Synthesis of 2-(5-((5-(4-chlorophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid derivatives and evaluation of their cytotoxicity and induction of apoptosis in human leukemia cells

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 6, 2009, Pages 2576-2584

  Chandrappa, S ^a   Kavitha, C V ^b   Shahabuddin, M S ^b   Vinaya, K ^a   Ananda Kumar, C S ^a   Ranganatha, S R ^a   Raghavan, Sathees C ^b   Rangappa, K S ^a  

^a UNIVERSITY OF MYSORE   (India)

^b INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

4 Oxo 2 thioxothiazolidinone; Anticancer agents; Antiproliferation; Apoptosis; DNA damage; Leukemia

Indexed keywords

2 [5 [[5 (4 CHLOROPHENYL)FURAN 2 YL]METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ACETIC ACID DERIVATIVE; BENZENE DERIVATIVE; CARBENE; CHLORINE DERIVATIVE; DNA FRAGMENT; FURAN DERIVATIVE; LACTATE DEHYDROGENASE; N (3 METHYLBENZYL) 2 [5 [[5 (4 CHLOROPHENYL)FURAN 2 YL]METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETAMIDE; N (4 METHOXYBENZYL) 2 [5 [[5 (4 CHLOROPHENYL)FURAN 2 YL]METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETAMIDE; N (4 METHYLBENZYL) 2 [5 [[5 (4 CHLOROPHENYL)FURAN 2 YL]METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETAMIDE; THIAZOLIDINE DERIVATIVE; TRYPAN BLUE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; INFRARED SPECTROSCOPY; LEUKEMIA CELL; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; FLOW CYTOMETRY; HUMANS; SPECTRUM ANALYSIS; THIAZOLIDINEDIONES; THIONES;

EID: 62149135930     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.01.016     Document Type: Article

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