Designing nonsaccharide, allosteric activators of antithrombin for accelerated inhibition of factor Xa

Journal of Medicinal Chemistry

Volumn 54, Issue 17, 2011, Pages 6125-6138

  Al Horani, Rami A ^a   Liang, Aiye ^a   Desai, Umesh R ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBIN; BLOOD CLOTTING FACTOR 10A INHIBITOR; BUFFER; TETRAHYDROISOQUINOLINE DERIVATIVE;

ALLOSTERISM; AMIDATION; ARTICLE; DEPROTECTION REACTION; HORNER WADSWORTH EMMONS REACTION; HUMAN; PH; PICTET SPENGLER REACTION; PROTEIN BINDING; SPECTROFLUOROMETRY; SULFATION;

ANTITHROMBINS; BINDING SITES; DRUG DESIGN; FACTOR XA; HUMANS; HYDROCARBONS, AROMATIC; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; SULFURIC ACID ESTERS; TETRAHYDROISOQUINOLINES;

EID: 80052343772     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2008387     Document Type: Article

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