Metal binding dictates conformation and function of the amyloid precursor protein (APP) E2 domain

Journal of Molecular Biology

Volumn 416, Issue 3, 2012, Pages 438-452

  Dahms, Sven O ^a   Könnig, Ina ^a   Roeser, Dirk ^a   Gührs, Karl Heinz ^a   Mayer, Magnus C ^b   Kaden, Daniela ^b   Multhaup, Gerd ^b   Than, Manuel E ^a  

^a FRITZ LIPMANN INSTITUTE   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Alzheimer's disease; conformational change; crystal structure; isothermal titration calorimetry (ITC); metal binding

Indexed keywords

AMYLOID PRECURSOR PROTEIN; AMYLOID PRECURSOR PROTEIN E2; COPPER; HISTIDINE; UNCLASSIFIED DRUG; ZINC;

ALZHEIMER DISEASE; ARTICLE; BINDING AFFINITY; BINDING SITE; BIOCHEMISTRY; CONCENTRATION (PARAMETERS); CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; METAL BINDING; MOLECULAR EVOLUTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN STRUCTURE; X RAY CRYSTALLOGRAPHY;

MAMMALIA;

EID: 84856713089     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2011.12.057     Document Type: Article

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