Neurotoxicity and gene-expressed profile in brain-injured mice caused by exposure to titanium dioxide nanoparticles

Journal of Biomedical Materials Research - Part A

Volumn 102, Issue 2, 2014, Pages 470-478

  Ze, Yuguan ^a   Hu, Renping ^a   Wang, Xiaochun ^a   Sang, Xuezi ^a   Ze, Xiao ^a   Li, Bi ^a   Su, Junju ^a   Wang, Yuan ^a   Guan, Ning ^a   Zhao, Xiaoyang ^a   Gui, Suxin ^a   Zhu, Liyuan ^a   Cheng, Zhe ^a   Cheng, Jie ^a   Sheng, Lei ^a   Sun, Qingqing ^a   Wang, Ling ^a   Hong, Fashui ^a,b  

^a SOOCHOW UNIVERSITY   (China)

^b Ministry of Science and Technology and Jiangsu Province   (China)

Author keywords

brain damage; gene expression profiling; mice; oxidative stress; titanium dioxide nanoparticles

Indexed keywords

BRAIN DAMAGE; GENE EXPRESSION PROFILING; HIPPOCAMPAL CELLS; LONG TERM EXPOSURE; MICE; MOLECULAR MECHANISM; NASAL ADMINISTRATION; TITANIUM DIOXIDE NANOPARTICLES;

AMINO ACIDS; CELL DEATH; GENE EXPRESSION; MAMMALS; NANOPARTICLES; OXIDATIVE STRESS; OXIDES; PROTEINS; SIGNAL TRANSDUCTION; TOXICITY;

TITANIUM DIOXIDE;

CYSTEINE; CYSTEINE SERINE RICH NUCLEAR PROTEIN 1; CYTOCHROME P450 2E1; DDIT4 PROTEIN; KREV INTERACTION TRAPPED PROTEIN 1; NANOPARTICLE; NUCLEAR PROTEIN; PROTEIN; PROTEIN SERINE THREONINE KINASE; TITANIUM DIOXIDE; TITANIUM DIOXIDE NANOPARTICLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN; BRAIN DEVELOPMENT; BRAIN INJURY; BRAIN TOXICITY; CONTROLLED STUDY; DNA REPAIR; DOWN REGULATION; FEMALE; GENE EXPRESSION; GENE FUNCTION; GLIA CELL; IMMUNE RESPONSE; LEARNING; MALE; MEMORY; METABOLISM; MICROARRAY ANALYSIS; MOUSE; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; TISSUE NECROSIS; UPREGULATION;

BRAIN DAMAGE; GENE EXPRESSION PROFILING; MICE; OXIDATIVE STRESS; TITANIUM DIOXIDE NANOPARTICLES;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN; BRAIN INJURIES; CELL PROLIFERATION; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; MICE; MICE, INBRED ICR; NANOPARTICLES; NERVE TISSUE PROTEINS; NEUROGLIA; NEUROTOXICITY SYNDROMES; OXIDATIVE STRESS; SUNSCREENING AGENTS; TITANIUM;

EID: 84890563090     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.34705     Document Type: Article

References (46)

