ATF4 and the integrated stress response are induced by ethanol and cytochrome P450 2E1 in human hepatocytes

Journal of Hepatology

Volumn 54, Issue 4, 2011, Pages 729-737

  Magne, Laurent ^a,b,e   Blanc, Etienne ^a,b   Legrand, Beatrice ^a,b   Lucas, Danièle ^c   Barouki, Robert ^a,b,d   Rouach, Hélène ^a,b   Garlatti, Michèle ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c UNIVERSITÉ DE BRETAGNE OCCIDENTALE   (France)

^d HÔPITAL NECKER ENFANTS MALADES   (France)

^e UNIVERSITÉ DE TOULOUSE   (France)

Author keywords

ATF4; CYP2E1; Ethanol; Integrated stress response; Liver; Toxicity

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; ACTIVATING TRANSCRIPTION FACTOR 4; ALCOHOL; ASPARAGINE; CYTOCHROME P450 2E1; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 34; HEME OXYGENASE 1; INITIATION FACTOR 2ALPHA; REACTIVE OXYGEN METABOLITE; SOMATOMEDIN BINDING PROTEIN 1; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ADENOVIRUS INFECTION; APOPTOSIS; ARTICLE; CELL DEATH; CELL SURVIVAL; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STRESS; TRANSCRIPTION REGULATION; UPREGULATION; WESTERN BLOTTING;

ACTIVATING TRANSCRIPTION FACTOR 4; CELLS, CULTURED; CYTOCHROME P-450 CYP2E1; ETHANOL; EUKARYOTIC INITIATION FACTOR-2; GENE EXPRESSION; HEP G2 CELLS; HEPATOCYTES; HUMANS; LIVER DISEASES, ALCOHOLIC; RISK FACTORS; RNA, MESSENGER; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL;

EID: 79952698822     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2010.07.023     Document Type: Article

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