메뉴 건너뛰기




Volumn 21, Issue 14, 2003, Pages 2787-2799

Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer

Author keywords

[No Author keywords available]

Indexed keywords

CETUXIMAB; CISPLATIN; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; GEFITINIB; MONOCLONAL ANTIBODY; PACLITAXEL; TRASTUZUMAB; TYROSINE KINASE RECEPTOR; ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR;

EID: 0041629450     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2003.01.504     Document Type: Review
Times cited : (1224)

References (100)
  • 2
    • 0034234854 scopus 로고    scopus 로고
    • Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2
    • Klapper L, Waterman H, Sela M, et al: Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2. Cancer Res 60:3384-3388, 2000
    • (2000) Cancer Res , vol.60 , pp. 3384-3388
    • Klapper, L.1    Waterman, H.2    Sela, M.3
  • 3
    • 0034600849 scopus 로고    scopus 로고
    • The ErbB signaling network: Receptor heterodimerization in development and cancer
    • Olayioye M, Neve R, Lane H, et al: The ErbB signaling network: Receptor heterodimerization in development and cancer. EMBO J 19:3159-3167, 2000
    • (2000) EMBO J , vol.19 , pp. 3159-3167
    • Olayioye, M.1    Neve, R.2    Lane, H.3
  • 4
    • 0034947649 scopus 로고    scopus 로고
    • EGF mutant receptor vIII as a molecular target in cancer therapy
    • Kuan CT, Wikstrand CJ, Bigner DD: EGF mutant receptor vIII as a molecular target in cancer therapy. Endocr Relat Cancer 8:83-96, 2001
    • (2001) Endocr Relat Cancer , vol.8 , pp. 83-96
    • Kuan, C.T.1    Wikstrand, C.J.2    Bigner, D.D.3
  • 5
    • 0033599039 scopus 로고    scopus 로고
    • EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
    • Prenzel N, Zwick E, Daub H, et al: EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 402:884-888, 1999
    • (1999) Nature , vol.402 , pp. 884-888
    • Prenzel, N.1    Zwick, E.2    Daub, H.3
  • 6
    • 0036596352 scopus 로고    scopus 로고
    • EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma
    • Liu D, Ghiso JA, Estrada Y, et al: EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma. Cancer Cell 1:445-457, 2002
    • (2002) Cancer Cell , vol.1 , pp. 445-457
    • Liu, D.1    Ghiso, J.A.2    Estrada, Y.3
  • 7
    • 0034644539 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Schlessinger J: Cell signaling by receptor tyrosine kinases. Cell 103:211-225, 2000
    • (2000) Cell , vol.103 , pp. 211-225
    • Schlessinger, J.1
  • 8
    • 0030795612 scopus 로고    scopus 로고
    • The ErbB signaling network in embryogenesis and oncogenesis: Signal diversification through combinatorial ligand-receptor interactions
    • Alroy I, Yarden Y: The ErbB signaling network in embryogenesis and oncogenesis: Signal diversification through combinatorial ligand-receptor interactions. FEBS Lett 410:83-86, 1997
    • (1997) FEBS Lett , vol.410 , pp. 83-86
    • Alroy, I.1    Yarden, Y.2
  • 9
    • 0031900740 scopus 로고    scopus 로고
    • Signal transduction through MAP kinase cascades
    • Lewis TS, Shapiro PS, Ahn NG: Signal transduction through MAP kinase cascades. Adv Cancer Res 74:49-139, 1998
    • (1998) Adv Cancer Res , vol.74 , pp. 49-139
    • Lewis, T.S.1    Shapiro, P.S.2    Ahn, N.G.3
  • 10
    • 0032881288 scopus 로고    scopus 로고
    • Chan TO, Rittenhouse SE, Tsichlis PN: AKT/PKB and other D3 phosphoinositide-regulated kinases: Kinase activation by phosphoinositide- dependent phosphorylation. Annu Rev Biochem 68:965-1014, 1999
    • Chan TO, Rittenhouse SE, Tsichlis PN: AKT/PKB and other D3 phosphoinositide-regulated kinases: Kinase activation by phosphoinositide- dependent phosphorylation. Annu Rev Biochem 68:965-1014, 1999
  • 11
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-Kinase-Akt pathway in human cancer
    • Vivanco I, Sawyers CL: The phosphatidylinositol 3-Kinase-Akt pathway in human cancer. Nat Rev Cancer 2:489-501, 2002
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 12
    • 0010233988 scopus 로고
    • Growth stimulation of A431 cells by EGF: Identification of high affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody
    • Kawamoto T, Sato JD, Le A, et al: Growth stimulation of A431 cells by EGF: Identification of high affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody. Proc Natl Acad Sci U S A 80:1337-1341, 1983
    • (1983) Proc Natl Acad Sci U S A , vol.80 , pp. 1337-1341
    • Kawamoto, T.1    Sato, J.D.2    Le, A.3
  • 13
    • 0020933452 scopus 로고    scopus 로고
    • Sato JD, Kawamoto T, Le AD, et al: Biological effect in vitro of monoclonal antibodies to human EGF receptors. MoI Biol Med 1:511-529, 1983
    • Sato JD, Kawamoto T, Le AD, et al: Biological effect in vitro of monoclonal antibodies to human EGF receptors. MoI Biol Med 1:511-529, 1983
  • 14
    • 0021363327 scopus 로고
    • Growth inhibition of human tumor cells in athymic mice by anti-epidermal growth factor receptor monoclonal antibodies
    • Masui H, Kawamoto T, Sato JD, et al: Growth inhibition of human tumor cells in athymic mice by anti-epidermal growth factor receptor monoclonal antibodies. Cancer Res 44:1002-1007, 1984
    • (1984) Cancer Res , vol.44 , pp. 1002-1007
    • Masui, H.1    Kawamoto, T.2    Sato, J.D.3
  • 15
    • 0037106273 scopus 로고    scopus 로고
    • Targeting the epidermal growth factor receptor for cancer therapy
    • suppl 18, s
    • Mendelsohn J: Targeting the epidermal growth factor receptor for cancer therapy. J Clin Oncol 20:1s-13s, 2002 (suppl 18)
    • (2002) J Clin Oncol , vol.20
    • Mendelsohn, J.1
  • 16
    • 0028955388 scopus 로고
    • Epidermal growth factor-related peptides and their receptors in human malignancies
    • Salomon D, Brandt R, Ciardiello F, et al: Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Hematol 19:183-232, 1995
    • (1995) Crit Rev Oncol Hematol , vol.19 , pp. 183-232
    • Salomon, D.1    Brandt, R.2    Ciardiello, F.3
  • 17
    • 0028800035 scopus 로고
    • Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors
    • Moscatello DK: Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors. Cancer Res 55:5536-5539, 1995
