-
1
-
-
79952232216
-
Global cancer statistics
-
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J. Clin. 61(2), 69-90 (2011
-
(2011)
CA Cancer J. Clin
, vol.61
, Issue.2
, pp. 69-90
-
-
Jemal, A.1
Bray, F.2
Center, M.M.3
Ferlay, J.4
Ward, E.5
Forman, D.6
-
2
-
-
84872967522
-
Cancer statistics 2013
-
Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J. Clin. 63(1), 11-30 (2013
-
(2013)
CA Cancer J. Clin
, vol.63
, Issue.1
, pp. 11-30
-
-
Siegel, R.1
Naishadham, D.2
Jemal, A.3
-
3
-
-
84873606312
-
Annual report to the nation on the status of cancer 1975.-2009, featuring the burden and trends in human papillomavirus (HPV)-Associated cancers and HPV vaccination coverage levels
-
Jemal A, Simard EP, Dorell C et al. Annual report to the nation on the status of cancer, 1975-2009, featuring the burden and trends in human papillomavirus (HPV)-Associated cancers and HPV vaccination coverage levels. J. Natl Cancer Inst. 105(3), 175-201 (2013
-
(2013)
J. Natl Cancer Inst
, vol.105
, Issue.3
, pp. 175-201
-
-
Jemal, A.1
Simard, E.P.2
Dorell, C.3
-
4
-
-
53949091845
-
Human papillomavirus infection and the primary and secondary prevention of cervical cancer
-
Suppl
-
Lowy DR, Solomon D, Hildesheim A, Schiller JT, Schiffman M. Human papillomavirus infection and the primary and secondary prevention of cervical cancer. Cancer 113(7 Suppl.), 1980-1993 (2008
-
(2008)
Cancer
, vol.113
, Issue.7
, pp. 19801993
-
-
Lowy, D.R.1
Solomon, D.2
Hildesheim, A.3
Schiller, J.T.4
Schiffman, M.5
-
5
-
-
21144433509
-
The carcinogenicity of human papillomavirus types reflects viral evolution
-
Schiffman M, Herrero R, Desalle R et al. The carcinogenicity of human papillomavirus types reflects viral evolution. Virology 337(1), 76-84 (2005
-
(2005)
Virology
, vol.337
, Issue.1
, pp. 76-84
-
-
Schiffman, M.1
Herrero, R.2
Desalle, R.3
-
6
-
-
72549102589
-
Human papillomavirus in head and neck cancer: Its role in pathogenesis and clinical implications
-
Chung CH, Gillison ML. Human papillomavirus in head and neck cancer: Its role in pathogenesis and clinical implications. Clin. Cancer Res. 15(22), 6758-6762 (2009
-
(2009)
Clin. Cancer Res
, vol.15
, Issue.22
, pp. 6758-6762
-
-
Chung, C.H.1
Gillison, M.L.2
-
7
-
-
0025187434
-
Detection of human papillomavirus type 16 DNA in carcinomas of the palatine tonsil
-
Niedobitek G, Pitteroff S, Herbst H et al. Detection of human papillomavirus type 16 DNA in carcinomas of the palatine tonsil. J. Clin. Pathol. 43(11), 918-921 (1990
-
(1990)
J. Clin. Pathol
, vol.43
, Issue.11
, pp. 918-921
-
-
Niedobitek, G.1
Pitteroff, S.2
Herbst, H.3
-
8
-
-
0026737285
-
Occurrence of p53 gene deletions and human papilloma virus infection in human head and neck cancer
-
Brachman DG, Graves D, Vokes E et al. Occurrence of p53 gene deletions and human papilloma virus infection in human head and neck cancer. Cancer Res. 52(17), 4832-4836 (1992
-
(1992)
Cancer Res
, vol.52
, Issue.17
, pp. 4832-4836
-
-
Brachman, D.G.1
Graves, D.2
Vokes, E.3
-
9
-
-
34248350674
-
Case-control study of human papillomavirus and oropharyngeal cancer
-
D'Souza G, Kreimer AR, Viscidi R et al. Case-control study of human papillomavirus and oropharyngeal cancer. N. Engl. J. Med. 356(19), 1944-1956 (2007
-
(2007)
N. Engl. J. Med
, vol.356
, Issue.19
, pp. 1944-1956
-
-
D'Souza, G.1
Kreimer, A.R.2
Viscidi, R.3
-
10
-
-
0035849153
-
Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck
-
Mork J, Lie AK, Glattre E et al. Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck. N. Engl J. Med. 344(15), 1125-1131 (2001
-
(2001)
N. Engl J. Med
, vol.344
, Issue.15
, pp. 1125-1131
-
-
Mork, J.1
Lie, A.K.2
Glattre, E.3
-
11
-
-
41449085148
-
Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers
-
Gillison ML, D'souza G, Westra W et al. Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers. J. Natl Cancer Inst. 100(6), 407-420 (2008
-
(2008)
J. Natl Cancer Inst
, vol.100
, Issue.6
, pp. 407-420
-
-
Gillison, M.L.1
D'souza, G.2
Westra, W.3
-
12
-
-
77954190940
-
Human papillomavirus and survival of patients with oropharyngeal cancer
-
Ang KK, Harris J, Wheeler R et al. Human papillomavirus and survival of patients with oropharyngeal cancer. N. Engl. J. Med. 363(1), 24-35 (2010
-
(2010)
N. Engl. J. Med
, vol.363
, Issue.1
, pp. 24-35
-
-
Ang, K.K.1
Harris, J.2
Wheeler, R.3
-
13
-
-
78149467806
-
Human papillomavirus predicts outcome in oropharyngeal cancer in patients treated primarily with surgery or radiation therapy
-
Hong AM, Dobbins TA, Lee CS et al. Human papillomavirus predicts outcome in oropharyngeal cancer in patients treated primarily with surgery or radiation therapy. Br. J. Cancer 103(10), 1510-1517 (2010
-
(2010)
Br. J. Cancer
, vol.103
, Issue.10
, pp. 1510-1517
-
-
Hong, A.M.1
Dobbins, T.A.2
Lee, C.S.3
-
14
-
-
83955164347
-
Atypical clinical behavior of p16-confirmed HPV-related oropharyngeal squamous cell carcinoma treated with radical radiotherapy
-
Huang SH, Perez-Ordonez B, Liu FF et al. Atypical clinical behavior of p16-confirmed HPV-related oropharyngeal squamous cell carcinoma treated with radical radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 82(1), 276-283 (2012
-
(2012)
Int. J. Radiat. Oncol. Biol. Phys
, vol.82
, Issue.1
, pp. 276-283
-
-
Huang, S.H.1
Perez-Ordonez, B.2
Liu, F.F.3
-
15
-
-
84871463423
-
Natural course of distant metastases following radiotherapy or chemoradiotherapy in HPV-related oropharyngeal cancer
-
Huang SH, Perez-Ordonez B, Weinreb I et al. Natural course of distant metastases following radiotherapy or chemoradiotherapy in HPV-related oropharyngeal cancer. Oral Oncol. 49(1), 79-85 (2013
-
(2013)
Oral Oncol
, vol.49
, Issue.1
, pp. 79-85
-
-
Huang, S.H.1
Perez-Ordonez, B.2
Weinreb, I.3
-
16
-
-
84880721268
-
A patient tumor transplant model of squamous cell cancer identifies PI3K inhibitors as candidate therapeutics in defined molecular bins
-
Keysar SB, Astling DP, Anderson RT et al. A patient tumor transplant model of squamous cell cancer identifies PI3K inhibitors as candidate therapeutics in defined molecular bins. Mol. Oncol. 7(4), 776-790 (2013
-
(2013)
Mol. Oncol
, vol.7
, Issue.4
, pp. 776-790
-
-
Keysar, S.B.1
Astling, D.P.2
Anderson, R.T.3
-
17
-
-
84874095453
-
Development and characterization of HPV-positive and HPV-negative head and neck squamous cell carcinoma tumorgrafts
-
Kimple RJ, Harari PM, Torres AD et al. Development and characterization of HPV-positive and HPV-negative head and neck squamous cell carcinoma tumorgrafts. Clin. Cancer Res. 19(4), 855-864 (2013
-
(2013)
Clin. Cancer Res
, vol.19
, Issue.4
, pp. 855-864
-
-
Kimple, R.J.1
Harari, P.M.2
Torres, A.D.3
-
18
-
-
84880259398
-
Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers
-
Lui VW, Hedberg ML, Li H et al. Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers. Cancer Discov. 3 (7), 761-769 (2013
-
(2013)
Cancer Discov
, vol.3
, Issue.7
, pp. 761-769
-
-
Lui, V.W.1
Hedberg, M.L.2
Li, H.3
-
19
-
-
84861719757
-
Patient-derived tumour xenografts as models for oncology drug development
-
Tentler JJ, Tan AC, Weekes CD et al. Patient-derived tumour xenografts as models for oncology drug development. Nat. Rev. Clin. Oncol. 9(6), 338-350 (2012
-
(2012)
Nat. Rev. Clin. Oncol
, vol.9
, Issue.6
, pp. 338-350
-
-
Tentler, J.J.1
Tan, A.C.2
Weekes, C.D.3
-
20
-
-
84880281635
-
Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers
-
Pickering CR, Zhang J, Yoo SY et al. Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers. Cancer Discov. 3(7), 770-781 2013
-
(2013)
Cancer Discov
, vol.3
, Issue.7
, pp. 770-781
-
-
Pickering, C.R.1
Zhang, J.2
Yoo, S.Y.3
-
21
-
-
80052158097
-
The mutational landscape of head and neck squamous cell carcinoma
-
Stransky N, Egloff AM, Tward AD et al. The mutational landscape of head and neck squamous cell carcinoma. Science 333(6046), 1157-1160 (2011
-
(2011)
Science
, vol.333
, Issue.6046
, pp. 1157-1160
-
-
Stransky, N.1
Egloff, A.M.2
Tward, A.D.3
-
22
-
-
80052177544
-
Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1
-
Agrawal N, Frederick MJ, Pickering CR et al. Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science 333(6046), 1154-1157 (2011
-
(2011)
Science
, vol.333
, Issue.6046
, pp. 1154-1157
-
-
Agrawal, N.1
Frederick, M.J.2
