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Volumn 18, Issue 9, 2012, Pages 2558-2568

mTOR as a molecular target in HPV-associated oral and cervical squamous carcinomas

Author keywords

[No Author keywords available]

Indexed keywords

EVEROLIMUS; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; PROTEIN P16; RAPAMYCIN;

EID: 84860363833     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-11-2824     Document Type: Article
Times cited : (153)

References (49)
  • 1
    • 59349121140 scopus 로고    scopus 로고
    • Papillomaviruses in the causation of human cancers - A brief historical account
    • zur Hausen H. Papillomaviruses in the causation of human cancers - a brief historical account. Virology 2009;384:260-5.
    • (2009) Virology , vol.384 , pp. 260-265
    • Zur Hausen, H.1
  • 2
    • 33646413672 scopus 로고    scopus 로고
    • The global health burden of infection-associated cancers in the year 2002
    • Parkin DM. The global health burden of infection-associated cancers in the year 2002. Int J Cancer 2006;118:3030-44.
    • (2006) Int J Cancer , vol.118 , pp. 3030-3044
    • Parkin, D.M.1
  • 4
    • 71649109232 scopus 로고    scopus 로고
    • Causes of oral cancer - An appraisal of controversies
    • Warnakulasuriya S. Causes of oral cancer - an appraisal of controversies. Br Dent J 2009;207:471-5.
    • (2009) Br Dent J , vol.207 , pp. 471-475
    • Warnakulasuriya, S.1
  • 6
    • 0022992205 scopus 로고
    • Detection of human papillomavirus DNA in oral mucosal lesions using in situ DNA-hybridization applied on paraffin sections
    • DOI 10.1016/0030-4220(86)90262-8
    • Syrjanen SM, Syrjanen KJ, Lamberg MA. Detection of human papillomavirus DNA in oral mucosal lesions using in situ DNA-hybridization applied on paraffin sections. Oral Surg Oral Med Oral Pathol 1986;62:660-7. (Pubitemid 17082759)
    • (1986) Oral Surgery Oral Medicine and Oral Pathology , vol.62 , Issue.6 , pp. 660-667
    • Syrjanen, S.M.1    Syrjanen, K.J.2    Lamberg, M.A.3
  • 7
    • 77955282693 scopus 로고    scopus 로고
    • HPV-associated head and neck cancer: A virus-related cancer epidemic
    • Marur S, D'Souza G, Westra WH, Forastiere AA. HPV-associated head and neck cancer: a virus-related cancer epidemic. Lancet Oncol 2010;11:781-9.
    • (2010) Lancet Oncol , vol.11 , pp. 781-789
    • Marur, S.1    D'Souza, G.2    Westra, W.H.3    Forastiere, A.A.4
  • 8
    • 39149104081 scopus 로고    scopus 로고
    • Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States
    • DOI 10.1200/JCO.2007.14.1713
    • Chaturvedi AK, Engels EA, Anderson WF, Gillison ML. Incidence trends for human papillomavirus-related and-unrelated oral squamous cell carcinomas in the united states. J Clin Oncol 2008;26:612-9. (Pubitemid 351264356)
    • (2008) Journal of Clinical Oncology , vol.26 , Issue.4 , pp. 612-619
    • Chaturvedi, A.K.1    Engels, E.A.2    Anderson, W.F.3    Gillison, M.L.4
  • 10
    • 77952312776 scopus 로고    scopus 로고
    • Sexual behaviours and the risk of head and neck cancers: A pooled analysis in the International Head and Neck Cancer Epidemiology (INHANCE) consortium
    • Heck JE, Berthiller J, Vaccarella S, Winn DM, Smith EM, Shan'gina O, et al. Sexual behaviours and the risk of head and neck cancers: a pooled analysis in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Int J Epidemiol 2010;39: 166-81.
