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Volumn 164, Issue 7, 2011, Pages 1857-1870

Bile pigment pharmacokinetics and absorption in the rat: Therapeutic potential for enteral administration

Author keywords

administration; antioxidant; bile pigment; excretion; half life; inflammation; kinetics; metabolism; oxidative stress

Indexed keywords

BILIRUBIN DERIVATIVE; BILIRUBIN DITAURATE; SODIUM BILIRUBINATE; SODIUM BILIVERDINATE; UNCLASSIFIED DRUG;

EID: 81355143343     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01413.x     Document Type: Article
Times cited : (34)

References (62)
  • 1
    • 0025968259 scopus 로고
    • Enterohepatic circulation of nonconjugated bilirubin in rats fed with human milk
    • Alonso EM, Whitington PF, Whitington SH, Rivard WA, Given G, (1991). Enterohepatic circulation of nonconjugated bilirubin in rats fed with human milk. J Pediatr 118: 425-430.
    • (1991) J Pediatr , vol.118 , pp. 425-430
    • Alonso, E.M.1    Whitington, P.F.2    Whitington, S.H.3    Rivard, W.A.4    Given, G.5
  • 3
    • 0017158737 scopus 로고
    • Metabolism of biliverdin. Biliary excretion of bile pigments after intravenous injection of biliverdin isomers
    • Barrowman JA, Bonnett R, Bray PJ, (1976). Metabolism of biliverdin. Biliary excretion of bile pigments after intravenous injection of biliverdin isomers. Biochim Biophys Acta 444: 333-337.
    • (1976) Biochim Biophys Acta , vol.444 , pp. 333-337
    • Barrowman, J.A.1    Bonnett, R.2    Bray, P.J.3
  • 6
    • 84981837007 scopus 로고
    • The biological importance of bile pigments. Bilirubin and biliverdin as antioxidants for vitamin A and essential fatty acids
    • Bernhard K, Ritzel G, Steiner KU, (1954). The biological importance of bile pigments. Bilirubin and biliverdin as antioxidants for vitamin A and essential fatty acids. Helv Chim Acta 37: 306-313.
    • (1954) Helv Chim Acta , vol.37 , pp. 306-313
    • Bernhard, K.1    Ritzel, G.2    Steiner, K.U.3
  • 7
    • 10644253618 scopus 로고    scopus 로고
    • a and aggregation of bilirubin: Titrimetric and ultracentrifugation studies on water-soluble pegylated conjugates of bilirubin and fatty acids
    • DOI 10.1021/bi0481491
    • Boiadjiev SE, Watters K, Wolf S, Lai BN, Welch WH, McDonagh AF, et al,. (2004). pKa and aggregation of bilirubin: titrimetric and ultracentrifugation studies on water-soluble pegylated conjugates of bilirubin and fatty acids. Biochemistry 43: 15617-15632. (Pubitemid 39647488)
    • (2004) Biochemistry , vol.43 , Issue.49 , pp. 15617-15632
    • Boiadjiev, S.E.1    Watters, K.2    Wolf, S.3    Lai, B.N.4    Welch, W.H.5    McDonagh, A.F.6    Lightner, D.A.7
  • 10
    • 0018396166 scopus 로고
    • Bilirubin. Solubility and interaction with albumin and phospholipid
    • Brodersen R, (1979). Bilirubin. Solubility and interaction with albumin and phospholipid. J Biol Chem 254: 2364-2369. (Pubitemid 9160050)
    • (1979) Journal of Biological Chemistry , vol.254 , Issue.7 , pp. 2364-2369
    • Brodersen, R.1
  • 11
    • 41649110419 scopus 로고    scopus 로고
    • In vitro permeability and metabolic stability of bile pigments and the effects of hydrophilic and lipophilic modification of biliverdin
    • DOI 10.1016/j.bmc.2008.02.008, PII S0968089608001181
    • Bulmer AC, Blanchfield JT, Coombes JS, Toth I, (2008a). In vitro permeability and stability of bile pigments and the effects of hydrophilic and lipophilic modification of biliverdin. Bioorg Med Chem 16: 3616-3625. (Pubitemid 351484046)
    • (2008) Bioorganic and Medicinal Chemistry , vol.16 , Issue.7 , pp. 3616-3625
    • Bulmer, A.C.1    Blanchfield, J.T.2    Coombes, Jeff.S.3    Toth, I.4
  • 12
    • 47649112255 scopus 로고    scopus 로고
    • Improved resistance to serum oxidation in Gilbert's syndrome: A mechanism for cardiovascular protection
    • Bulmer AC, Blanchfield JT, Toth I, Fassett RG, Coombes JS, (2008b). Improved resistance to serum oxidation in Gilbert's syndrome: a mechanism for cardiovascular protection. Atherosclerosis 199: 390-396.
