Phosphorylation of FOXO3a on Ser-7 by p38 promotes its nuclear localization in response to doxorubicin

Journal of Biological Chemistry

Volumn 287, Issue 2, 2012, Pages 1545-1555

  Ho, Ka Kei ^a   McGuire, Victoria A ^b   Koo, Chuay Yeng ^a   Muir, Kyle W ^a   De Olano, Natalia ^a   Maifoshie, Evie ^a   Kelly, Douglas J ^a,c   McGovern, Ursula B ^a   Monteiro, Lara J ^a   Gomes, Ana R ^a   Nebreda, Angel R ^d   Campbell, David G ^b   Arthur, J Simon C ^b   Lam, Eric W F ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BREAST CARCINOMA CELLS; CELLULAR PROCESS; CO-IMMUNOPRECIPITATIONS; DIRECT INTERACTIONS; DOXORUBICIN; FORKHEAD TRANSCRIPTIONS; IMMUNOFLUORESCENCE STAINING; IN-VITRO; MASS SPECTROMETRIC ANALYSIS; MCF-7 CELLS; MOUSE-FIBROBLASTS; NUCLEAR ACCUMULATION; NUCLEAR LOCALIZATION; NUCLEAR TRANSLOCATIONS; P38 MAPK; PHOSPHOPEPTIDES; RE-LOCALIZATION; STRESS-ACTIVATED KINASE; WILD TYPES;

AMINO ACIDS; CELL CULTURE; CELL DEATH; ENZYME ACTIVITY; TRANSCRIPTION FACTORS;

PHOSPHORYLATION;

DOXORUBICIN; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR FKHRL1;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL METABOLISM; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE MAPPING; GENE TRANSLOCATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; SITE DIRECTED MUTAGENESIS; UPREGULATION;

ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID SUBSTITUTION; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CELL LINE, TUMOR; CELL NUCLEUS; DOXORUBICIN; ENZYME INHIBITORS; FORKHEAD TRANSCRIPTION FACTORS; HEK293 CELLS; HUMANS; IMIDAZOLES; MICE; MICE, KNOCKOUT; MUTATION, MISSENSE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PYRIDINES;

EID: 84855496023     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.284224     Document Type: Article

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