-
1
-
-
80052511813
-
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
-
Mihaylova MM, Shaw RJ. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol 2011; 13: 1016-1023.
-
(2011)
Nat Cell Biol
, vol.13
, pp. 1016-1023
-
-
Mihaylova, M.M.1
Shaw, R.J.2
-
2
-
-
84858782079
-
AMPK: A nutrient and energy sensor that maintains energy homeostasis
-
Hardie DG, Ross FA, Hawley SA. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol 2012; 13: 251-262.
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 251-262
-
-
Hardie, D.G.1
Ross, F.A.2
Hawley, S.A.3
-
3
-
-
67749111502
-
The LKB1-AMPK pathway: Metabolism and growth control in tumour suppression
-
Shackelford DB, Shaw RJ. The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat Rev Cancer 2009; 9: 563-575.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 563-575
-
-
Shackelford, D.B.1
Shaw, R.J.2
-
4
-
-
84859778293
-
MTOR signaling in growth control and disease
-
Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell 2012; 149: 274-293.
-
(2012)
Cell
, vol.149
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
-
5
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 2006; 124: 471-484.
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
6
-
-
67349217986
-
Molecular mechanisms of mTOR-mediated translational control
-
Ma XM, Blenis J. Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol 2009; 10: 307-318.
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 307-318
-
-
Ma, X.M.1
Blenis, J.2
-
7
-
-
34249679614
-
MTOR complex1-S6K1 signaling: At the crossroads of obesity, diabetes and cancer
-
Dann SG, Selvaraj A, Thomas G. mTOR complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer. Trends Mol Med 2007; 13: 252-259.
-
(2007)
Trends Mol Med
, vol.13
, pp. 252-259
-
-
Dann, S.G.1
Selvaraj, A.2
Thomas, G.3
-
8
-
-
44449161481
-
The TSC1-TSC2 complex: A molecular switchboard controlling cell growth
-
Huang J, Manning BD. The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochem J 2008; 412: 179-190.
-
(2008)
Biochem J
, vol.412
, pp. 179-190
-
-
Huang, J.1
Manning, B.D.2
-
10
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003; 115: 577-590.
-
(2003)
Cell
, vol.115
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.L.3
-
11
-
-
42949139481
-
AMPK phosphorylation of raptor mediates a metabolic checkpoint
-
Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS et al. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 2008; 30: 214-226.
-
(2008)
Mol Cell
, vol.30
, pp. 214-226
-
-
Gwinn, D.M.1
Shackelford, D.B.2
Egan, D.F.3
Mihaylova, M.M.4
Mery, A.5
Vasquez, D.S.6
-
12
-
-
3142594193
-
The LKB1 tumor suppressor negatively regulates mTOR signaling
-
Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA et al. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell 2004; 6: 91-99.
-
(2004)
Cancer Cell
, vol.6
, pp. 91-99
-
-
Shaw, R.J.1
Bardeesy, N.2
Manning, B.D.3
Lopez, L.4
Kosmatka, M.5
Depinho, R.A.6
-
13
-
-
3042818799
-
Regulation of the TSC pathway by LKB1: Evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome
-
Corradetti MN, Inoki K, Bardeesy N, DePinho RA, Guan KL. Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev 2004; 18: 1533-1538.
-
(2004)
Genes Dev
, vol.18
, pp. 1533-1538
-
-
Corradetti, M.N.1
Inoki, K.2
Bardeesy, N.3
Depinho, R.A.4
Guan, K.L.5
-
14
-
-
1542618348
-
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
-
Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA et al. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci USA 2004; 101: 3329-3335.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 3329-3335
-
-
Shaw, R.J.1
Kosmatka, M.2
Bardeesy, N.3
Hurley, R.L.4
Witters, L.A.5
Depinho, R.A.6
-
15
-
-
77952562382
-
Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply
-
Choo AY, Kim SG, Vander Heiden MG, Mahoney SJ, Vu H, Yoon SO et al. Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply. Mol Cell 2010; 38: 487-499.
-
(2010)
Mol Cell
, vol.38
, pp. 487-499
-
-
Choo, A.Y.1
Kim, S.G.2
Vander Heiden, M.G.3
Mahoney, S.J.4
Vu, H.5
Yoon, S.O.6
-
16
-
-
79952281400
-
Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1
-
Zheng M, Wang YH, Wu XN, Wu SQ, Lu BJ, Dong MQ et al. Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1. Nat Cell Biol 2011; 13: 263-272.