    • (1995) Cancer Res , vol.55 , pp. 5536-5539
    • Moscatello, D.K.1
  • 18
    • 0028146767 scopus 로고
    • A mutant epidermal growth factor receptor common in human gltoma confers enhanced tumorigenicity
    • Nishikawa R: A mutant epidermal growth factor receptor common in human gltoma confers enhanced tumorigenicity. Proc Natl Acad Sci U S A 91:7727-7731, 1994
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 7727-7731
    • Nishikawa, R.1
  • 19
    • 0032478998 scopus 로고    scopus 로고
    • Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival
    • Grandis JR, Meinem MF, Gooding WE, et al: Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival. J Natl Cancer Inst 90:824-832, 1998
    • (1998) J Natl Cancer Inst , vol.90 , pp. 824-832
    • Grandis, J.R.1    Meinem, M.F.2    Gooding, W.E.3
  • 20
    • 0027159063 scopus 로고
    • Differential expression of the epidermal growth factor receptor and its ligands in primary non-small cell lung cancers and adjacent benign lung
    • Rusch V, Baselga J, Cordon-Cardo C, et al: Differential expression of the epidermal growth factor receptor and its ligands in primary non-small cell lung cancers and adjacent benign lung. Cancer Res 53:2379-2385, 1993
    • (1993) Cancer Res , vol.53 , pp. 2379-2385
    • Rusch, V.1    Baselga, J.2    Cordon-Cardo, C.3
  • 21
    • 0023279387 scopus 로고
    • Tumor growth modulation by a monoclonal antibody to the epidermal growth factor receptor: Immunologically mediated and effector cell-independent effects
    • Rodeck U, Herlyn M, Herlyn D, et al: Tumor growth modulation by a monoclonal antibody to the epidermal growth factor receptor: Immunologically mediated and effector cell-independent effects. Cancer Res 47:3692-3696, 1987
    • (1987) Cancer Res , vol.47 , pp. 3692-3696
    • Rodeck, U.1    Herlyn, M.2    Herlyn, D.3
  • 22
    • 0024261027 scopus 로고
    • Efficacy of antibodies to epidermal growth factor receptor against KB carcinoma in vitro and in nude mice
    • Aboud-Pirak E, Hurwitz E, Pirak ME, et al: Efficacy of antibodies to epidermal growth factor receptor against KB carcinoma in vitro and in nude mice. J Natl Cancer Inst 80:1605-1611, 1988
    • (1988) J Natl Cancer Inst , vol.80 , pp. 1605-1611
    • Aboud-Pirak, E.1    Hurwitz, E.2    Pirak, M.E.3
  • 23
    • 0034087465 scopus 로고    scopus 로고
    • Recombinant antibody toxins specific for ErbB2 and EGF receptor inhibit the in vitro growth of human head and neck cancer cells and cause rapid regression in vivo
    • Azemar M, Schmidt M, Arlt F, et al: Recombinant antibody toxins specific for ErbB2 and EGF receptor inhibit the in vitro growth of human head and neck cancer cells and cause rapid regression in vivo. Int J Cancer 86:269-275, 2000
    • (2000) Int J Cancer , vol.86 , pp. 269-275
    • Azemar, M.1    Schmidt, M.2    Arlt, F.3
  • 24
    • 0035879822 scopus 로고    scopus 로고
    • Antisense oligonucleotides targeting the epidermal growth factor receptor inhibit proliferation, induce apoptosis, and cooperate with cytotoxic drugs in human cancer cell lines
    • Ciardiello F, Caputo R, Troiani T, et al: Antisense oligonucleotides targeting the epidermal growth factor receptor inhibit proliferation, induce apoptosis, and cooperate with cytotoxic drugs in human cancer cell lines. Int J Cancer 93:172-178, 2001
    • (2001) Int J Cancer , vol.93 , pp. 172-178
    • Ciardiello, F.1    Caputo, R.2    Troiani, T.3
  • 25
    • 0032522815 scopus 로고    scopus 로고
    • Inhibition of tumor growth by ribozyme-mediated suppression of aberrant epidermal growth factor receptor gene expression
    • Yamazaki H, Kijima H, Ohmishi Y, et al: Inhibition of tumor growth by ribozyme-mediated suppression of aberrant epidermal growth factor receptor gene expression. J Natl Cancer Inst 90:581-587, 1998
    • (1998) J Natl Cancer Inst , vol.90 , pp. 581-587
    • Yamazaki, H.1    Kijima, H.2    Ohmishi, Y.3
  • 26
    • 0029812091 scopus 로고    scopus 로고
    • Intracellular expression of a single-chain antibody directed to the EGFR leads to growth inhibition of tumor cells
    • Jannot CB, Beerli RR, Mason S, et al: Intracellular expression of a single-chain antibody directed to the EGFR leads to growth inhibition of tumor cells. Oncogene 13:275-282, 1996
    • (1996) Oncogene , vol.13 , pp. 275-282
    • Jannot, C.B.1    Beerli, R.R.2    Mason, S.3
  • 27
    • 0021254542 scopus 로고
    • Monoclonal anti-epidermal growth factor receptor antibodies which are inhibitors of epidermal growth factor binding and antagonists of epidermal growth factor-stimulated tyrosine protein kinase activity
    • Gill GN, Kawamoto T, Cochet C, et al: Monoclonal anti-epidermal growth factor receptor antibodies which are inhibitors of epidermal growth factor binding and antagonists of epidermal growth factor-stimulated tyrosine protein kinase activity. J Biol Chem 259:7755-7760, 1984
    • (1984) J Biol Chem , vol.259 , pp. 7755-7760
    • Gill, G.N.1    Kawamoto, T.2    Cochet, C.3
  • 28
    • 0028116305 scopus 로고
    • Antibody-induced epidermal growth factor dimerization mediates inhibition of autocrine proliferation of A431 squamous carcinoma cells
    • Fan Z, Lu Y, Wu X, et al: Antibody-induced epidermal growth factor dimerization mediates inhibition of autocrine proliferation of A431 squamous carcinoma cells. J Biol Chem 269:27595-27602, 1994
    • (1994) J Biol Chem , vol.269 , pp. 27595-27602
    • Fan, Z.1    Lu, Y.2    Wu, X.3
  • 29
    • 0030801361 scopus 로고    scopus 로고
    • Unliganded epidermal growth factor receptor dimerization induced by direct interaction of quinazolines with the ATP binding site
    • Arteaga CL, Ramsey TT, Shawver LK, et al: Unliganded epidermal growth factor receptor dimerization induced by direct interaction of quinazolines with the ATP binding site. J Biol Chem 272:23247-23254, 1997
    • (1997) J Biol Chem , vol.272 , pp. 23247-23254
    • Arteaga, C.L.1    Ramsey, T.T.2    Shawver, L.K.3
  • 30
    • 0035423120 scopus 로고    scopus 로고
    • Signaling-inactive epidermal growth factor receptor/ligand complexes in intact carcinoma cells by quinazoline tyrosine kinase inhibitors
