Pten regulates development and lactation in the mammary glands of dairy cows

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Wang, Zhuoran ^a   Hou, Xiaoming ^a   Qu, Bo ^a   Wang, Jie ^a   Gao, Xuejun ^a   Li, Qingzhang ^a  

^a NORTHEAST AGRICULTURAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CASEIN; CYCLIN D1; GLUCOSE TRANSPORTER 1; INITIATION FACTOR 4E BINDING PROTEIN 1; LACTOSE; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; S6 KINASE; SMALL INTERFERING RNA; STAT5 PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRIACYLGLYCEROL; CASEIN; GLUCOSE; MESSENGER RNA; PROLACTIN;

ANIMAL CELL; ARTICLE; BREAST DEVELOPMENT; BREAST EPITHELIUM; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CULTURE MEDIUM; DAIRY CATTLE; DOWN REGULATION; FEMALE; FLOW CYTOMETRY; GENE OVEREXPRESSION; IMMUNOHISTOCHEMISTRY; LACTATION; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; QUANTITATIVE ANALYSIS; RNA EXTRACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; ANIMAL; BOVINE; CELL CYCLE; CELL SURVIVAL; DAIRYING; DRUG EFFECTS; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; UDDER;

ANIMALS; CASEINS; CATTLE; CELL CYCLE; CELL SURVIVAL; DAIRYING; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLUCOSE; LACTATION; LACTOSE; MAMMARY GLANDS, ANIMAL; PROLACTIN; PTEN PHOSPHOHYDROLASE; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSFECTION; TRIGLYCERIDES;

EID: 84904265158     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0102118     Document Type: Article

References (54)

