STAT5a/PPARγ pathway regulates involucrin expression in keratinocyte differentiation

Journal of Investigative Dermatology

Volumn 127, Issue 7, 2007, Pages 1728-1735

  Dai, Xiuju ^a   Sayama, Koji ^a   Shirakata, Yuji ^a   Hanakawa, Yasushi ^a   Yamasaki, Kenshi ^a   Tokumaru, Sho ^a   Yang, Lujun ^a   Wang, Xiaoling ^a   Hirakawa, Satoshi ^a   Tohyama, Mikiko ^a   Yamauchi, Toshimasa ^b   Takashi, Kadowaki ^b   Kagechika, Hiroyuki ^c   Hashimoto, Koji ^a  

^a EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INVOLUCRIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; STAT5 PROTEIN; BENZOIC ACID DERIVATIVE; BIPHENYL DERIVATIVE; DIAZEPINYLBENZOIC ACID; MESSENGER RNA; PROTEIN PRECURSOR; RETINOID X RECEPTOR; UNCLASSIFIED DRUG;

ADIPOGENESIS; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; DIMERIZATION; DOWN REGULATION; FUNCTIONAL PROTEOMICS; HUMAN; HUMAN CELL; KERATINOCYTE; NEWBORN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN TRANSPORT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; CYTOLOGY; DRUG ANTAGONISM; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGY; TRANSACTIVATION;

BENZOIC ACIDS; BIPHENYL COMPOUNDS; CELL DIFFERENTIATION; CELLS, CULTURED; GENE EXPRESSION REGULATION; HUMANS; KERATINOCYTES; PPAR GAMMA; PROTEIN PRECURSORS; RETINOID X RECEPTORS; RNA, MESSENGER; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR; TRANS-ACTIVATION (GENETICS);

EID: 34250676484     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/sj.jid.5700758     Document Type: Article

References (39)