    • Lichtner RB, Menrad A, Sommer A, et al: Signaling-inactive epidermal growth factor receptor/ligand complexes in intact carcinoma cells by quinazoline tyrosine kinase inhibitors. Cancer Res 61:5790-5795, 2001
    • (2001) Cancer Res , vol.61 , pp. 5790-5795
    • Lichtner, R.B.1    Menrad, A.2    Sommer, A.3
  • 31
    • 0034043977 scopus 로고    scopus 로고
    • Site-directed irreversible inhibitors of the erbB family tyrosine kinases as novel chemotherapeutic agents for cancer
    • Fry D: Site-directed irreversible inhibitors of the erbB family tyrosine kinases as novel chemotherapeutic agents for cancer. Anticancer Drug Des 15:3-16, 2000
    • (2000) Anticancer Drug Des , vol.15 , pp. 3-16
    • Fry, D.1
  • 32
    • 0037096945 scopus 로고    scopus 로고
    • Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion
    • Lal A, Glazer CA, Martinson HM, et al: Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion. Cancer Res 62:3335-3339, 2002
    • (2002) Cancer Res , vol.62 , pp. 3335-3339
    • Lal, A.1    Glazer, C.A.2    Martinson, H.M.3
  • 33
    • 0034629485 scopus 로고    scopus 로고
    • Reversible G(1) arrest induced by inhibition of the epidermal growth factor receptor tyrosine kinase requires up-regulation of p27(KIP1) independent of MAPK activity
    • Busse D, Doughty R, Ramsey T, et al: Reversible G(1) arrest induced by inhibition of the epidermal growth factor receptor tyrosine kinase requires up-regulation of p27(KIP1) independent of MAPK activity. J Biol Chem 275:6987-6995, 2000
    • (2000) J Biol Chem , vol.275 , pp. 6987-6995
    • Busse, D.1    Doughty, R.2    Ramsey, T.3
  • 34
    • 0035418622 scopus 로고    scopus 로고
    • Activated extracellular signal-regulated kinases: Association with epidermal growth factor receptor/transforming growth factor alpha expression in head and neck squamous carcinoma and inhibition by anti-EGF receptor treatments
    • Albanell J, Codony-Servat J, Rojo F, et al: Activated extracellular signal-regulated kinases: Association with epidermal growth factor receptor/transforming growth factor alpha expression in head and neck squamous carcinoma and inhibition by anti-EGF receptor treatments. Cancer Res 61:6500-6510, 2001
    • (2001) Cancer Res , vol.61 , pp. 6500-6510
    • Albanell, J.1    Codony-Servat, J.2    Rojo, F.3
  • 35
    • 0037388251 scopus 로고    scopus 로고
    • ZD1839, a specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, induces the formation of inactive EGFR/HER2 and EGFR/HER3 heterodimers and prevents heregulin signaling in HER2-overexpression breast cancer cells
    • Anido J, Matar P, Albanell J, et al: ZD1839, a specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, induces the formation of inactive EGFR/HER2 and EGFR/HER3 heterodimers and prevents heregulin signaling in HER2-overexpression breast cancer cells. Clin Cancer Res 9:1274-1283, 2003
    • (2003) Clin Cancer Res , vol.9 , pp. 1274-1283
    • Anido, J.1    Matar, P.2    Albanell, J.3
  • 36
    • 0035476803 scopus 로고    scopus 로고
    • The tyrosine kinase inhibitor ZD1839 ("Iressa") inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells
    • Moasser MM, Basso A, Averbuch SD, et al: The tyrosine kinase inhibitor ZD1839 ("Iressa") inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells. Cancer Res 61:7184-7188, 2001
    • (2001) Cancer Res , vol.61 , pp. 7184-7188
    • Moasser, M.M.1    Basso, A.2    Averbuch, S.D.3
  • 37
    • 0036225446 scopus 로고    scopus 로고
    • Cooperative inhibitory effect of ZD1839 ("Iressa") in combination with trastuzumab ("Herceptin") on human breast cancer cell growth
    • Normanno N, Campiglio M, De Luca A, et al: Cooperative inhibitory effect of ZD1839 ("Iressa") in combination with trastuzumab ("Herceptin") on human breast cancer cell growth. Ann Oncol 13:65-72, 2002
    • (2002) Ann Oncol , vol.13 , pp. 65-72
    • Normanno, N.1    Campiglio, M.2    De Luca, A.3
  • 38
    • 0035893560 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZDI839 (Iressa) inhibits HER2/Neu (erb-2)- overexpressing breast cancer cells in vitro and in vivo
    • Moulder SL, Yakes M, Muthuswamy SK, et al: Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZDI839 (Iressa) inhibits HER2/Neu (erb-2)- overexpressing breast cancer cells in vitro and in vivo. Cancer Res 61:8887-8895, 2001
    • (2001) Cancer Res , vol.61 , pp. 8887-8895
    • Moulder, S.L.1    Yakes, M.2    Muthuswamy, S.K.3
  • 40
    • 0029670014 scopus 로고    scopus 로고
    • 1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody
    • 1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody. Oncogene 12:1397-1403, 1996
    • (1996) Oncogene , vol.12 , pp. 1397-1403
    • Wu, X.1    Rubin, M.2    Fan, Z.3
  • 41
    • 0029776415 scopus 로고    scopus 로고
    • Anti-epidermal growth factor receptor monoclonal antibody 225 up-regulates p27KIP1 and induces G1 arrest in prostatic cancer cell line DU145
    • Peng D, Fan Z, Lu Y, et al: Anti-epidermal growth factor receptor monoclonal antibody 225 up-regulates p27KIP1 and induces G1 arrest in prostatic cancer cell line DU145. Cancer Res 56:3666-3669, 1996
    • (1996) Cancer Res , vol.56 , pp. 3666-3669
    • Peng, D.1    Fan, Z.2    Lu, Y.3
  • 42
    • 0030774045 scopus 로고    scopus 로고
    • Induction of apoptosis and cell cycle arrest by CP-358, 774, an inhibitor of epidermal growth factor receptor tysosine kinase
    • Moyer JD, Barbacci ES, Iwata KT, et al: Induction of apoptosis and cell cycle arrest by CP-358, 774, an inhibitor of epidermal growth factor receptor tysosine kinase. Cancer Res 57:4838-4848, 1997
    • (1997) Cancer Res , vol.57 , pp. 4838-4848
    • Moyer, J.D.1    Barbacci, E.S.2    Iwata, K.T.3
  • 43
    • 0001076235 scopus 로고    scopus 로고
    • ZD1839, an epidermal growth factor receptor tyrosine kinase inhibitor, upregulates p27Kip1 inducing Gl arrest and enhancing the antitumor effect of interferon alpha
    • abstr
    • Budillon A, Di Gennaro E, Barbarino M, et al: ZD1839, an epidermal growth factor receptor tyrosine kinase inhibitor, upregulates p27Kip1 inducing Gl arrest and enhancing the antitumor effect of interferon alpha. Proc Am Assoc Cancer Res 41:4910, 2000 (abstr)
