Spleen injury and apoptotic pathway in mice caused by titanium dioxide nanoparticules

Toxicology Letters

Volumn 195, Issue 2-3, 2010, Pages 161-168

  Li, Na ^a   Duan, Yanmei ^a   Hong, Mengmeng ^a   Zheng, Lei ^a   Fei, Min ^a   Zhao, Xiaoyang ^a   Wang, Jue ^a   Cui, Yaling ^a   Liu, Huiting ^a   Cai, Jingwei ^a   Gong, Songjie ^a   Wang, Han ^a   Hong, Fashui ^a  

^a SOOCHOW UNIVERSITY   (China)

Author keywords

Apoptotic pathway; Mice; Oxidative stress; Spleen; Titanium dioxide nanoparticules

Indexed keywords

ACTIN; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; MESSENGER RNA; NANOPARTICLE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; TITANIUM DIOXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL ULTRASTRUCTURE; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOMODULATION; LIPID PEROXIDATION; LYMPH NODE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPLEEN CELL; SPLEEN INJURY;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 9; CYTOKINES; FEMALE; LIPID PEROXIDATION; METAL NANOPARTICLES; MICE; MICE, INBRED ICR; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; SPLEEN; TITANIUM;

MUS;

EID: 77952551025     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2010.03.1116     Document Type: Article

References (51)