Pickering, C.R.3
-
23
-
-
84874645357
-
Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation
-
Morris LG, Kaufman AM, Gong Y et al. Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation. Nat. Genet. 45(3), 253-261 (2013
-
(2013)
Nat. Genet
, vol.45
, Issue.3
, pp. 253-261
-
-
Morris, L.G.1
Kaufman, A.M.2
Gong, Y.3
-
24
-
-
0028955388
-
Epidermal growth factor-related peptides and their receptors in human malignancies
-
Salomon DS, Brandt R, Ciardiello F, Normanno N. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit. Rev. Oncol. Hematol. 19(3), 183-232 (1995
-
(1995)
Crit. Rev. Oncol. Hematol
, vol.19
, Issue.3
, pp. 183-232
-
-
Salomon, D.S.1
Brandt, R.2
Ciardiello, F.3
Normanno, N.4
-
25
-
-
0041629450
-
Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer
-
Mendelsohn J, Baselga J. Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J. Clin. Oncol. 21(14), 2787-2799 (2003
-
(2003)
J. Clin. Oncol
, vol.21
, Issue.14
, pp. 2787-2799
-
-
Mendelsohn, J.1
Baselga, J.2
-
26
-
-
33748188459
-
Epidermal growth factor receptor biology in head and neck cancer
-
Kalyankrishna S, Grandis Jr. Epidermal growth factor receptor biology in head and neck cancer. J. Clin. Oncol. 24(17), 2666-2672 (2006
-
(2006)
J. Clin. Oncol
, vol.24
, Issue.17
, pp. 2666-2672
-
-
Kalyankrishna, S.1
Grandis, J.R.2
-
27
-
-
0027183870
-
Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer
-
Grandis JR, Tweardy DJ. Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer. Cancer Res. 53(15), 3579-3584 (1993
-
(1993)
Cancer Res
, vol.53
, Issue.15
, pp. 3579-3584
-
-
Grandis, J.R.1
Tweardy, D.J.2
-
28
-
-
0037115674
-
Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma
-
Ang KK, Berkey BA, Tu X et al. Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma. Cancer Res. 62(24), 7350-7356 (2002
-
(2002)
Cancer Res
, vol.62
, Issue.24
, pp. 7350-7356
-
-
Ang, K.K.1
Berkey, B.A.2
Tu, X.3
-
29
-
-
33947140297
-
Combined analysis of HPV-DNA, p16 and EGFR expression to predict prognosis in oropharyngeal cancer
-
Reimers N, Kasper HU, Weissenborn SJ et al. Combined analysis of HPV-DNA, p16 and EGFR expression to predict prognosis in oropharyngeal cancer. Int. J. Cancer 120(8), 1731-1738 (2007
-
(2007)
Int. J. Cancer
, vol.120
, Issue.8
, pp. 1731-1738
-
-
Reimers, N.1
Kasper, H.U.2
Weissenborn, S.J.3
-
30
-
-
33749035470
-
Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting
-
Sok JC, Coppelli FM, Thomas SM et al. Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting. Clin. Cancer Res. 12(17), 5064-5073 (2006
-
(2006)
Clin. Cancer Res
, vol.12
, Issue.17
, pp. 5064-5073
-
-
Sok, J.C.1
Coppelli, F.M.2
Thomas, S.M.3
-
31
-
-
79961000118
-
Expression of amphiregulin and EGFRvIII affect outcome of patients with squamous cell carcinoma of the head and neck receiving cetuximab-docetaxel treatment
-
Tinhofer I, Klinghammer K, Weichert W et al. Expression of amphiregulin and EGFRvIII affect outcome of patients with squamous cell carcinoma of the head and neck receiving cetuximab-docetaxel treatment. Clin. Cancer Res. 17(15), 5197-5204 (2011
-
(2011)
Clin. Cancer Res
, vol.17
, Issue.15
, pp. 5197-5204
-
-
Tinhofer, I.1
Klinghammer, K.2
Weichert, W.3
-
32
-
-
70749140937
-
Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation
-
Jaiswal BS, Janakiraman V, Kljavin NM et al. Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation. Cancer Cell 16(6), 463-474 (2009
-
(2009)
Cancer Cell
, vol.16
, Issue.6
, pp. 463-474
-
-
Jaiswal, B.S.1
Janakiraman, V.2
Kljavin, N.M.3
-
34
-
-
33646706052
-
Oncogenic PI3K and its role in cancer
-
Samuels Y, Ericson K. Oncogenic PI3K and its role in cancer. Curr. Opin. Oncol. 18(1), 77-82 (2006
-
(2006)
Curr. Opin. Oncol
, vol.18
, Issue.1
, pp. 77-82
-
-
Samuels, Y.1
Ericson, K.2
-
35
-
-
82755168803
-
Genomic dissection of the epidermal growth factor receptor (EGFR)/PI3K pathway reveals frequent deletion of the EGFR phosphatase PTPRS in head and neck cancers
-
Morris LG, Taylor BS, Bivona TG et al. Genomic dissection of the epidermal growth factor receptor (EGFR)/PI3K pathway reveals frequent deletion of the EGFR phosphatase PTPRS in head and neck cancers. Proc. Natl Acad. Sci. USA 108(47), 19024-19029 (2011
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, Issue.47
, pp. 19024-19029
-
-
Morris, L.G.1
Taylor, B.S.2
Bivona, T.G.3
-
36
-
-
84877018611
-
PTEN deficiency contributes to the development and progression of head and neck cancer
-
Squarize CH, Castilho RM, Abrahao AC, Molinolo A, Lingen MW, Gutkind JS. PTEN deficiency contributes to the development and progression of head and neck cancer. Neoplasia 15(5), 461-471 (2013
-
(2013)
Neoplasia
, vol.15
, Issue.5
, pp. 461-471
-
-
Squarize, C.H.1
Castilho, R.M.2
Abrahao, A.C.3
Molinolo, A.4
Lingen, M.W.5
Gutkind, J.S.6
-
37
-
-
84867607610
-
Tbx3 represses PTEN and is over-expressed in head and neck squamous cell carcinoma
-
Burgucu D, Guney K, Sahinturk D et al. Tbx3 represses PTEN and is over-expressed in head and neck squamous cell carcinoma. BMC Cancer 12, 481 (2012
-
(2012)
BMC Cancer
, vol.12
, pp. 481
-
-
Burgucu, D.1
Guney, K.2
Sahinturk, D.3
-
38
-
-
84863797648
-
Loss of TGF-beta signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation
-
Bian Y, Hall B, Sun ZJ et al. Loss of TGF-beta signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation. Oncogene 31(28), 3322-3332 (2012
-
(2012)
Oncogene
, vol.31
, Issue.28
, pp. 3322-3332
-
-
Bian, Y.1
Hall, B.2
Sun, Z.J.3
-
39
-
-
84878220465
-
Targeted next-generation sequencing of head and neck squamous cell carcinoma identifies novel genetic alterations in HPV+ and HPV-Tumors
-
Lechner M, Frampton G, Fenton T et al. Targeted next-generation sequencing of head and neck squamous cell carcinoma identifies novel genetic alterations in HPV+ and HPV-Tumors. Genome Med. 5(5), 49 (2013
-
(2013)
Genome Med
, vol.5
, Issue.5
, pp. 49
-
-
Lechner, M.1
Frampton, G.2
Fenton, T.3
-
40
-
-
84860363833
-
Mtor as a molecular target in HPV-Associated oral and cervical squamous carcinomas
-
Molinolo AA, Marsh C, El Dinali M et al. mTOR as a molecular target in HPV-Associated oral and cervical squamous carcinomas. Clin. Cancer Res. 18(9), 2558-2568 (2012
-
(2012)
Clin. Cancer Res
, vol.18
, Issue.9
, pp. 2558-2568
-
-
Molinolo, A.A.1
Marsh, C.2
El Dinali, M.3
-
41
-
-
84881137446
-
PI3K/mTOR inhibitor PF-04691502 antitumor activity is enhanced with induction of wild-Type TP53 in human xenograft and murine knockout models of head and neck cancer
-
Herzog A, Bian Y, Broek RV et al. PI3K/mTOR inhibitor PF-04691502 antitumor activity is enhanced with induction of wild-Type TP53 in human xenograft and murine knockout models of head and neck cancer. Clin. Cancer Res. 19(14), 3808-3819 (2013
-
(2013)
Clin. Cancer Res
, vol.19
, Issue.14
, pp. 3808-3819
-
-
Herzog, A.1
Bian, Y.2
Broek, R.V.3
-
42
-
-
84875978234
-
Biomarker-directed therapy of squamous carcinomas of the head and neck: Targeting PI3K/PTEN/mTOR pathway
-
Holsinger FC, Piha-Paul SA, Janku F et al. Biomarker-directed therapy of squamous carcinomas of the head and neck: Targeting PI3K/PTEN/mTOR pathway. J. Clin. Oncol. 31(9), e137-e140 (2013
-
(2013)
J. Clin. Oncol
, vol.31
, Issue.9
-
-
Holsinger, F.C.1
Piha-Paul, S.A.2
Janku, F.3
-
43
-
-
84877584488
-
A Phase 1 study of everolimus plus docetaxel plus cisplatin as induction chemotherapy for patients with locally and/or regionally advanced head and neck cancer
-
Fury MG, Sherman E, Ho AL et al. A Phase 1 study of everolimus plus docetaxel plus cisplatin as induction chemotherapy for patients with locally and/or regionally advanced head and neck cancer. Cancer 119(10), 1823-1831 (2013
-
(2013)
Cancer
, vol.119
, Issue.10
, pp. 1823-1831
-
-
Fury, M.G.1
Sherman, E.2
Ho, A.L.3
-
44
-
-
84863436028
-
A Phase I study of temsirolimus plus carboplatin plus paclitaxel for patients with recurrent or metastatic (R/M) head and neck squamous cell cancer (HNSCC
-
Fury MG, Sherman E, Ho A et al. A Phase I study of temsirolimus plus carboplatin plus paclitaxel for patients with recurrent or metastatic (R/M) head and neck squamous cell cancer (HNSCC). Cancer Chemother. Pharmacol. 70(1), 121-128 (2012
-
(2012)
Cancer Chemother. Pharmacol
, vol.70
, Issue.1
, pp. 121-128
-
-
Fury, M.G.1