    • (2000) Proc Am Assoc Cancer Res , vol.41 , pp. 4910
    • Budillon, A.1    Di Gennaro, E.2    Barbarino, M.3
  • 44
    • 0028969852 scopus 로고
    • Apoptosis induced by an anti-epidermal growth factor receptor monoclonal antibody in a human colorectal carcinoma cell line and its delay by insulin
    • Wu X, Fan Z, Masui H, et al: Apoptosis induced by an anti-epidermal growth factor receptor monoclonal antibody in a human colorectal carcinoma cell line and its delay by insulin. J Clin Invest 95:1897-1905, 1995
    • (1995) J Clin Invest , vol.95 , pp. 1897-1905
    • Wu, X.1    Fan, Z.2    Masui, H.3
  • 45
    • 0032572699 scopus 로고    scopus 로고
    • Nuclear targeting of Bax during apoptosis in human colorectal cancer cells
    • Mandal M, Adam L, Mendelsohn J, et al: Nuclear targeting of Bax during apoptosis in human colorectal cancer cells. Oncogene 17:999-1007, 1998
    • (1998) Oncogene , vol.17 , pp. 999-1007
    • Mandal, M.1    Adam, L.2    Mendelsohn, J.3
  • 46
    • 0034038282 scopus 로고    scopus 로고
    • Induction of apoptosis and activation of the caspase cascade by anti-EGF receptor monoclonal antibodies in DiFi human colon cancer cells do not involve the c-jun N-terminal kinase activity
    • Liu B, Fang M, Schmidt M, et al: Induction of apoptosis and activation of the caspase cascade by anti-EGF receptor monoclonal antibodies in DiFi human colon cancer cells do not involve the c-jun N-terminal kinase activity. Br J Cancer 82:1991-1999, 2000
    • (2000) Br J Cancer , vol.82 , pp. 1991-1999
    • Liu, B.1    Fang, M.2    Schmidt, M.3
  • 47
    • 0001223491 scopus 로고    scopus 로고
    • Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases downregulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: Angiogenic implications for signal transduction therapy of solid tumors
    • Petit AM, Rak J, Hung MC, et al: Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases downregulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: Angiogenic implications for signal transduction therapy of solid tumors. Am J Pathol 151:1523-1530, 1997
    • (1997) Am J Pathol , vol.151 , pp. 1523-1530
    • Petit, A.M.1    Rak, J.2    Hung, M.C.3
  • 48
    • 0032972944 scopus 로고    scopus 로고
    • Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice
    • Perrotte P, Matsumoto T, Inoue K, et al: Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice. Clin Cancer Res 5:257-264, 1999
    • (1999) Clin Cancer Res , vol.5 , pp. 257-264
    • Perrotte, P.1    Matsumoto, T.2    Inoue, K.3
  • 49
    • 0034212763 scopus 로고    scopus 로고
    • Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma
    • Bruns CJ, Solorzano CC, Harbison MT, et al: Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. Cancer Res 60:2926-2935, 2000
    • (2000) Cancer Res , vol.60 , pp. 2926-2935
    • Bruns, C.J.1    Solorzano, C.C.2    Harbison, M.T.3
  • 50
    • 0034896362 scopus 로고    scopus 로고
    • Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 ('Iressa'), a selective epidermal growth factor receptor tyrosine kinase inhibitor
    • Ciardiello F, Caputo R, Bianco R, et al: Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 ('Iressa'), a selective epidermal growth factor receptor tyrosine kinase inhibitor. Clin Cancer Res 7:1459-1465, 2001
    • (2001) Clin Cancer Res , vol.7 , pp. 1459-1465
    • Ciardiello, F.1    Caputo, R.2    Bianco, R.3
  • 51
    • 0034652487 scopus 로고    scopus 로고
    • Epidermal growth factor-like ligands differentially up-regulate matrix metalloproteinase 9 in head and neck squamous carcinoma cells
    • O-charoenrat P, Modjtahedi H, Rhys-Evans P, et al: Epidermal growth factor-like ligands differentially up-regulate matrix metalloproteinase 9 in head and neck squamous carcinoma cells. Cancer Res 60:1121-1128, 2000
    • (2000) Cancer Res , vol.60 , pp. 1121-1128
    • O-charoenrat, P.1    Modjtahedi, H.2    Rhys-Evans, P.3
  • 52
    • 0033505391 scopus 로고    scopus 로고
    • Differential modulation of proliferation, matrix metalloproteinase expression and invasion of human head and neck squamous carcinoma cells by c-erbB ligands
    • O-charoenrat P, Rhys-Evans P, Court W, et al: Differential modulation of proliferation, matrix metalloproteinase expression and invasion of human head and neck squamous carcinoma cells by c-erbB ligands. Clin Exp Metastasis 17:631-639, 1999
    • (1999) Clin Exp Metastasis , vol.17 , pp. 631-639
    • O-charoenrat, P.1    Rhys-Evans, P.2    Court, W.3
  • 53
    • 0003018496 scopus 로고    scopus 로고
    • Blockade of EGF-R signaling with anti-EGFR monoclonal antibody (Mab) C225 inhibits matrix metalloproteinase-9 (MMP-9) expression and invasion of human transitional cell carcinoma (TCC) in vitro and in vivo
    • abstr
    • Matsumoto T, Perrotte P, Bar-Eli M, et al: Blockade of EGF-R signaling with anti-EGFR monoclonal antibody (Mab) C225 inhibits matrix metalloproteinase-9 (MMP-9) expression and invasion of human transitional cell carcinoma (TCC) in vitro and in vivo. Proc Am Assoc Cancer Res 39:83, 1998 (abstr)
    • (1998) Proc Am Assoc Cancer Res , vol.39 , pp. 83
    • Matsumoto, T.1    Perrotte, P.2    Bar-Eli, M.3
  • 54
    • 0027290650 scopus 로고
    • Antitumor effects of doxorubicin in combination with anti-epidermal growth factor receptor monoclonal antibodies
    • Baselga J, Norton L, Masui H, et al: Antitumor effects of doxorubicin in combination with anti-epidermal growth factor receptor monoclonal antibodies. J Natl Cancer Inst 85:1327-1333, 1993
    • (1993) J Natl Cancer Inst , vol.85 , pp. 1327-1333
    • Baselga, J.1    Norton, L.2    Masui, H.3
  • 55
    • 0027428571 scopus 로고
    • Antitumor effect of anti-EGF receptor monoclonal antibodies plus cis-Diaminedichloroplatinum (cis-DDP) on well established A431 cell xenografts
    • Fan Z, Baselga J, Masui H, et al: Antitumor effect of anti-EGF receptor monoclonal antibodies plus cis-Diaminedichloroplatinum (cis-DDP) on well established A431 cell xenografts. Cancer Res 53:4637-4642, 1993
