Designing allosteric regulators of thrombin. Exosite 2 features multiple subsites that can be targeted by sulfated small molecules for inducing inhibition

Journal of Medicinal Chemistry

Volumn 56, Issue 12, 2013, Pages 5059-5070

  Sidhu, Preetpal Singh ^a   Abdel Aziz, May H ^a   Sarkar, Aurijit ^a   Mehta, Akul Y ^a   Zhou, Qibing ^a,b   Desai, Umesh R ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ARGININE; BENZOFURAN DERIVATIVE; DIMER; FIBRINOGEN; GAMMA FIBRINOGEN; HEPARIN; HEPARIN DERIVATIVE; HEPARIN OCTASACCHARIDE; HIRUDIN; LYSINE; TETRAMER; THROMBIN; THROMBIN INHIBITOR; UNCLASSIFIED DRUG;

ALLOSTERISM; AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; DIMERIZATION; DRUG DESIGN; DRUG INHIBITION; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; MICHAELIS MENTEN KINETICS; MOLECULAR RECOGNITION; MOLECULE; MUTAGENESIS; STRUCTURE ACTIVITY RELATION; SULFATION;

ALLOSTERIC REGULATION; BENZOFURANS; BINDING SITES; BLOOD COAGULATION; DIMERIZATION; DRUG DESIGN; HUMANS; KINETICS; MODELS, MOLECULAR; PROTEIN CONFORMATION; SERINE PROTEINASE INHIBITORS; SUBSTRATE SPECIFICITY; SULFATES; THROMBIN;

EID: 84879593914     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400369q     Document Type: Article

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