Mechanism of heparin activation of antithrombin. Role of individual residues of the pentasaccharide activating sequence in the recognition of native and activated states of antithrombin

Journal of Biological Chemistry

Volumn 273, Issue 13, 1998, Pages 7478-7487

  Desai, Umesh R ^a   Petitou, Maurice ^b   Björk, Ingemar ^c   Olson, Steven T ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b SANOFI   (France)

^c SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBIN; HEPARIN; PENTASACCHARIDE; SERINE PROTEINASE INHIBITOR;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; CARBOHYDRATE ANALYSIS; CHEMICAL REACTION KINETICS; HEPARINIZATION; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; PRIORITY JOURNAL; REGULATORY MECHANISM;

ANTITHROMBIN III; BINDING, COMPETITIVE; ENZYME ACTIVATION; FACTOR XA; HEPARIN; HUMANS; KINETICS; MODELS, CHEMICAL; OLIGOSACCHARIDES; PROTEIN CONFORMATION; SPECTROMETRY, FLUORESCENCE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032571333     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.13.7478     Document Type: Article

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