1. Jeurink PV, van Bergenhenegouwen J, Jimenez E, Knippeis LM, Fernandez L, et al. (2013) Human milk: a source of more life than we imagine. Benef Microbes 4: 17-30.
2. Schmitt-Ney M, Doppler W, Ball RK, Groner B (1991) β-casein gene promoter activity is regulated by the hormone mediated relief of transcriptional repression and a mammary-gland-specific nuclear factor. Mol Cell Biol 11: 3745-3755. (Pubitemid 21895762)
3. Gouilleux F, Wakao H, Mundt V, Groner B (1994). Prolactin induces phosphorylation of Tyr694 of STAT5 (MGF), a prerequisite for DNA binding and induction of transcription. EMBO J 13: 4361-4369. (Pubitemid 24295208)
4. Kristopher CC, Lisa MA, Linda AS (2009) Complex prolactin crosstalk in breast cancer: New therapeutic implications. Mol Cell Endocrinol 307: 1-7.
5. Goldstein JL, Bose-Boyd RA, Brown MS (2006) Protein sensors for membrane sterols. Cell 124: 35-46.
6. Anderson SM, Rudolph MC, McManaman JL, Neville MC (2007) Secretory activation in the mammary gland: it's not just about milk protein synthesis! Breast Cancer Res 9: 204.
7. Cantley LC, Neel BG (1999) New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc. NatL Acad. Sci. U.S.A 96: 4240-4245. (Pubitemid 29190320)
8. Hollander MC, Blumenthal GM, Dennis PA (2011) PTEN loss in the continuum of common cancers, rare syndromes and mouse models. Nat Rev Cancer 11: 289-301.
9. Simpson L, Parsons R (2001) PTEN: life as a tumor suppressor. Exp Cell Res 264: 29-41. (Pubitemid 32989079)
10. Song MS, Salmena L, Pandolfi PP (2012) The functions and regulation of the PTEN tumour suppressor. Nat Rev Mol Cell Biol 13: 283-296.
11. Ortega-Molina A, Serrano M (2013) PTEN in cancer, metabolism, and aging. Trends Endocrinol Metab 24: 184-189.
12. Dupont J, Renou JP, Shani M, Hennighausen L, LeRoith D (2002) PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium. J Clin Invest 110: 815-825.
13. Chen CC, Stairs DB, Boxer RB, Belka GK, Horseman ND, et al. (2012) Autocrine prolactin induced by the Pten-Akt pathway is required for lactation initiation and provides a direct link between the Akt and Stat5 pathways. Genes Dev 26: 2154-2168.
14. Chen CC, Boxer RB, Stairs DB, Portocarrero CP, Horton RH, et al. (2010) Akt is required for Stat5 activation and mammary differentiation. Breast Cancer Res 12: R72.
15. Kark T, Bagi Z, Lizanecz E, Pa?sztor ET, Erdei N, et al. (2008) Tissue-specific regulation of microvascular diameter: opposite functional roles of neuronal and smooth muscle located vanilloid receptor-1. Molecular Pharmacology 73: 1405-1412. (Pubitemid 351574830)
16. Ke Z, Liu HY, Zhou MM, Liu JX (2010) Establishment and characterization of a lactating bovine mammary epithelial cell model for the study of milk synthesis. Cell Biol.Int 34: 717-721.
17. Liu H, Zhao K, Liu J (2013) Effects of Glucose Availability on Expression of the Key Genes Involved in Synthesis of Milk Fat, Lactose and Glucose Metabolism in Bovine Mammary Epit helial Cells. PLoS ONE 8: e66092.
18. Alcorn J, Lu X, Moscow JA, McNamara PJ (2002) Transporter gene expression in Lactating and nonlactating human mammary epithelial cells using real-time reverse transcription polymerase chain reaction. J Pharmacol Exp Ther 303: 487-496. (Pubitemid 35231217)
19. Macheda ML, Williams ED, Best JD, Wlodek ME, Rogers S (2003) Expression and localisation of GLUT1 and GLUT12 glucose transporters in the pregnant and lactating rat mammary gland. Cell Tissue Res 311: 91-97. (Pubitemid 35478228)
20. Rutledge RG, Cote C (2003) Mathematics of quantitative kinetic PCR and the application of standard curves. Nucleic Acids Res 31: e93.
21. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408. (Pubitemid 34164012)
22. Hou T, Yang CL, Tong CJ, Zhang HT, Xiao J, et al. (2014) Overexpression of ASAP1 is associated with poor prognosis in epithelial ovarian cancer. Int J Clin Exp Pathol 7: 280-287.
23. Li HM, Wang CM, Li QZ, Gao XJ (2012) MiR-15a decreases bovine mammary epithelial cell viability and lactation and regulates growth hormone receptor expression. Molecules 17: 12037-12048.
24. Liu JL, Sheng X, Hortobagyi ZK, Mao Z, Gallick GE, et al. (2005) Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation. Mol Cell Biol 25: 6211-6224. (Pubitemid 40946569)
25. Qi XF, Zheng L, Kim CS, Lee KJ, Kim DH, et al. (2013) CpG oligodeoxynucleotide induces apoptosis and cell cycle arrest in A20 lymphoma cells via TLR9-mediated pathways. Mol Immunol 54: 327-337.
26. Chan GK, Kleinheinz TL, Peterson D, Moffat JG (2013) A simple high-content cell cycle assay reveals frequent discrepancies between cell number and ATP and MTS proliferation assays. PLoS ONE 8: 1-15.
27. Hu H, Wang JQ, Bu DP, Wei HY, Zhou LY, et al. (2009) In vitro culture and characterization of a mammary epithelial cell line from Chinese Holstein dairy cow. PLoS ONE 4: e7636.