Sherman, E.2
Ho, A.3
-
45
-
-
84875722517
-
A Phase II study of temsirolimus and erlotinib in patients with recurrent and/or metastatic, platinum-refractory head and neck squamous cell carcinoma
-
Bauman JE, Arias-Pulido H, Lee SJ et al. A Phase II study of temsirolimus and erlotinib in patients with recurrent and/or metastatic, platinum-refractory head and neck squamous cell carcinoma. Oral. Oncol. 49(5), 461-467 (2013
-
(2013)
Oral. Oncol
, vol.49
, Issue.5
, pp. 461-467
-
-
Bauman, J.E.1
Arias-Pulido, H.2
Lee, S.J.3
-
46
-
-
33745697763
-
Targeting the c-Met signaling pathway in cancer
-
Peruzzi B, Bottaro DP. Targeting the c-Met signaling pathway in cancer. Clin. Cancer Res. 12(12), 3657-3660 (2006
-
(2006)
Clin. Cancer Res
, vol.12
, Issue.12
, pp. 3657-3660
-
-
Peruzzi, B.1
Bottaro, D.P.2
-
47
-
-
0038724909
-
C-Met: Structure, functions and potential for therapeutic inhibition
-
Ma PC, Maulik G, Christensen J, Salgia R. c-Met: Structure, functions and potential for therapeutic inhibition. Cancer Metastasis Rev. 22(4), 309-325 (2003
-
(2003)
Cancer Metastasis Rev
, vol.22
, Issue.4
, pp. 309-325
-
-
Ma, P.C.1
Maulik, G.2
Christensen, J.3
Salgia, R.4
-
48
-
-
10744226251
-
The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesis
-
Saucier C, Khoury H, Lai KM et al. The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesis. Proc. Natl Acad. Sci. USA 101(8), 2345-2350 (2004
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, Issue.8
, pp. 2345-2350
-
-
Saucier, C.1
Khoury, H.2
Lai, K.M.3
-
49
-
-
16644370962
-
Overexpression of c-met in oral SCC promotes hepatocyte growth factor-induced disruption of cadherin junctions and invasion
-
Murai M, Shen X, Huang L et al. Overexpression of c-met in oral SCC promotes hepatocyte growth factor-induced disruption of cadherin junctions and invasion. Int. J. Oncol. 25(4), 831-840 (2004
-
(2004)
Int. J. Oncol
, vol.25
, Issue.4
, pp. 831-840
-
-
Murai, M.1
Shen, X.2
Huang, L.3
-
50
-
-
0035882576
-
Role of HGF/c-met system in invasion and metastasis of oral squamous cell carcinoma cells in vitro and its clinical significance
-
Uchida D, Kawamata H, Omotehara F et al. Role of HGF/c-met system in invasion and metastasis of oral squamous cell carcinoma cells in vitro and its clinical significance. Int. J. Cancer 93(4), 489-496 (2001
-
(2001)
Int. J. Cancer
, vol.93
, Issue.4
, pp. 489-496
-
-
Uchida, D.1
Kawamata, H.2
Omotehara, F.3
-
51
-
-
28844489538
-
Expression of hepatocyte growth factor and c-Met in hypopharyngeal squamous cell carcinoma
-
Kim CH, Moon SK, Bae JH et al. Expression of hepatocyte growth factor and c-Met in hypopharyngeal squamous cell carcinoma. Acta Otolaryngol. 126(1), 88-94 (2006
-
(2006)
Acta Otolaryngol
, vol.126
, Issue.1
, pp. 88-94
-
-
Kim, C.H.1
Moon, S.K.2
Bae, J.H.3
-
52
-
-
66149135285
-
The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma
-
Seiwert TY, Jagadeeswaran R, Faoro L et al. The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma. Cancer Res. 69(7), 3021-3031 (2009
-
(2009)
Cancer Res
, vol.69
, Issue.7
, pp. 3021-3031
-
-
Seiwert, T.Y.1
Jagadeeswaran, R.2
Faoro, L.3
-
53
-
-
0346753584
-
Prevalence and clinical impact of Met Y1253D-Activating point mutation in radiotherapy-Treated squamous cell cancer of the oropharynx
-
Aebersold DM, Landt O, Berthou S et al. Prevalence and clinical impact of Met Y1253D-Activating point mutation in radiotherapy-Treated squamous cell cancer of the oropharynx. Oncogene 22(52), 8519-8523 (2003
-
(2003)
Oncogene
, vol.22
, Issue.52
, pp. 8519-8523
-
-
Aebersold, D.M.1
Landt, O.2
Berthou, S.3
-
54
-
-
66649131963
-
HGF and c-Met participate in paracrine tumorigenic pathways in head and neck squamous cell cancer
-
Knowles LM, Stabile LP, Egloff AM et al. HGF and c-Met participate in paracrine tumorigenic pathways in head and neck squamous cell cancer. Clin. Cancer Res. 15(11), 3740-3750 (2009
-
(2009)
Clin. Cancer Res
, vol.15
, Issue.11
, pp. 3740-3750
-
-
Knowles, L.M.1
Stabile, L.P.2
Egloff, A.M.3
-
55
-
-
19944428576
-
Genetic and expression profiles of squamous cell carcinoma of the head and neck correlate with cisplatin sensitivity and resistance in cell lines and patients
-
Akervall J, Guo X, Qian CN et al. Genetic and expression profiles of squamous cell carcinoma of the head and neck correlate with cisplatin sensitivity and resistance in cell lines and patients. Clin. Cancer Res. 10(24), 8204-8213 (2004
-
(2004)
Clin. Cancer Res
, vol.10
, Issue.24
, pp. 8204-8213
-
-
Akervall, J.1
Guo, X.2
Qian, C.N.3
-
56
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
Engelman JA, Zejnullahu K, Mitsudomi T et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 316(5827), 1039-1043 (2007
-
(2007)
Science
, vol.316
, Issue.5827
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
-
57
-
-
79960300164
-
Dual blockade of EGFR and c-Met abrogates redundant signaling and proliferation in head and neck carcinoma cells
-
Xu H, Stabile LP, Gubish CT, Gooding WE, Grandis JR, Siegfried JM. Dual blockade of EGFR and c-Met abrogates redundant signaling and proliferation in head and neck carcinoma cells. Clin. Cancer Res. 17(13), 4425-4438 (2011
-
(2011)
Clin. Cancer Res
, vol.17
, Issue.13
, pp. 4425-4438
-
-
Xu, H.1
Stabile, L.P.2
Gubish, C.T.3
Gooding, W.E.4
Grandis, J.R.5
Siegfried, J.M.6
-
58
-
-
43249095919
-
Tumor angiogenesis
-
Kerbel RS Tumor angiogenesis. N. Engl. J. Med. 358(19), 2039-2049 (2008
-
(2008)
N. Engl. J. Med
, vol.358
, Issue.19
, pp. 2039-2049
-
-
Kerbel, R.S.1
-
59
-
-
41149172647
-
Angiogenic heterogeneity in head and neck squamous cell carcinoma: Biological and therapeutic implications
-
Hasina R, Whipple ME, Martin LE, Kuo WP, Ohno-Machado L, Lingen MW. Angiogenic heterogeneity in head and neck squamous cell carcinoma: Biological and therapeutic implications. Lab. Invest. 88(4), 342-353 (2008
-
(2008)
Lab. Invest
, vol.88
, Issue.4
, pp. 342-353
-
-
Hasina, R.1
Whipple, M.E.2
Martin, L.E.3
Kuo, W.P.4
Ohno-Machado, L.5
Lingen, M.W.6
-
60
-
-
0034111116
-
Prognostic significance of vascular endothelial growth factor protein levels in oral and oropharyngeal squamous cell carcinoma
-
Smith BD, Smith GL, Carter D, Sasaki CT, Haffty BG. Prognostic significance of vascular endothelial growth factor protein levels in oral and oropharyngeal squamous cell carcinoma. J. Clin. Oncol. 18(10), 2046-2052 (2000
-
(2000)
J. Clin. Oncol
, vol.18
, Issue.10
, pp. 2046-2052
-
-
Smith, B.D.1
Smith, G.L.2
Carter, D.3
Sasaki, C.T.4
Haffty, B.G.5
-
61
-
-
0141752813
-
Arterial endothelium-specific activin receptor-like kinase 1 expression suggests its role in arterialization and vascular remodeling
-
Seki T, Yun J, Oh SP. Arterial endothelium-specific activin receptor-like kinase 1 expression suggests its role in arterialization and vascular remodeling. Circ. Res. 93(7), 682-689 (2003
-
(2003)
Circ. Res
, vol.93
, Issue.7
, pp. 682-689
-
-
Seki, T.1
Yun, J.2
Oh, S.P.3
-
62
-
-
76149089505
-
Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis
-
Cunha SI, Pardali E, Thorikay M et al. Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis. J. Exp. Med. 207(1), 85-100 (2010
-
(2010)
J. Exp. Med
, vol.207
, Issue.1
, pp. 85-100
-
-
Cunha, S.I.1
Pardali, E.2
Thorikay, M.3
-
63
-
-
84880500232
-
The expression of activin receptor-like kinase 1 among patients with head and neck cancer
-
Chien CY, Chuang HC, Chen CH et al. The expression of activin receptor-like kinase 1 among patients with head and neck cancer. Otolaryngol. Head Neck Surg. 148(6), 965-973 (2013
-
(2013)
Otolaryngol. Head Neck Surg
, vol.148
, Issue.6
, pp. 965-973
-
-
Chien, C.Y.1
Chuang, H.C.2
Chen, C.H.3
-
64
-
-
45549096553
-
Cancer stem cells in head and neck squamous cell cancer
-
Prince MEP, Ailles LE. Cancer stem cells in head and neck squamous cell cancer. J. Clin. Oncol. 26(17), 2871-2875 (2008
-
(2008)
J. Clin. Oncol
, vol.26
, Issue.17
, pp. 2871-2875
-
-
Prince, M.E.P.1
Ailles, L.E.2
-
65
-
-
84878111732
-
Molecular phenotype predicts sensitivity of squamous cell carcinoma of the head and neck to epidermal growth factor receptor inhibition
-
Young NR, Liu J, Pierce C et al. Molecular phenotype predicts sensitivity of squamous cell carcinoma of the head and neck to epidermal growth factor receptor inhibition. Mol. Oncol. 7(3), 359-368 (2013
