Characterization of a heparin-binding site on the catalytic domain of factor XIa: Mechanism of heparin acceleration of factor XIa inhibition by the serpins antithrombin and C1-inhibitor

Biochemistry

Volumn 48, Issue 7, 2009, Pages 1517-1524

  Yang, Likui ^a   Sun, Mao Fu ^b   Gailani, David ^b   Rezaie, Alireza R ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACCELERATING EFFECTS; ALLOSTERIC MECHANISMS; ANTITHROMBIN; CATALYTIC DOMAINS; CHARGE NEUTRALIZATIONS; EXPRESSION SYSTEMS; HEPARIN-BINDING SITES; INHIBITION RATE CONSTANTS; ORDERS OF MAGNITUDES; SECOND ORDERS; SERPINS; WILD TYPES;

BINDING ENERGY; BINDING SITES; DATA STORAGE EQUIPMENT; RATE CONSTANTS;

POLYSACCHARIDES;

ANTITHROMBIN; BLOOD CLOTTING FACTOR 11A; COMPLEMENT COMPONENT C1S INHIBITOR; HEPARIN; SERINE PROTEINASE INHIBITOR; COMPLEMENT COMPONENT C1; COMPLEMENT INHIBITOR; RECOMBINANT PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; HUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; WILD TYPE; CHEMISTRY; DRUG ANTAGONISM; KINETICS; METABOLISM;

ANTITHROMBINS; BINDING SITES; CATALYTIC DOMAIN; COMPLEMENT C1; COMPLEMENT INACTIVATING AGENTS; FACTOR XIA; HEPARIN; HUMANS; KINETICS; RECOMBINANT PROTEINS;

EID: 61749093027     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi802298r     Document Type: Article

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