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Volumn 3, Issue 1, 2014, Pages 1-12

Inhibition of neutral sphingomyelinases in skeletal muscle attenuates fatty-acid induced defects in metabolism and stress

Author keywords

C2C12 myotubes; Cellular stress; Ceramide; Insulin resistance; Oxidative capacity; Sphingomyelinase; T2DM

Indexed keywords


EID: 84903999673     PISSN: None     EISSN: 21931801     Source Type: Journal    
DOI: 10.1186/2193-1801-3-255     Document Type: Article
Times cited : (16)

References (64)
  • 2
    • 33845514376 scopus 로고    scopus 로고
    • Skeletal muscle mitochondrial functions, mitochondrial DNA copy numbers, and gene transcript profiles in type 2 diabetic and nondiabetic subjects at equal levels of low or high insulin and euglycemia
    • Asmann YW, Stump CS, Short KR, Coenen-Schimke JM, Guo Z, Bigelow ML, Nair KS: Skeletal muscle mitochondrial functions, mitochondrial DNA copy numbers, and gene transcript profiles in type 2 diabetic and nondiabetic subjects at equal levels of low or high insulin and euglycemia. Diabetes 2006, 55: 3309-3319.
    • (2006) Diabetes , vol.55 , pp. 3309-3319
    • Asmann, Y.W.1    Stump, C.S.2    Short, K.R.3    Coenen-Schimke, J.M.4    Guo, Z.5    Bigelow, M.L.6    Nair, K.S.7
  • 3
    • 0024237258 scopus 로고
    • Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans
    • Baron AD, Brechtel G, Wallace P, Edelman SV: Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans. Am J Physiol 1988, 255: E769-E774.
    • (1988) Am J Physiol , vol.255
    • Baron, A.D.1    Brechtel, G.2    Wallace, P.3    Edelman, S.V.4
  • 4
    • 77957740947 scopus 로고    scopus 로고
    • Effect of high fat diet enriched with unsaturated and diet rich in saturated fatty acids on sphingolipid metabolism in rat skeletal muscle
    • Blachnio-Zabielska A, Baranowski M, Zabielski P, Gorski J: Effect of high fat diet enriched with unsaturated and diet rich in saturated fatty acids on sphingolipid metabolism in rat skeletal muscle. J Cell Physiol 2010, 225: 786-791.
    • (2010) J Cell Physiol , vol.225 , pp. 786-791
    • Blachnio-Zabielska, A.1    Baranowski, M.2    Zabielski, P.3    Gorski, J.4
  • 5
    • 84870299468 scopus 로고    scopus 로고
    • Sphingolipid content of human adipose tissue: relationship to adiponectin and insulin resistance
    • Blachnio-Zabielska AU, Koutsari C, Tchkonia T, Jensen MD: Sphingolipid content of human adipose tissue: relationship to adiponectin and insulin resistance. Obesity (Silver Spring) 2012, 20: 2341-2347.
    • (2012) Obesity (Silver Spring) , vol.20 , pp. 2341-2347
    • Blachnio-Zabielska, A.U.1    Koutsari, C.2    Tchkonia, T.3    Jensen, M.D.4
  • 6
    • 4544355465 scopus 로고    scopus 로고
    • Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36
    • Bonen A, Parolin ML, Steinberg GR, Calles-Escandon J, Tandon NN, Glatz JF, Luiken JJ, Heigenhauser GJ, Dyck DJ: Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36. FASEB J 2004, 18: 1144-1146.
    • (2004) FASEB J , vol.18 , pp. 1144-1146
    • Bonen, A.1    Parolin, M.L.2    Steinberg, G.R.3    Calles-Escandon, J.4    Tandon, N.N.5    Glatz, J.F.6    Luiken, J.J.7    Heigenhauser, G.J.8    Dyck, D.J.9
  • 8
    • 0038321436 scopus 로고    scopus 로고
    • Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes
    • Bouzakri K, Roques M, Gual P, Espinosa S, Guebre-Egziabher F, Riou JP, Laville M, Le Marchand-Brustel Y, Tanti JF, Vidal H: Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes. Diabetes 2003, 52: 1319-1325.
    • (2003) Diabetes , vol.52 , pp. 1319-1325
    • Bouzakri, K.1    Roques, M.2    Gual, P.3    Espinosa, S.4    Guebre-Egziabher, F.5    Riou, J.P.6    Laville, M.7    Le Marchand-Brustel, Y.8    Tanti, J.F.9    Vidal, H.10
  • 10
    • 84871690973 scopus 로고    scopus 로고
    • The sphingosine-1-phosphate analog FTY720 reduces muscle ceramide content and improves glucose tolerance in high fat-fed male mice
    • Bruce CR, Risis S, Babb JR, Yang C, Lee-Young RS, Henstridge DC, Febbraio MA: The sphingosine-1-phosphate analog FTY720 reduces muscle ceramide content and improves glucose tolerance in high fat-fed male mice. Endocrinology 2013, 154: 65-76.
