Designing allosteric inhibitors of factor XIa. Lessons from the interactions of sulfated pentagalloylglucopyranosides

Journal of Medicinal Chemistry

Volumn 57, Issue 11, 2014, Pages 4805-4818

  Al Horani, Rami A ^a   Desai, Umesh R ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACRYLAMIDE; BLOOD CLOTTING FACTOR 11; BLOOD CLOTTING FACTOR 11A; BLOOD CLOTTING FACTOR 11A INHIBITOR; BLOOD CLOTTING INHIBITOR; ENZYME PRECURSOR; HEPARIN; PENTAGALLOYLGLUCOPYRANOSIDE DERIVATIVE; SULFATE; THROMBIN; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; BINDING SITE; CONFORMATIONAL TRANSITION; DRUG BINDING; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; SULFATION;

ALLOSTERIC REGULATION; ANTICOAGULANTS; CATALYTIC DOMAIN; ENZYME PRECURSORS; FACTOR XIA; GLUCOSIDES; HEPARIN; HUMANS; KINETICS; MODELS, MOLECULAR; PROTEIN BINDING; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFURIC ACID ESTERS; THERMODYNAMICS; THROMBIN;

EID: 84902438454     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm500311e     Document Type: Article

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