-
(2013)
Mol. Oncol
, vol.7
, Issue.3
, pp. 359-368
-
-
Young, N.R.1
Liu, J.2
Pierce, C.3
-
66
-
-
33745045658
-
Leukemia-Associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes
-
Malecki MJ, Sanchez-Irizarry C, Mitchell JL et al. Leukemia-Associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes. Mol. Cell Biol. 26(12), 4642-4651 (2006
-
(2006)
Mol. Cell Biol
, vol.26
, Issue.12
, pp. 4642-4651
-
-
Malecki, M.J.1
Sanchez-Irizarry, C.2
Mitchell, J.L.3
-
67
-
-
34948908663
-
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia
-
Palomero T, Sulis ML, Cortina M et al. Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia. Nat. Med. 13(10), 1203-1210 (2007
-
(2007)
Nat. Med
, vol.13
, Issue.10
, pp. 1203-1210
-
-
Palomero, T.1
Sulis, M.L.2
Cortina, M.3
-
68
-
-
48649093670
-
EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer
-
Kolev V, Mandinova A, Guinea-Viniegra J et al. EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer. Nat. Cell. Biol. 10(8), 902-911 (2008
-
(2008)
Nat. Cell. Biol
, vol.10
, Issue.8
, pp. 902-911
-
-
Kolev, V.1
Mandinova, A.2
Guinea-Viniegra, J.3
-
69
-
-
84864793869
-
Vismodegib in basal cell carcinoma
-
Amaria RN, Bowles DW, Lewis KD, Jimeno A. Vismodegib in basal cell carcinoma. Drugs Today (Barc.) 48(7), 459-467 (2012
-
(2012)
Drugs Today (Barc
, vol.48
, Issue.7
, pp. 459-467
-
-
Amaria, R.N.1
Bowles, D.W.2
Lewis, K.D.3
Jimeno, A.4
-
70
-
-
84878037234
-
Phase I study of the Hedgehog pathway inhibitor IPI-926 in adult patients with solid tumors
-
Jimeno A, Weiss GJ, Miller WH Jr et al. Phase I study of the Hedgehog pathway inhibitor IPI-926 in adult patients with solid tumors. Clin. Cancer Res. 19(10), 2766-2774 (2013
-
(2013)
Clin. Cancer Res
, vol.19
, Issue.10
, pp. 2766-2774
-
-
Jimeno, A.1
Weiss, G.J.2
Miller Jr., W.H.3
-
71
-
-
33745728170
-
Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells
-
Liu S, Dontu G, Mantle ID et al. Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res. 66(12), 6063-6071 (2006
-
(2006)
Cancer Res
, vol.66
, Issue.12
, pp. 6063-6071
-
-
Liu, S.1
Dontu, G.2
Mantle, I.D.3
-
72
-
-
33947254016
-
Blockade of Hedgehog signaling inhibits pancreatic cancer invasion and metastases: A new paradigm for combination therapy in solid cancers
-
Feldmann G, Dhara S, Fendrich V et al. Blockade of Hedgehog signaling inhibits pancreatic cancer invasion and metastases: A new paradigm for combination therapy in solid cancers. Cancer Res. 67(5), 2187-2196 (2007
-
(2007)
Cancer Res
, vol.67
, Issue.5
, pp. 2187-2196
-
-
Feldmann, G.1
Dhara, S.2
Fendrich, V.3
-
73
-
-
58749087502
-
Cross talk between Hedgehog and epithelial-mesenchymal transition pathways in gastric pit cells and in diffuse-Type gastric cancers
-
Ohta H, Aoyagi K, Fukaya M et al. Cross talk between Hedgehog and epithelial-mesenchymal transition pathways in gastric pit cells and in diffuse-Type gastric cancers. Br. J. Cancer 100(2), 389-398 (2009
-
(2009)
Br. J. Cancer
, vol.100
, Issue.2
, pp. 389-398
-
-
Ohta, H.1
Aoyagi, K.2
Fukaya, M.3
-
74
-
-
35148832569
-
Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression
-
Lo HW, Hsu SC, Xia W et al. Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression. Cancer Res. 67(19), 9066-9076 (2007
-
(2007)
Cancer Res
, vol.67
, Issue.19
, pp. 9066-9076
-
-
Lo, H.W.1
Hsu, S.C.2
Xia, W.3
-
75
-
-
67650999875
-
The basics of epithelial-mesenchymal transition
-
Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J. Clin. Invest. 119(6), 1420-1428 (2009
-
(2009)
J. Clin. Invest
, vol.119
, Issue.6
, pp. 1420-1428
-
-
Kalluri, R.1
Weinberg, R.A.2
-
76
-
-
63049123066
-
Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
-
Polyak K, Weinberg RA. Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits. Nat. Rev. Cancer 9(4), 265-273 (2009
-
(2009)
Nat. Rev. Cancer
, vol.9
, Issue.4
, pp. 265-273
-
-
Polyak, K.1
Weinberg, R.A.2
-
77
-
-
67650070517
-
Hedgehog and epithelial-mesenchymal transition signaling in normal and malignant epithelial cells of the esophagus
-
Isohata N, Aoyagi K, Mabuchi T et al. Hedgehog and epithelial-mesenchymal transition signaling in normal and malignant epithelial cells of the esophagus. Int. J. Cancer 125(5), 1212-1221 (2009
-
(2009)
Int. J. Cancer
, vol.125
, Issue.5
, pp. 1212-1221
-
-
Isohata, N.1
Aoyagi, K.2
Mabuchi, T.3
-
78
-
-
60549104260
-
Epidermal growth factor receptor signaling synergizes with Hedgehog/GLI in oncogenic transformation via activation of the MEK/ERK/JUN pathway
-
Schnidar H, Eberl M, Klingler S et al. Epidermal growth factor receptor signaling synergizes with Hedgehog/GLI in oncogenic transformation via activation of the MEK/ERK/JUN pathway. Cancer Res. 69(4), 1284-1292 (2009
-
(2009)
Cancer Res
, vol.69
, Issue.4
, pp. 1284-1292
-
-
Schnidar, H.1
Eberl, M.2
Klingler, S.3
-
79
-
-
74049138338
-
The sonic Hedgehog signaling pathway is reactivated in human renal cell carcinoma and plays orchestral role in tumor growth
-
Dormoy V, Danilin S, Lindner V et al. The sonic Hedgehog signaling pathway is reactivated in human renal cell carcinoma and plays orchestral role in tumor growth. Mol. Cancer 8, 123 (2009
-
(2009)
Mol. Cancer
, vol.8
, pp. 123
-
-
Dormoy, V.1
Danilin, S.2
Lindner, V.3
-
80
-
-
68849105590
-
Regulation of the Hedgehog signaling by the mitogen-Activated protein kinase cascade in gastric cancer
-
Seto M, Ohta M, Asaoka Y et al. Regulation of the Hedgehog signaling by the mitogen-Activated protein kinase cascade in gastric cancer. Mol. Carcinog. 48(8), 703-712 (2009
-
(2009)
Mol. Carcinog
, vol.48
, Issue.8
, pp. 703-712
-
-
Seto, M.1
Ohta, M.2
Asaoka, Y.3
-
81
-
-
0242270878
-
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
-
Thayer SP, Di Magliano MP, Heiser PW et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 425(6960), 851-856 (2003
-
(2003)
Nature
, vol.425
, Issue.6960
, pp. 851-856
-
-
Thayer, S.P.1
Di Magliano, M.P.2
Heiser, P.W.3
-
82
-
-
33846237601
-
Hedgehog-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity
-
Clement V, Sanchez P, De Tribolet N, Radovanovic I, Ruiz I Altaba A. Hedgehog-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity. Curr. Biol. 17(2), 165-172 (2007
-
(2007)
Curr. Biol
, vol.17
, Issue.2
, pp. 165-172
-
-
Clement, V.1
Sanchez, P.2
De Tribolet, N.3
Radovanovic, I.4
Ruiz I Altaba, A.5
-
83
-
-
79954447907
-
Glioma-Associated oncogene family zinc finger 1 expression and metastasis in patients with head and neck squamous cell carcinoma treated with radiation therapy (RTOG 9003
-
Chung CH, Dignam JJ, Hammond ME et al. Glioma-Associated oncogene family zinc finger 1 expression and metastasis in patients with head and neck squamous cell carcinoma treated with radiation therapy (RTOG 9003). J. Clin. Oncol. 29(10), 1326-1334 (2011
-
(2011)
J. Clin. Oncol
, vol.29
, Issue.10
, pp. 1326-1334
-
-
Chung, C.H.1
Dignam, J.J.2
Hammond, M.E.3
-
84
-
-
77955066199
-
Sipuleucel-T immunotherapy for castration-resistant prostate cancer
-
Kantoff PW, Higano CS, Shore ND et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N. Engl. J. Med. 363(5), 411-422 (2010
-
(2010)
N. Engl. J. Med
, vol.363
, Issue.5
, pp. 411-422
-
-
Kantoff, P.W.1
Higano, C.S.2
Shore, N.D.3
-
85
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi FS, O'day SJ, Mcdermott DF et al. Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363(8), 711-723 (2010
-
(2010)
N. Engl. J. Med
, vol.363
, Issue.8
, pp. 711-723
-
-
Hodi, F.S.1
O'day, S.J.2
Mcdermott, D.F.3
-
86
-
-
84881539749
-
Immune alterations and immunotherapy prospects in head and neck cancer
-
Varilla V, Atienza J, Dasanu CA. Immune alterations and immunotherapy prospects in head and neck cancer. Expert Opin. Biol. Ther. 13(9), 1241-1256 (2013
-
(2013)
Expert Opin. Biol. Ther
, vol.13
, Issue.9
, pp. 1241-1256
-
-
Varilla, V.1
Atienza, J.2
Dasanu, C.A.3
-
88
-
-
84871571023
-
Immunotherapy for head and neck cancer patients: Shifting the balance
-
Turksma AW, Braakhuis BJ, Bloemena E, Meijer CJ, Leemans CR, Hooijberg E. Immunotherapy for head and neck cancer patients: Shifting the balance. Immunotherapy 5(1), 49-61 (2013
-
(2013)
Immunotherapy
, vol.5
, Issue.1
, pp. 49-61
-
-
Turksma, A.W.1
Braakhuis, B.J.2
Bloemena, E.3