    • (1993) Cancer Res , vol.53 , pp. 4637-4642
    • Fan, Z.1    Baselga, J.2    Masui, H.3
  • 56
    • 0001687355 scopus 로고
    • Antitumor activity of paclitaxel in combination with anti-growth factor receptor monoclonal antibodies in breast cancer xenografts
    • abstr
    • Baselga J, Norton L, Coplan K, et al: Antitumor activity of paclitaxel in combination with anti-growth factor receptor monoclonal antibodies in breast cancer xenografts. Proc Am Assoc Cancer Res 35:2262, 1994 (abstr)
    • (1994) Proc Am Assoc Cancer Res , vol.35 , pp. 2262
    • Baselga, J.1    Norton, L.2    Coplan, K.3
  • 57
    • 0032904485 scopus 로고    scopus 로고
    • Antitumor activity of sequential treatment with topotecan and anti-epidermal growth factor receptor antibody
    • Ciardiello F, Bianco R, Damiano V, et al: Antitumor activity of sequential treatment with topotecan and anti-epidermal growth factor receptor antibody. Clin Cancer Res 5:909-916, 1999
    • (1999) Clin Cancer Res , vol.5 , pp. 909-916
    • Ciardiello, F.1    Bianco, R.2    Damiano, V.3
  • 58
    • 0034068319 scopus 로고    scopus 로고
    • Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor
    • Ciardiello F, Caputo R, Bianco R, et al: Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor. Clin Cancer Res 6:2053-2063, 2000
    • (2000) Clin Cancer Res , vol.6 , pp. 2053-2063
    • Ciardiello, F.1    Caputo, R.2    Bianco, R.3
  • 59
    • 0034489914 scopus 로고    scopus 로고
    • Efficacy of cytotoxic agents against human tumor xenographs is markedly enhanced by coadministration of ZD1839 ('Iressa') an inhibitor of tyrosine kinase
    • Sirotnak FM, Zakowsky MF, Miller VA, et al: Efficacy of cytotoxic agents against human tumor xenographs is markedly enhanced by coadministration of ZD1839 ('Iressa') an inhibitor of tyrosine kinase. Clin Cancer Res 6:4885-4892, 2000
    • (2000) Clin Cancer Res , vol.6 , pp. 4885-4892
    • Sirotnak, F.M.1    Zakowsky, M.F.2    Miller, V.A.3
  • 60
    • 0033966576 scopus 로고    scopus 로고
    • In vivo enhancement of tumor radioresponse by C225 antiepidermal growth factor receptor antibody
    • Milas L, Mason K, Hunter N, et al: In vivo enhancement of tumor radioresponse by C225 antiepidermal growth factor receptor antibody. Clin Cancer Res 6:701-708, 2000
    • (2000) Clin Cancer Res , vol.6 , pp. 701-708
    • Milas, L.1    Mason, K.2    Hunter, N.3
  • 61
    • 0000606812 scopus 로고    scopus 로고
    • Combination of ZD1839 ('Iressa'), an EGFR tyrosine kinase inhibitor, and radiotherapy increases antitumor efficacy in a human colon cancer xenograft model
    • abstr
    • Williams K, Telfer B, Stratford I, et al: Combination of ZD1839 ('Iressa'), an EGFR tyrosine kinase inhibitor, and radiotherapy increases antitumor efficacy in a human colon cancer xenograft model. Proc Am Assoc Cancer Res 42:3840, 2001 (abstr)
    • (2001) Proc Am Assoc Cancer Res , vol.42 , pp. 3840
    • Williams, K.1    Telfer, B.2    Stratford, I.3
  • 62
    • 0027442527 scopus 로고
    • Therapeutic potential of chimeric and murine anti-(epidermal growth factor receptor) antibodies in a metastasis model for human melanoma
    • Naramura M, Gillies SD, Mendelsohn J, et al: Therapeutic potential of chimeric and murine anti-(epidermal growth factor receptor) antibodies in a metastasis model for human melanoma. Cancer Immunol Immunother 37:343-349, 1993
    • (1993) Cancer Immunol Immunother , vol.37 , pp. 343-349
    • Naramura, M.1    Gillies, S.D.2    Mendelsohn, J.3
  • 63
    • 0034076307 scopus 로고    scopus 로고
    • Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets
    • Clynes RA, Towers TL, Presta LG, et al: Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets. Nat Med 6:443-446, 2000
    • (2000) Nat Med , vol.6 , pp. 443-446
    • Clynes, R.A.1    Towers, T.L.2    Presta, L.G.3
  • 64
    • 0030697807 scopus 로고    scopus 로고
    • PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner
    • Bos M, Mendelsohn J, Kim YM, et al: PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner. Clin Cancer Res 3:2099-2106, 1997
    • (1997) Clin Cancer Res , vol.3 , pp. 2099-2106
    • Bos, M.1    Mendelsohn, J.2    Kim, Y.M.3
  • 65
    • 0028819660 scopus 로고
    • Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model
    • Goldstein NI, Prewett M, Zuklys K, et al: Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model. Clin Cancer Res 1:1311-1318, 1995
    • (1995) Clin Cancer Res , vol.1 , pp. 1311-1318
    • Goldstein, N.I.1    Prewett, M.2    Zuklys, K.3
  • 66
    • 0001409147 scopus 로고    scopus 로고
    • Safety profile of the monoclonal antibody (MOAB) IMC-C225, an anti-epidermal growth factor receptor (EGFR) used in the treatment of EGFR-positive tumors
    • abstr 1862
    • Cohen R, Falcey JW, Paulter VJ, et al: Safety profile of the monoclonal antibody (MOAB) IMC-C225, an anti-epidermal growth factor receptor (EGFR) used in the treatment of EGFR-positive tumors. Proc Am Soc Clin Oncol 19:474a, 2000 (abstr 1862)
    • (2000) Proc Am Soc Clin Oncol , vol.19
    • Cohen, R.1    Falcey, J.W.2    Paulter, V.J.3
  • 67
    • 0001355931 scopus 로고    scopus 로고
    • Low immunogenicity of a chimeric monoclonal antibody (MOAB), IMC-C225, used to treat epidermal growth factor receptor-positive tumors
    • abstr 808
    • Khazaeli MB, LoBuglio AF, Falcey JW, et al: Low immunogenicity of a chimeric monoclonal antibody (MOAB), IMC-C225, used to treat epidermal growth factor receptor-positive tumors. Proc Am Soc Clin Oncol 19:207a, 2000 (abstr 808)
    • (2000) Proc Am Soc Clin Oncol , vol.19
    • Khazaeli, M.B.1    LoBuglio, A.F.2    Falcey, J.W.3
  • 68
    • 19244366949 scopus 로고    scopus 로고
    • Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin
    • Baselga J, Pfister D, Cooper MR, et al: Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin. J Clin Oncol 18:904-914, 2000
    • (2000) J Clin Oncol , vol.18 , pp. 904-914
    • Baselga, J.1    Pfister, D.2    Cooper, M.R.3
  • 69
    • 0034895886 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-targeted therapy with C225 and cisplatin in patients with head and neck cancer