    • (2008) Atherosclerosis , vol.199 , pp. 390-396
    • Bulmer, A.C.1    Blanchfield, J.T.2    Toth, I.3    Fassett, R.G.4    Coombes, J.S.5
  • 15
    • 10544256489 scopus 로고
    • Metabolism of I-131-labelled human albumin
    • Cohen S, Freeman T, McFarlane A, (1961). Metabolism of I-131-labelled human albumin. Clin Sci 20: 161-170.
    • (1961) Clin Sci , vol.20 , pp. 161-170
    • Cohen, S.1    Freeman, T.2    McFarlane, A.3
  • 17
    • 0020591955 scopus 로고
    • Effect of milk feeding on intestinal bilirubin absorption in the rat
    • DOI 10.1016/S0022-3476(83)80429-6
    • Gartner LM, Lee KS, Moscioni AD, (1983). Effect of milk feeding on intestinal bilirubin absorption in the rat. J Pediatr 103: 464-471. (Pubitemid 13000470)
    • (1983) Journal of Pediatrics , vol.103 , Issue.3 , pp. 464-471
    • Gartner, L.M.1    Lee, K.S.2    Moscioni, A.D.3
  • 18
    • 0030842164 scopus 로고    scopus 로고
    • Effect of fasting on the uptake of bilirubin and sulfobromophthalein by the isolated perfused rat liver
    • DOI 10.1053/gast.1997.v113.pm9352876
    • Gartner U, Goeser T, Wolkoff AW, (1997). Effect of fasting on the uptake of bilirubin and sulfobromophthalein by the isolated perfused rat liver. Gastroenterology 113: 1707-1713. (Pubitemid 27461260)
    • (1997) Gastroenterology , vol.113 , Issue.5 , pp. 1707-1713
    • Gartner, U.1    Goeser, T.2    Wolkoff, A.W.3
  • 19
    • 0019419595 scopus 로고
    • Bilirubin kinetics in intact rats and isolated perfused liver. Evidence for hepatic deconjugation of bilirubin glucuronides
    • Gollan J, Hammaker L, Licko V, Schmid R, (1981). Bilirubin kinetics in intact rats and isolated perfused liver. Evidence for hepatic deconjugation of bilirubin glucuronides. J Clin Invest 67: 1003-1015. (Pubitemid 11090538)
    • (1981) Journal of Clinical Investigation , vol.67 , Issue.4 , pp. 1003-1015
    • Gollan, J.1    Hammaker, L.2    Licko, V.3    Schmid, R.4
  • 20
    • 0017374660 scopus 로고
    • Biliverdin IX alpha: A new probe of hepatic bilirubin metabolism
    • Gollan JL, McDonagh AF, Schmidt R, (1977). Biliverdin IX alpha: a new probe of hepatic bilirubin metabolism. Gastroenterology 72: 1186.