Meijer, C.J.4
Leemans, C.R.5
Hooijberg, E.6
-
89
-
-
79955081407
-
Immune suppression in head and neck cancers: A review
-
Duray A, Demoulin S, Hubert P, Delvenne P, Saussez S. Immune suppression in head and neck cancers: A review. Clin. Dev. Immunol. 2010, 701657 (2010
-
(2010)
Clin. Dev. Immunol
, vol.2010
, pp. 701657
-
-
Duray, A.1
Demoulin, S.2
Hubert, P.3
Delvenne, P.4
Saussez, S.5
-
90
-
-
0032698214
-
Fas ligand is expressed on human squamous cell carcinomas of the head and neck, and it promotes apoptosis of T lymphocytes
-
Gastman BR, Atarshi Y, Reichert TE et al. Fas ligand is expressed on human squamous cell carcinomas of the head and neck, and it promotes apoptosis of T lymphocytes. Cancer Res. 59(20), 5356-5364 (1999
-
(1999)
Cancer Res
, vol.59
, Issue.20
, pp. 5356-5364
-
-
Gastman, B.R.1
Atarshi, Y.2
Reichert, T.E.3
-
91
-
-
45249087021
-
Oral cancer cell lines can use multiple ligands, including Fas-L, TRAIL and TNF-Alpha, to induce apoptosis in Jurkat T cells: Possible mechanisms for immune escape by head and neck cancers
-
Kassouf N, Thornhill MH. Oral cancer cell lines can use multiple ligands, including Fas-L, TRAIL and TNF-Alpha, to induce apoptosis in Jurkat T cells: Possible mechanisms for immune escape by head and neck cancers. Oral Oncol. 44(7), 672-682 (2008
-
(2008)
Oral Oncol
, vol.44
, Issue.7
, pp. 672-682
-
-
Kassouf, N.1
Thornhill, M.H.2
-
92
-
-
31544455880
-
Prognostic value of tumor-infiltrating CD4+ T-cell subpopulations in head and neck cancers
-
Badoual C, Hans S, Rodriguez J et al. Prognostic value of tumor-infiltrating CD4+ T-cell subpopulations in head and neck cancers. Clin. Cancer Res. 12(2), 465-472 (2006
-
(2006)
Clin. Cancer Res
, vol.12
, Issue.2
, pp. 465-472
-
-
Badoual, C.1
Hans, S.2
Rodriguez, J.3
-
93
-
-
33846484246
-
Relationships between regulatory T cells and CD8+ effector populations in patients with squamous cell carcinoma of the head and neck
-
Chikamatsu K, Sakakura K, Whiteside TL, Furuya N. Relationships between regulatory T cells and CD8+ effector populations in patients with squamous cell carcinoma of the head and neck. Head Neck 29(2), 120-127 (2007
-
(2007)
Head Neck
, vol.29
, Issue.2
, pp. 120-127
-
-
Chikamatsu, K.1
Sakakura, K.2
Whiteside, T.L.3
Furuya, N.4
-
94
-
-
52449125138
-
T regulatory type 1 cells in squamous cell carcinoma of the head and neck: Mechanisms of suppression and expansion in advanced disease
-
Bergmann C, Strauss L, Wang Y et al. T regulatory type 1 cells in squamous cell carcinoma of the head and neck: Mechanisms of suppression and expansion in advanced disease. Clin. Cancer Res. 14(12), 3706-3715 (2008
-
(2008)
Clin. Cancer Res
, vol.14
, Issue.12
, pp. 3706-3715
-
-
Bergmann, C.1
Strauss, L.2
Wang, Y.3
-
95
-
-
78650849488
-
Toll-like receptors in regulatory T cells of patients with head and neck cancer
-
Wild CA, Brandau S, Lindemann M et al. Toll-like receptors in regulatory T cells of patients with head and neck cancer. Arch Otolaryngol. Head Neck Surg. 136(12), 1253-1259 (2010
-
(2010)
Arch Otolaryngol. Head Neck Surg
, vol.136
, Issue.12
, pp. 1253-1259
-
-
Wild, C.A.1
Brandau, S.2
Lindemann, M.3
-
96
-
-
46849090082
-
Dysregulation in immune functions is reflected in tumor cell cytotoxicity by peripheral blood mononuclear cells from head and neck squamous cell carcinoma patients
-
Bose A, Chakraborty T, Chakraborty K, Pal S, Baral R. Dysregulation in immune functions is reflected in tumor cell cytotoxicity by peripheral blood mononuclear cells from head and neck squamous cell carcinoma patients. Cancer Immun. 8, 10 (2008
-
(2008)
Cancer Immun
, vol.8
, pp. 10
-
-
Bose, A.1
Chakraborty, T.2
Chakraborty, K.3
Pal, S.4
Baral, R.5
-
97
-
-
0035925912
-
Serum soluble interleukin-2 receptor concentrations as an independent prognostic marker in head and neck cancer
-
Tartour E, Mosseri V, Jouffroy T et al. Serum soluble interleukin-2 receptor concentrations as an independent prognostic marker in head and neck cancer. Lancet 357(9264), 1263-1264 (2001
-
(2001)
Lancet
, vol.357
, Issue.9264
, pp. 1263-1264
-
-
Tartour, E.1
Mosseri, V.2
Jouffroy, T.3
-
98
-
-
79952785016
-
Dendritic cell generation and CD4+ CD25high FOXP3+ regulatory t cells in human head and neck carcinoma during radio-chemotherapy
-
Schuler PJ, Borger V, Bolke E et al. Dendritic cell generation and CD4+ CD25high FOXP3+ regulatory t cells in human head and neck carcinoma during radio-chemotherapy. Eur. J. Med. Res. 16(2), 57-62 (2011
-
(2011)
Eur. J. Med. Res
, vol.16
, Issue.2
, pp. 57-62
-
-
Schuler, P.J.1
Borger, V.2
Bolke, E.3
-
99
-
-
34247118386
-
Functional alteration of myeloid dendritic cells through head and neck cancer
-
Brocks CP, Pries R, Frenzel H, Ernst M, Schlenke P, Wollenberg B. Functional alteration of myeloid dendritic cells through head and neck cancer. Anticancer Res. 27(2), 817-824 (2007
-
(2007)
Anticancer Res
, vol.27
, Issue.2
, pp. 817-824
-
-
Brocks, C.P.1
Pries, R.2
Frenzel, H.3
Ernst, M.4
Schlenke, P.5
Wollenberg, B.6
-
100
-
-
33947523413
-
Low levels of circulating invariant natural killer T cells predict poor clinical outcome in patients with head and neck squamous cell carcinoma
-
Molling JW, Langius JA, Langendijk JA et al. Low levels of circulating invariant natural killer T cells predict poor clinical outcome in patients with head and neck squamous cell carcinoma. J. Clin. Oncol. 25(7), 862-868 (2007
-
(2007)
J. Clin. Oncol
, vol.25
, Issue.7
, pp. 862-868
-
-
Molling, J.W.1
Langius, J.A.2
Langendijk, J.A.3
-
101
-
-
84883134703
-
Evaluation of human papillomavirus antibodies and risk of subsequent head and neck cancer
-
Kreimer AR, Johansson M, Waterboer T et al. Evaluation of human papillomavirus antibodies and risk of subsequent head and neck cancer. J. Clin. Oncol. 31(21), 2708-2715 (2013
-
(2013)
J. Clin. Oncol
, vol.31
, Issue.21
, pp. 2708-2715
-
-
Kreimer, A.R.1
Johansson, M.2
Waterboer, T.3
-
102
-
-
77955303005
-
Spectral clustering of microarray data elucidates the roles of microenvironment remodeling and immune responses in survival of head and neck squamous cell carcinoma
-
Thurlow JK, Pena Murillo CL, Hunter KD et al. Spectral clustering of microarray data elucidates the roles of microenvironment remodeling and immune responses in survival of head and neck squamous cell carcinoma. J. Clin. Oncol. 28(17), 2881-2888 (2010
-
(2010)
J. Clin. Oncol
, vol.28
, Issue.17
, pp. 2881-2888
-
-
Thurlow, J.K.1
Pena Murillo, C.L.2
Hunter, K.D.3
-
103
-
-
65449131740
-
The relationship between human papillomavirus status and other molecular prognostic markers in head and neck squamous cell carcinomas
-
Kong CS, Narasimhan B, Cao H et al. The relationship between human papillomavirus status and other molecular prognostic markers in head and neck squamous cell carcinomas. Int. J. Radiat. Oncol. Biol. Phys. 74(2), 553-561 (2009
-
(2009)
Int. J. Radiat. Oncol. Biol. Phys
, vol.74
, Issue.2
, pp. 553-561
-
-
Kong, C.S.1
Narasimhan, B.2
Cao, H.3
-
104
-
-
84875475811
-
Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-Associated head and neck squamous cell carcinoma
-
Lyford-Pike S, Peng S, Young GD et al. Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-Associated head and neck squamous cell carcinoma. Cancer Res. 73(6), 1733-1741 (2013
-
(2013)
Cancer Res
, vol.73
, Issue.6
, pp. 1733-1741
-
-
Lyford-Pike, S.1
Peng, S.2
Young, G.D.3
-
105
-
-
84871966600
-
PD-1-expressing tumor-infiltrating T cells are a favorable prognostic biomarker in HPV-Associated head and neck cancer
-
Badoual C, Hans S, Merillon N et al. PD-1-expressing tumor-infiltrating T cells are a favorable prognostic biomarker in HPV-Associated head and neck cancer. Cancer Res. 73(1), 128-138 (2013
-
(2013)
Cancer Res
, vol.73
, Issue.1
, pp. 128-138
-
-
Badoual, C.1
Hans, S.2
Merillon, N.3
-
111
-
-
0028819660
-
Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model
-
Goldstein NI, Prewett M, Zuklys K, Rockwell P, Mendelsohn J. Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model. Clin. Cancer Res. 1(11), 1311-1318 (1995
-
(1995)
Clin. Cancer Res
, vol.1
, Issue.11
, pp. 1311-1318
-
-
Goldstein, N.I.1
Prewett, M.2
Zuklys, K.3
Rockwell, P.4
Mendelsohn, J.5
-
112
-
-
0035254521
-