-
(2011)
Nat Cell Biol
, vol.13
, pp. 263-272
-
-
Zheng, M.1
Wang, Y.H.2
Wu, X.N.3
Wu, S.Q.4
Lu, B.J.5
Dong, M.Q.6
-
17
-
-
84872272443
-
Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex
-
Kim SG, Hoffman GR, Poulogiannis G, Buel GR, Jang YJ, Lee KW et al. Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex. Mol Cell 2013; 49: 172-185.
-
(2013)
Mol Cell
, vol.49
, pp. 172-185
-
-
Kim, S.G.1
Hoffman, G.R.2
Poulogiannis, G.3
Buel, G.R.4
Jang, Y.J.5
Lee, K.W.6
-
18
-
-
84873665112
-
Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival
-
Efeyan A, Zoncu R, Chang S, Gumper I, Snitkin H, Wolfson RL et al. Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival. Nature 2013; 493: 679-683.
-
(2013)
Nature
, vol.493
, pp. 679-683
-
-
Efeyan, A.1
Zoncu, R.2
Chang, S.3
Gumper, I.4
Snitkin, H.5
Wolfson, R.L.6
-
19
-
-
2342496712
-
FoxOs at the crossroads of cellular metabolism, differentiation, and transformation
-
Accili D, Arden KC. FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 2004; 117: 421-426.
-
(2004)
Cell
, vol.117
, pp. 421-426
-
-
Accili, D.1
Arden, K.C.2
-
20
-
-
34249281690
-
Stressing the role of FoxO proteins in lifespan and disease
-
van der Horst A, Burgering BM. Stressing the role of FoxO proteins in lifespan and disease. Nat Rev Mol Cell Biol 2007; 8: 440-450.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 440-450
-
-
Van Der Horst, A.1
Burgering, B.M.2
-
22
-
-
33745307617
-
Ras, PI(3)K and mTOR signalling controls tumour cell growth
-
Shaw RJ, Cantley LC. Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature 2006; 441: 424-430.
-
(2006)
Nature
, vol.441
, pp. 424-430
-
-
Shaw, R.J.1
Cantley, L.C.2
-
23
-
-
0036501277
-
A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells
-
Kwiatkowski DJ, Zhang H, Bandura JL, Heiberger KM, Glogauer M, el-Hashemite N et al. A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells. Hum Mol Genet 2002; 11: 525-534.
-
(2002)
Hum Mol Genet
, vol.11
, pp. 525-534
-
-
Kwiatkowski, D.J.1
Zhang, H.2
Bandura, J.L.3
Heiberger, K.M.4
Glogauer, M.5
El-Hashemite, N.6
-
24
-
-
0035902509
-
A germline Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice
-
Kobayashi T, Minowa O, Sugitani Y, Takai S, Mitani H, Kobayashi E et al. A germline Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice. Proc Natl Acad Sci USA 2001; 98: 8762-8767.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 8762-8767
-
-
Kobayashi, T.1
Minowa, O.2
Sugitani, Y.3
Takai, S.4
Mitani, H.5
Kobayashi, E.6
-
25
-
-
78249255491
-
FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis
-
Gan B, Lim C, Chu G, Hua S, Ding Z, Collins M et al. FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis. Cancer Cell 2010; 18: 472-484.
-
(2010)
Cancer Cell
, vol.18
, pp. 472-484
-
-
Gan, B.1
Lim, C.2
Chu, G.3
Hua, S.4
Ding, Z.5
Collins, M.6
-
26
-
-
33846295218
-
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis
-
Paik JH, Kollipara R, Chu G, Ji H, Xiao Y, Ding Z et al. FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell 2007; 128: 309-323.
-
(2007)
Cell
, vol.128
, pp. 309-323
-
-
Paik, J.H.1
Kollipara, R.2
Chu, G.3
Ji, H.4
Xiao, Y.5
Ding, Z.6
-
27
-
-
0037068461
-
Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation
-
Bardeesy N, Sinha M, Hezel AF, Signoretti S, Hathaway NA, Sharpless NE et al. Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature 2002; 419: 162-167.
