Novel zinc-binding site in the E2 domain regulates amyloid precursor-like protein 1 (APLP1) oligomerization

Journal of Biological Chemistry

Volumn 289, Issue 27, 2014, Pages 19019-19030

  Mayer, Magnus C ^a   Kaden, Daniela ^a   Schauenburg, Linda ^a   Hancock, Mark A ^b   Voigt, Philipp ^c,d,g   Roeser, Dirk ^e   Barucker, Christian ^b   Than, Manuel E ^e   Schaefer, Michael ^f   Multhaup, Gerhard ^a,b  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b MCGILL UNIVERSITY   (Canada)

^c Molekulare Pharmakologie und Zellbiologie   (Germany)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^e FRITZ LIPMANN INSTITUTE   (Germany)

^f UNIVERSITY OF LEIPZIG   (Germany)

^g NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OLIGOMERIZATION; ZINC;

EXTRACELLULAR; MOLECULAR LEVELS; OLIGOMERIC COMPLEXES; ZINC BINDING; ZINC-BINDING SITES;

OLIGOMERS;

AMYLOID PRECURSOR LIKE PROTEIN 1; AMYLOID PRECURSOR LIKE PROTEIN 2; AMYLOID PRECURSOR PROTEIN; COPPER ION; MEMBRANE PROTEIN; METAL ION; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; ZINC;

ARTICLE; BINDING SITE; FLUORESCENCE RESONANCE ENERGY TRANSFER; FLUORESCENCE SPECTROSCOPY; GEL PERMEATION CHROMATOGRAPHY; IMMOBILIZED METAL AFFINITY CHROMATOGRAPHY; IMMUNODETECTION; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE; SURFACE PLASMON RESONANCE;

AMYLOID PRECURSOR PROTEIN (APP); FLUORESCENCE RESONANCE ENERGY TRANSFER (FRET); MASS SPECTROMETRY (MS); METALLOPROTEIN; ZINC;

AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN PRECURSOR; BINDING SITES; COPPER; HEK293 CELLS; HUMANS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; ZINC;

EID: 84903842312     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.570382     Document Type: Article

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