Head and neck cancer as a clinical model for molecular targeting of therapy: Combining EGFR blockade with radiation
-
Harari PM, Huang SM. Head and neck cancer as a clinical model for molecular targeting of therapy: Combining EGFR blockade with radiation. Int. J. Radiat Oncol. Biol. Phys. 49(2), 427-433 (2001
-
(2001)
Int. J. Radiat Oncol. Biol. Phys
, vol.49
, Issue.2
, pp. 427-433
-
-
Harari, P.M.1
Huang, S.M.2
-
113
-
-
32144433159
-
Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck
-
Bonner JA, Harari PM, Giralt J et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N. Engl. J. Med. 354(6), 567-578 (2006
-
(2006)
N. Engl. J. Med
, vol.354
, Issue.6
, pp. 567-578
-
-
Bonner, J.A.1
Harari, P.M.2
Giralt, J.3
-
114
-
-
73249143536
-
Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a Phase 3 randomised trial, and relation between cetuximab-induced rash and survival
-
Bonner JA, Harari PM, Giralt J et al. Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a Phase 3 randomised trial, and relation between cetuximab-induced rash and survival. Lancet Oncol. 11(1), 21-28 (2010
-
(2010)
Lancet Oncol
, vol.11
, Issue.1
, pp. 21-28
-
-
Bonner, J.A.1
Harari, P.M.2
Giralt, J.3
-
115
-
-
34250180582
-
Open-label, uncontrolled, multicenter Phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based therapy
-
Vermorken JB, Trigo J, Hitt R et al. Open-label, uncontrolled, multicenter Phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based therapy. J. Clin. Oncol. 25(16), 2171-2177 (2007
-
(2007)
J. Clin. Oncol
, vol.25
, Issue.16
, pp. 2171-2177
-
-
Vermorken, J.B.1
Trigo, J.2
Hitt, R.3
-
116
-
-
51649085865
-
Platinum-based chemotherapy plus cetuximab in head and neck cancer
-
Vermorken JB, Mesia R, Rivera F et al. Platinum-based chemotherapy plus cetuximab in head and neck cancer. N. Engl. J. Med. 359(11), 1116-1127 (2008
-
(2008)
N. Engl. J. Med
, vol.359
, Issue.11
, pp. 1116-1127
-
-
Vermorken, J.B.1
Mesia, R.2
Rivera, F.3
-
117
-
-
84875734469
-
Predictive value of epidermal growth factor receptor expression for first-line chemotherapy plus cetuximab in patients with head and neck and colorectal cancer: Analysis of data from the EXTREME and CRYSTAL studies
-
Licitra L, Storkel S, Kerr KM et al. Predictive value of epidermal growth factor receptor expression for first-line chemotherapy plus cetuximab in patients with head and neck and colorectal cancer: Analysis of data from the EXTREME and CRYSTAL studies. Eur. J. Cancer 49(6), 1161-1168 (2013
-
(2013)
Eur. J. Cancer
, vol.49
, Issue.6
, pp. 1161-1168
-
-
Licitra, L.1
Storkel, S.2
Kerr, K.M.3
-
118
-
-
84877018563
-
Treatment response of HPV-positive and HPV-negative head and neck squamous cell carcinoma cell lines
-
Nagel R, Martens-De Kemp SR, Buijze M, Jacobs G, Braakhuis BJ, Brakenhoff RH. Treatment response of HPV-positive and HPV-negative head and neck squamous cell carcinoma cell lines. Oral Oncol. 49(6), 560-566 (2013
-
(2013)
Oral Oncol
, vol.49
, Issue.6
, pp. 560-566
-
-
Nagel, R.1
Martens-De Kemp, S.R.2
Buijze, M.3
Jacobs, G.4
Braakhuis, B.J.5
Brakenhoff, R.H.6
-
119
-
-
80255134559
-
Concurrent cisplatin and radiation versus cetuximab and radiation for locally advanced head-And-neck cancer
-
Koutcher L, Sherman E, Fury M et al. Concurrent cisplatin and radiation versus cetuximab and radiation for locally advanced head-And-neck cancer. Int. J. Radiat. Oncol. Biol. Phys. 81(4), 915-922 (2011
-
(2011)
Int. J. Radiat. Oncol. Biol. Phys
, vol.81
, Issue.4
, pp. 915-922
-
-
Koutcher, L.1
Sherman, E.2
Fury, M.3
-
120
-
-
70350653741
-
Nuclear EGFR contributes to acquired resistance to cetuximab
-
Li C, Iida M, Dunn EF, Ghia AJ, Wheeler DL. Nuclear EGFR contributes to acquired resistance to cetuximab. Oncogene 28(43), 3801-3813 (2009
-
(2009)
Oncogene
, vol.28
, Issue.43
, pp. 3801-3813
-
-
Li, C.1
Iida, M.2
Dunn, E.F.3
Ghia, A.J.4
Wheeler, D.L.5
-
121
-
-
79955525586
-
Primary resistance to cetuximab in a panel of patient-derived tumour xenograft models: Activation of MET as one mechanism for drug resistance
-
Krumbach R, Schuler J, Hofmann M, Giesemann T, Fiebig HH, Beckers T. Primary resistance to cetuximab in a panel of patient-derived tumour xenograft models: Activation of MET as one mechanism for drug resistance. Eur. J. Cancer 47(8), 1231-1243 (2011
-
(2011)
Eur. J. Cancer
, vol.47
, Issue.8
, pp. 1231-1243
-
-
Krumbach, R.1
Schuler, J.2
Hofmann, M.3
Giesemann, T.4
Fiebig, H.H.5
Beckers, T.6
-
122
-
-
78650842574
-
Mechanisms underlying resistance to cetuximab in the HNSCC cell line: Role of AKT inhibition in bypassing this resistance
-
Rebucci M, Peixoto P, Dewitte A et al. Mechanisms underlying resistance to cetuximab in the HNSCC cell line: Role of AKT inhibition in bypassing this resistance. Int. J. Oncol. 38(1), 189-200 (2011
-
(2011)
Int. J. Oncol
, vol.38
, Issue.1
, pp. 189-200
-
-
Rebucci, M.1
Peixoto, P.2
Dewitte, A.3
-
123
-
-
34548238762
-
Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab
-
Khambata-Ford S, Garrett CR, Meropol NJ et al. Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab. J. Clin. Oncol. 25(22), 3230-3237 (2007
-
(2007)
J. Clin. Oncol
, vol.25
, Issue.22
, pp. 3230-3237
-
-
Khambata-Ford, S.1
Garrett, C.R.2
Meropol, N.J.3
-
124
-
-
84872525097
-
Dual targeting of EGFR and HER3 with MEHD7945A overcomes acquired resistance to EGFR inhibitors and radiation
-
Huang S, Li C, Armstrong EA et al. Dual targeting of EGFR and HER3 with MEHD7945A overcomes acquired resistance to EGFR inhibitors and radiation. Cancer Res. 73(2), 824-833 (2013
-
(2013)
Cancer Res
, vol.73
, Issue.2
, pp. 824-833
-
-
Huang, S.1
Li, C.2
Armstrong, E.A.3
-
125
-
-
84875454018
-
Xct inhibition depletes CD44v-expressing tumor cells that are resistant to EGFR-Targeted therapy in head and neck squamous cell carcinoma
-
Yoshikawa M, Tsuchihashi K, Ishimoto T et al. xCT inhibition depletes CD44v-expressing tumor cells that are resistant to EGFR-Targeted therapy in head and neck squamous cell carcinoma. Cancer Res. 73(6), 1855-1866 (2013
-
(2013)
Cancer Res
, vol.73
, Issue.6
, pp. 1855-1866
-
-
Yoshikawa, M.1
Tsuchihashi, K.2
Ishimoto, T.3
-
126
-
-
42449134408
-
Epithelial to mesenchymal transition in head and neck squamous carcinoma: Association of Src activation with E-cadherin down-regulation, vimentin expression, and aggressive tumor features
-
Mandal M, Myers JN, Lippman SM et al. Epithelial to mesenchymal transition in head and neck squamous carcinoma: Association of Src activation with E-cadherin down-regulation, vimentin expression, and aggressive tumor features. Cancer 112(9), 2088-2100 (2008
-
(2008)
Cancer
, vol.112
, Issue.9
, pp. 2088-2100
-
-
Mandal, M.1
Myers, J.N.2
Lippman, S.M.3
-
127
-
-
84879785532
-
Cisplatin and fluorouracil with or without panitumumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck (SPECTRUM): An open-label Phase 3 randomised trial
-
Vermorken JB, Stohlmacher-Williams J, Davidenko I et al. Cisplatin and fluorouracil with or without panitumumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck (SPECTRUM): An open-label Phase 3 randomised trial. Lancet Oncol. 14(8), 697-710 (2013
-
(2013)
Lancet Oncol
, vol.14
, Issue.8
, pp. 697-710
-
-
Vermorken, J.B.1
Stohlmacher-Williams, J.2
Davidenko, I.3
-
128
-
-
79953183347
-
Zalutumumab plus best supportive care versus best supportive care alone in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck after failure of platinum-based chemotherapy: An open-label, randomised Phase 3 trial
-
Machiels JP, Subramanian S, Ruzsa A et al. Zalutumumab plus best supportive care versus best supportive care alone in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck after failure of platinum-based chemotherapy: An open-label, randomised Phase 3 trial. Lancet Oncol. 12(4), 333-343 (2011
-
(2011)
Lancet Oncol
, vol.12
, Issue.4
, pp. 333-343
-
-
Machiels, J.P.1
Subramanian, S.2
Ruzsa, A.3
-
129
-
-
79960885569
-
Membranous expression of Her3 is associated with a decreased survival in head and neck squamous cell carcinoma
-
Takikita M, Xie R, Chung JY et al. Membranous expression of Her3 is associated with a decreased survival in head and neck squamous cell carcinoma. J. Transl. Med. 9, 126 (2011
-
(2011)
J. Transl. Med
, vol.9
, pp. 126
-
-
Takikita, M.1
Xie, R.2