    • (2010) Int J Epidemiol , vol.39 , pp. 166-181
    • Heck, J.E.1    Berthiller, J.2    Vaccarella, S.3    Winn, D.M.4    Smith, E.M.5    Shan'Gina, O.6
  • 13
    • 65349173893 scopus 로고    scopus 로고
    • Effect of HPV-associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck
    • Lassen P, Eriksen JG, Hamilton-Dutoit S, Tramm T, Alsner J, Overgaard J. Effect of HPV-associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck. J Clin Oncol 2009;27:1992-8.
    • (2009) J Clin Oncol , vol.27 , pp. 1992-1998
    • Lassen, P.1    Eriksen, J.G.2    Hamilton-Dutoit, S.3    Tramm, T.4    Alsner, J.5    Overgaard, J.6
  • 16
    • 70449709569 scopus 로고    scopus 로고
    • Racial survival disparity in head and neck cancer results from low prevalence of human papillomavirus infection in black oropharyngeal cancer patients
    • Phila
    • Settle K, Posner MR, Schumaker LM, Tan M, Suntharalingam M, Goloubeva O, et al. Racial survival disparity in head and neck cancer results from low prevalence of human papillomavirus infection in black oropharyngeal cancer patients. Cancer Prev Res (Phila) 2009;2: 776-81.
    • (2009) Cancer Prev Res , vol.2 , pp. 776-781
    • Settle, K.1    Posner, M.R.2    Schumaker, L.M.3    Tan, M.4    Suntharalingam, M.5    Goloubeva, O.6
  • 18
    • 33845942433 scopus 로고    scopus 로고
    • p16INK4A immunohistochemistry is superior to HPV in situ hybridization for the detection of high-risk HPV in atypical squamous metaplasia
    • DOI 10.1097/01.pas.0000213347.65014.ee, PII 0000047820070100000004
    • Kong CS, Balzer BL, Troxell ML, Patterson BK, Longacre TA. p16INK4A immunohistochemistry is superior to HPV in situ hybridization for the detection of high-risk HPV in atypical squamous metaplasia. Am J Surg Pathol 2007;31:33-43. (Pubitemid 46036900)
    • (2007) American Journal of Surgical Pathology , vol.31 , Issue.1 , pp. 33-43
    • Kong, C.S.1    Balzer, B.L.2    Troxell, M.L.3    Patterson, B.K.4    Longacre, T.A.5
  • 20
    • 77449138742 scopus 로고    scopus 로고
    • Head and neck squamous cell cancer and the human papillomavirus: Summary of a National Cancer Institute State of the Science Meeting, November 9-10, 2008, Washington, D.C.
    • Adelstein DJ, Ridge JA, Gillison ML, Chaturvedi AK, D'Souza G, Gravitt PE, et al. Head and neck squamous cell cancer and the human papillomavirus: summary of a National Cancer Institute State of the Science Meeting, November 9-10, 2008, Washington, D.C. Head Neck 2009;31:1393-422.
    • (2009) Head Neck , vol.31 , pp. 1393-1422
    • Adelstein, D.J.1    Ridge, J.A.2    Gillison, M.L.3    Chaturvedi, A.K.4    D'Souza, G.5    Gravitt, P.E.6
  • 22
    • 77956260879 scopus 로고    scopus 로고
    • Rac1 is required for epithelial stem cell function during dermal and oral mucosal wound healing but not for tissue homeostasis in mice
    • Castilho R, Squarize CH, Leelahavanichkul K, Zheng Y, Bugge T, Gutkind JS. Rac1 is required for epithelial stem cell function during dermal and oral mucosal wound healing but not for tissue homeostasis in mice. PLos One 2010;5:e10503.
    • (2010) PLos One , vol.5
    • Castilho, R.1    Squarize, C.H.2    Leelahavanichkul, K.3    Zheng, Y.4    Bugge, T.5    Gutkind, J.S.6
  • 24
    • 0028915024 scopus 로고
    • The use of general primers GP5 and GP6 elongated at their 30 ends with adjacent highly conserved sequences improves human papillomavirus detection by PCR
    • de Roda Husman AM,Walboomers JM, van den Brule AJ, Meijer CJ, Snijders PJ. The use of general primers GP5 and GP6 elongated at their 30 ends with adjacent highly conserved sequences improves human papillomavirus detection by PCR. J Gen Virol 1995;76: 1057-62.