    • (1977) Gastroenterology , vol.72 , pp. 1186
    • Gollan, J.L.1    McDonagh, A.F.2    Schmidt, R.3
  • 21
    • 0021811240 scopus 로고
    • Effects of anesthetic agents on bile pigment excretion in the rat
    • DOI 10.1002/hep.1840050415
    • Gourley GR, Mogilevsky W, Arend RA, Siegel FL, Odell GB, (1985). Effects of anesthetic agents on bile pigment excretion in the rat. Hepatology 5: 610-614. (Pubitemid 15029732)
    • (1985) Hepatology , vol.5 , Issue.4 , pp. 610-614
    • Gourley, G.R.1    Mogilevsky, W.2    Arend, R.A.3
  • 22
    • 0026761329 scopus 로고
    • Ionization and self-association of unconjugated bilirubin, determined by rapid solvent partition from chloroform, with further studies of bilirubin solubility
    • Hahm JS, Ostrow JD, Mukerjee P, Celic L, (1992). Ionization and self-association of unconjugated bilirubin, determined by rapid solvent partition from chloroform, with further studies of bilirubin solubility. J Lipid Res 33: 1123-1137.
    • (1992) J Lipid Res , vol.33 , pp. 1123-1137
    • Hahm, J.S.1    Ostrow, J.D.2    Mukerjee, P.3    Celic, L.4
  • 24
    • 0014753551 scopus 로고
    • Preparation and properties of specifically labeled radiochemically stable 3H-bilirubin
    • Howe RB, Berk PD, Bloomer JR, Berlin NI, (1970). Preparation and properties of specifically labeled radiochemically stable 3H-bilirubin. J Lab Clin Med 75: 499-502.
    • (1970) J Lab Clin Med , vol.75 , pp. 499-502
    • Howe, R.B.1    Berk, P.D.2    Bloomer, J.R.3    Berlin, N.I.4
  • 25
    • 0033774170 scopus 로고    scopus 로고
    • Recent advances in bilirubin metabolism research: The molecular mechanism of hepatocyte bilirubin transport and its clinical relevance
    • Kamisako T, Kobayashi Y, Takeuchi K, Ishihara T, Higuchi K, Tanaka Y, et al,. (2000). Recent advances in bilirubin metabolism research: the molecular mechanism of hepatocyte bilirubin transport and its clinical relevance. J Gastroenterol 35: 659-664.
    • (2000) J Gastroenterol , vol.35 , pp. 659-664
    • Kamisako, T.1    Kobayashi, Y.2    Takeuchi, K.3    Ishihara, T.4    Higuchi, K.5    Tanaka, Y.6
  • 26
    • 0029929151 scopus 로고    scopus 로고
    • Fasting-related hyperbilirubinemia in rats: The effect of decreased intestinal motility
    • DOI 10.1053/gast.1996.v111.pm8698202
    • Kotal P, Vitek L, Fevery J, (1996). Fasting-related hyperbilirubinemia in rats: the effect of decreased intestinal motility. Gastroenterology 111: 217-223. (Pubitemid 26226902)
    • (1996) Gastroenterology , vol.111 , Issue.1 , pp. 217-223
    • Kotal, P.1    Vitek, L.2    Fevery, J.3
  • 27
    • 75449134720 scopus 로고
    • Intestinal absorption of bilirubin
    • Lester R, (1963). Intestinal absorption of bilirubin. Ann N Y Acad Sci 111: 290-294.
    • (1963) Ann N y Acad Sci , vol.111 , pp. 290-294
    • Lester, R.1
  • 28
    • 0013985768 scopus 로고
    • Bile pigment excretion: A comparison of the biliary excretion of bilirubin and bilirubin derivatives
    • Lester R, Klein PD, (1966). Bile pigment excretion: a comparison of the biliary excretion of bilirubin and bilirubin derivatives. J Clin Invest 45: 1839-1846.
    • (1966) J Clin Invest , vol.45 , pp. 1839-1846
    • Lester, R.1    Klein, P.D.2
  • 29
    • 0000937233 scopus 로고
    • Intestinal absorption of bile pigments I: The enterohepatic circulation of bilirubin in the rat
    • Lester R, Schmidt R, (1963a). Intestinal absorption of bile pigments I: the enterohepatic circulation of bilirubin in the rat. J Clin Invest 42: 736-746.