1. 2 particles as a component of nanoparticle risk management. Toxicol Lett 2007; 171: 99-110.
2. Colvin VL,. The potential environmental impact of engineered nanomaterials. Nat Biotechnol 2003; 21: 1166-1170.
3. Long TC, Tajuba J, Sama P, Saleh N, Swartz C, Parker J, Hester S, Lowry GV, Veronesi B,. Nanosize titanium dioxide stimulates reactive oxygen species in brain microglia and damages neurons in vitro. Environ Health Perspect 2007; 115 (11): 1631-1637.
4. 2 nanoparticles. Toxicology 2008; 254: 82-90.
5. 2 nanoparticles in the anatase, rutile crystal phases. Toxicol Lett 2008; 183: 72-80.
6. 2 nanoparticles in hairless mice and porcine skin after subchronic dermal exposure. Toxicol Lett 2009; 191: 1-8.
7. 2 delivered to the abdominal cavity. Biomaterials 2010; 31: 99-105.
8. 2 nanoparticles. Biomaterials 2010; 31: 8043-8050.
9. Shin JA, Lee E J, Seo SM, Kim HS, Kang JL, Park EM,. Nanosized titanium dioxide enhanced inflammatory responses in the septic brain of mouse. Neuroscience 2010; 165: 445-454.
10. Laakso MP, Lehtovirta M, Partanen K, Riekkinen PJ, Soininen H,. Hippocampus in Alzheimer's disease: A 3-year follow-up MRI study. Biol Psychiatr 2006; 6: 557-561.
11. Hu RP, Zheng L, Zhang T, Cui YL, Gao GD, Cheng Z, Chen J, Tang M, Hong FS,. Molecular mechanism of hippocampal apoptosis of mice following exposure to titanium dioxide nanoparticles. J Hazard Mater 2011; 191: 32-40.
12. 2 nanoparticles on synaptic plasticity in hippocampal dentate gyrus area: An in vivo study in anesthetized rats. Biol Trace Elem Res 2011; 143: 1616-1628.
13. Shimizu M, Tainaka H, Oba T, Mizuo K, Umezawa M, Takeda K,. Maternal exposure to nanoparticulate titanium dioxide during the prenatal period alters gene expression related to brain development in the mouse. Part Fibre Toxicol 2009; 6: 20.
14. Jackson P, Halappanavar S, Hougaard KS, Williams A, Madsen AM, Lamson JS, Andersen O, Yauk C, Wallin H, Vogel U,. Maternal inhalation of surface-coated nanosized titanium dioxide (UV-Titan) in C57BL/6 mice: Effects in prenatally exposed offspring on hepatic DNA damage and gene expression. Nanotoxicology 2013; 7 (1): 85-96.
15. Tochigi M, Iwamoto K, Bundo M, Sasaki T, Kato N, Kato T,. Gene expression profiling of major depression and suicide in the prefrontal cortex of postmortem brains. Neurosci Res 2008; 60: 184-191.
16. Yang P, Lu C, Hua N, Du Y,. Titanium dioxide nanoparticles co-doped with Fe3+ and Eu3+ ions for photocatalysis. Mater Lett 2002; 57: 794-801.
17. National Institutes of Health (NIH). Guide for the Care and Use of Laboratory Animals. Washington: National Academy Press; 1996.
18. Wang JX, Zhou GQ, Chen CY, Yu HW, Wang TC, Ma YM, Jia G, Gao YX, Li B, Sun J, Li YF, Jia F, Zhao YL, Chai ZF,. Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration. Toxicol Lett 2007; 168: 176-185.
19. Bregman CL, Adler RR, Morton DG, Regan KS, Yano BL,. Recommended tissue list for histopathologic examination in repeat-dose toxicity and carcinogenicity studies: A proposal of the society of toxicologic pathology (STP). Toxicol Pathol 2003; 31 (2): 252-253.
20. Oliveira CP, Lopasso FP, Laurindo FR, Leitao RM, Laudanna AA,. Protection against liver ischemia-reperfusion injury in rats by silymarin or verapamil. Transpl Proc 2001; 33: 3010-3014.
21. Nourooz-Zadeh J, Tajaddini-Sarmadi J, Wolff SP,. Measurement of plasma hydroperoxide concentrations by the ferrous oxidation-xylenol orange assay in conjunction with triphenylphosphine. Anal Biochem 1994; 220: 403-409.
22. Buege JA, Aust SD,. Microsomal lipid peroxidation. Meth Enzymol 1978; 52: 302-310.
23. Fagan JM, Bogdan GS, Sohar I,. Quantitation of oxidative damage to tissue proteins. Int J Biochem Cell Biol 1999; 31: 751-757.
24. Kacharmina JE, Crino PB, Eberwine J,. Preparation of cDNA from single cells and subcellular regions. cDNA preparation and characterization. Meth Enzymol 1999; 303: 13-18.