    • (1995) J Gen Virol , vol.76 , pp. 1057-1062
    • De Roda Husman, A.M.1    Walboomers, J.M.2    Van Den Brule, A.J.3    Meijer, C.J.4    Snijders, P.J.5
  • 26
    • 13944263935 scopus 로고    scopus 로고
    • Human papillomavirus types in head and neck squamous cell carcinomas worldwide: A systemic review
    • DOI 10.1158/1055-9965.EPI-04-0551
    • Kreimer AR, Clifford GM, Boyle P, Franceschi S.Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidemiol Biomarkers Prev 2005;14: 467-75. (Pubitemid 40270113)
    • (2005) Cancer Epidemiology Biomarkers and Prevention , vol.14 , Issue.2 , pp. 467-475
    • Kreimer, A.R.1    Clifford, G.M.2    Boyle, P.3    Franceschi, S.4
  • 27
    • 78650510609 scopus 로고    scopus 로고
    • mTOR: From growth signal integration to cancer, diabetes and ageing
    • Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 2011;12:21-35.
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3
  • 28
    • 49649124944 scopus 로고    scopus 로고
    • Snail up-regulates proinflammatory mediators and inhibits differentiation in oral keratinocytes
    • Lyons JG, Patel V, Roue NC, Fok SY, Soon LL, Halliday GM, et al. Snail up-regulates proinflammatory mediators and inhibits differentiation in oral keratinocytes. Cancer Res 2008;68:4525-30.
    • (2008) Cancer Res , vol.68 , pp. 4525-4530
    • Lyons, J.G.1    Patel, V.2    Roue, N.C.3    Fok, S.Y.4    Soon, L.L.5    Halliday, G.M.6
  • 29
    • 39449120471 scopus 로고    scopus 로고
    • A retroinhibition approach reveals a tumor cell-autonomous response to rapamycin in head and neck cancer
    • DOI 10.1158/0008-5472.CAN-07-1756
    • Amornphimoltham P, Patel V, Leelahavanichkul K, Abraham RT, Gutkind JS. A retroinhibition approach reveals a tumor cell-autonomous response to rapamycin in head and neck cancer. Cancer Res 2008;68:1144-53. (Pubitemid 351272233)
    • (2008) Cancer Research , vol.68 , Issue.4 , pp. 1144-1153
    • Amornphimoltham, P.1    Patel, V.2    Leelahavanichkul, K.3    Abraham, R.T.4    Gutkind, J.S.5
  • 30
    • 34547943509 scopus 로고    scopus 로고
    • Current topics in the epidemiology of oral cavity and oropharyngeal cancers
    • DOI 10.1002/hed.20573
    • Gillison ML. Current topics in the epidemiology of oral cavity and oropharyngeal cancers. Head Neck 2007;29:779-92. (Pubitemid 47265534)
    • (2007) Head and Neck , vol.29 , Issue.8 , pp. 779-792
    • Gillison, M.L.1
  • 31
    • 79957446230 scopus 로고    scopus 로고
    • Advances in cervical cancer treatment
    • Downs L. Advances in cervical cancer treatment. Gynecol Oncol 2011;121:431-3.