    • (1963) J Clin Invest , vol.42 , pp. 736-746
    • Lester, R.1    Schmidt, R.2
  • 30
    • 0001491391 scopus 로고
    • Intestinal absorption of bile pigments II: Bilirubin absorption in man
    • Lester R, Schmidt R, (1963b). Intestinal absorption of bile pigments II: bilirubin absorption in man. N Engl J Med 269: 178-182.
    • (1963) N Engl J Med , vol.269 , pp. 178-182
    • Lester, R.1    Schmidt, R.2
  • 31
    • 36949087377 scopus 로고
    • Enterohepatic circulation of bilirubin
    • Lester R, Ostrow JD, Schmid R, (1961). Enterohepatic circulation of bilirubin. Nature 192: 372.
    • (1961) Nature , vol.192 , pp. 372
    • Lester, R.1    Ostrow, J.D.2    Schmid, R.3
  • 32
    • 0030053208 scopus 로고    scopus 로고
    • On the acid dissociation constants of bilirubin and biliverdin. pKa values from 13C NMR spectroscopy
    • Lightner DA, Holmes DL, McDonagh AF, (1996). On the acid dissociation constants of bilirubin and biliverdin. pKa values from 13C NMR spectroscopy. J Biol Chem 271: 2397-2405.
    • (1996) J Biol Chem , vol.271 , pp. 2397-2405
    • Lightner, D.A.1    Holmes, D.L.2    McDonagh, A.F.3
  • 33
    • 34548761301 scopus 로고    scopus 로고
    • ''Iatrogenic Gilbert syndrome''- A strategy for reducing vascular and cancer risk by increasing plasma unconjugated bilirubin
    • DOI 10.1016/j.mehy.2006.12.069, PII S0306987707004690
    • McCarty MF, (2007). 'Iatrogenic Gilbert syndrome'-a strategy for reducing vascular and cancer risk by increasing plasma unconjugated bilirubin. Med Hypotheses 69: 974-994. (Pubitemid 47430241)
    • (2007) Medical Hypotheses , vol.69 , Issue.5 , pp. 974-994
    • McCarty, M.F.1
  • 34
    • 0001285005 scopus 로고
    • Bile pigments: Bilatrienes and 5,15-biladienes
    • Dolphin D. (ed.). Academic Press: New York
    • McDonagh AF, (1979). Bile pigments: bilatrienes and 5,15-biladienes. In:, Dolphin D, (ed.). The Porphyrins, Vol. VI. Academic Press: New York.
    • (1979) The Porphyrins , vol.6
    • McDonagh, A.F.1
  • 36
    • 0038362297 scopus 로고    scopus 로고
    • Biological properties and therapeutic potential of bilirubin
    • McGeary RP, Szyczew AJ, Toth I, (2003). Biological properties and therapeutic potential of bilirubin. Mini Rev Med Chem 3: 253-256.
    • (2003) Mini Rev Med Chem , vol.3 , pp. 253-256
    • McGeary, R.P.1    Szyczew, A.J.2    Toth, I.3
  • 37
    • 0141838887 scopus 로고    scopus 로고
    • On how the conformation of biliverdins influences their reduction to bilirubins: A biological and molecular modeling study
    • DOI 10.1016/S0968-0896(03)00479-6
    • Mora ME, Bari SE, Awruch J, Delfino JM, (2003). On how the conformation of biliverdins influences their reduction to bilirubins: a biological and molecular modeling study. Bioorg Med Chem 11: 4661-4672. (Pubitemid 37194271)
    • (2003) Bioorganic and Medicinal Chemistry , vol.11 , Issue.21 , pp. 4661-4672
    • Mora, M.E.1    Bari, S.E.2    Awruch, J.3    Delfino, J.M.4
  • 38
    • 34248388495 scopus 로고    scopus 로고
    • Low solubility of unconjugated bilirubin in dimethylsulfoxide-water systems: Implications for pKa determinations
    • Mukerjee P, Ostrow JD, Tiribelli C, (2002). Low solubility of unconjugated bilirubin in dimethylsulfoxide-water systems: implications for pKa determinations. BMC Biochem 3: 17.
