Downregulated microRNA-32 expression induced by high glucose inhibits cell cycle progression via PTEN upregulation and Akt inactivation in bone marrow-derived mesenchymal stem cells

Biochemical and Biophysical Research Communications

Volumn 433, Issue 4, 2013, Pages 526-531

  Zhu, Guiying ^a   Chai, Jiake ^a   Ma, Li ^a   Duan, Hongjie ^a   Zhang, Haijun ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

G0 G1 phase; High glucose; Mesenchymal stem cells (MSCs); MicroRNAs; Phosphatase and tensin homologs deleted on chromosome 10 (PTEN); Phosphatidylinositol 3 kinase (PI3K) AKT signaling pathway

Indexed keywords

GLUCOSE; MICRORNA; MICRORNA 32; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CONTROLLED STUDY; DOWN REGULATION; HYPERGLYCEMIA; MESENCHYMAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; UPREGULATION;

3' UNTRANSLATED REGIONS; ANIMALS; BLOTTING, WESTERN; BONE MARROW; CELL CYCLE; CELLS, CULTURED; COMPUTATIONAL BIOLOGY; DOWN-REGULATION; ENZYME ACTIVATION; GLUCOSE; HYPERGLYCEMIA; MESENCHYMAL STROMAL CELLS; MICRORNAS; OLIGONUCLEOTIDES; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RATS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSFECTION; UP-REGULATION;

RATTUS;

EID: 84876482359     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.03.018     Document Type: Article

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