Chung, J.Y.3
-
130
-
-
84874544754
-
High heregulin expression is associated with activated HER3 and may define an actionable biomarker in patients with squamous cell carcinomas of the head and neck
-
Shames DS, Carbon J, Walter K et al. High heregulin expression is associated with activated HER3 and may define an actionable biomarker in patients with squamous cell carcinomas of the head and neck. PLoS ONE 8(2), e56765 (2013
-
(2013)
PLoS ONE
, vol.8
, Issue.2
-
-
Shames, D.S.1
Carbon, J.2
Walter, K.3
-
131
-
-
80054765331
-
A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies
-
Schaefer G, Haber L, Crocker LM et al. A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies. Cancer Cell 20(4), 472-486 (2011
-
(2011)
Cancer Cell
, vol.20
, Issue.4
, pp. 472-486
-
-
Schaefer, G.1
Haber, L.2
Crocker, L.M.3
-
132
-
-
84857502654
-
Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): A multicentre, open-label, randomised Phase 3 trial
-
Rosell R, Carcereny E, Gervais R et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): A multicentre, open-label, randomised Phase 3 trial. Lancet Oncol. 13(3), 239-246 (2012
-
(2012)
Lancet Oncol
, vol.13
, Issue.3
, pp. 239-246
-
-
Rosell, R.1
Carcereny, E.2
Gervais, R.3
-
133
-
-
1842772526
-
Multicenter Phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck
-
Soulieres D, Senzer NN, Vokes EE, Hidalgo M, Agarwala SS, Siu LL. Multicenter Phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck. J. Clin. Oncol. 22(1), 77-85 (2004
-
(2004)
J. Clin. Oncol
, vol.22
, Issue.1
, pp. 77-85
-
-
Soulieres, D.1
Senzer, N.N.2
Vokes, E.E.3
Hidalgo, M.4
Agarwala, S.S.5
Siu, L.L.6
-
134
-
-
34250208469
-
Phase I/II trial of erlotinib and cisplatin in patients with recurrent or metastatic squamous cell carcinoma of the head and neck: A Princess Margaret Hospital Phase II consortium and National Cancer Institute of Canada Clinical Trials Group Study
-
Siu LL, Soulieres D, Chen EX et al. Phase I/II trial of erlotinib and cisplatin in patients with recurrent or metastatic squamous cell carcinoma of the head and neck: A Princess Margaret Hospital Phase II consortium and National Cancer Institute of Canada Clinical Trials Group Study. J. Clin. Oncol. 25(16), 2178-2183 (2007
-
(2007)
J. Clin. Oncol
, vol.25
, Issue.16
, pp. 2178-2183
-
-
Siu, L.L.1
Soulieres, D.2
Chen, E.X.3
-
135
-
-
84876079071
-
Cisplatin and radiotherapy with or without erlotinib in locally advanced squamous cell carcinoma of the head and neck: A randomized Phase II trial
-
Martins RG, Parvathaneni U, Bauman JE et al. Cisplatin and radiotherapy with or without erlotinib in locally advanced squamous cell carcinoma of the head and neck: A randomized Phase II trial. J. Clin. Oncol. 31(11), 1415-1421 (2013
-
(2013)
J. Clin. Oncol
, vol.31
, Issue.11
, pp. 1415-1421
-
-
Martins, R.G.1
Parvathaneni, U.2
Bauman, J.E.3
-
136
-
-
69949162760
-
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
-
Mok TS, Wu YL, Thongprasert S et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N. Engl. J. Med. 361(10), 947-957 (2009
-
(2009)
N. Engl. J. Med
, vol.361
, Issue.10
, pp. 947-957
-
-
Mok, T.S.1
Wu, Y.L.2
Thongprasert, S.3
-
137
-
-
64649097892
-
Phase iii study of gefitinib compared with intravenous methotrexate for recurrent squamous cell carcinoma of the head and neck [corrected]
-
Stewart JS, Cohen EE, Licitra L et al. Phase III study of gefitinib compared with intravenous methotrexate for recurrent squamous cell carcinoma of the head and neck [corrected]. J. Clin. Oncol. 27(11), 1864-1871 (2009
-
(2009)
J. Clin. Oncol
, vol.27
, Issue.11
, pp. 1864-1871
-
-
Stewart, J.S.1
Cohen, E.E.2
Licitra, L.3
-
138
-
-
84876073132
-
Phase III randomized, placebo-controlled trial of docetaxel with or without gefitinib in recurrent or metastatic head and neck cancer: An Eastern Cooperative Oncology Group trial J
-
Argiris A, Ghebremichael M, Gilbert J et al. Phase III randomized, placebo-controlled trial of docetaxel with or without gefitinib in recurrent or metastatic head and neck cancer: An Eastern Cooperative Oncology Group trial J. Clin. Oncol. 31(11), 1405-1414 (2013
-
(2013)
Clin. Oncol
, vol.31
, Issue.11
, pp. 1405-1414
-
-
Argiris, A.1
Ghebremichael, M.2
Gilbert, J.3
-
139
-
-
84859873106
-
A Phase II study of lapatinib in recurrent/metastatic squamous cell carcinoma of the head and neck
-
De Souza JA, Davis DW, Zhang Y et al. A Phase II study of lapatinib in recurrent/metastatic squamous cell carcinoma of the head and neck. Clin. Cancer Res. 18(8), 2336-2343 (2012
-
(2012)
Clin. Cancer Res
, vol.18
, Issue.8
, pp. 2336-2343
-
-
De Souza, J.A.1
Davis, D.W.2
Zhang, Y.3
-
140
-
-
84867621201
-
Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker
-
Solca F, Dahl G, Zoephel A et al. Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker. J. Pharmacol. Exp. Ther 343(2), 342-350 (2012
-
(2012)
J. Pharmacol. Exp. Ther
, vol.343
, Issue.2
, pp. 342-350
-
-
Solca, F.1
Dahl, G.2
Zoephel, A.3
-
141
-
-
49149118719
-
BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models
-
Li D, Ambrogio L, Shimamura T et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene 27(34), 4702-4711 (2008
-
(2008)
Oncogene
, vol.27
, Issue.34
, pp. 4702-4711
-
-
Li, D.1
Ambrogio, L.2
Shimamura, T.3
-
142
-
-
84872445077
-
A randomized, open-label, Phase II study of afatinib (BIBW 2992) versus cetuximab in recurrent or metastatic squamous cell carcinoma of the head and neck-final data
-
AZ, USA 26-28 January
-
Seiwert T, Fayette J, Cupissol D et al. A randomized, open-label, Phase II study of afatinib (BIBW 2992) versus cetuximab in recurrent or metastatic squamous cell carcinoma of the head and neck-final data Presented at: Multidisciplinary Head and Neck Cancer Symposium. AZ, USA, 26-28 January 2012
-
(2012)
Presented at: Multidisciplinary Head and Neck Cancer Symposium
-
-
Seiwert, T.1
Fayette, J.2
Cupissol, D.3
-
143
-
-
84888043119
-
A randomized, open-label, Phase II study of afatinib versus cetuximab in patients (pts with recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC): Analysis of stage 2 (S2) following crossover
-
Abstract 6001
-
Cupissol D, Seiwert TY, Fayette J. et al. A randomized, open-label, Phase II study of afatinib versus cetuximab in patients (pts) with recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC): Analysis of stage 2 (S2) following crossover. J. Clin. Oncol. 31, Abstract 6001 (2013
-
(2013)
J. Clin. Oncol
, vol.31
-
-
Cupissol, D.1
Seiwert, T.Y.2
Fayette, J.3
-
144
-
-
84873542842
-
Dacomitinib, an irreversible Pan-ErbB inhibitor significantly abrogates growth in head and neck cancer models that exhibit low response to cetuximab
-
Ather F, Hamidi H, Fejzo MS et al. Dacomitinib, an irreversible Pan-ErbB inhibitor significantly abrogates growth in head and neck cancer models that exhibit low response to cetuximab. PLoS ONE 8(2), e56112 (2013
-
(2013)
PLoS ONE
, vol.8
, Issue.2
-
-
Ather, F.1
Hamidi, H.2
Fejzo, M.S.3
-
145
-
-
84874569165
-
A Phase II trial of dacomitinib, an oral pan-human EGF receptor (HER) inhibitor, as first-line treatment in recurrent and/or metastatic squamous-cell carcinoma of the head and neck
-
Abdul Razak AR, Soulieres D, Laurie SA et al. A Phase II trial of dacomitinib, an oral pan-human EGF receptor (HER) inhibitor, as first-line treatment in recurrent and/or metastatic squamous-cell carcinoma of the head and neck. Ann. Oncol. 24(3), 761-769 (2013
-
(2013)
Ann. Oncol
, vol.24
, Issue.3
, pp. 761-769
-
-
Abdul Razak, A.R.1
Soulieres, D.2
Laurie, S.A.3
-
146
-
-
79952660192
-
New phosphatidylinositol 3-kinase inhibitors for cancer
-
Bowles DW, Jimeno A. New phosphatidylinositol 3-kinase inhibitors for cancer. Expert Opin. Investig. Drugs 20(4), 507-518 (2011
-
(2011)
Expert Opin. Investig. Drugs
, vol.20
, Issue.4
, pp. 507-518
-
-
Bowles, D.W.1
Jimeno, A.2
-
147
-
-
84856071447
-
Phase I, dose-escalation study of BKM120, an oral pan-class I PI3K inhibitor, in patients with advanced solid tumors
-
Bendell JC, Rodon J, Burris HA et al. Phase I, dose-escalation study of BKM120, an oral pan-class I PI3K inhibitor, in patients with advanced solid tumors. J. Clin. Oncol. 30(3), 282-290 (2012
-
(2012)
J. Clin. Oncol
, vol.30
, Issue.3
, pp. 282-290
-
-
Bendell, J.C.1