1. Ariyoshi K, Nosaka T, Yamada K, Onishi M, Oka Y, Miyajima A et al. (2000) Constitutive activation of STAT5 by a point mutation in the SH2 domain. J Biol Chem 275:24407-13
2. Coffer PJ, Koenderman L, de Groot RP (2000) The role of STATs in myeloid differentiation and leukemia. Oncogene 19:2511-22
3. Dai X, Yamasaki K, Shirakata Y, Sayama K, Hashimoto K (2004) All-transretinoic acid induces interleukin-8 via the nuclear factor-kappaB and p38 mitogen-activated protein kinase pathways in normal human keratinocytes. J Invest Dermatol 123:1078-85
4. Demerjian M, Man MQ, Choi EH, Brown BE, Crumrine D, Chang S et al. (2006) Topical treatment with thiazolidinediones, activators of peroxisome proliferator-activated receptor-gamma, normalizes epidermal homeostasis in a murine hyperproliferative disease model. Exp Dermatol 15:154-60
5. Dignam JD, Martin PL, Shastry BS, Roeder RG (1983) Eukaryotic gene transcription with purified components. Methods Enzymol 101:582-98
6. Eckert RL, Crish JF, Efimova T, Dashti SR, Deucher A, Bone F et al. (2004) Regulation of involucrin gene expression. J Invest Dermatol 123:13-22
7. Ellis CN, Varani J, Fisher GJ, Zeigler ME, Pershadsingh HA, Benson SC et al. (2000) Troglitazone improves psoriasis and normalizes models of proliferative skin disease: ligands for peroxisome proliferator-activated receptor-gamma inhibit keratinocyte proliferation. Arch Dermatol 136:609-16
8. Fajas L, Auboeuf D, Raspe E, Schoonjans K, Lefebvre AM, Saladin R et al. (1997) The organization, promoter analysis, and expression of the human PPARγ gene. J Biol Chem 272:18779-89
9. Fajas L, Fruchart JC, Auwerx J (1998) PPARgamma3 mRNA: a distinct PPARγ mRNA subtype transcribed from an independent promoter. FEBS Lett 438:55-60
10. Floyd ZE, Stephens JM (2003) STAT5A promotes adipogenesis in nonprecursor cells and associates with the glucocorticoid receptor during adipocyte differentiation. Diabetes 52:308-14
11. Grimley PM, Dong F, Rui H (1999) Stat5a and Stat5b: fraternal twins of signal transduction and transcriptional activation. Cytokine Growth Factor Rev 10:131-57
12. Gurnell M, Wentworth JM, Agostini M, Adams M, Collingwood TN, Provenzano C et al. (2000) A dominant-negative peroxisome proliferator-activated receptor gamma (PPARgamma) mutant is a constitutive repressor and inhibits PPARgamma-mediated adipogenesis. J Biol Chem 275:5754-9
13. Horvath CM (2000) STAT proteins and transcriptional responses to extracellular signals. Trends Biochem Sci 25:496-502
14. Ikeda K, Nakajima H, Suzuki K, Watanabe N, Kagami S, Iwamoto I (2005) Stat5a is essential for the proliferation and survival of murine mast cells. Int Arch Allergy Immunol 137(Suppl 1):45-50
15. Juge-Aubry C, Pernin A, Favez T, Burger AG, Wahli W, Meier CA et al. (1997) DNA binding properties of peroxisome proliferator-activated receptor subtypes on various natural peroxisome proliferator response elements. Importance of the 5′-flanking region. J Biol Chem 272:25252-9
16. Kuenzli S, Saurat JH (2003) Peroxisome proliferator-activated receptors in cutaneous biology. Br J Dermatol 149:229-36
17. Levy DE, Gilliland DG (2000) Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in mice. Oncogene 19:2505-10
18. Mao-Qiang M, Fowler AJ, Schmuth M, Lau P, Chang S, Brown BE et al. (2004) Peroxisome-proliferator-activated receptor (PPAR)-gamma activation stimulates keratinocyte differentiation. J Invest Dermatol 123:305-12
19. Matsuura H, Adachi H, Smart RC, Xu X, Arata J, Jetten AM (1999) Correlation between expression of peroxisome proliferator-activated receptor beta and squamous differentiation in epidermal and tracheobronchial epithelial cells. Mol Cell Endocrinol 147:85-92
20. Meirhaeghe A, Fajas L, Gouilleux F, Cottel D, Helbecque N, Auwerx J et al. (2003) A functional polymorphism in a STAT5B site of the human PPAR gamma 3 gene promoter affects height and lipid metabolism in a French population. Arterioscler Thromb Vasc Biol 23:289-94
21. Miyake S, Makimura M, Kanegae Y, Harada S, Sato Y, Takamori K et al. (1996) Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome. Proc Natl Acad Sci USA 93:1320-4
22. Nanbu-Wakao R, Morikawa Y, Matsumura I, Masuho Y, Muramatsu MA, Senba E et al. (2002) Stimulation of 3T3-L1 adipogenesis by signal transducer and activator of transcription 5. Mol Endocrinol 16:1565-76
23. Nishio H, Matsui K, Tsuji H, Tamura A, Suzuki K (2001) Immunolocalisation of the janus kinases (JAK) - signal transducers and activators of transcription (STAT) pathway in human epidermis. J Anat 198:581-9
24. Olsen H, Haldosen LA (2006) Peroxisome proliferator-activated receptor gamma regulates expression of signal transducer and activator of transcription 5A. Exp Cell Res 312:1371-80
25. Poumay Y, Jolivet G, Pittelkow MR, Herphelin F, De Potter IY, Mitev V et al. (1999) Human epidermal keratinocytes upregulate expression of the prolactin receptor after the onset of terminal differentiation, but do not respond to prolactin. Arch Biochem Biophys 364:247-53
26. Rivier M, Safonova I, Lebrun P, Griffiths CE, Ailhaud G, Michel S (1998) Differential expression of peroxisome proliferator-activated receptor subtypes during the differentiation of human keratinocytes. J Invest Dermatol 111:1116-21
27. Rosen ED, Walkey CJ, Puigserver P, Spiegelman BM (2000) Transcriptional regulation of adipogenesis. Genes Dev 14:1293-307
28. Sayama K, Hanakawa Y, Shirakata Y, Yamasaki K, Sawada Y, Sun L et al. (2001) Apoptosis signal-regulating kinase 1 (ASK1) is an intracellular inducer of keratinocyte differentiation. J Biol Chem 276:999-1004
29. Sayama K, Yamasaki K, Hanakawa Y, Shirakata Y, Tokumaru S, Ijuin T et al. (2002) Phosphatidylinositol 3-kinase is a key regulator of early phase differentiation in keratinocytes. J Biol Chem 277:40390-6
30. Segaert S, Garmyn M, Degreef H, Bouillon R (1998) Anchorage-dependent expression of the vitamin D receptor in normal human keratinocytes. J Invest Dermatol 111:551-8
31. Shirakata Y, Ueno H, Hanakawa Y, Kameda K, Yamasaki K, Tokumaru S et al. (2004) TGF-beta is not involved in early phase growth inhibition of keratinocytes by 1alpha,25(OH)2vitamin D3. J Dermatol Sci 36:41-50
32. Stephens JM, Morrison RF, Wu Z, Farmer SR (1999) PPARgamma ligand-dependent induction of STAT1, STAT5A, and STAT5B during adipogenesis. Biochem Biophys Res Commun 262:216-22
33. Stewart WC, Baugh JE Jr, Floyd ZE, Stephens JM (2004) STAT 5 activators can replace the requirement of FBS in the adipogenesis of 3T3-L1 cells. Biochem Biophys Res Commun 324:355-9
34. Varley CL, Stahlschmidt J, Smith B, Stower M, Southgate J (2004) Activation of peroxisome proliferator-activated receptor-gamma reverses squamous metaplasia and induces transitional differentiation in normal human urothelial cells. Am J Pathol 164:1789-98
35. Wakita H, Takigawa M (1999) Activation of epidermal growth factor receptor promotes late terminal differentiation of cell-matrix interaction-disrupted keratinocytes. J Biol Chem 274:37285-91
36. Watt FM, Jordan PW, O'Neill CH (1988) Cell shape controls terminal differentiation of human epidermal keratinocytes. Proc Natl Acad Sci USA 85:5576-80
37. Westergaard M, Henningsen J, Svendsen ML, Johansen C, Jensen UB, Schroder HD et al. (2001) Modulation of keratinocyte gene expression and differentiation by PPAR-selective ligands and tetradecylthioacetic acid. J Invest Dermatol 116:702-12
38. Yahata Y, Shirakata Y, Tokumaru S, Yamasaki K, Sayama K, Hanakawa Y et al. (2003) Nuclear translocation of phosphorylated STAT3 is essential for vascular endothelial growth factor-induced human dermal microvascular endothelial cell migration and tube formation. J Biol Chem 278:40026-31
39. Yamauchi T, Waki H, Kamon J, Murakami K, Motojima K, Komeda K et al. (2001) Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes. J Clin Invest 108:1001-13