The expression of activin receptorlike kinase 1 among patients with head and neck cancer

Otolaryngology - Head and Neck Surgery (United States)

Volumn 148, Issue 6, 2013, Pages 965-973

  Chien, Chih Yen ^a,b   Chuang, Hui Ching ^a,b   Chen, Chang Han ^a,b   Fang, Fu Min ^a,b   Chen, Wei Chih ^a,b   Huang, Chao Cheng ^a,b   Huang, Hsuan Ying ^a,b  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Activin receptorlike kinase 1; Extracapsular spread of lymph node; Head and neck squamous cell carcinoma; Lymph node metastasis; Neck metastasis

Indexed keywords

ACTIVIN RECEPTOR LIKE KINASE 1; ANTINEOPLASTIC AGENT; ACTIVIN RECEPTOR 2; ACVRL1 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER PROGNOSIS; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURGERY; CONTROLLED STUDY; FEMALE; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; LYMPH VESSEL METASTASIS; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ACTIVIN RECEPTOR-LIKE KINASE 1; COHORT ANALYSIS; COMPARATIVE STUDY; CONFIDENCE INTERVAL; DISEASE FREE SURVIVAL; EXTRACAPSULAR SPREAD OF LYMPH NODE; GENE EXPRESSION REGULATION; GENETICS; HEAD AND NECK TUMOR; KAPLAN MEIER METHOD; LYMPH NODE; LYMPH NODE DISSECTION; METHODOLOGY; MIDDLE AGED; MORTALITY; MULTIMODALITY CANCER THERAPY; NECK METASTASIS; NONPARAMETRIC TEST; PATHOLOGY; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; RETROSPECTIVE STUDY; RISK; SQUAMOUS CELL CARCINOMA; SURVIVAL; TREATMENT OUTCOME; TUMOR INVASION;

ACTIVIN RECEPTOR-LIKE KINASE 1; EXTRACAPSULAR SPREAD OF LYMPH NODE; HEAD AND NECK SQUAMOUS CELL CARCINOMA; LYMPH NODE METASTASIS; NECK METASTASIS;

ACTIVIN RECEPTORS, TYPE II; ADULT; AGED; CARCINOMA, SQUAMOUS CELL; COHORT STUDIES; COMBINED MODALITY THERAPY; CONFIDENCE INTERVALS; DISEASE-FREE SURVIVAL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEAD AND NECK NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; LYMPH NODE EXCISION; LYMPH NODES; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; ODDS RATIO; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RETROSPECTIVE STUDIES; STATISTICS, NONPARAMETRIC; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

MLCS; MLOWN;

EID: 84880500232     PISSN: 01945998     EISSN: 10976817     Source Type: Journal    
DOI: 10.1177/0194599813479556     Document Type: Article

References (26)

1. Greenlee RT, Hill-Harmon MB, Murray T, Thun M. Cancer statistics, 2001. CA Cancer J Clin. 2001;51:15-36.
2. Cancer Registry Annual Report in Taiwan Area. Taipei, ROC: Department of Health EY; 2006.
3. Folkman J. What is the evidence that tumors are angiogenesis dependent?. J Natl Cancer Inst. 1990;82:4-6.
4. Folkman J. Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis. N Engl J Med. 1995;333:1757-1763.
5. Weidner N. Intratumor microvessel density as a prognostic factor in cancer. Am J Pathol. 1995;147:9-19.
6. Polverini PJ, Leibovich SJ. Induction of neovascularization in vivo and endothelial proliferation in vitro by tumor-associated macrophages. Lab Invest. 1984;51:635-642.
7. Oh SP, Seki T, Goss KA, et al. Activin receptorlike kinase 1 modulates transforming growth factorbeta 1 signaling in the regulation of angiogenesis. Proc Natl Acad Sci U S A. 2000;97:2626-2631.
8. Hu-Lowe DD, Chen E, Zhang L, et al. Targeting activin receptorlike kinase 1 inhibits angiogenesis and tumorigenesis through a mechanism of action complementary to anti-VEGF therapies. Cancer Res. 2011;71:1362-1373.
9. Abdalla SA, Letarte M. Hereditary haemorrhagic telangiectasia: current views on genetics and mechanisms of disease. J Med Genet. 2006;43:97-110.
10. Al-Swiahb JN, Chen CH, Chuang HC, Fang FM, Tasi HT, Chien CY. Clinical, pathological and molecular determinants in squamous cell carcinoma of the oral cavity. Future Oncol. 2010;6:837-850.
11. Chen CH, Chien CY, Huang CC, et al. Expression of FLJ10540 is correlated with aggressiveness of oral cavity squamous cell carcinoma by stimulating cell migration and invasion through increased FOXM1 and MMP-2 activity. Oncogene. 2009;28:2723-2737.
12. Chuang HC, Su CY, Huang HY, Chien CY, Chen CM, Huang CC. High expression of CD105 as a prognostic predictor of early tongue cancer. Laryngoscope. 2006;116:1175-1179.
13. Chien CY, Su CY, Hwang CF, et al. Clinicopathologic significance of CD105 expression in squamous cell carcinoma of the hypopharynx. Head Neck. 2006;28:441-446.
14. Marioni G, Staffieri A, Manzato E, et al. A higher CD105-assessed microvessel density and worse prognosis in elderly patients with laryngeal carcinoma. Arch Otolaryngol Head Neck Surg. 2011;137:175-180.
15. Martone T, Rosso P, Albera R, et al. Prognostic relevance of CD1051 microvessel density in HNSCC patient outcome. Oral Oncol. 2005;41:147-155.
16. Chen CH, Su CY, Chien CY, et al. Overexpression of beta2-microglobulin is associated with poor survival in patients with oral cavity squamous cell carcinoma and contributes to oral cancer cell migration and invasion. Br J Cancer. 2008;99: 1453-1461.
17. Su AI, Wiltshire T, Batalov S, et al. A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci U S A. 2004;101:6062-6067.
18. Garrido-Martin EM, Blanco FJ, Fernandez LA, et al. Characterization of the human activin-A receptor type IIlike kinase 1 (ACVRL1) promoter and its regulation by Sp1. BMC Mol Biol. 2010;11:51.
19. Srinivasan S, Hanes MA, Dickens T, et al. A mouse model for hereditary hemorrhagic telangiectasia (HHT) type 2. Hum Mol Genet. 2003;12:473-482.
20. Cunha SI, Pietras K. ALK1 as an emerging target for antiangiogenic therapy of cancer. Blood. 2011;117:6999-7006.
21. Goumans MJ, Valdimarsdottir G, Itoh S, Rosendahl A, Sideras P, ten Dijke P. Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors. EMBO J. 2002;21:1743-1753.
22. Shi Y, Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell. 2003;113:685-700.
23. Mallet C, Vittet D, Feige JJ, Bailly S. TGFbeta1 induces vasculogenesis and inhibits angiogenic sprouting in an embryonic stem cell differentiation model: respective contribution of ALK1 and ALK5. Stem Cells. 2006;24:2420-2427.
24. Freudlsperger C, Bian Y, Contag Wise S, et al. TGF-b and NF-kB signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers [published online May 28, 2012]. Oncogene. doi:10.1038/onc.2012. 171.
25. Jonson T, Albrechtsson E, Axelson J, et al. Altered expression of TGFB receptors and mitogenic effects of TGFB in pancreatic carcinomas. Int J Oncol. 2001;19:71-81.
26. Lamouille S, Mallet C, Feige J, et al. Activin receptorlike kinase 1 is implicated in the maturation phase of angiogenesis. Blood. 2002;100:4495-4501. Hospital Tissue Bank Hospital Tissue Bank