Autocrine prolactin induced by the Pten-Akt pathway is required for lactation initiation and provides a direct link between the Akt and Stat5 pathways

Genes and Development

Volumn 26, Issue 19, 2012, Pages 2154-2168

  Chen, Chien Chung ^a,b   Stairs, Douglas B ^a,b   Boxer, Robert B ^a,b   Belka, George K ^a,b   Horseman, Nelson D ^c   Alvarez, James V ^a,b   Chodosh, Lewis A ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF CINCINNATI   (United States)

Author keywords

Akt; Differentiation; Lactation; Mammary gland; Pten; Stat5

Indexed keywords

CYTOKERATIN 8; JANUS KINASE; JANUS KINASE 2; MILK PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROLACTIN; PROTEIN AKT1; PROTEIN KINASE B; STAT5 PROTEIN; STAT5A PROTEIN; STAT5B PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; BREAST EPITHELIUM; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; GENE DELETION; IMMUNOBLOTTING; IMMUNOFLUORESCENCE TEST; LACTATION; MAMMARY GLAND; MOUSE; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROLACTIN BLOOD LEVEL; PROTEIN EXPRESSION;

ANIMALS; AUTOCRINE COMMUNICATION; CELL DIFFERENTIATION; CELLS, CULTURED; DOWN-REGULATION; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION; LACTATION; MAMMARY GLANDS, ANIMAL; MICE; MILK PROTEINS; PREGNANCY; PROLACTIN; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; STAT5 TRANSCRIPTION FACTOR;

MUS; RODENTIA;

EID: 84867163539     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.197343.112     Document Type: Article

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