. (2008) Vitamin D receptor activators can protect against vascular calcification. J. Am. Soc. Nephrol. 19, 1509-1519
96. Covic, A., Kothawala, P., Bernal, M., Robbins, S., Chalian, A. and Goldsmith., D. (2009) Systematic review of the evidence underlying the association between mineral metabolism disturbances and risk of all-cause mortality, cardiovascular mortality and cardiovascular events in chronic kidney disease. Nephrol. Dial. Transplant. 24, 1506-1523
97. Lopez, I., Aguilera-Tejero, E., Mendoza, F. J., Almaden, Y., Perez, J., Martin, D. and Rodriguez, M. (2006) Calcimimetic R-568 decreases extraosseous calcifications in uremic rats treated with calcitriol. J. Am. Soc. Nephrol. 17, 795-804
98. Tamura, K., Suzuki, Y., Matsushita, M., Fujii, H., Miyaura, C., Aizawa, S. and Kogo, H. (2007) Prevention of aortic calcification by etidronate in the renal failure rat model. Eur. J. Pharmacol. 558, 159-166
99. Saito, E., Wachi, H., Sato, F., Sugitani, H. and Seyama, Y. (2007) Treatment with vitamin k2 combined with bisphosphonates synergistically inhibits calcification in cultured smooth muscle cells. J. Atheroscler. Thromb. 14, 317-324
100. Nitta, K., Akiba, T., Suzuki, K., Uchida, K.,Watanabe, R., Majima, K., Aoki, T. and Nihei, H. (2004) Effects of cyclic intermittent etidronate therapy on coronary artery calcification in patients receiving long-term hemodialysis. Nephrol. Dial. Transplant. 44, 680-688
101. Hashiba, H., Aizawa, S., Tamura, K. and Kogo, H. (2006) Inhibition of the progression of aortic calcification by etidronate treatment in hemodialysis patients: long-term effects. Ther. Apher. Dial. 10, 59-64
102. Persy, V., De Broe, M. and Ketteler, M. (2006) Bisphosphonates prevent experimental vascular calcification: Treat the bone to cure the vessels? Kidney Int. 70, 1537-1538