25. You YH, Song YY, Meng FL, He LH, Zhang MJ, Yan XM, Zhang JZ,. Time-series gene expression profiles in AGS cells stimulated with Helicobacter pylori. World J Gastroenterol 2010; 16: 1385-1396.
26. Grober Oli MV, Mutarelli M, Giurato G, Ravo M, Cicatiello L, De Filippo MR, Ferraro L, Nassa G, Papa MF, Paris O, Tarallo R, Luo S, Schroth GP, Benes V, Weisz A,. Global analysis of estrogen receptor beta binding to breast cancer cell genome reveals an extensive interplay with estrogen receptor alpha for target gene regulation. BMC Genom 2011; 12: 36.
27. Ke LD, Chen Z,. A reliability test of standard-based quantitative PCR: Exogenous vs endogenous standards. Mol Cell Probes 2000; 14 (2): 127-135.
28. Liu WH, Saint DA,. Validation of a quantitative method for real time PCR kinetics. Biochem Biophys Res Commun 2002; 294: 347-353.
29. Livak KJ, Schmittgen TD,. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001; 25: 402-408.
30. Lu YK, Cederbaum AI,. CYP2E1 and oxidative liver injury by alcohol. Free Radical Biol Med 2008; 44: 723-738.
31. Matsumoto H, Fujimiya T, Fukui Y,. Role of alcohol dehydrogenase in rat ethanol elimination kinetics. Alcohol Alcohol 1994; 29 (suppl 1): 15-20.
32. Sidhu JS, Liu F, Boyle SM, Omiecinski CJ,. PI3K inhibitors reverse the suppressive actions of insulin on Cyp2e1 expression by activating stress-response pathways in primary rat hepatocytes. Mol Pharmacol 2001; 59 (5): 1138-1146.
33. Waterham HR, Wanders RJ,. Biochemical and genetic aspects of 7-dehydro-cholesterol reductase and Smith-Lemli-Opitz syndrome. Biochim Biophys Acta 2001; 1529: 340-356.
34. Goitre L, Balzac F, Degani S, Degan P, Marchi S, Pinton P, Retta SF,. KRIT1 regulates the homeostasis of intracellular reactive oxygen species. PLoS ONE 2010; 5: e11786.
35. Gingras S, Pelletier S, Boyd K, Ihle JN,. Characterization of a family of novel cysteine-serine-rich nuclear proteins (CSRNP). PLoS One 2007; 2: e808.
36. Gustavsson M, Wilson MA, Mallard C, Rousset C, Johnston MV, Hagberg H,. Global gene expression in the developing rat brain after hypoxic preconditioning: Involvement of apoptotic mechanisms? Pediatric Res 2007; 61: 444-450.
37. Cui YL, Liu HT, Ze YG, ZL Zhang, Hu YY, Cheng Z, Cheng J, Hu RP, Gao GD, Wang L, Tang M, Hong FS,. Gene expression in liver injury caused by long-term exposure to titanium dioxide nanoparticles in mice. Toxicol Sci 2012; 128: 171-185.
38. Mountney A, Zahner MR, Lorenzini I, Oudega M, Schramm LP, Schnaar RL,. Sialidase enhances recovery from spinal cord contusion injury. Proc Natl Acad Sci USA 2010; 22: 343-352.
39. Davis RS,. Fc receptor-like molecules. Annu Rev Immunol 2007; 25: 525-560.
40. Bou-Gharios G, Ponticos M, Rajkumar V, Abraham D,. Extra-cellular matrix in vascular networks. Cell Prolif 2004; 37: 207-220.
41. Zhou XT, Ji FT, An JH, Zhao FX, Shi FJ, Huang FR, Li Y, Jiao SM, Yan DS, Chen XY, Chen JF, Qu J,. Experimental murine myopia induces collagen type Iα1 (COL1A1) DNA methylation and altered COL1A1 messenger RNA expression in sclera. Mole Vision 2012; 18: 1312-1324.
42. Waldegger S, Barth P, Raber G, Lang F,. Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume. Proc Natl Acad Sci USA 1997; 94: 4440-4445.
43. Klaus FP, Almada M, Lindner R, Laufer J, Jeyaraj S, Lang F, Boehmer C,. Up-regulation of hypertonicity-activated myo-inositol transporter SMIT1 by the cell volume-sensitive protein kinase SGK1. J Physiol 2008; 586: 1539-1547.
44. MacDonald BT, Tamai K, He X,. Wnt/beta-catenin signaling: Components, mechanisms, and diseases. Dev Cell 2009; 17: 9-26.
45. Saab BJ, Georgiou J, Nath A, Lee FJ, Wang M, Michalon A, Liu F, Mansuy IM, Roder JC,. NCS-1 in the dentate gyrus promotes exploration, synaptic plasticity, and rapid acquisition of spatial memory. Neuron 2009; 63: 643-656.
46. Duan J, Wainwright MS, Comeron JM, Saitou N, Sanders AR, Gelernter J, Gejman PV,. Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor. Hum Mol Genet 2003; 12: 205-216.