    • Shin DM, Donato NJ, Perez-Soler R, et al: Epidermal growth factor receptor-targeted therapy with C225 and cisplatin in patients with head and neck cancer. Clin Cancer Res 7:1204-1213, 2001
    • (2001) Clin Cancer Res , vol.7 , pp. 1204-1213
    • Shin, D.M.1    Donato, N.J.2    Perez-Soler, R.3
  • 70
    • 0000583326 scopus 로고    scopus 로고
    • Monoclonal antibody (MoAb) IMC-C225, an anti-epidermal growth factor receptor (EGFR), for patients with EGFR-positive tumors refractory to or in relapse from previous therapeutic regimens
    • abstr 1860
    • Rubin M, Shin D, Pasmantier M, et al: Monoclonal antibody (MoAb) IMC-C225, an anti-epidermal growth factor receptor (EGFR), for patients with EGFR-positive tumors refractory to or in relapse from previous therapeutic regimens. Proc Am Soc Clin Oncol 19:474a, 2000 (abstr 1860)
    • (2000) Proc Am Soc Clin Oncol , vol.19
    • Rubin, M.1    Shin, D.2    Pasmantier, M.3
  • 71
    • 0002823211 scopus 로고    scopus 로고
    • Cetuximab (IMC-C225) plus irinotecan (CPT-11) is active in CPT-11-refractory colorectal cancer (CRC) that expresses epidermal growth factor receptor (EGFR)
    • abstr
    • Saltz L, Rubin M, Hochster H, et al: Cetuximab (IMC-C225) plus irinotecan (CPT-11) is active in CPT-11-refractory colorectal cancer (CRC) that expresses epidermal growth factor receptor (EGFR). Proc Am Soc Clin Oncol 20:7A, 2001 (abstr)
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Saltz, L.1    Rubin, M.2    Hochster, H.3
  • 72
    • 84871470258 scopus 로고    scopus 로고
    • Saltz L, Rubin M, Hochster H, et al: Acne-like rash predicts response in patients ,treated with cetuximab (IMC-225) plus irinotecan (CPT-11) in CPT-11 refractory colorectal cancer that expresses EGFR. Proc AACR-NCI-EORTC. J Clin Invest 68:559, 2001 (suppl, abstr)
    • Saltz L, Rubin M, Hochster H, et al: Acne-like rash predicts response in patients ,treated with cetuximab (IMC-225) plus irinotecan (CPT-11) in CPT-11 refractory colorectal cancer that expresses EGFR. Proc AACR-NCI-EORTC. J Clin Invest 68:559, 2001 (suppl, abstr)
  • 73
    • 0000229081 scopus 로고    scopus 로고
    • Efficacy and safety of the anti-epidermal growth factor antibody IMC-C225 in combination with cisplatin in patients with recurrent squamous cell carcinoma of the head and neck refractory to cisplatin containing chemotherapy
    • abstr
    • Hong WK, Arquette M, Nabell L, et al: Efficacy and safety of the anti-epidermal growth factor antibody IMC-C225 in combination with cisplatin in patients with recurrent squamous cell carcinoma of the head and neck refractory to cisplatin containing chemotherapy. Proc Am Soc Clin Oncol 20:895, 2001 (abstr)
    • (2001) Proc Am Soc Clin Oncol , vol.20 , pp. 895
    • Hong, W.K.1    Arquette, M.2    Nabell, L.3
  • 74
    • 0001407134 scopus 로고    scopus 로고
    • Cetuximab (C225) plus cisplatin/carboplatin is active in patients (pts) with recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN) progressing on a same dose and schedule platinum based agent
    • abstr
    • Baselga J, Trigo JM, Bourthis J, et al: Cetuximab (C225) plus cisplatin/carboplatin is active in patients (pts) with recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN) progressing on a same dose and schedule platinum based agent. Proc Am Soc Clin Oncol 21:900, 2002 (abstr)
    • (2002) Proc Am Soc Clin Oncol , vol.21 , pp. 900
    • Baselga, J.1    Trigo, J.M.2    Bourthis, J.3
  • 75
    • 0001407135 scopus 로고    scopus 로고
    • Single agent IMC-C225 (Erbitux) has activity in CPT-11-refractory colorectal cancer (CRC) that expresses the epidermal growth factor receptor (EGFR)
    • abstr
    • Saltz L, Meropol NJ, Loehrer PJ, et al: Single agent IMC-C225 (Erbitux) has activity in CPT-11-refractory colorectal cancer (CRC) that expresses the epidermal growth factor receptor (EGFR). Proc Am Soc Clin Oncol 21:504, 2002 (abstr)
    • (2002) Proc Am Soc Clin Oncol , vol.21 , pp. 504
    • Saltz, L.1    Meropol, N.J.2    Loehrer, P.J.3
  • 76
    • 0001413605 scopus 로고    scopus 로고
    • Phase III trial comparing cisplatin (C) + placebo (P) to C + anti-epidermal growth factor antibody (EGF-R) C225 in patients (pts) with metastatic/recurrent head & neck cancer (HNC)
    • abstr
    • Burtness BA, Li Y, Flood W, et al: Phase III trial comparing cisplatin (C) + placebo (P) to C + anti-epidermal growth factor antibody (EGF-R) C225 in patients (pts) with metastatic/recurrent head & neck cancer (HNC). Proc Am Soc Clin Oncol 21:901, 2002 (abstr)
    • (2002) Proc Am Soc Clin Oncol , vol.21 , pp. 901
    • Burtness, B.A.1    Li, Y.2    Flood, W.3
  • 77
    • 0001391575 scopus 로고    scopus 로고
    • Phase II study of anti-epidermal growth factor receptor (EGFr) antibody cetuximab (IMC-C225) in combination with gemcitabine in patients with advanced pancreatic cancer
    • abstr
    • Abbruzzese JL, Rosenberg A, Xiong Q, et al: Phase II study of anti-epidermal growth factor receptor (EGFr) antibody cetuximab (IMC-C225) in combination with gemcitabine in patients with advanced pancreatic cancer. Proc Am Soc Clin Oncol 20:518, 2001 (abstr)
    • (2001) Proc Am Soc Clin Oncol , vol.20 , pp. 518
    • Abbruzzese, J.L.1    Rosenberg, A.2    Xiong, Q.3
  • 78
    • 0011720039 scopus 로고    scopus 로고
    • A phase II study of Erbitux (IMC-C225), an epidermal growth factor receptor (EGFR) blocking antibody, in combination with docetaxel in chemotherapy refractory/resistant patients with advanced non-small-cell lung cancer (NSCLC)
    • abstr 1168
    • Kim ES, Mauer AM, Fossella FV, et al: A phase II study of Erbitux (IMC-C225), an epidermal growth factor receptor (EGFR) blocking antibody, in combination with docetaxel in chemotherapy refractory/resistant patients with advanced non-small-cell lung cancer (NSCLC). Proc Am Soc Clin Oncol 21, 2002 (abstr 1168)
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Kim, E.S.1    Mauer, A.M.2    Fossella, F.V.3
  • 79
    • 0035398021 scopus 로고    scopus 로고
    • Phase I study of anti-epidermal growth factor receptor antibody cetuximab in combination with radiation therapy in patients with advanced head and neck cancer
