Glioma-associated oncogene family zinc finger 1 expression and metastasis in patients with head and neck squamous cell carcinoma treated with Radiation Therapy (RTOG 9003)

Journal of Clinical Oncology

Volumn 29, Issue 10, 2011, Pages 1326-1334

  Chung, Christine H ^{a,b,c,d,e,f,g,h,i,j,k,l}   Dignam, James J ^{a,b,c,d,e,f,g,h,i,j,k,l}   Hammond, M Elizabeth ^{a,b,c,d,e,f,g,h,i,j,k,l}   Klimowicz, Alexander C ^{a,b,c,d,e,f,g,h,i,j,k,l}   Petrillo, Stephanie K ^{a,b,c,d,e,f,g,h,i,j,k,l}   Magliocco, Anthony ^{a,b,c,d,e,f,g,h,i,j,k,l}   Jordan, Richard ^{a,b,c,d,e,f,g,h,i,j,k,l}   Trotti, Andy ^{a,b,c,d,e,f,g,h,i,j,k,l}   Spencer, Sharon ^{a,b,c,d,e,f,g,h,i,j,k,l}   Cooper, Jay S ^{a,b,c,d,e,f,g,h,i,j,k,l}   Le, Quynh Thu ^{a,b,c,d,e,f,g,h,i,j,k,l}   Ang, K Kian ^{a,b,c,d,e,f,g,h,i,j,k,l}  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b RADIATION THERAPY ONCOLOGY GROUP   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d LDS HOSPITAL   (United States)

^e UNIVERSITY OF CALGARY   (Canada)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g STANFORD UNIVERSITY MEDICAL CENTER   (United States)

^h H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

ⁱ UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^j NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^k Maimonides Cancer Center   (United States)

^l UNIVERSITY OF TEXAS   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; EPIDERMAL GROWTH FACTOR RECEPTOR; GLIOMA ASSOCIATED ONCOGENE FAMILY ZINC FINGER 1; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ADULT; AGED; ARTICLE; CANCER RADIOTHERAPY; DISEASE COURSE; DISEASE SEVERITY; FEMALE; HEAD AND NECK CARCINOMA; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; KARNOFSKY PERFORMANCE STATUS; MAJOR CLINICAL STUDY; MALE; METASTASIS; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA;

AGED; BETA CATENIN; CANADA; CARCINOMA, SQUAMOUS CELL; DISEASE PROGRESSION; DOSE FRACTIONATION; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; NEOPLASM STAGING; PROPORTIONAL HAZARDS MODELS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RISK ASSESSMENT; RISK FACTORS; SURVIVAL RATE; TIME FACTORS; TISSUE ARRAY ANALYSIS; TRANSCRIPTION FACTORS; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL; UNITED STATES;

EID: 79954447907     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2010.32.3295     Document Type: Article

References (56)