    • (2013) Endocrinology , vol.154 , pp. 65-76
    • Bruce, C.R.1    Risis, S.2    Babb, J.R.3    Yang, C.4    Lee-Young, R.S.5    Henstridge, D.C.6    Febbraio, M.A.7
  • 11
    • 0038532298 scopus 로고    scopus 로고
    • A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids
    • Chavez JA, Knotts TA, Wang LP, Li G, Dobrowsky RT, Florant GL, Summers SA: A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids. J Biol Chem 2003, 278: 10297-10303.
    • (2003) J Biol Chem , vol.278 , pp. 10297-10303
    • Chavez, J.A.1    Knotts, T.A.2    Wang, L.P.3    Li, G.4    Dobrowsky, R.T.5    Florant, G.L.6    Summers, S.A.7
  • 12
    • 21244442275 scopus 로고    scopus 로고
    • Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling
    • Chavez JA, Holland WL, Bär J, Sandhoff K, Summers SA: Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling. J Biol Chem 2005, 280: 20148-20153.
    • (2005) J Biol Chem , vol.280 , pp. 20148-20153
    • Chavez, J.A.1    Holland, W.L.2    Bär, J.3    Sandhoff, K.4    Summers, S.A.5
  • 14
    • 0036084833 scopus 로고    scopus 로고
    • Effect of prolonged exercise
    • Ceramides and sphingomyelins in skeletal muscles of the rat: content and composition
    • Dobrzyń A, Górski J, Ceramides and sphingomyelins in skeletal muscles of the rat: content and composition: Effect of prolonged exercise. Am J Physiol Endocrinol Metab 2002, 282: E277-E285.
    • (2002) Am J Physiol Endocrinol Metab , vol.282
    • Dobrzyń, A.1    Górski, J.2
  • 15
    • 0034112806 scopus 로고    scopus 로고
    • Intramuscular lipid content is increased in obesity and decreased by weight loss
    • Goodpaster BH, Theriault R, Watkins SC, Kelley DE: Intramuscular lipid content is increased in obesity and decreased by weight loss. Metabolism 2000, 49: 467-472.
    • (2000) Metabolism , vol.49 , pp. 467-472
    • Goodpaster, B.H.1    Theriault, R.2    Watkins, S.C.3    Kelley, D.E.4
  • 16
    • 0035217707 scopus 로고    scopus 로고
    • Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes
    • Goodpaster BH, He J, Watkins S, Kelley DE: Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes. J Clin Endocrinol Metab 2001, 86: 5755-5761.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 5755-5761
    • Goodpaster, B.H.1    He, J.2    Watkins, S.3    Kelley, D.E.4
  • 17
    • 63249117466 scopus 로고    scopus 로고
    • Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity ofinsulin resistance
    • Haus JM, Kashyap SR, Kasumov T, Zhang R, Kelly KR, Defronzo RA, Kirwan JP: Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity ofinsulin resistance. Diabetes 2009, 58: 337-343.
    • (2009) Diabetes , vol.58 , pp. 337-343
    • Haus, J.M.1    Kashyap, S.R.2    Kasumov, T.3    Zhang, R.4    Kelly, K.R.5    Defronzo, R.A.6    Kirwan, J.P.7
  • 18
    • 0035083645 scopus 로고    scopus 로고
    • Skeletal muscle lipid content and oxidative enzyme activity in relation to muscle fiber type in type 2 diabetes and obesity
    • He J, Watkins S, Kelley DE: Skeletal muscle lipid content and oxidative enzyme activity in relation to muscle fiber type in type 2 diabetes and obesity. Diabetes 2001, 50: 817-823.
    • (2001) Diabetes , vol.50 , pp. 817-823
    • He, J.1    Watkins, S.2    Kelley, D.E.3
  • 19
    • 1642503772 scopus 로고    scopus 로고
    • Exercise and training effects on ceramide metabolism in human skeletal muscle
    • Helge JW, Dobrzyn A, Saltin B, Gorski J: Exercise and training effects on ceramide metabolism in human skeletal muscle. Exp Physiol 2004, 89: 119-127.