    • (2002) BMC Biochem , vol.3 , pp. 17
    • Mukerjee, P.1    Ostrow, J.D.2    Tiribelli, C.3
  • 39
    • 0020633859 scopus 로고
    • Liquid-chromatographic assay and identification of mono- and diester conjugates of bilirubin in normal serum
    • Muraca M, Blanckaert N, (1983). Liquid-chromatographic assay and identification of mono- and diester conjugates of bilirubin in normal serum. Clin Chem 29: 1767-1771. (Pubitemid 13017237)
    • (1983) Clinical Chemistry , vol.29 , Issue.10 , pp. 1767-1771
    • Muraca, M.1    Blanckaert, N.2
  • 40
    • 0027452195 scopus 로고
    • A beneficial role of bile pigments as an endogenous tissue protector: Anti-complement effects of biliverdin and conjugated bilirubin
    • DOI 10.1016/0304-4165(93)90013-X
    • Nakagami T, Toyomura K, Kinoshita T, Morisawa S, (1993). A beneficial role of bile pigments as an endogenous tissue protector: anti-complement effects of biliverdin and conjugated bilirubin. Biochim Biophys Acta 1158: 189-193. (Pubitemid 23291461)
    • (1993) Biochimica et Biophysica Acta - General Subjects , vol.1158 , Issue.2 , pp. 189-193
    • Nakagami, T.1    Toyomura, K.2    Kinoshita, T.3    Morisawa, S.4
  • 41
    • 0018561802 scopus 로고
    • Correlation of cholesterol and bilirubin solubilization in bile salt solution
    • Nakama T, Furusawa T, Itoh H, Hisadome T, (1979). Correlation of cholesterol and bilirubin solubilization in bile salt solution. Gastroenterol Jpn 6: 565-572. (Pubitemid 10121268)
    • (1979) Gastroenterologia Japonica , vol.14 , Issue.6 , pp. 565-572
    • Nakama, T.1    Furusawa, T.2    Itoh, H.3    Hisadome, T.4
  • 44
    • 34249326928 scopus 로고    scopus 로고
    • Revalidation and rationale for high pKa values of unconjugated bilirubin
    • Ostrow JD, Mukerjee P, (2007). Revalidation and rationale for high pKa values of unconjugated bilirubin. BMC Biochem 8: 7.
    • (2007) BMC Biochem , vol.8 , pp. 7
    • Ostrow, J.D.1    Mukerjee, P.2
  • 45
    • 0023970342 scopus 로고
    • Molecular and micellar associations in the pH-dependent stable and metastable dissolution of unconjugated bilirubin by bile salts
    • Ostrow JD, Celic L, Mukerjee P, (1988). Molecular and micellar associations in the pH-dependent stable and metastable dissolution of unconjugated bilirubin by bile salts. J Lipid Res 29: 335-348.
    • (1988) J Lipid Res , vol.29 , pp. 335-348
    • Ostrow, J.D.1    Celic, L.2    Mukerjee, P.3
  • 46
    • 0043268709 scopus 로고    scopus 로고
    • Heme oxygenase-1: Unleashing the protective properties of heme
    • DOI 10.1016/S1471-4906(03)00181-9
    • Otterbein LE, Soares MP, Yamashita K, Bach FH, (2003). Heme oxygenase-1: unleashing the protective properties of heme. Trends Immunol 24: 449-455. (Pubitemid 36928103)
    • (2003) Trends in Immunology , vol.24 , Issue.8 , pp. 449-455
    • Otterbein, L.E.1    Soares, M.P.2    Yamashita, K.3    Bach, F.H.4
  • 48
    • 0017714160 scopus 로고
    • 14C]bilirubin metabolism in normal subjects and patients with compensated cirrhosis
    • Owens D, Jones EA, Carson ER, (1977). Studies on the kinetics of unconjugated [14C]bilirubin metabolism in normal subjects and patients with compensated cirrhosis. Clin Sci Mol Med 52: 555-570. (Pubitemid 8131034)
    • (1977) Clinical Science and Molecular Medicine , vol.52 , Issue.6 , pp. 555-570
