Discovery of allosteric modulators of factor XIa by targeting hydrophobic domains adjacent to its heparin-binding site

Journal of Medicinal Chemistry

Volumn 56, Issue 6, 2013, Pages 2415-2428

  Karuturi, Rajesh ^a   Al Horani, Rami A ^a   Mehta, Shrenik C ^a   Gailani, David ^b   Desai, Umesh R ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANION; ANTITHROMBOCYTIC AGENT; BLOOD CLOTTING FACTOR 11A; BLOOD CLOTTING INHIBITOR; CATION; DERMATAN SULFATE HEXASACCHARIDE; HEPARIN; HEPARIN PENTASACCHARIDE; OCTASACCHARIDE; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING COMPETITION; BINDING SITE; CONTROLLED STUDY; DRUG DEVELOPMENT; FLUORESCENCE ANALYSIS; HUMAN; HYDROLYSIS; HYDROPHOBICITY; MOLECULAR LIBRARY; MUTAGENESIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION;

ALLOSTERIC REGULATION; BIOMIMETIC MATERIALS; CATALYTIC DOMAIN; DRUG DISCOVERY; FACTOR XIA; GLYCOSAMINOGLYCANS; HEPARIN; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; PROTEASE INHIBITORS; QUINAZOLINONES; SULFATES;

EID: 84875743348     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301757v     Document Type: Article

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