1. Afaq F., Abidi P., Matin R., Rahman Q. Cytotoxicity, pro-oxidant effects and antioxidant depletion in rat lung alveolar macrophages exposed to ultrafine titanium dioxide. J. Appl. Toxicol. 1998, 18:307-312.
2. Arys A., Philippart C., Dourov N., He Y., Le Q.T., Pireaux J.J. Analysis of titanium dental implants after failure of osseointegration: combined histological, electron microscopy, and X-ray photoelectron spectroscopy approach. J. Biomed. Mater. Res. 1998, 43:300-312.
3. Bernier J., Brousseau P., Krystyniak K., Tryphonas H., Fournier M. Immunotoxicity of heavy metals in relation to Great Lakes. Environ. Health Perspect. 1995, 103(Suppl. 9):23-34.
4. Borm P.J., Robbins D., Haubold S., Kuhlbusch T., Fissan H., Donaldson K., Schins R., Stone V., Kreyling W., Lademann J., Krutmann J., Warheit D., Oberdorster E. The potential risks of nanomaterials: a review carried out for ECETOC. Particle Fibre Toxicol. 2006, 3:11.
5. Brien W.W., Salvati E.A., Betts F., Bullough P., Wright T., Rimnac C., Buly R., Garvin K. Metal levels in cemented total hip arthroplasty. A comparison of well-fixed and loose implants. Clin. Orthop. Relat. Res. 1992, 66-74.
6. Buege J.A., Aust S.D. Microsomal lipid peroxidation. Methods Enzymol. 1978, 52:302-310.
7. Buly R.L., Huo M.H., Salvati E., Brien W., Bansal M. Titanium wear debris in failed cemented total hip arthroplasty. An analysis of 71 cases. J. Arthroplasty 1992, 7:315-323.
8. Burns L.A., Meade B.J., Munson A.E. Toxic responses of the immune system. Cassaret and Doull's Toxicology: The Basic Science of Poisons 1995, 355-402. McGraw-Hill, New York. C.D. Klaassen (Ed.).
9. Chen J.Y., Dong X., Zhao J., Tang G.P. In vivo acute toxicity of titanium dioxide nanoparticles to mice after intraperitoneal injection. J. Appl. Toxicol. 2009, 29:330-337.
10. Chen F.Q., Gerion D. Fluorescent CdSe/ZnS nanocrystal-peptide conjugates for long-term, nontoxic imaging and nuclear targeting in living cells. Nano Lett. 2004, 4:1827-1832.
11. 3 composite membranes for environmental applications. Appl. Catal. B-Environ. 2006, 63:60-67.
12. Cunningham B.W., Orbegoso C.M., Dmitriev A.E., Hallab N.J., Sefter J.C., McAfee P.C. The effect of titanium particulate on development and maintenance of a posterolateral spinal arthrodesis: an in vivo rabbit model. Spine 2002, 27:1971-1981.
13. Duan Y.M., Liu J., Ma L.L., Li N., Liu H.T., Wang J., Zheng L., Liu C., Wang X.F., Zhang X.Y., Yan J.Y., Wang H., Hong F.S. Toxicological characteristics of nanoparticulate anatase titanium dioxide in mice. Biomaterials 2010, 31:894-899.
14. Dunford R., Salinaro A., Cai L., Serpone N., Horikoshi S., Hidaka H., Knowland J. Chemical oxidation and DNA damage catalyzed by inorganic sunscreen ingredients. Toxicol. Lett. 1995, 80:61-67.
15. 2. AIChE J. 2005, 51:2298-2310.
16. Federici G., Shaw B.J., Handy R.D. Toxicity of titanium dioxide nanoparticles to rainbow trout (Oncorhynchus mykiss): Gill injury, oxidative stress, and other physiological effects. Aquat. Toxicol. 2007, 84:415-430.
17. Fisher J., Egerton T. Kirk-Othmer Encyclopedia of Chemical Technology 2001, John Wiley & Sons, New York, (Titanium Compounds, Inorganic).
18. Fridovich I. The biology in oxygen radical. Science 1978, 201:875-888.
19. Gurr J., Wang A.S.S., Chen C., Jan K. Ultrafine titanium dioxide particle in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells. Toxicology 2005, 213:66-73.
20. Hockenbery D.M., Oltvai Z.N., Yin X.M., Milliman C.L., Korsmeyer S.J. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 1993, 75:241-251.
21. Jiang W., Kim B.Y.S., Rutka J.T., Chan W.C.W. Nanoparticle-mediated cellular response is size-dependent. Nat. Nanotechnol. 2008, 3:145-150.
22. Kandasamy K., Srinivasula S.M., Alnemri E.S., Thompson C.B., Korsmeyer S.J., Bryant J.L., Srivastava R.K. Involvement of proapoptotic molecules Bax and Bak in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced mitochondrial disruption and apoptosis: differential regulation of cytochrome c and Smac/DIABLO release. Cancer Res. 2003, 63:1712-1721.
23. Ke L.D., Chen Z. A reliability test of standard-based quantitative PCR: exogenous vs endogenous standards. Mol. Cell. Probes 2000, 14(2):127-135.