    • Owens, D.1    Jones, E.A.2    Carson, E.R.3
  • 49
    • 0023760413 scopus 로고
    • Interactions of unconjugated bilirubin with bile salts
    • Rege RV, Webster CC, Ostrow JD, (1988). Interactions of unconjugated bilirubin with bile salts. J Lipid Res 29: 1289-1296. (Pubitemid 18261052)
    • (1988) Journal of Lipid Research , vol.29 , Issue.10 , pp. 1289-1296
    • Rege, R.V.1    Webster, C.C.2    Ostrow, J.D.3
  • 50
    • 33746967110 scopus 로고    scopus 로고
    • Biliverdin-induced brainstem auditory evoked potential abnormalities in the jaundiced Gunn rat
    • DOI 10.1016/j.brainres.2006.06.005, PII S0006899306017082
    • Rice AC, Shapiro SM, (2006). Biliverdin-induced brainstem auditory evoked potential abnormalities in the jaundiced Gunn rat. Brain Res 1107: 215-221. (Pubitemid 44205127)
    • (2006) Brain Research , vol.1107 , Issue.1 , pp. 215-221
    • Rice, A.C.1    Shapiro, S.M.2
  • 51
    • 0026653663 scopus 로고
    • The origins and kinetics of bilirubin in healthy dogs, in comparison with man
    • Rothuizen J, van den Brom WE, Fevery J, (1992). The origins and kinetics of bilirubin in healthy dogs, in comparison with man. J Hepatol 15: 25-34.
    • (1992) J Hepatol , vol.15 , pp. 25-34
    • Rothuizen, J.1    Van Den Brom, W.E.2    Fevery, J.3
  • 52
    • 34247546562 scopus 로고    scopus 로고
    • Restoring HOmeostasis: is heme oxygenase-1 ready for the clinic?
    • DOI 10.1016/j.tips.2007.03.006, PII S0165614707000776
    • Scott JR, Chin BY, Bilban MH, Otterbein LE, (2007). Restoring HOmeostasis: is heme oxygenase-1 ready for the clinic? Trends Pharmacol Sci 28: 200-205. (Pubitemid 46661005)
    • (2007) Trends in Pharmacological Sciences , vol.28 , Issue.5 , pp. 200-205
    • Scott, J.R.1    Chin, B.Y.2    Bilban, M.H.3    Otterbein, L.E.4
  • 53
    • 0021930316 scopus 로고
    • Reverse-phase h.p.l.c. separation, quantification and preparation of bilirubin and its conjugates from native bile. Quantitative analysis of the intact tetrapyrroles based on h.p.l.c. of their ethyl anthranilate azo derivatives
    • Spivak W, Carey MC, (1985). Reverse-phase HPLC separation, quantification and preparation of bilirubin and its conjugates from native bile. Quantitative analysis of the intact tetrapyrroles based on HPLC of their ethyl anthranilate azo derivatives. Biochem J 225: 787-805. (Pubitemid 15174267)
    • (1985) Biochemical Journal , vol.225 , Issue.3 , pp. 787-805
    • Spivak, W.1    Carey, M.C.2
  • 54
    • 0023132858 scopus 로고
    • Bilirubin is an antioxidant of possible physiological importance
    • Stocker R, Yamamoto Y, McDonagh AF, Glazer AN, Ames BN, (1987). Bilirubin is an antioxidant of possible physiological importance. Science 235: 1043-1046. (Pubitemid 17049750)
    • (1987) Science , vol.235 , Issue.4792 , pp. 1043-1046
    • Stocker, R.1    Yamamoto, Y.2    McDonagh, A.F.3
  • 55
    • 0042834374 scopus 로고    scopus 로고
    • Enterohepatic cycling of bilirubin as a cause of 'black' pigment gallstones in adult life
    • DOI 10.1046/j.1365-2362.2003.01214.x
    • Vitek L, Carey MC, (2003). Enterohepatic cycling of bilirubin as a cause of 'black' pigment gallstones in adult life. Eur J Clin Invest 33: 799-810. (Pubitemid 37082867)
    • (2003) European Journal of Clinical Investigation , vol.33 , Issue.9 , pp. 799-810
