Relationships between regulatory T cells and CD8+ effector populations in patients with squamous cell carcinoma of the head and neck

Head and Neck

Volumn 29, Issue 2, 2007, Pages 120-127

  Chikamatsu, Kazuaki ^a   Sakakura, Koichi ^a   Whiteside, Theresa L ^b   Furuya, Nobuhiko ^a  

^a GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

CD4+CD25+ regulatory T cells (Treg); Squamous cell carcinoma of the head and neck (SCCHN); Tc1; Tc2; Th1; Th2

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 4; IONOMYCIN; PHORBOL 13 ACETATE 12 MYRISTATE;

ADULT; AGED; ARTICLE; CANCER IMMUNOLOGY; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; EFFECTOR CELL; EX VIVO STUDY; FLOW CYTOMETRY; HEAD AND NECK CARCINOMA; HUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SQUAMOUS CELL CARCINOMA; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH2 CELL;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; CASE-CONTROL STUDIES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FLOW CYTOMETRY; HEAD AND NECK NEOPLASMS; HUMANS; INTERFERON TYPE II; INTERLEUKIN-4; MIDDLE AGED; T-LYMPHOCYTES, REGULATORY; TH1 CELLS; TH2 CELLS;

EID: 33846484246     PISSN: 10433074     EISSN: 10970347     Source Type: Journal    
DOI: 10.1002/hed.20490     Document Type: Article

References (28)

1. Mosmann TR, Coffman RL. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989;7:145-173.
2. Salgame P, Abrams JS, Clayberger C, Goldstein H, Convit J, Modlin RL, Bloom BR, Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science 1991;254:279-282.
3. + T cells showing B cell helper function and reduced cytolytic activity in human immunodeficiency virus type I infection. J Exp Med 1994;180:489-495.
4. Murphy KM. T lymphocyte differentiation in the periphery. Curr Opin Immunol 1998;10:226-232.
5. O'Garra A, Arai N. The molecular basis of T helper 1 and T helper 2 cell differentiation. Trends Cell Biol 2000;10:542-550.
6. Croft M, Carter L, Swain SL, Dutton RW. Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles. J Exp Med 1994;180:1715-1728.
7. Sakaguchi S. Regulatory T cells: key controllers of immunologic self-tolerance. Cell 2000;101:455-458.
8. + suppressor T cells. J Exp Med 2001;193:F41-F46.
9. + regulatory T cells in a colorectal carcinoma patient is mediated by transforming growth factor-β. Cancer Res 2002;62:5267-5272.
10. Liyanage UK, Moore TT, Joo H-G, et al. Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma. J Immunol 2002;169:2756-2761.
11. Ito N, Nakamura H, Tanaka Y, Ohgi S. Lung carcinoma: analysis of T helper type 1 and 2 cells and T cytotoxic type 1 and 2 cells by intracellular cytokine detection with flow cytometry. Cancer 1999;85:2359-2367.
12. Schondorf T, Engel H, Lindemann C, Kolhagen H, von Rucker AA, Mallmann P. Cellular characteristics of peripheral blood lymphocytes and tumour-infiltrating lymphocytes in patients with gynaecological tumours. Cancer Immunol Immunother 1997;44:88-96.
13. Podhorecka M, Dmoszynska A, Rolinski J, Wasik E. T type 1/type 2 subsets balance in B-cell chronic lymphocytic leukemia the three-color flow cytometry analysis. Leuk Res 2002;26:657-660.
14. Tabata T, Hazama S, Yoshino S, Oka M. Th2 subset dominance among peripheral blood T lymphocytes in patients with digestive cancers. Am J Surg 1999;177:203-208.
15. Mori T, Takada R, Watanabe R, Okamoto S, Ikeda Y. T-helper (Th)1/Th2 imbalance in patients with previously untreated B-cell diffuse large cell lymphoma. Cancer Immunol Immunother 2001;50:566-568.
16. Sakakura K, Chikamatsu K, Takahashi K, Whiteside TL, Furuya N. Maturation of circulating dendritic cells and imbalance of T cell subsets in patients with squamous cell carcinoma of the head and neck. Cancer Immunol Immunother 2005;55:151-159.
17. + T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer. Cancer Res 2001;61:4766-4772.
18. Agarwal A, Rani M, Saha GK, Valarmathi TM, Bahadur S, Mohanti BK, Das SN. Disregulated expression of the Th2 cytokine gene in patients with intraoral squamous cell carcinoma. Immunol Invest 2003;32:17-30.
19. Sparano A, Lathers DMR, Achille N, Petruzzelli GJ, Young MRI. Modulation of Th1 and Th2 cytokine profiles and their association with advanced head and neck squamous cell carcinoma. Otolaryngol Head Neck Surg 2004;131:573-576.
20. Lathers DMR, Achille NJ, Young MRI. Incomplete Th2 skewing of cytokines in plasma of patients with squamous cell carcinoma of the head and neck. Hum Immunol 2003;64:1160-1166.
21. Hoffmann TK, Dworacki G, Tsukishiro T, Meidenbauer N, Gooding W, Johnson JT, Whiteside TL. Spontaneous apoptosis of circulating T lymphocytes in patients with head and neck cancer and its clinical importance. Clin Cancer Res 2002;8:2553-2562.
22. Whiteside TL. Apoptosis of immune cells in the tumor microenvironment and peripheral circulation of patients with cancer: implications for immunotherapy. Vaccine 2002;20:A46-A51.
23. + T cells of patients with squamous cell carcinoma of the head and neck. Clin Cancer Res 2004;10:5101-5110.
24. + T cells. Curr Opin Immunol 2003;15:690-696.
25. Ramsdell F. Foxp3 and natural regulatory T cells: key to a cell lineage? Immunity 2003;19:165-168.
26. Bruder D, Probst-Kepper M, Westendorf AM, et al. Neurophilin-1: a surface marker of regulatory T cells. Eur J Immunol 2004;34:623-630.
27. Kemp RA, Ronchese F. Tumor-specific Tc1, but not Tc2, cells deliver protective antitumor immunity. J Immunol 2001;167:6497-6502.
28. Do J-S, Choi Y-H, Shin S-H, Yi HK, Hwang PH, Nam S-Y Committed memory effector type 2 cytotoxic T (Tc2) cells are ineffective in protective anti-tumor immunity. Immunol Lett 2004;95:77-84.