    • (2004) Exp Physiol , vol.89 , pp. 119-127
    • Helge, J.W.1    Dobrzyn, A.2    Saltin, B.3    Gorski, J.4
  • 20
    • 77955556016 scopus 로고    scopus 로고
    • Effect of physical training on mitochondrial respiration and reactive oxygen species release in skeletal muscle in patients with obesity and type 2 diabetes
    • Hey-Mogensen M, Højlund K, Vind BF, Wang L, Dela F, Beck-Nielsen H, Fernström M, Sahlin K: Effect of physical training on mitochondrial respiration and reactive oxygen species release in skeletal muscle in patients with obesity and type 2 diabetes. Diabetologia 2010, 53: 1976-1985.
    • (2010) Diabetologia , vol.53 , pp. 1976-1985
    • Hey-Mogensen, M.1    Højlund, K.2    Vind, B.F.3    Wang, L.4    Dela, F.5    Beck-Nielsen, H.6    Fernström, M.7    Sahlin, K.8
  • 22
    • 70350380866 scopus 로고    scopus 로고
    • Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity
    • Hu W, Bielawski J, Samad F, Merrill AH Jr, Cowart LA: Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity. J Lipid Res 2009, 50: 1852-1862.
    • (2009) J Lipid Res , vol.50 , pp. 1852-1862
    • Hu, W.1    Bielawski, J.2    Samad, F.3    Merrill Jr., A.H.4    Cowart, L.A.5
  • 23
    • 0036300538 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha
    • Itani SI, Ruderman NB, Schmieder F, Boden G: Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Diabetes 2002, 51: 2005-2011.
    • (2002) Diabetes , vol.51 , pp. 2005-2011
    • Itani, S.I.1    Ruderman, N.B.2    Schmieder, F.3    Boden, G.4
  • 25
    • 0036788293 scopus 로고    scopus 로고
    • Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes
    • Kelley DE, He J, Menshikova EV, Ritov VB: Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 2002, 51: 2944-2950.
    • (2002) Diabetes , vol.51 , pp. 2944-2950
    • Kelley, D.E.1    He, J.2    Menshikova, E.V.3    Ritov, V.B.4
  • 26
    • 50249150303 scopus 로고    scopus 로고
    • FTY720, a sphingosine-1-phosphate receptor modulator, reverses high-fat diet-induced weight gain, insulinresistance and adipose tissue inflammation in C57BL/6 mice
    • Kendall MR, Hupfeld CJ: FTY720, a sphingosine-1-phosphate receptor modulator, reverses high-fat diet-induced weight gain, insulinresistance and adipose tissue inflammation in C57BL/6 mice. Diabetes Obes Metab 2008, 10: 802-805.
    • (2008) Diabetes Obes Metab , vol.10 , pp. 802-805
    • Kendall, M.R.1    Hupfeld, C.J.2
  • 27
    • 0032698470 scopus 로고    scopus 로고
    • Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes
    • Kim YB, Nikoulina SE, Ciaraldi TP, Henry RR, Kahn BB: Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes. J Clin Invest 1999, 104: 733-741.
    • (1999) J Clin Invest , vol.104 , pp. 733-741
    • Kim, Y.B.1    Nikoulina, S.E.2    Ciaraldi, T.P.3    Henry, R.R.4    Kahn, B.B.5
  • 28
    • 33749338109 scopus 로고    scopus 로고
    • Insulin regulation of skeletal muscle PDK4 mRNA expression is impaired in acute insulin-resistant states
    • Kim YI, Lee FN, Choi WS, Lee S, Youn JH: Insulin regulation of skeletal muscle PDK4 mRNA expression is impaired in acute insulin-resistant states. Diabetes 2006, 55: 2311-2317.
    • (2006) Diabetes , vol.55 , pp. 2311-2317
    • Kim, Y.I.1    Lee, F.N.2    Choi, W.S.3    Lee, S.4    Youn, J.H.5
  • 31
    • 84856093324 scopus 로고    scopus 로고
    • Mitochondrial regulators of fatty acid metabolism reflect metabolic dysfunction in type 2 diabetes mellitus
    • Kulkarni SS, Salehzadeh F, Fritz T, Zierath JR, Krook A, Osler ME: Mitochondrial regulators of fatty acid metabolism reflect metabolic dysfunction in type 2 diabetes mellitus. Metabolism 2012, 61: 175-185.
    • (2012) Metabolism , vol.61 , pp. 175-185
    • Kulkarni, S.S.1    Salehzadeh, F.2    Fritz, T.3    Zierath, J.R.4    Krook, A.5    Osler, M.E.6
  • 33
    • 0029853098 scopus 로고    scopus 로고
    • Lipid mediators of insulin resistance: ceramide signalling down-regulates GLUT4 gene transcription in 3T3-L1 adipocytes
    • Long SD, Pekala PH: Lipid mediators of insulin resistance: ceramide signalling down-regulates GLUT4 gene transcription in 3T3-L1 adipocytes. Biochem J 1996, 319: 179-184.