1. Ingham PW: Hedgehog signaling: A tale of two lipids. Science 294:1879-1881, 2001 (Pubitemid 33101576)
2. Chiang C, Litingtung Y, Lee E, et al: Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383:407-413, 1996 (Pubitemid 26330823)
3. Fietz MJ, Concordet JP, Barbosa R: The hedgehog gene family in Drosophila and vertebrate development. Dev Suppl 43-51, 1994
4. Nüsslein-Volhard C, Lohs-Schardin M, Sander K, et al: A dorso-ventral shift of embryonic primordia in a new maternal-effect mutant of Drosophila. Nature 283:474-476, 1980 (Pubitemid 10142615)
5. Berman DM, Karhadkar SS, Maitra A, et al: Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature 425:846-851, 2003 (Pubitemid 37351469)
6. Thayer SP, di Magliano MP, Heiser PW, et al: Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 425:851-856, 2003 (Pubitemid 37355945)
7. Berman DM, Karhadkar SS, Hallahan AR, et al: Medulloblastoma growth inhibition by hedgehog pathway blockade. Science 297:1559-1561, 2002 (Pubitemid 34971004)
8. Stecca B, Ruiz i Altaba A: Brain as a paradigm of organ growth: Hedgehog-Gli signaling in neural stem cells and brain tumors. J Neurobiol 64:476-490, 2005 (Pubitemid 41114054)
9. Gailani MR, Ståhle-Bäckdahl M, Leffell DJ, et al: The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas. Nat Genet 14:78-81, 1996 (Pubitemid 26301550)
10. Gailani MR, Bale AE: Developmental genes and cancer: Role of patched in basal cell carcinoma of the skin. J Natl Cancer Inst 89:1103-1109, 1997 (Pubitemid 27337923)
11. Stecca B, Mas C, Ruiz i Altaba A: Interference with HH-GLI signaling inhibits prostate cancer. Trends Mol Med 11:199-203, 2005 (Pubitemid 40692308)
12. Sanchez P, Hernández AM, Stecca B, et al: Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling. Proc Natl Acad Sci U S A 101:12561-12566, 2004 (Pubitemid 39122063)
13. Watkins DN, Berman DM, Baylin SB: Hedgehog signaling: Progenitor phenotype in small-cell lung cancer. Cell Cycle 2:196-198, 2003
14. Watkins DN, Berman DM, Burkholder SG, et al: Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature 422:313-317, 2003 (Pubitemid 36378358)
15. Schneider S, Thurnher D, Kloimstein P, et al: Expression of the Sonic hedgehog pathway in squamous cell carcinoma of the skin and the mucosa of the head and neck. Head Neck 33:244-250, 2011
16. Chuang PT, McMahon AP: Vertebrate Hedgehog signalling modulated by induction of a Hedgehogbinding protein. Nature 397:617-621, 1999
17. Jiang J, Struhl G: Protein kinase A and hedgehog signaling in Drosophila limb development. Cell 80:563-572, 1995
18. Jiang J, Struhl G: Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb. Nature 391:493-496, 1998 (Pubitemid 28086550)
19. Katoh Y, Katoh M: Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review). Int J Mol Med 18:1019-1023, 2006
20. Pan Y, Bai CB, Joyner AL, et al: Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. Mol Cell Biol 26:3365-3377, 2006
21. Wang B, Fallon JF, Beachy PA: Hedgehogregulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell 100:423-434, 2000
22. Lemjabbar-Alaoui H, Dasari V, Sidhu SS, et al: Wnt and Hedgehog are critical mediators of cigarette smokeinduced lung cancer. PLoS One 1: e93, 2006
23. Stecca B, Mas C, Clement V, et al: Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways. Proc Natl Acad Sci U S A 104:5895-5900, 2007 (Pubitemid 47175630)
24. Ji Z, Mei FC, Xie J, et al: Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells. J Biol Chem 282:14048-14055, 2007 (Pubitemid 47100411)
25. Riobó NA, Lu K, Ai X, et al: Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling. Proc Natl Acad Sci U S A 103:4505-4510, 2006
26. Dennler S, André J, Alexaki I, et al: Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo. Cancer Res 67:6981-6986, 2007 (Pubitemid 47105546)
27. Kasper M, Schnidar H, Neill GW, et al: Selective modulation of Hedgehog/GLI target gene expression by epidermal growth factor signaling in human keratinocytes. Mol Cell Biol 26:6283-6298, 2006 (Pubitemid 44204544)
28. Katoh Y, Katoh M: WNT antagonist, SFRP1, is Hedgehog signaling target. Int J Mol Med 17:171-175, 2006
29. Chung CH, Parker JS, Ely K, et al: Gene expression profiles identify epithelial-to-mesenchymal transition and activation of nuclear factor-kappaB signaling as characteristics of a high-risk head and neck squamous cell carcinoma. Cancer Res 66:8210-8218, 2006 (Pubitemid 44299189)