    • (2011) Gynecol Oncol , vol.121 , pp. 431-433
    • Downs, L.1
  • 32
    • 0030875607 scopus 로고    scopus 로고
    • Randomised study of radical surgery versus radiotherapy for stage Ib-IIa cervical cancer
    • DOI 10.1016/S0140-6736(97)02250-2
    • Landoni F, Maneo A, Colombo A, Placa F, Milani R, Perego P, et al. Randomised study of radical surgery versus radiotherapy for stage Ib-IIa cervical cancer. Lancet 1997;350:535-40. (Pubitemid 27348428)
    • (1997) Lancet , vol.350 , Issue.9077 , pp. 535-540
    • Landoni, F.1    Maneo, A.2    Colombo, A.3    Placa, F.4    Milani, R.5    Perego, P.6    Favini, G.7    Ferri, L.8    Mangioni, C.9
  • 33
    • 0027769876 scopus 로고
    • A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
    • DOI 10.1038/366704a0
    • Serrano M, Hannon GJ, Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993;366: 704-7. (Pubitemid 24036021)
    • (1993) Nature , vol.366 , Issue.6456 , pp. 704-707
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 34
    • 0024535228 scopus 로고
    • The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product
    • Dyson N, Howley PM, Munger K, Harlow E. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 1989;243:934-7. (Pubitemid 19066153)
    • (1989) Science , vol.243 , Issue.4893 , pp. 934-937
    • Dyson, N.1    Howley, P.M.2    Munger, K.3    Harlow, E.4
  • 35
    • 77955176135 scopus 로고    scopus 로고
    • p16 positive oropharyngeal squamous cell carcinoma: An entity with a favorable prognosis regardless of tumor HPV status
    • Lewis JS Jr, Thorstad WL, Chernock RD, Haughey BH, Yip JH, Zhang Q, et al. p16 positive oropharyngeal squamous cell carcinoma: an entity with a favorable prognosis regardless of tumor HPV status.Am J Surg Pathol 2010;34:1088-96.
    • (2010) Am J Surg Pathol , vol.34 , pp. 1088-1096
    • Lewis Jr., J.S.1    Thorstad, W.L.2    Chernock, R.D.3    Haughey, B.H.4    Yip, J.H.5    Zhang, Q.6
  • 36
    • 79952140358 scopus 로고    scopus 로고
    • Human papillomavirus E7 oncoprotein induces KDM6A and KDM6B histone demethylase expression and causes epigenetic reprogramming
    • McLaughlin-Drubin ME, Crum CP, Munger K. Human papillomavirus E7 oncoprotein induces KDM6A and KDM6B histone demethylase expression and causes epigenetic reprogramming. Proc Natl Acad Sci U S A 2011;108:2130-5.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 2130-2135
    • McLaughlin-Drubin, M.E.1    Crum, C.P.2    Munger, K.3
  • 37
    • 79951727256 scopus 로고    scopus 로고
    • Alterations in the tumor suppressor gene p16 INK4A are associated with aggressive behavior of penile carcinomas
    • Poetsch M, Hemmerich M, Kakies C, Kleist B, Wolf E, Dorp F, et al. Alterations in the tumor suppressor gene p16 INK4A are associated with aggressive behavior of penile carcinomas. Virchows Archiv 2010;458:221-9.
    • (2010) Virchows Archiv , vol.458 , pp. 221-229
    • Poetsch, M.1    Hemmerich, M.2    Kakies, C.3    Kleist, B.4    Wolf, E.5    Dorp, F.6
  • 39
    • 77956024826 scopus 로고    scopus 로고
    • The human papillomavirus type 16 E6 oncoprotein activatesmTORC1 signaling and increases protein synthesis
    • Spangle JM, Munger K. The human papillomavirus type 16 E6 oncoprotein activatesmTORC1 signaling and increases protein synthesis. J Virol 2010;84:9398-407.
    • (2010) J Virol , vol.84 , pp. 9398-9407
    • Spangle, J.M.1    Munger, K.2
  • 41
    • 3042818799 scopus 로고    scopus 로고
    • Regulation of the TSC pathway by LKB1: Evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome
    • DOI 10.1101/gad.1199104
    • Corradetti MN, Inoki K, Bardeesy N, DePinho RA, Guan KL. Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev 2004;18:1533-8. (Pubitemid 38868905)
    • (2004) Genes and Development , vol.18 , Issue.13 , pp. 1533-1538
    • Corradetti, M.N.1    Inoki, K.2    Bardeesy, N.3    DePinho, R.A.4    Guan, K.-L.5
  • 43
    • 67149137763 scopus 로고    scopus 로고
    • Morphoproteomic evidence of constitutively activated and overexpressed mTOR pathway in cervical squamous carcinoma and high grade squamous intraepithelial lesions
    • Feng W, Duan X, Liu J, Xiao J, Brown RE. Morphoproteomic evidence of constitutively activated and overexpressed mTOR pathway in cervical squamous carcinoma and high grade squamous intraepithelial lesions. Int J Clin Exp Pathol 2009;2:249-60.