    • Robert F, Ezekiel MP, Spencer SA, et al: Phase I study of anti-epidermal growth factor receptor antibody cetuximab in combination with radiation therapy in patients with advanced head and neck cancer. J Clin Oncol 19:3234-3243, 2001
    • (2001) J Clin Oncol , vol.19 , pp. 3234-3243
    • Robert, F.1    Ezekiel, M.P.2    Spencer, S.A.3
  • 80
    • 0033559606 scopus 로고    scopus 로고
    • Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemotherapy
    • Yang X-D, Jia X-C, Corvalan JRF, et al: Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemotherapy. Cancer Res 59:1236-1243, 1999
    • (1999) Cancer Res , vol.59 , pp. 1236-1243
    • Yang, X.-D.1    Jia, X.-C.2    Corvalan, J.R.F.3
  • 81
    • 0000568621 scopus 로고    scopus 로고
    • Phase II clinical trial evaluating the safety and effectiveness of ABX-EGF in renal cell cancer (RCC)
    • abstr
    • Schwartz G, Dutcher JP, Vogelzang NJ, et al: Phase II clinical trial evaluating the safety and effectiveness of ABX-EGF in renal cell cancer (RCC). Proc Am Soc Clin Oncol 21:91, 2002 (abstr)
    • (2002) Proc Am Soc Clin Oncol , vol.21 , pp. 91
    • Schwartz, G.1    Dutcher, J.P.2    Vogelzang, N.J.3
  • 82
    • 0000363733 scopus 로고    scopus 로고
    • Results of a phase I trial of the humanized anti epidermal growth factor receptor (EGFR) monoclonal antibody EMD 72000 in patients with EGFR expressing solid tumors
    • abstr
    • Tewes M, Schleucher N, Dirsch O, et al: Results of a phase I trial of the humanized anti epidermal growth factor receptor (EGFR) monoclonal antibody EMD 72000 in patients with EGFR expressing solid tumors. Proc Am Soc Clin Oncol 21:378, 2002 (abstr)
    • (2002) Proc Am Soc Clin Oncol , vol.21 , pp. 378
    • Tewes, M.1    Schleucher, N.2    Dirsch, O.3
  • 83
    • 0037968876 scopus 로고    scopus 로고
    • A phase I pharmacokinetic (PK) and serial tumor and skin pharmacodynamic (PD) study of weekly, every 2 weeks or every 3 weeks 1-hour (h) infusion EMD72000, an humanized monoclonal anti-epidermal growth factor receptor (EGFR) antibody, in patients (p) with advanced tumors known to overexpress the EGFR
    • suppl 7, abstr
    • Tabernero J, Rojo F, JimÈnez E, et al: A phase I pharmacokinetic (PK) and serial tumor and skin pharmacodynamic (PD) study of weekly, every 2 weeks or every 3 weeks 1-hour (h) infusion EMD72000, an humanized monoclonal anti-epidermal growth factor receptor (EGFR) antibody, in patients (p) with advanced tumors known to overexpress the EGFR. Eur J Cancer 38:69, 2002 (suppl 7, abstr)
    • (2002) Eur J Cancer , vol.38 , pp. 69
    • Tabernero, J.1    Rojo, F.2    JimÈnez, E.3
  • 84
    • 0010433354 scopus 로고    scopus 로고
    • Use of the anti-EGFR antibody h-R3 in combination with radiotherapy in the treatment of advanced head and neck cancer
    • abstr
    • Crombet T, Osorio M, Cruz T, et al: Use of the anti-EGFR antibody h-R3 in combination with radiotherapy in the treatment of advanced head and neck cancer. Proc Am Soc Clin Oncol 21:53, 2002 (abstr)
    • (2002) Proc Am Soc Clin Oncol , vol.21 , pp. 53
    • Crombet, T.1    Osorio, M.2    Cruz, T.3
  • 85
    • 0028826233 scopus 로고
    • In vitro and in vivo stability and anti-tumour efficacy of an anti-EGFR/anti-CD3 F(ab′)2 bispecific monoclonal antibody
    • Negri DR, Tosi E, Valota O, et al: In vitro and in vivo stability and anti-tumour efficacy of an anti-EGFR/anti-CD3 F(ab′)2 bispecific monoclonal antibody. Br J Cancer 72:928-933, 1995
    • (1995) Br J Cancer , vol.72 , pp. 928-933
    • Negri, D.R.1    Tosi, E.2    Valota, O.3
  • 86
    • 0030727901 scopus 로고    scopus 로고
    • Clinical experience with CD64-directed immunotherapy
    • Curnow RT: Clinical experience with CD64-directed immunotherapy. An overview. Cancer Immunol Immunother 45:210-215, 1997
    • (1997) An overview. Cancer Immunol Immunother , vol.45 , pp. 210-215
    • Curnow, R.T.1
  • 87
    • 0000375696 scopus 로고    scopus 로고
    • A phase I trial of the epidermal growth factor receptor (EGFR)-directed bispecific antibody (BsAB) MDX-447 in patients with solid tumors
    • abstr 1667
    • Pfister DG, Lipton A, Belt R, et al: A phase I trial of the epidermal growth factor receptor (EGFR)-directed bispecific antibody (BsAB) MDX-447 in patients with solid tumors. Proc Am Soc Clin Oncol 18:433a, 1999 (abstr 1667)
    • (1999) Proc Am Soc Clin Oncol , vol.18
    • Pfister, D.G.1    Lipton, A.2    Belt, R.3
  • 88
    • 0031567893 scopus 로고    scopus 로고
    • Cytolytic and cytostatic properties of an anti-human Fc gammaRI (CD64) × epidermal growth factor bispecific fusion protein
    • Goldstein J, Graziano RF, Sundarapandiyan K, et al: Cytolytic and cytostatic properties of an anti-human Fc gammaRI (CD64) × epidermal growth factor bispecific fusion protein. J Immunol 158:872-879, 1997
    • (1997) J Immunol , vol.158 , pp. 872-879
    • Goldstein, J.1    Graziano, R.F.2    Sundarapandiyan, K.3
  • 89
    • 0000285504 scopus 로고    scopus 로고
    • ZD1839, an epidermal growth factor tyrosine kinase inhibitor selected for clinical development
    • abstr
    • Woodburn JR, Barker AJ, Gibson KH, et al: ZD1839, an epidermal growth factor tyrosine kinase inhibitor selected for clinical development. Proc Am Assoc Cancer Res 38:4521, 1997 (abstr)
    • (1997) Proc Am Assoc Cancer Res , vol.38 , pp. 4521
    • Woodburn, J.R.1    Barker, A.J.2    Gibson, K.H.3
  • 90
    • 0000046996 scopus 로고    scopus 로고
    • ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI): Inhibition of c-fos mRNA, an intermediate marker of EGFR activation, correlates with tumor growth inhibition
    • abstr
    • Woodburn J, Kendrcw J, Fennell M, et al: ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI): Inhibition of c-fos mRNA, an intermediate marker of EGFR activation, correlates with tumor growth inhibition. Proc Am Assoc Cancer Res 41:2552, 2000 (abstr)
    • (2000) Proc Am Assoc Cancer Res , vol.41 , pp. 2552
    • Woodburn, J.1    Kendrcw, J.2    Fennell, M.3
  • 91
    • 0002200965 scopus 로고    scopus 로고