24. Khangarot B.S., Rathore R.S., Tripathi D.M. Effects of chromium on humoral and cell-mediated immune responses and host resistance to disease in a fresh catfish, Saccobranchus fosillis (Bloch). Ecotoxicol. Environ. Safe. 1999, 43:11-20.
25. Krocova Z., Macela A., Kroca M., Hernychova L. The immunomodulatory effects of lead and cadmium on the cells of immune system in vitro. Toxicol. In Vitro 2000, 14:33-40.
26. Lawrence D.A., McCabe M.J. Immunomodulation by metals. Int. Immunopharmacol. 2002, 2:293-302.
27. 2 and liver DNA from mice in vivo. Nanoscale Res. Lett. 2010, 5:108-115.
28. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001, 25:402-408.
29. 2 particles. Biol. Trace Elem. Res. 2009, 129(1):170-180.
30. 2 to mice: liver injury, oxidative stress. Toxicol. Environ. Chem. 2010, 92(1):175-186.
31. Liu R., Yin L.H., Pu Y.P., Liang G.Y., Zhang J., Su Y.Y., Xiao Z.P., Ye B. Pulmonary toxicity induced by three forms of titanium dioxide nanoparticles via intra-tracheal instillation in rats. Prog. Nat. Sci. 2009, 19(5):573-579.
32. Liu W.H., David A. Saint validation of a quantitative method for real time PCR kinetics. Biophys. Res. Commun. 2002, 294:347-353.
33. Long T.C., Saleh N., Tilton R.D., Lowry G., Veronesi B. Titanium dioxide (P25) produces reactive oxygen species in immortalized brain microglia (BV2): implications for nanoparticle neurotoxicity. Environ. Sci. Technol. 2006, 40:4346-4352.
34. 2 stimulates ROS in brain microglia and damages neurons in vitro. Environ. Health Perspect. 2007, 115:1631-1637.
35. Lynch I., Dawson K.A., Linse S. Detecting cryptic epitopes created by nanoparticles. Science's STKE-Signal Transduction Knowledge Environ. 2006, 14.
36. 2. Nanoscale Res. Lett. 2009, 4:1275-2128.
37. 2 delivered to the abdominal cavity. Biomaterials 2010, 31:99-105.
38. Ne A., Xia T., Madler L., Li N. Toxic potential of materials at the nanolevel. Science 2006, 311:622-627.
39. Nel A., Xia T., Madler L., Li N. Toxic potential of materials at the nanolevel. Science 2006, 311(5761):622-627.
40. Nourooz-Zadeh J., Tajaddini-Sarmadi J., Wolff S.P. Measurement of plasma hydroperoxide concentrations by the ferrous oxidation-xylenol orange assay in conjunction with triphenylphosphine. Anal. Biochem. 1994, 220:403-409.
41. Oliveira C.P., Lopasso F.P., Laurindo F.R., Leitao R.M., Laudanna A.A. Protection against liver ischemia-reperfusion injury in rats by silymarin or verapamil. Transplant. Proc. 2001, 33:3010-3014.
42. Ott M., Gogvadze V., Orrenius S., Zhivotovsky B. Mitochondria, oxidative stress and cell death. Apoptosis 2007, 12(5):913-922.
43. Scown T.M., van Aerle R.Y., Johnston B.D., Cumberland S., Lead J.R., Richard O., Tyler C.R. High doses of intravenously administered titanium dioxide nanoparticles accumulate in the kidneys of rainbow trout but with no observable impairment of renal function. Toxicol. Sci. 2009, 109(2):372-380.
44. Suliman A., Lam A., Datta R., Srivastava R.K. Intracellular mechanisms of TRAIL: apoptosis through mitochondrial-dependent and -independent pathways. Oncogene 2001, 20:2122-2133.
45. Tarabishy A.B., Aldabagh B., Sun Y., Imamura Y., Mukherjee P.K., Lass J.H., Ghannoum M.A., Pearlman E. MyD88 regulation of Fusarium keratitis is dependent on TLR4 and IL-1R1 but not TLR2. J. Immunol. 2008, 181:593-600.
46. Ueda S., Masutani H., Nakamura H., Tanaka T., Ueno M., Yodoi J. Redox control of cell death. Antioxid. Redox Signal. 2002, 4(3):405-414.
47. Wang J.X., Zhou G.Q., Chen C.Y., Yu H.W., Wang T.C., Ma Y.M., Jia G., Gao Y.X., Li B., Sun J., Li Y.F., Jia F., Zhao Y.L., Chai Z.F. Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration. Toxicol. Lett. 2007, 168:176-185.
48. 2 nanoparticles. Toxicology 2008, 254:82-90.
49. 2 particles: differential responses related to surface properties. Toxicology 2007, 230:90-104.
50. 2 particles as a component of nanoparticle risk management. Toxicol. Lett. 2007, 171:99-110.
51. Yao J.C., Jiang Z.Z., Duan W.G., Huang J.F., Zhang L.Y., Hu L., Li F., Xiao Y.J., Shu B., Liu C.H. Involvement of mitochondrial pathway in triptolide-induced cytotoxicity in human normal liver L-02 cells. Biol. Pharm. Bull. 2008, 31:592-597.