-
(2002)
Nature
, vol.419
, pp. 162-167
-
-
Bardeesy, N.1
Sinha, M.2
Hezel, A.F.3
Signoretti, S.4
Hathaway, N.A.5
Sharpless, N.E.6
-
28
-
-
0032741978
-
Tsc2(/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background
-
Onda H, Lueck A, Marks PW, Warren HB, Kwiatkowski DJ. Tsc2(/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background. J Clin Invest 1999; 104: 687-695.
-
(1999)
J Clin Invest
, vol.104
, pp. 687-695
-
-
Onda, H.1
Lueck, A.2
Marks, P.W.3
Warren, H.B.4
Kwiatkowski, D.J.5
-
29
-
-
25444524850
-
Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity
-
Hahn-Windgassen A, Nogueira V, Chen CC, Skeen JE, Sonenberg N, Hay N. Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. J Biol Chem 2005; 280: 32081-32089.
-
(2005)
J Biol Chem
, vol.280
, pp. 32081-32089
-
-
Hahn-Windgassen, A.1
Nogueira, V.2
Chen, C.C.3
Skeen, J.E.4
Sonenberg, N.5
Hay, N.6
-
30
-
-
67549101188
-
Role of BNIP3 and NIX in cell death, autophagy, and mitophagy
-
Zhang J, Ney PA. Role of BNIP3 and NIX in cell death, autophagy, and mitophagy. Cell Death Differ 2009; 16: 939-946.
-
(2009)
Cell Death Differ
, vol.16
, pp. 939-946
-
-
Zhang, J.1
Ney, P.A.2
-
31
-
-
68149147330
-
BNIP3 subfamily BH3-only proteins: Mitochondrial stress sensors in normal and pathological functions
-
Chinnadurai G, Vijayalingam S, Gibson SB. BNIP3 subfamily BH3-only proteins: mitochondrial stress sensors in normal and pathological functions. Oncogene 2008; 27(Suppl 1): S114-S127.
-
(2008)
Oncogene
, vol.27
, Issue.SUPPL. 1
-
-
Chinnadurai, G.1
Vijayalingam, S.2
Gibson, S.B.3
-
32
-
-
62849105988
-
The role of Bcl-2 family member BNIP3 in cell death and disease: NIPping at the heels of cell death
-
Burton TR, Gibson SB. The role of Bcl-2 family member BNIP3 in cell death and disease: NIPping at the heels of cell death. Cell Death Differ 2009; 16: 515-523.
-
(2009)
Cell Death Differ
, vol.16
, pp. 515-523
-
-
Burton, T.R.1
Gibson, S.B.2
-
33
-
-
37248999267
-
Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb
-
Li Y, Wang Y, Kim E, Beemiller P, Wang CY, Swanson J et al. Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb. J Biol Chem 2007; 282: 35803-35813.
-
(2007)
J Biol Chem
, vol.282
, pp. 35803-35813
-
-
Li, Y.1
Wang, Y.2
Kim, E.3
Beemiller, P.4
Wang, C.Y.5
Swanson, J.6
-
34
-
-
36448940798
-
FoxO3 controls autophagy in skeletal muscle in vivo
-
Mammucari C, Milan G, Romanello V, Masiero E, Rudolf R, Del Piccolo P et al. FoxO3 controls autophagy in skeletal muscle in vivo. Cell Metab 2007; 6: 458-471.
-
(2007)
Cell Metab
, vol.6
, pp. 458-471
-
-
Mammucari, C.1
Milan, G.2
Romanello, V.3
Masiero, E.4
Rudolf, R.5
Del Piccolo, P.6
-
35
-
-
34848861463
-
The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor
-
Greer EL, Oskoui PR, Banko MR, Maniar JM, Gygi MP, Gygi SP et al. The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor. J Biol Chem 2007; 282: 30107-30119.
-
(2007)
J Biol Chem
, vol.282
, pp. 30107-30119
-
-
Greer, E.L.1
Oskoui, P.R.2
Banko, M.R.3
Maniar, J.M.4
Gygi, M.P.5
Gygi, S.P.6
-
36
-
-
84855496023
-
Phosphorylation of FOXO3a on Ser-7 by p38 promotes its nuclear localization in response to doxorubicin
-
Ho KK, McGuire VA, Koo CY, Muir KW, de Olano N, Maifoshie E et al. Phosphorylation of FOXO3a on Ser-7 by p38 promotes its nuclear localization in response to doxorubicin. J Biol Chem 2012; 287: 1545-1555.