Rodon, J.2
Burris, H.A.3
-
148
-
-
84864493357
-
A multicenter Phase I trial of PX-866, an oral irreversible phosphatidylinositol 3-kinase inhibitor, in patients with advanced solid tumors
-
Hong DS, Bowles DW, Falchook GS et al. A multicenter Phase I trial of PX-866, an oral irreversible phosphatidylinositol 3-kinase inhibitor, in patients with advanced solid tumors. Clin. Cancer Res. 18(15), 4173-4182 (2012
-
(2012)
Clin. Cancer Res
, vol.18
, Issue.15
, pp. 4173-4182
-
-
Hong, D.S.1
Bowles, D.W.2
Falchook, G.S.3
-
157
-
-
84867334724
-
A Phase 2 study of bevacizumab with cisplatin plus intensity-modulated radiation therapy for stage III/IVB head and neck squamous cell cancer
-
Fury MG, Lee NY, Sherman E et al. A Phase 2 study of bevacizumab with cisplatin plus intensity-modulated radiation therapy for stage III/IVB head and neck squamous cell cancer. Cancer 118(20), 5008-5014 (2012
-
(2012)
Cancer
, vol.118
, Issue.20
, pp. 5008-5014
-
-
Fury, M.G.1
Lee, N.Y.2
Sherman, E.3
-
158
-
-
79952741923
-
Phase II trial of pemetrexed and bevacizumab in patients with recurrent or metastatic head and neck cancer
-
Argiris A, Karamouzis MV, Gooding WE et al. Phase II trial of pemetrexed and bevacizumab in patients with recurrent or metastatic head and neck cancer. J. Clin. Oncol. 29(9), 1140-1145 (2011
-
(2011)
J. Clin. Oncol
, vol.29
, Issue.9
, pp. 1140-1145
-
-
Argiris, A.1
Karamouzis, M.V.2
Gooding, W.E.3
-
160
-
-
0035394833
-
Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: A role for altered tumor angiogenesis
-
Viloria-Petit A, Crombet T, Jothy S et al. Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: A role for altered tumor angiogenesis. Cancer Res. 61(13), 5090-5101 (2001
-
(2001)
Cancer Res
, vol.61
, Issue.13
, pp. 5090-5101
-
-
Viloria-Petit, A.1
Crombet, T.2
Jothy, S.3
-
161
-
-
62349097073
-
Erlotinib and bevacizumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck: A Phase I/II study
-
Cohen EE, Davis DW, Karrison TG et al. Erlotinib and bevacizumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck: A Phase I/II study. Lancet Oncol. 10(3), 247-257 (2009
-
(2009)
Lancet Oncol
, vol.10
, Issue.3
, pp. 247-257
-
-
Cohen, E.E.1
Davis, D.W.2
Karrison, T.G.3
-
162
-
-
84871554687
-
Cetuximab and bevacizumab: Preclinical data and Phase II trial in recurrent or metastatic squamous cell carcinoma of the head and neck
-
Argiris A, Kotsakis AP, Hoang T et al. Cetuximab and bevacizumab: Preclinical data and Phase II trial in recurrent or metastatic squamous cell carcinoma of the head and neck. Ann. Oncol. 24(1), 220-225 (2013
-
(2013)
Ann. Oncol
, vol.24
, Issue.1
, pp. 220-225
-
-
Argiris, A.1
Kotsakis, A.P.2
Hoang, T.3
-
163
-
-
79959850956
-
ALK1 as an emerging target for antiangiogenic therapy of cancer
-
Cunha SI, Pietras K. ALK1 as an emerging target for antiangiogenic therapy of cancer. Blood 117(26), 6999-7006 (2011
-
(2011)
Blood
, vol.117
, Issue.26
, pp. 6999-7006
-
-
Cunha, S.I.1
Pietras, K.2
-
164
-
-
84903207419
-
A Phase 1 dose escalating study with ACE-041, a novel inhibitor of ALK1 mediated angiogenesis, in patients with advanced solid tumors
-
FL, USA 2-6 April
-
Bendell JC, Gordon M, Hurwitz H et al. A Phase 1 dose escalating study with ACE-041, a novel inhibitor of ALK1 mediated angiogenesis, in patients with advanced solid tumors Presented at: AACR 102nd Annual Meeting 2011. FL, USA, 2-6 April 2011
-
(2011)
Presented at: AACR 102nd Annual Meeting 2011
-
-
Bendell, J.C.1
Gordon, M.2
Hurwitz, H.3
-
166
-
-
84878605390
-
Hedgehog signaling alters reliance on EGF receptor signaling and mediates anti-EGFR therapeutic resistance in head and neck cancer
-
Keysar SB, Le PN, Anderson RT et al. Hedgehog signaling alters reliance on EGF receptor signaling and mediates anti-EGFR therapeutic resistance in head and neck cancer. Cancer Res. 73(11), 3381-3392 (2013
-
(2013)
Cancer Res
, vol.73
, Issue.11
, pp. 3381-3392
-
-
Keysar, S.B.1
Le, P.N.2
Anderson, R.T.3
-
167
-
-
33645215414
-
Association of CTLA-4 gene polymorphism with oral squamous cell carcinoma
-
Wong YK, Chang KW, Cheng CY, Liu CJ. Association of CTLA-4 gene polymorphism with oral squamous cell carcinoma. J. Oral Pathol. Med. 35(1), 51-54 (2006
-
(2006)
J. Oral Pathol. Med
, vol.35
, Issue.1
, pp. 51-54
-
-
Wong, Y.K.1
Chang, K.W.2
Cheng, C.Y.3
Liu, C.J.4
-
169
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian SL, Hodi FS, Brahmer JR et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N. Engl. J. Med. 366(26), 2443-2454 (2012
-
(2012)
N. Engl. J. Med
, vol.366
, Issue.26
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
-
170
-
-
84880924865
-
TLR8 stimulation enhances cetuximab-mediated natural killer cell lysis of head and neck cancer cells and dendritic cell cross-priming of EGFR-specific CD8+ T cells
-
Stephenson RM, Lim CM, Matthews M, Dietsch G, Hershberg R, Ferris RL. TLR8 stimulation enhances cetuximab-mediated natural killer cell lysis of head and neck cancer cells and dendritic cell cross-priming of EGFR-specific CD8+ T cells. Cancer Immunol. Immunother. 62(8), 1347-1357 (2013
-
(2013)
Cancer Immunol. Immunother
, vol.62
, Issue.8
, pp. 1347-1357
-
-
Stephenson, R.M.1
Lim, C.M.2
Matthews, M.3
Dietsch, G.4
Hershberg, R.5
Ferris, R.L.6
-
171
-
-
84863258367
-
Lm-LLO-based immunotherapies and HPV-Associated disease
-
Wallecha A, French C, Petit R, Singh R, Amin A, Rothman J. Lm-LLO-based immunotherapies and HPV-Associated disease. J. Oncol. 2012, 542851 (2012
-
(2012)
J. Oncol
, vol.2012
, pp. 542851
-
-
Wallecha, A.1
French, C.2
Petit, R.3
Singh, R.4
Amin, A.5
Rothman, J.6
-
173
-
-
68349152636
-
Administration of HPV DNA vaccine via electroporation elicits the strongest CD8+ T cell immune responses compared with intramuscular injection and intradermal gene gun delivery
-
Best SR, Peng S, Juang CM et al. Administration of HPV DNA vaccine via electroporation elicits the strongest CD8+ T cell immune responses compared with intramuscular injection and intradermal gene gun delivery. Vaccine 27(40), 5450-5459 (2009
-
(2009)
Vaccine
, vol.27
, Issue.40
, pp. 5450-5459
-
-
Best, S.R.1
Peng, S.2
Juang, C.M.3
-
174
-
-
84867437406
-
Immunotherapy against HPV16/18 generates potent TH1 and cytotoxic cellular immune responses
-
155ra138
-
Bagarazzi ML, Yan J, Morrow MP et al. Immunotherapy against HPV16/18 generates potent TH1 and cytotoxic cellular immune responses. Sci. Transl. Med. 4(155), 155ra138 (2012
-
(2012)
Sci. Transl. Med
, vol.4
, Issue.155
-
-
Bagarazzi, M.L.1
Yan, J.2
Morrow, M.P.3
-
175
-
-
84875421186
-
Deintensification candidate subgroups in human papillomavirus-related oropharyngeal cancer according to minimal risk of distant metastasis
-
O'sullivan B, Huang SH, Siu LL et al. Deintensification candidate subgroups in human papillomavirus-related oropharyngeal cancer according to minimal risk of distant metastasis. J. Clin. Oncol. 31(5), 543-550 (2013
-
(2013)
J. Clin. Oncol
, vol.31
, Issue.5
, pp. 543-550
-
-
O'sullivan, B.1
Huang, S.H.2
Siu, L.L.3
-
176
-
-
84880428460
-
Reduced prevalence of oral human papillomavirus (HPV) 4 years after bivalent HPV vaccination in a randomized clinical trial in Costa Rica
-
Herrero R, Quint W, Hildesheim A et al. Reduced prevalence of oral human papillomavirus (HPV) 4 years after bivalent HPV vaccination in a randomized clinical trial in Costa Rica. PLoS ONE 8(7), e68329 (2013
-
(2013)
PLoS ONE
, vol.8
, Issue.7
-
-
Herrero, R.1
Quint, W.2
Hildesheim, A.3
-
177
-
-
84874736849
-
PIK3CA mutations in advanced cancers: Characteristics and outcomes
-
Janku F, Wheler JJ, Naing A et al. PIK3CA mutations in advanced cancers: Characteristics and outcomes. Oncotarget 3(12), 1566-1575 (2012
-
(2012)
Oncotarget
, vol.3
, Issue.12
, pp. 1566-1575
-
-
Janku, F.1
Wheler, J.J.2
Naing, A.3
-
178
-
-
84863338519
-
PI3K/AKT/mTOR inhibitors in patients with breast and gynecologic malignancies harboring PIK3CA mutations
-
Janku F, Wheler JJ, Westin SN et al. PI3K/AKT/mTOR inhibitors in patients with breast and gynecologic malignancies harboring PIK3CA mutations. J. Clin. Oncol. 30(8), 777-782 (2012.
-
(2012)
J. Clin. Oncol
, vol.30
, Issue.8
, pp. 777-782
-
-
Janku, F.1
Wheler, J.J.2
Westin, S.N.3
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