Synthesis and biological evaluation of thiazolidine-2,4-dione and 2,4-thione derivatives as inhibitors of translation initiation

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 21, 2004, Pages 5401-5405

  Chen, Han ^a   Fan, Yun Hua ^a   Natarajan, Amarnath ^a   Guo, Yuhong ^a   Iyasere, Julia ^a   Harbinski, Fred ^a   Luus, Lia ^a   Christ, William ^a   Aktas, Huseyin ^a,b   Halperin, Jose A ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Cancer therapy; Thiazolidine 2,4 dione; Thiazolidine 2,4 thione; Translation initiation inhibitors

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; INITIATION FACTOR 2; THIAZOLIDINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CANCER GROWTH; CANCER INHIBITION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; TRANSLATION INITIATION;

ANTINEOPLASTIC AGENTS; CALCIUM; CELL LINE, TUMOR; CELL PROLIFERATION; EUKARYOTIC INITIATION FACTOR-2; HUMANS; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; THIAZOLIDINEDIONES; THIONES; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 5344277530     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.08.017     Document Type: Article

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