The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator of hepatotoxicity

Archives of Toxicology

Volumn 88, Issue 6, 2014, Pages 1267-1280

  Campos, Gisela ^a   Schmidt Heck, Wolfgang ^b   Ghallab, Ahmed ^a,h   Rochlitz, Katharina ^a   Pütter, Larissa ^a   Medinas, Danilo B ^c,d   Hetz, Claudio ^c,d,e,f   Widera, Agata ^a   Cadenas, Cristina ^a   Begher Tibbe, Brigitte ^a   Reif, Raymond ^a   Günther, Georgia ^a   Sachinidis, Agapios ^g   Hengstler, Jan G ^a   Godoy, Patricio ^a,i  

^a TU DORTMUND UNIVERSITY   (Germany)

^b HANS KNÖLL INSTITUTE   (Germany)

^c UNIVERSITY OF CHILE   (Chile)

^d UNIVERSITY OF CHILE   (Chile)

^e Neurounion Biomedical Foundation ^*  (Chile)

^f HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^g UNIVERSITY OF COLOGNE   (Germany)

^h South Valley University   (Egypt)

ⁱ UNIVERSITY OF CONCEPCIÓN   (Chile)

Author keywords

ER stress; Gene arrays; Hepatotoxicity; Signal transduction

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CARBON TETRACHLORIDE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MESSENGER RNA; X BOX BINDING PROTEIN 1; ATF4 PROTEIN, MOUSE; DNA BINDING PROTEIN; REGULATORY FACTOR X TRANSCRIPTION FACTORS; TRANSCRIPTION FACTOR;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BINDING SITE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE MODEL; ENDOPLASMIC RETICULUM STRESS; GENE CLUSTER; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC ANALYZER; INFANT; LIVER CELL; LIVER TOXICITY; MALE; MOUSE; MOUSE MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RNA SPLICING; UNFOLDED PROTEIN RESPONSE; UPREGULATION; WILD TYPE; ANIMAL; C57BL MOUSE; CELL DEATH; DOSE RESPONSE; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; TIME; TOXICITY;

ACTIVATING TRANSCRIPTION FACTOR 4; ANIMALS; APOPTOSIS; CARBON TETRACHLORIDE; CELL DEATH; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HEPATOCYTES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RNA, MESSENGER; TIME FACTORS; TRANSCRIPTION FACTOR CHOP; TRANSCRIPTION FACTORS; UNFOLDED PROTEIN RESPONSE;

EID: 84903454604     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1240-8     Document Type: Article

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