Structural insights into the design of small molecule inhibitors that selectively antagonize Mcl-1

Journal of Medicinal Chemistry

Volumn 53, Issue 5, 2010, Pages 2314-2318

  Bernardo, Paul H ^a   Sivaraman, Thirunavukkarasu ^b   Wan, Kah Fei ^c   Xu, Jin ^a   Krishnamoorthy, Janarthanan ^b   Sons, Chun Meng ^d   Tian, Liming ^a   Chin, Jasmine S F ^a   Lim, Diane S W ^a   Mok, Henry Y K ^b   Yu, Victor C ^b   Tong, Joo Chuan ^d,e   Chai, Christina L L ^a  

^a INSTITUTE OF CHEMICAL AND ENGINEERING SCIENCES   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c Agency for Science   (Singapore)

^d INSTITUTE FOR INFOCOMM RESEARCH   (Singapore)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BCL XL; PROTEIN MCL 1; RHODANINE;

ARTICLE; COMPUTER MODEL; DRUG BINDING; DRUG SCREENING; DRUG STRUCTURE; MOLECULAR DOCKING; NUCLEAR MAGNETIC RESONANCE;

ANTINEOPLASTIC AGENTS; CYCLIN D1; FLUORESCENCE POLARIZATION; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINES;

EID: 77949416396     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm901469p     Document Type: Article

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