28. Boutinaud M, Guinard FJ, Helene J (2004) The number and activity of mammary epithelial cells, determining factors for milk production. Reprod Nutr Dev 44: 499-508. (Pubitemid 39618492)
29. Santos SJ, Aupperlee MD, Xie J, Durairaj S, Miksicek R, et al. (2009) Progesterone receptor A-regulated gene expression in mammary organoid cultures. J Steroid Biochem Mol Biol 115: 161-172.
30. Cui W, Li Q, Feng L, Ding W (2011) MiR-126-3p regulates progesterone receptors and involves development and lactation of mouse mammary gland. Mol Cell Biochem 355: 17-25.
31. Moon SH, Kim DK, Cha Y, Jeon J, Song J, et al. (2013) PI3K/Akt and Stat3 signaling regulated by PTEN control of the cancer stem cell population, proliferation and senescence in a glioblastoma cell line. Int J Oncol 42: 921-928.
32. Tanaka T, Haneda S, Imakawa K, Sakai S, Nagaoka K (2009) A microRNA, miR-101a, controls mammary gland development by regulating cyclooxygenase-2 expression. Differentiation 77: 181-187.
33. Blanco AC, Canamero M, Cecilia Y, Pequeno B, Renner O, et al. (2010) Exploring the gain of function contribution of AKT to mammary tumorigenesis in mouse models. PLoS ONE 5: 1-12.
34. Zhou BR, Huang QH, Xu Y, Di W, Yin ZQ, et al. (2012) Dihydrotestosterone induces SREBP-1 expression and lipogenesis through the phosphoinositide 3-kinase/Akt pathway in HaCaT cells. Lipids Health Dis. 11: 156-161.
35. Manning BD, Cantley LC (2007) AKT/PKB signaling: navigating down-stream. Cell 129: 1261-1274.
36. Chalhoub N, Baker SJ (2009) PTEN and the PI3-kinase pathway in cancer. Annu Rev Pathol 4: 127-150.
37. Weng LP, Brown JL, Eng C (2001) PTEN coordinates G(1) arrest by downregulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model. Hum. Mol. Genet 10: 599-604. (Pubitemid 32229364)
38. Saqcena M, Menon D, Patel D, Mukhopadhyay S, Chow V, et al. (2013) Amino Acids and mTOR Mediate Distinct Metabolic Checkpoints in Mammalian G1 Cell Cycle. PLoS ONE 8: 1-11.
39. Mikhail V (2013) M(o)TOR of aging: mTOR as a universal molecular hypothalamus. Aging 5L: 490-494.
40. Bian CX, Shi Z, Meng Q, Jiang Y, Liu LZ, et al. (2010) P70S6K 1 regulation of angiogenesis through VEGF and HIF-1alpha expression. Biochem Biophys Res Commun 398: 395-399.
41. Goo CK, Lim HY, Ho QS, Too HP, Clement MV, et al. (2012) PTEN/Akt signaling controls mitochondrial respiratory capacity through 4E-BP1. PLoS ONE 7: 1-13.
42. Maehama T, Taylor GS, Dixon JE (2001) PTEN and myotubularin: novel phosphoinositide. Annu. Rev Biochem 70: 247-279.
43. Mao J, Molenaar AJ, Wheeler TT, Seyfert HM (2002) STAT5 binding contributes to lactational stimulation of promoter III expressiing the bovine acelyl-CoA carboxylase alpha-encoding gene in the mammary gland. J Mol Endocrmol. 29: 73-88. (Pubitemid 34965747)
44. Dong Y, Zhang L, Zhang S, Bai Y, Chen H, et al. (2012) Phosphatase of Regenerating Liver 2 (PRL2) Is Essential for Placental Development by Down-regulating PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) and Activating Akt Protein. J Biol Chem. 287: 32172-32179.
45. Lee HJ, Ormandy CJ (2012) Elf5, hormones and cell fate. Trends Endocrinol Metab 23: 292-298.
46. Harris J, Stanford PM, Sutherland K, Oakes SR, Naylor MJ, et al. (2006) Socs2 and Elf5 mediate prolactin-induced mammary gland development. Mol Endocrinol 20: 1177-1187.
47. Stephane P, Mikael LD, Sylvie A, Roger LG, Sonia D, et al. (2008) Human and simian immunodeficiency viruses deregulate early hematopoiesis through a Nef/PPARc/STAT5 signaling pathway in macaques. J Clin Invest 118: 1765-1775.
48. Dai X, Sayama K, Shirakata Y, Hanakawa Y, Yamasaki K, et al. (2007) STAT5/PPARc pathway regulates involucrin expression in keratinocyte differentiation. J Invest Dermatol 127: 1728-1735. (Pubitemid 46933408)
49. Porstmann T, Griffiths B, Chung YL, Delpuech O, Griffiths JR, et al. (2005) PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP. Oncogene 24: 6465-6481. (Pubitemid 41486630)
50. Zhu G, Chai J, Ma L, Duan H, Zhang H (2013) Downregulated microRNA-32 expression induced by high glucose inhibits cell cycle progression via PTEN upregulation and Akt inactivation in bone marrow-derived mese nchymal stem cells. Biochem Biophys Res Commun 433: 526-531.
51. Trott JF, Horigan KC, Gloviczki JM, Costa KM, Freking BA, et al. (2009) Tissue-specific regulation of porcine prolactin receptor expression by estrogen, progesterone, and prolactin. J Endocrinol 202: 153-166.
52. Jeanette N, Gunnar B, Marie KJ (2006) Nuclear Jak2 and transcription factor NF1-C2: a novel mechanism of prolactin signaling in mammary epithelial cells. Mol Cell Biol 26: 5663-5674.
53. Nira BJ, Eric R. Hugo ER, Terry D (2006) Focus on prolactin as a metabolic hormone. Trends Endocrinol Metab 17: 110-116.
54. Liu XF, Meng L, Li QZ, Lu LM, Tong HL, et al. (2012) Stat5a increases lactation of dairy cow mammary gland epithelial cells cultured in vitro. In Vitro Cell. Dev. Biol.-Animal 48: 554-561.