    • (2009) Int J Clin Exp Pathol , vol.2 , pp. 249-260
    • Feng, W.1    Duan, X.2    Liu, J.3    Xiao, J.4    Brown, R.E.5
  • 44
    • 51649124020 scopus 로고    scopus 로고
    • Pharmacodynamic-guided modified continuous reassessment method-based, dose-finding study of rapamycin in adult patients with solid tumors
    • Jimeno A, Rudek MA, Kulesza P, Ma WW, Wheelhouse J, Howard A, et al. Pharmacodynamic-guided modified continuous reassessment method-based, dose-finding study of rapamycin in adult patients with solid tumors. J Clin Oncol 2008;26:4172-9.
    • (2008) J Clin Oncol , vol.26 , pp. 4172-4179
    • Jimeno, A.1    Rudek, M.A.2    Kulesza, P.3    Ma, W.W.4    Wheelhouse, J.5    Howard, A.6
  • 45
    • 38849208347 scopus 로고    scopus 로고
    • Antitumor activity of rapamycin in a phase I trial for patients with recurrent PTEN-deficient glioblastoma
    • Cloughesy TF, Yoshimoto K, Nghiemphu P, Brown K, Dang J, Zhu S, et al. Antitumor activity of rapamycin in a phase I trial for patients with recurrent PTEN-deficient glioblastoma. PLoS Med 2008; 5:e8.
    • (2008) PLoS Med , vol.5
    • Cloughesy, T.F.1    Yoshimoto, K.2    Nghiemphu, P.3    Brown, K.4    Dang, J.5    Zhu, S.6
  • 46
    • 68849099331 scopus 로고    scopus 로고
    • Comparison of radiosensitizing effects of the mammalian target of rapamycin inhibitor CCI-779 to cisplatin in experimental models of head and neck squamous cell carcinoma
    • Ekshyyan O, Rong Y, Rong X, Pattani KM, Abreo F, Caldito G, et al. Comparison of radiosensitizing effects of the mammalian target of rapamycin inhibitor CCI-779 to cisplatin in experimental models of head and neck squamous cell carcinoma. Mol Cancer Ther 2009;8: 2255-65.
    • (2009) Mol Cancer Ther , vol.8 , pp. 2255-2265
    • Ekshyyan, O.1    Rong, Y.2    Rong, X.3    Pattani, K.M.4    Abreo, F.5    Caldito, G.6
  • 47
    • 78649642994 scopus 로고    scopus 로고
    • Pharmacodynamic evaluation of temsirolimus in patients with newly diagnosed advanced-stage head and neck squamous cell carcinoma
    • Ekshyyan O, Mills GM, Lian T, Amirghahari N, Rong X, Lowery-Nordberg M, et al. Pharmacodynamic evaluation of temsirolimus in patients with newly diagnosed advanced-stage head and neck squamous cell carcinoma. Head Neck 2010;32:1619-28.
    • (2010) Head Neck , vol.32 , pp. 1619-1628
    • Ekshyyan, O.1    Mills, G.M.2    Lian, T.3    Amirghahari, N.4    Rong, X.5    Lowery-Nordberg, M.6
  • 49
    • 79960613394 scopus 로고    scopus 로고
    • Common toxicities of mammalian target of rapamycin inhibitors
    • Soefje SA, Karnad A, Brenner AJ. Common toxicities of mammalian target of rapamycin inhibitors. Target Oncol 2011;6:125-9.
    • (2011) Target Oncol , vol.6 , pp. 125-129
    • Soefje, S.A.1    Karnad, A.2    Brenner, A.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.