Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an α-ketothiazole arginine

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 11, 2006, Pages 3049-3054

  Deng, Hongfeng ^a   Bannister, Thomas D ^a   Jin, Lei ^a   Babine, Robert E ^a   Quinn, Jesse ^a   Nagafuji, Pamela ^a   Celatka, Cassandra A ^a   Lin, Jian ^a   Lazarova, Tsvetelina I ^a   Rynkiewicz, Michael J ^a   Bibbins, Frank ^a   Pandey, Pramod ^a   Gorga, Joan ^a   Meyers, Harold V ^a   Abdel Meguid, Sherin S ^a   Strickler, James E ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Ketothiazole arginine; Anticoagulant; Factor XIa inhibitor; X ray crystal structure

Indexed keywords

ALPHA KETOTHIAZOLE ARGININE; ANTICOAGULANT AGENT; ARGININE DERIVATIVE; BLOOD CLOTTING FACTOR 11A INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SYNTHESIS; IC 50; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

AMIDES; ARGININE; CRYSTALLOGRAPHY, X-RAY; FACTOR XIA; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 33646069281     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.02.052     Document Type: Article

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