    • Vitek, L.1    Carey, M.C.2
  • 56
    • 0038541723 scopus 로고    scopus 로고
    • Intestinal colonization leading to fecal urobilinoid excretion may play a role in the pathogenesis of neonatal jaundice
    • DOI 10.1097/00005176-200003000-00015
    • Vitek L, Kotal P, Jirsa M, Malina J, Cerna M, Chmelar D, et al,. (2000). Intestinal colonization leading to fecal urobilinoid excretion may play a role in the pathogenesis of neonatal jaundice. J Pediatr Gastroenterol Nutr 30: 294-298. (Pubitemid 30366837)
    • (2000) Journal of Pediatric Gastroenterology and Nutrition , vol.30 , Issue.3 , pp. 294-298
    • Vitek, L.1    Kotal, P.2    Jirsa, M.3    Malina, J.4    Cerna, M.5    Chmelar, D.6    Fevery, J.7
  • 58
    • 33645213641 scopus 로고    scopus 로고
    • Identification of bilirubin reduction products formed by Clostridium perfringens isolated from human neonatal fecal flora
    • Vitek L, Majer F, Muchova L, Zelenka J, Jiraskova A, Branny P, et al,. (2006). Identification of bilirubin reduction products formed by Clostridium perfringens isolated from human neonatal fecal flora. J Chromatogr B Analyt Technol Biomed Life Sci 833: 149-157.
    • (2006) J Chromatogr B Analyt Technol Biomed Life Sci , vol.833 , pp. 149-157
    • Vitek, L.1    Majer, F.2    Muchova, L.3    Zelenka, J.4    Jiraskova, A.5    Branny, P.6
  • 59
    • 4043058702 scopus 로고    scopus 로고
    • Bilirubin inhibits iNOS expression and NO production in response to endotoxin in rats
    • DOI 10.1002/hep.20334
    • Wang WW, Smith DL, Zucker SD, (2004). Bilirubin inhibits iNOS expression and NO production in response to endotoxin in rats. Hepatology 40: 424-433. (Pubitemid 39062860)
    • (2004) Hepatology , vol.40 , Issue.2 , pp. 424-433
    • Wang, W.W.1    Smith, D.L.H.2    Zucker, S.D.3
  • 60
    • 0018364450 scopus 로고
    • Solubilization of unconjugated bilirubin by bile salts
    • DOI 10.1007/BF01968199
    • Wosiewitz U, Schroebler S, (1979). Solubilization of unconjugated bilirubin by bile salts. Experientia 35: 717-718. (Pubitemid 9193859)
    • (1979) Experientia , vol.35 , Issue.6 , pp. 717-718
    • Wosiewitz, U.1    Schroebler, S.2
  • 61
    • 0028870140 scopus 로고
    • Kinetics of bilirubin transfer between serum albumin and membrane vesicles. Insight into the mechanism of organic anion delivery to the hepatocyte plasma membrane
    • Zucker SD, Goessling W, Gollan JL, (1995). Kinetics of bilirubin transfer between serum albumin and membrane vesicles. Insight into the mechanism of organic anion delivery to the hepatocyte plasma membrane. J Biol Chem 270: 1074-1081.
    • (1995) J Biol Chem , vol.270 , pp. 1074-1081
    • Zucker, S.D.1    Goessling, W.2    Gollan, J.L.3
  • 62
    • 0033574696 scopus 로고    scopus 로고
    • Unconjugated bilirubin exhibits spontaneous diffusion through model lipid bilayers and native hepatocyte membranes
    • DOI 10.1074/jbc.274.16.10852
    • Zucker SD, Goessling W, Hoppin AG, (1999). Unconjugated bilirubin exhibits spontaneous diffusion through model lipid bilayers and native hepatocyte membranes. J Biol Chem 274: 10852-10862. (Pubitemid 29191067)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.16 , pp. 10852-10862
    • Zucker, S.D.1    Goessling, W.2    Hoppin, A.G.3


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