    • Intermittent oral ZD1839 (Iressa), a novel epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), shows evidence of good tolerability and activity: Final results from a phase I study
    • abstr
    • Ferry D, Hammond L, Ranson M, et al: Intermittent oral ZD1839 (Iressa), a novel epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), shows evidence of good tolerability and activity: Final results from a phase I study. Proc Am Soc Clin Oncol 19:5E, 2000 (abstr)
    • (2000) Proc Am Soc Clin Oncol , vol.19
    • Ferry, D.1    Hammond, L.2    Ranson, M.3
  • 92
    • 0000004189 scopus 로고    scopus 로고
    • A phase I intermittent dose-escalation trial of ZD1839 (Iressa) in Japanese patients with solid malignant tumors
    • abstr
    • Nakagawa K, Yamamoto N, Kudoh S, et al: A phase I intermittent dose-escalation trial of ZD1839 (Iressa) in Japanese patients with solid malignant tumors. Proc Am Soc Clin Oncol 19:711, 2000 (abstr)
    • (2000) Proc Am Soc Clin Oncol , vol.19 , pp. 711
    • Nakagawa, K.1    Yamamoto, N.2    Kudoh, S.3
  • 93
    • 0000240853 scopus 로고    scopus 로고
    • Continuous administration of ZD1839 (Iressa), a novel oral epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), in patients with five selected tumor types: Evidence of activity and good tolerability
    • abstr
    • Baselga J, Herbst R, LoRusso P, et al: Continuous administration of ZD1839 (Iressa), a novel oral epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), in patients with five selected tumor types: Evidence of activity and good tolerability. Proc Am Soc Clin Oncol 19:686, 2000 (abstr)
    • (2000) Proc Am Soc Clin Oncol , vol.19 , pp. 686
    • Baselga, J.1    Herbst, R.2    LoRusso, P.3
  • 94
    • 0036139727 scopus 로고    scopus 로고
    • Pharmacodynamic studies of the EGF receptor inhibitor ZD1839 (Iressa) in skin from cancer patients: Histopathological and molecular consequences of receptor inhibition
    • Albanell J, Rojo F, Averbuch S, et al: Pharmacodynamic studies of the EGF receptor inhibitor ZD1839 (Iressa) in skin from cancer patients: Histopathological and molecular consequences of receptor inhibition. J Clin Oncol 20:110-124, 2002
    • (2002) J Clin Oncol , vol.20 , pp. 110-124
    • Albanell, J.1    Rojo, F.2    Averbuch, S.3
  • 95
    • 0003336304 scopus 로고    scopus 로고
    • Final results from a phase II trial of ZD1839 (Iressa) for patients with advanced non-small-cell lung cancer (IDEAL 1)
    • abstr 1188
    • Fukuoka M, Yano S, Giaccone G, et al: Final results from a phase II trial of ZD1839 (Iressa) for patients with advanced non-small-cell lung cancer (IDEAL 1). Proc Am Soc Clin Oncol 21, 2002 (abstr 1188)
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Fukuoka, M.1    Yano, S.2    Giaccone, G.3
  • 96
    • 0001303063 scopus 로고    scopus 로고
    • A phase II trial of ZD1839 (Iressa) in advanced non-small cell lung cancer (NSCLC) patients who had failed platinum- and docetaxel-based regimens (IDEAL 2)
    • abstr 1166
    • Kris MG, Natale RB, Herbst RS, et al: A phase II trial of ZD1839 (Iressa) in advanced non-small cell lung cancer (NSCLC) patients who had failed platinum- and docetaxel-based regimens (IDEAL 2). Proc Am Soc Clin Oncol 21, 2002 (abstr 1166)
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Kris, M.G.1    Natale, R.B.2    Herbst, R.S.3
  • 97
    • 0001159137 scopus 로고    scopus 로고
    • A pilot trial demonstrates the safety of ZD1839 (Iressa), an oral epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), in combination with carboplatin (C) and paclitaxel (P) in previously untreated advanced non-small cell lung cancer (NSCLC)
    • abstr 1301
    • Miller V, Johnson D, Heelan R, et al: A pilot trial demonstrates the safety of ZD1839 (Iressa), an oral epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), in combination with carboplatin (C) and paclitaxel (P) in previously untreated advanced non-small cell lung cancer (NSCLC). Proc Am Soc Clin Oncol 20:326a, 2001 (abstr 1301)
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Miller, V.1    Johnson, D.2    Heelan, R.3
  • 98
    • 84871466915 scopus 로고    scopus 로고
    • Giaccone G, Gonzales-Larriba J, Smit E, et al: ZD1839 (Iressa), an orally-active, selective, epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), is well tolerated in combination with gemcitabine and cisplatin, in patients with advanced solid tumours: Preliminary tolerability, efficacy and pharmacokinetic results. Eur J Cancer 37:102, 2001 (suppl 6, abstr)
    • Giaccone G, Gonzales-Larriba J, Smit E, et al: ZD1839 (Iressa), an orally-active, selective, epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), is well tolerated in combination with gemcitabine and cisplatin, in patients with advanced solid tumours: Preliminary tolerability, efficacy and pharmacokinetic results. Eur J Cancer 37:102, 2001 (suppl 6, abstr)
  • 99
    • 0002806626 scopus 로고    scopus 로고
    • A phase III trial of ZD1839 (Iressa) in combination with gemcitabine and cisplatin in chemotherapy-naive patients with advanced non-small-cell lung cancer (INTACT 1)
    • suppl, abstr
    • Giaccone G, Johnson D, Manegold C, et al: A phase III trial of ZD1839 (Iressa) in combination with gemcitabine and cisplatin in chemotherapy-naive patients with advanced non-small-cell lung cancer (INTACT 1). Ann Oncol 5:40, 2002 (suppl, abstr)
    • (2002) Ann Oncol , vol.5 , pp. 40
    • Giaccone, G.1    Johnson, D.2    Manegold, C.3
  • 100
    • 84871473152 scopus 로고    scopus 로고
    • Johnson D, Herbst R, Giaccone G, et al: ZD1839 (Iressa) in combination with paclitaxel & carboplatin in chemotherapy-naive patients with advanced non-small-cell lung cancer (NSCLC): Results from a phase III clinical trial (INTACT 2). Ann Oncol 5:468, 2002 (suppl, abstr)
    • Johnson D, Herbst R, Giaccone G, et al: ZD1839 (Iressa) in combination with paclitaxel & carboplatin in chemotherapy-naive patients with advanced non-small-cell lung cancer (NSCLC): Results from a phase III clinical trial (INTACT 2). Ann Oncol 5:468, 2002 (suppl, abstr)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.