    • (1996) Biochem J , vol.319 , pp. 179-184
    • Long, S.D.1    Pekala, P.H.2
  • 35
    • 0036092239 scopus 로고    scopus 로고
    • Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes
    • McGarry JD: Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes 2002, 51: 7-18.
    • (2002) Diabetes , vol.51 , pp. 7-18
    • McGarry, J.D.1
  • 36
    • 34547468943 scopus 로고    scopus 로고
    • Improved skeletal muscle oxidative enzyme activity and restoration of PGC-1 alpha and PPAR beta/delta gene expression upon rosiglitazone treatment in obese patients with type 2 diabetes mellitus
    • Mensink M, Hesselink MK, Russell AP, Schaart G, Sels JP, Schrauwen P: Improved skeletal muscle oxidative enzyme activity and restoration of PGC-1 alpha and PPAR beta/delta gene expression upon rosiglitazone treatment in obese patients with type 2 diabetes mellitus. Int J Obes (Lond) 2007, 31: 1302-1310.
    • (2007) Int J Obes (Lond) , vol.31 , pp. 1302-1310
    • Mensink, M.1    Hesselink, M.K.2    Russell, A.P.3    Schaart, G.4    Sels, J.P.5    Schrauwen, P.6
  • 38
    • 84863994594 scopus 로고    scopus 로고
    • Palmitate-induced PTP1B expression is mediated by ceramide-JNK and nuclear factor κB (NF-κB) activation
    • MohammadTaghvaei N, Taheripak G, Taghikhani M, Meshkani R: Palmitate-induced PTP1B expression is mediated by ceramide-JNK and nuclear factor κB (NF-κB) activation. Cell Signal 2012, 24: 1964-1970.
    • (2012) Cell Signal , vol.24 , pp. 1964-1970
    • MohammadTaghvaei, N.1    Taheripak, G.2    Taghikhani, M.3    Meshkani, R.4
  • 40
    • 0031750246 scopus 로고    scopus 로고
    • Pioglitazone time-dependently reduces tumour necrosis factor-alpha level in muscle and improves metabolic abnormalities in Wistar fatty rats
    • Murase K, Odaka H, Suzuki M, Tayuki N, Ikeda H: Pioglitazone time-dependently reduces tumour necrosis factor-alpha level in muscle and improves metabolic abnormalities in Wistar fatty rats. Diabetologia 1998, 41: 257-264.
    • (1998) Diabetologia , vol.41 , pp. 257-264
    • Murase, K.1    Odaka, H.2    Suzuki, M.3    Tayuki, N.4    Ikeda, H.5
  • 41
    • 33746334169 scopus 로고    scopus 로고
    • Altered fiber distribution and fiber-specific glycolytic and oxidative enzyme activity in skeletal muscle of patients with type 2 diabetes
    • Oberbach A, Bossenz Y, Lehmann S, Niebauer J, Adams V, Paschke R, Schön MR, Blüher M, Punkt K: Altered fiber distribution and fiber-specific glycolytic and oxidative enzyme activity in skeletal muscle of patients with type 2 diabetes. Diabetes Care 2006, 29: 895-900.
    • (2006) Diabetes Care , vol.29 , pp. 895-900
    • Oberbach, A.1    Bossenz, Y.2    Lehmann, S.3    Niebauer, J.4    Adams, V.5    Paschke, R.6    Schön, M.R.7    Blüher, M.8    Punkt, K.9
  • 44
    • 4544242908 scopus 로고    scopus 로고
    • Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells
    • Powell DJ, Turban S, Gray A, Hajduch E, Hundal HS: Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells. Biochem J 2004, 382: 619-629.
    • (2004) Biochem J , vol.382 , pp. 619-629
    • Powell, D.J.1    Turban, S.2    Gray, A.3    Hajduch, E.4    Hundal, H.S.5
  • 46
    • 70349338640 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate increases glucose uptake through trans-activation of insulin receptor
    • Rapizzi E, Taddei ML, Fiaschi T, Donati C, Bruni P, Chiarugi P: Sphingosine 1-phosphate increases glucose uptake through trans-activation of insulin receptor. Cell Mol Life Sci 2009, 66: 3207-3218.