-
(2012)
J Biol Chem
, vol.287
, pp. 1545-1555
-
-
Ho, K.K.1
McGuire, V.A.2
Koo, C.Y.3
Muir, K.W.4
De Olano, N.5
Maifoshie, E.6
-
37
-
-
4544299668
-
Focus on kidney cancer
-
Linehan WM, Zbar B. Focus on kidney cancer. Cancer Cell 2004; 6: 223-228.
-
(2004)
Cancer Cell
, vol.6
, pp. 223-228
-
-
Linehan, W.M.1
Zbar, B.2
-
39
-
-
84866097174
-
Two-step activation of FOXO3 by AMPK generates a coherent feed-forward loop determining excitotoxic cell fate
-
Davila D, Connolly NMC, Bonner H, Weisova P, Dussmann H, Concannon CG et al. Two-step activation of FOXO3 by AMPK generates a coherent feed-forward loop determining excitotoxic cell fate. Cell Death Differ 2012; 19: 1677-1688.
-
(2012)
Cell Death Differ
, vol.19
, pp. 1677-1688
-
-
Davila, D.1
Connolly, N.M.C.2
Bonner, H.3
Weisova, P.4
Dussmann, H.5
Concannon, C.G.6
-
40
-
-
61849135453
-
Tumor suppressors and cell metabolism: A recipe for cancer growth
-
Jones RG, Thompson CB. Tumor suppressors and cell metabolism: a recipe for cancer growth. Genes Dev 2009; 23: 537-548.
-
(2009)
Genes Dev
, vol.23
, pp. 537-548
-
-
Jones, R.G.1
Thompson, C.B.2
-
41
-
-
77952373274
-
FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1
-
Khatri S, Yepiskoposyan H, Gallo CA, Tandon P, Plas DR. FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1. J Biol Chem 2010; 285: 15960-15965.
-
(2010)
J Biol Chem
, vol.285
, pp. 15960-15965
-
-
Khatri, S.1
Yepiskoposyan, H.2
Gallo, C.A.3
Tandon, P.4
Plas, D.R.5
-
42
-
-
77951911593
-
FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor
-
Chen CC, Jeon SM, Bhaskar PT, Nogueira V, Sundararajan D, Tonic I et al. FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor. Dev Cell 2010; 18: 592-604.
-
(2010)
Dev Cell
, vol.18
, pp. 592-604
-
-
Chen, C.C.1
Jeon, S.M.2
Bhaskar, P.T.3
Nogueira, V.4
Sundararajan, D.5
Tonic, I.6
-
43
-
-
58049196780
-
MTORC1- dependent and -independent regulation of stem cell renewal, differentiation, and mobilization
-
Gan B, Sahin E, Jiang S, Sanchez-Aguilera A, Scott KL, Chin L et al. mTORC1- dependent and -independent regulation of stem cell renewal, differentiation, and mobilization. Proc Natl Acad Sci USA 2008; 105: 19384-19389.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 19384-19389
-
-
Gan, B.1
Sahin, E.2
Jiang, S.3
Sanchez-Aguilera, A.4
Scott, K.L.5
Chin, L.6
-
44
-
-
78649874959
-
Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells
-
Gan B, Hu J, Jiang S, Liu Y, Sahin E, Zhuang L et al. Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature 2010; 468: 701-704.
-
(2010)
Nature
, vol.468
, pp. 701-704
-
-
Gan, B.1
Hu, J.2
Jiang, S.3
Liu, Y.4
Sahin, E.5
Zhuang, L.6
-
45
-
-
33745840203
-
50-AMPactivated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments
-
Laderoute KR, Amin K, Calaoagan JM, Knapp M, Le T, Orduna J et al. 50-AMPactivated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments. Mol Cell Biol 2006; 26: 5336-5347.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 5336-5347
-
-
Laderoute, K.R.1
Amin, K.2
Calaoagan, J.M.3
Knapp, M.4
Le, T.5
Orduna, J.6
-
46
-
-
23744454765
-
Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control
-
Gan B, Melkoumian ZK, Wu X, Guan KL, Guan JL. Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control. J Cell Biol 2005; 170: 379-389.
-
(2005)
J Cell Biol
, vol.170
, pp. 379-389
-
-
Gan, B.1
Melkoumian, Z.K.2
Wu, X.3
Guan, K.L.4
Guan, J.L.5
|