Nano-sized titanium dioxide-induced splenic toxicity: A biological pathway explored using microarray technology

Journal of Hazardous Materials

Volumn 278, Issue , 2014, Pages 180-188

  Sheng, Lei ^a   Wang, Ling ^b   Sang, Xuezi ^a   Zhao, Xiaoyang ^a   Hong, Jie ^a   Cheng, Shen ^a   Yu, Xiaohong ^a   Liu, Dong ^a   Xu, Bingqing ^a   Hu, Renping ^a   Sun, Qingqing ^a   Cheng, Jie ^a   Cheng, Zhe ^a   Gui, Suxin ^a   Hong, Fashui ^a  

^a MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

^b SOOCHOW UNIVERSITY   (China)

Author keywords

Gene expressed profile; Spleen injury; Splenic dysfunction; Titanium dioxide nanoparticles

Indexed keywords

CELL DEATH; GENE EXPRESSION; MAMMALS; NANOPARTICLES; OXIDES; SIGNAL TRANSDUCTION; TOXICITY;

GENE-EXPRESSED PROFILE; INTRAGASTRIC ADMINISTRATION; MACROPHAGE INFILTRATIONS; MICROARRAY TECHNOLOGIES; MOLECULAR MECHANISM; SPLEEN INJURY; SPLENIC DYSFUNCTION; TITANIUM DIOXIDE NANOPARTICLES;

TITANIUM DIOXIDE;

ACTIVATING TRANSCRIPTION FACTOR 4; B7 ANTIGEN; CD14 ANTIGEN; CD28 ANTIGEN; CD86 ANTIGEN; CXCL13 CHEMOKINE; CYTOCHROME P450 2E1; EOTAXIN 2; EXTRACELLULAR SUPEROXIDE DISMUTASE; MELATONIN 1 RECEPTOR; MELATONIN 2 RECEPTOR; TITANIUM DIOXIDE NANOPARTICLE; NANOPARTICLE; RNA; TITANIUM; TITANIUM DIOXIDE;

APOPTOSIS; BIOASSAY; GENE EXPRESSION; IMMUNE RESPONSE; INFILTRATION; INJURY; MOLECULAR ANALYSIS; OXIDE; PARTICLE SIZE; RODENT; TOXICITY;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BODY WEIGHT; CELL DIVISION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOSKELETON; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; INFLAMMATION; ION TRANSPORT; METABOLIC STRESS; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; SPLEEN INJURY; ANIMAL; BLOOD CELL COUNT; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENETICS; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; ORGAN SIZE; PATHOLOGY; SPLEEN; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

ANIMALS; BLOOD CELL COUNT; FEMALE; GENE EXPRESSION PROFILING; MICE, INBRED ICR; MICROARRAY ANALYSIS; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; ORGAN SIZE; RNA; SPLEEN; TITANIUM;

EID: 84902958103     PISSN: 03043894     EISSN: 18733336     Source Type: Journal    
DOI: 10.1016/j.jhazmat.2014.06.005     Document Type: Article

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