    • (2009) Cell Mol Life Sci , vol.66 , pp. 3207-3218
    • Rapizzi, E.1    Taddei, M.L.2    Fiaschi, T.3    Donati, C.4    Bruni, P.5    Chiarugi, P.6
  • 49
    • 0033588253 scopus 로고    scopus 로고
    • Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway inC2C12 skeletal muscle cells pretreated with palmitate
    • Schmitz-Peiffer C, Craig DL, Biden TJ: Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway inC2C12 skeletal muscle cells pretreated with palmitate. J Biol Chem 1999, 274: 24202-24210.
    • (1999) J Biol Chem , vol.274 , pp. 24202-24210
    • Schmitz-Peiffer, C.1    Craig, D.L.2    Biden, T.J.3
  • 50
    • 2542593338 scopus 로고    scopus 로고
    • Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes
    • Schrauwen P, Hesselink MK: Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes. Diabetes 2004, 53: 1412-1417.
    • (2004) Diabetes , vol.53 , pp. 1412-1417
    • Schrauwen, P.1    Hesselink, M.K.2
  • 51
    • 33748755008 scopus 로고    scopus 로고
    • Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes
    • Senn JJ: Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes. J Biol Chem 2006, 281: 26865-26875.
    • (2006) J Biol Chem , vol.281 , pp. 26865-26875
    • Senn, J.J.1
  • 52
    • 46649108016 scopus 로고    scopus 로고
    • Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1
    • Shah C, Yang G, Lee I, Bielawski J, Hannun YA, Samad F: Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1. J Biol Chem 2008, 283: 13538-13548.
    • (2008) J Biol Chem , vol.283 , pp. 13538-13548
    • Shah, C.1    Yang, G.2    Lee, I.3    Bielawski, J.4    Hannun, Y.A.5    Samad, F.6
  • 53
    • 0030740621 scopus 로고    scopus 로고
    • Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM
    • Simoneau JA, Kelley DE: Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM. J Appl Physiol (1985) 1997, 83: 166-171.
    • (1997) J Appl Physiol (1985) , vol.83 , pp. 166-171
    • Simoneau, J.A.1    Kelley, D.E.2
  • 57
    • 35349003573 scopus 로고    scopus 로고
    • Elevated free fatty acids attenuate the insulin-induced suppression of PDK4 gene expression in human skeletal muscle: potential role of intramuscular long-chain acyl-coenzyme A
    • Tsintzas K, Chokkalingam K, Jewell K, Norton L, Macdonald IA, Constantin-Teodosiu D: Elevated free fatty acids attenuate the insulin-induced suppression of PDK4 gene expression in human skeletal muscle: potential role of intramuscular long-chain acyl-coenzyme A. J Clin Endocrinol Metab 2007, 92: 3967-3972.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 3967-3972
    • Tsintzas, K.1    Chokkalingam, K.2    Jewell, K.3    Norton, L.4    Macdonald, I.A.5    Constantin-Teodosiu, D.6
  • 58
    • 33845401821 scopus 로고    scopus 로고
    • Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulinresistance
    • Turpin SM, Lancaster GI, Darby I, Febbraio MA, Watt MJ: Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulinresistance. Am J Physiol Endocrinol Metab 2006, 291: E1341-E1350.
    • (2006) Am J Physiol Endocrinol Metab , vol.291
    • Turpin, S.M.1    Lancaster, G.I.2    Darby, I.3    Febbraio, M.A.4    Watt, M.J.5
  • 61
    • 59849098608 scopus 로고    scopus 로고
    • Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-inducedinsulin resistance in rat skeletal muscle cells
    • Watson ML, Coghlan M, Hundal HS: Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-inducedinsulin resistance in rat skeletal muscle cells. Biochem J 2009, 417: 791-801.
    • (2009) Biochem J , vol.417 , pp. 791-801
    • Watson, M.L.1    Coghlan, M.2    Hundal, H.S.3
  • 63
    • 78649660058 scopus 로고    scopus 로고
    • Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6skeletal muscle cells: role of oxidative stress
    • Yuzefovych L, Wilson G, Rachek L: Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6skeletal muscle cells: role of oxidative stress. Am J Physiol Endocrinol Metab 2010, 299: E1096-E1105.
    • (2010) Am J Physiol Endocrinol Metab , vol.299
    • Yuzefovych, L.1    Wilson, G.2    Rachek, L.3
  • 64
    • 33847308760 scopus 로고    scopus 로고
    • The path to insulin resistance: paved with ceramides?
    • Zierath JR: The path to insulin resistance: paved with ceramides?Cell Metab 2007, 5: 161-163.
    • (2007) Cell Metab , vol.5 , pp. 161-163
    • Zierath, J.R.1


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