Design, synthesis and evaluation of novel rhodanine-containing sorafenib analogs as potential antitumor agents

Archiv der Pharmazie

Volumn 344, Issue 6, 2011, Pages 349-357

  Li, Wei ^a   Zhai, Xin ^a   Zhong, Zheng ^b   Li, Guangyue ^a   Pu, Yongxiao ^a   Gong, Ping ^a,c  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b State Food and Drug Administration   (China)

^c NONE   (China)

Author keywords

Antitumor activity; Design; Rhodanine containing sorafenib analogs; Structure activity relationship

Indexed keywords

4 (4 (5 (2 FLUOROBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL)PHENOXY) N METHYLPICOLINAMIDE; 4 (4 (5 (2,3 DICHLOROBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL)PHENOXY) N METHYLPICOLINAMIDE; 4 (4 (5 (2,4 DICHLOROBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL)PHENOXY) N METHYLPICOLINAMIDE; 4 (4 (5 (2,4 DIFLUOROBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL)PHENOXY) N METHYLPICOLINAMIDE; 4 (4 (5 (2,4 DIMETHOXYBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL)PHENOXY) N METHYLPICOLINAMIDE; 4 (4 (5 (3 BROMO 4 HYDROXY 5 METHOXYBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL)PHENOXY) N METHYLPICOLINAMIDE; 4 (4 (5 (3 HYDROXY 4 METHOXYBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL)PHENOXY) N METHYLPICOLINAMIDE; 4 (4 (5 (3 HYDROXYBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL)PHENOXY) N METHYLPICOLINAMIDE; 4 (4 (5 (3,4 DIFLUOROBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL)PHENOXY) N METHYLPICOLINAMIDE; 4 (4 (5 (3,4 DIHYDROXYBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL)PHENOXY) N METHYLPICOLINAMIDE; 4 (4 (5 (4 FLUOROBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL)PHENOXY) N METHYLPICOLINAMIDE; 4 (4 (5 (4 HYDROXY 3 METHOXYBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL)PHENOXY) N METHYLPICOLINAMIDE; 4 (4 (5 (4 HYDROXY 3,5 DIMETHOXYBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL)PHENOXY) N METHYLPICOLINAMIDE; 4 (4 (5 (4 HYDROXYBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL)PHENOXY) N METHYLPICOLINAMIDE; 4 (4 (5 (4 METHOXYBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL)PHENOXY) N METHYLPICOLINAMIDE; 4 (4 (5 (BENZO[D][1,3]DIOXOL 5 YLMETHYLENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL)PHENOXY) N METHYLPICOLINAMIDE; 4 (4 (5 BENZYLIDENE 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL) PHENOXY) N METHYLPICOLINAMIDE; 4 (4 AMINOPHENOXY) N METHYLPICOLINAMIDE; 4 (4 ISOTHIOCYANATOPHENOXY) N METHYLPICOLINAMIDE; 4 CHLORO N METHYLPICOLINAMIDE; 4 CHLOROPICOLINOYL CHLORIDE; N METHYL 4 (4 (4 OXO 2 THIOXO 5 (2,3,4 TRIHYDROXYBENZYLIDENE)THIAZOLIDIN 3 YL)PHENOXY)PICOLINAMIDE; N METHYL 4 (4 (4 OXO 2 THIOXO 5 (2,3,4 TRIMETHOXYBENZYLIDENE)THIAZOLIDIN 3 YL) PHENOXY)PICOLINAMIDE; N METHYL 4 (4 (4 OXO 2 THIOXO 5 (2,4,6 TRIMETHOXYBENZYLIDENE)THIAZOLIDIN 3 YL) PHENOXY)PICOLINAMIDE; N METHYL 4 (4 (4 OXO 2 THIOXO 5 (3,4,5 TRIMETHOXYBENZYLIDENE)THIAZOLIDIN 3 YL) PHENOXY)PICOLINAMIDE; N METHYL 4 (4 (4 OXO 2 THIOXOTHIAZOLIDIN 3 YL) PHENOXY)PICOLINAMIDE; PYRIDINE DERIVATIVE; RHODANINE; SORAFENIB; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

ANTINEOPLASTIC AGENTS; BENZENESULFONATES; CELL LINE, TUMOR; CELL PROLIFERATION; HT29 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; NEOPLASMS; PYRIDINES; RHODANINE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79958188912     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.201000326     Document Type: Article

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