30. Von Hoff DD, LoRusso PM, Rudin CM, et al: Inhibition of the hedgehog pathway in advanced basalcell carcinoma. N Engl J Med 361:1164-1172, 2009
31. Rudin CM, Hann CL, Laterra J, et al: Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N Engl J Med 361:1173-1178, 2009
32. Low JA, de Sauvage FJ: Clinical experience with Hedgehog pathway inhibitors. J Clin Oncol 28:5321-5326, 2010
33. Fu KK, Pajak TF, Trotti A, et al: A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: First report of RTOG 9003. Int J Radiat Oncol Biol Phys 48:7-16, 2000 (Pubitemid 30488207)
34. Chung CH, Zhang Q, Hammond E: Integrating epidermal growth factor receptor assay with clinical parameters improves risk classification for relapse and survival in head-and-neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys [epub ahead of print on August 21, 2010]
35. Psyrri A, Yu Z, Weinberger PM, et al: Quantitative determination of nuclear and cytoplasmic epidermal growth factor receptor expression in oropharyngeal squamous cell cancer by using automated quantitative analysis. Clin Cancer Res 11:5856-5862, 2005 (Pubitemid 41170313)
36. Cox DR: Regression model and life tables. J R Stat Soc B 34:187-220, 1972
37. Prentice RL, Kalbfleisch JD, Peterson AV Jr, et al: The analysis of failure times in the presence of competing risks. Biometrics 34:541-554, 1978 (Pubitemid 9067879)
38. Therneau TM, Grambsch P, Fleming TR: Martingale-based residuals for survival models. Biometrika 77:147-160, 1990
39. Korn EL, Dorey FJ: Applications of crude incidence curves. Stat Med 11:813-829, 1992
40. Kaplan EL, Meier P: Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:467-481, 1958
41. Chang IM, Gelman R, Pagano M: Corrected group prognostic curves and summary statistics. J Chronic Dis 35:669-674, 1982 (Pubitemid 12099867)
42. Ang KK, Berkey BA, Tu X, et al: Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma. Cancer Res 62:7350-7356, 2002 (Pubitemid 36025259)
43. Mori Y, Okumura T, Tsunoda S, et al: Gli-1 expression is associated with lymph node metastasis and tumor progression in esophageal squamous cell carcinoma. Oncology 70:378-389, 2006 (Pubitemid 46066131)
44. Yoshikawa R, Nakano Y, Tao L, et al: Hedgehog signal activation in oesophageal cancer patients undergoing neoadjuvant chemoradiotherapy. Br J Cancer 98:1670-1674, 2008 (Pubitemid 351684687)
45. Posner MR, Hershock DM, Blajman CR, et al: Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer. N Engl J Med 357:1705-1715, 2007 (Pubitemid 350005152)
46. Ingham PW, McMahon AP: Hedgehog signaling in animal development: Paradigms and principles. Genes Dev 15:3059-3087, 2001 (Pubitemid 33115673)
47. van den Brink GR: Hedgehog signaling in development and homeostasis of the gastrointestinal tract. Physiol Rev 87:1343-1375, 2007 (Pubitemid 350033824)
48. Yauch RL, Gould SE, Scales SJ, et al: A paracrine requirement for hedgehog signalling in cancer. Nature 455:406-410, 2008
49. Frank-Kamenetsky M, Zhang XM, Bottega S, et al: Small-molecule modulators of Hedgehog signaling: Identification and characterization of Smoothened agonists and antagonists. J Biol 1:10, 2002
50. Hosoya T, Arai MA, Koyano T, et al: Naturally occurring small-molecule inhibitors of hedgehog/GLI-mediated transcription. Chembiochem 9:1082-1092, 2008
51. Chen JK, Taipale J, Cooper MK, et al: Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev 16:2743-2748, 2002 (Pubitemid 35253140)
52. Williams JA: Hedgehog signaling pathway as a target for therapeutic intervention in basal cell carcinoma. Drug News Perspect 16:657-662, 2003 (Pubitemid 38198688)
53. Rahnama F, Shimokawa T, Lauth M, et al: Inhibition of GLI1 gene activation by Patched1. Biochem J 394:19-26, 2006 (Pubitemid 43259651)
54. Taipale J, Chen JK, Cooper MK, et al: Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature 406:1005-1009, 2000
55. Chari NS, McDonnell TJ: The sonic hedgehog signaling network in development and neoplasia. Adv Anat Pathol 14:344-352, 2007 (Pubitemid 47312290)
56. Lauth M, Toftgård R: Non-canonical activation of GLI transcription factors: Implications for targeted anticancer therapy. Cell Cycle 6:2458-2463, 2007 (Pubitemid 350058663)