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Volumn 3, Issue 4, 2014, Pages 394-407

Rictor/mTORC2 facilitates central regulation of energy and glucose homeostasis

Author keywords

AgRP neurons; CNS insulin; Energy balance; Food intake; MTORC2; Obesity; POMC neurons; Rictor

Indexed keywords

AGOUTI RELATED PROTEIN; CRE LOXP RECOMBINASE; HYPOTHALAMIC OREXIGENIC NEUROPEPTIDE; LEPTIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; NEUROPEPTIDE; PROOPIOMELANOCORTIN; PROTEIN KINASE B; PROTEIN KINASE C ALPHA; RAPAMYCIN INSENSITIVE COMPANION OF TOR; RECOMBINASE; SERINE; UNCLASSIFIED DRUG;

EID: 84902329648     PISSN: 22128778     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmet.2014.01.014     Document Type: Article
Times cited : (58)

References (85)
  • 1
    • 84856078168 scopus 로고    scopus 로고
    • Deconvoluting mTOR biology
    • Weber J.D., Gutmann D.H. Deconvoluting mTOR biology. Cell Cycle 2012, 11:236-248.
    • (2012) Cell Cycle , vol.11 , pp. 236-248
    • Weber, J.D.1    Gutmann, D.H.2
  • 2
    • 78649348967 scopus 로고    scopus 로고
    • Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
    • Sengupta S., Peterson T.R., Sabatini D.M. Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Molecular Cell 2010, 40:310-322.
    • (2010) Molecular Cell , vol.40 , pp. 310-322
    • Sengupta, S.1    Peterson, T.R.2    Sabatini, D.M.3
  • 3
    • 79960470913 scopus 로고    scopus 로고
    • MTOR complex 2 signaling and functions
    • Oh W.J., Jacinto E. mTOR complex 2 signaling and functions. Cell Cycle 2011, 10:2305-2316.
    • (2011) Cell Cycle , vol.10 , pp. 2305-2316
    • Oh, W.J.1    Jacinto, E.2
  • 4
    • 1542781732 scopus 로고    scopus 로고
    • Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B
    • Bae S.S., Cho H., Mu J., Birnbaum M.J. Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B. Journal of Biological Chemistry 2003, 278:49530-49536.
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 49530-49536
    • Bae, S.S.1    Cho, H.2    Mu, J.3    Birnbaum, M.J.4
  • 5
    • 37549000623 scopus 로고    scopus 로고
    • Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity
    • Kumar A., Harris T.E., Keller S.R., Choi K.M., Magnuson M.A., et al. Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity. Molecular and Cellular Biology 2008, 28:61-70.
    • (2008) Molecular and Cellular Biology , vol.28 , pp. 61-70
    • Kumar, A.1    Harris, T.E.2    Keller, S.R.3    Choi, K.M.4    Magnuson, M.A.5
  • 6
    • 0034703229 scopus 로고    scopus 로고
    • Role of brain insulin receptor in control of body weight and reproduction
    • Bruning J.C., Gautam D., Burks D.J., Gillette J., Schubert M., et al. Role of brain insulin receptor in control of body weight and reproduction. Science 2000, 289:2122-2125.
    • (2000) Science , vol.289 , pp. 2122-2125
    • Bruning, J.C.1    Gautam, D.2    Burks, D.J.3    Gillette, J.4    Schubert, M.5
  • 7
    • 0036913187 scopus 로고    scopus 로고
    • Hypothalamic insulin signaling is required for inhibition of glucose production
    • Obici S., Zhang B.B., Karkanias G., Rossetti L. Hypothalamic insulin signaling is required for inhibition of glucose production. Nature Medicine 2002, 8:1376-1382.
    • (2002) Nature Medicine , vol.8 , pp. 1376-1382
    • Obici, S.1    Zhang, B.B.2    Karkanias, G.3    Rossetti, L.4
  • 8
    • 0037315042 scopus 로고    scopus 로고
    • Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia
    • Niswender K.D., Morrison C.D., Clegg D.J., Olson R., Baskin D.G., et al. Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia. Diabetes 2003, 52:227-231.
    • (2003) Diabetes , vol.52 , pp. 227-231
    • Niswender, K.D.1    Morrison, C.D.2    Clegg, D.J.3    Olson, R.4    Baskin, D.G.5
  • 11
    • 0036228770 scopus 로고    scopus 로고
    • Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B
    • Cheng A., Uetani N., Simoncic P.D., Chaubey V.P., Lee-Loy A., et al. Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B. Developmental Cell 2002, 2:497-503.
    • (2002) Developmental Cell , vol.2 , pp. 497-503
    • Cheng, A.1    Uetani, N.2    Simoncic, P.D.3    Chaubey, V.P.4    Lee-Loy, A.5
  • 12
    • 9244219587 scopus 로고    scopus 로고
    • Region-specific leptin resistance within the hypothalamus of diet-induced obese mice
    • Munzberg H., Flier J.S., Bjorbaek C. Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology 2004, 145:4880-4889.
    • (2004) Endocrinology , vol.145 , pp. 4880-4889
    • Munzberg, H.1    Flier, J.S.2    Bjorbaek, C.3
  • 14
    • 0031733326 scopus 로고    scopus 로고
    • Effect of fasting and leptin deficiency on hypothalamic neuropeptide Y gene transcription invivo revealed by expression of a lacZ reporter gene
    • Schwartz M.W., Erickson J.C., Baskin D.G., Palmiter R.D. Effect of fasting and leptin deficiency on hypothalamic neuropeptide Y gene transcription invivo revealed by expression of a lacZ reporter gene. Endocrinology 1998, 139:2629-2635.
    • (1998) Endocrinology , vol.139 , pp. 2629-2635
    • Schwartz, M.W.1    Erickson, J.C.2    Baskin, D.G.3    Palmiter, R.D.4
  • 17
    • 30044447631 scopus 로고    scopus 로고
    • Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons
    • Morton G.J., Gelling R.W., Niswender K.D., Morrison C.D., Rhodes C.J., et al. Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons. Cell Metabolism 2005, 2:411-420.
    • (2005) Cell Metabolism , vol.2 , pp. 411-420
    • Morton, G.J.1    Gelling, R.W.2    Niswender, K.D.3    Morrison, C.D.4    Rhodes, C.J.5
  • 18
    • 0036627597 scopus 로고    scopus 로고
    • Multiple neural systems controlling food intake and body weight
    • Berthoud H.R. Multiple neural systems controlling food intake and body weight. Neuroscience & Biobehavioral Reviews 2002, 26:393-428.
    • (2002) Neuroscience & Biobehavioral Reviews , vol.26 , pp. 393-428
    • Berthoud, H.R.1
  • 19
    • 24944438230 scopus 로고    scopus 로고
    • Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus
    • De Souza C.T., Araujo E.P., Bordin S., Ashimine R., Zollner R.L., et al. Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology 2005, 146:4192-4199.
    • (2005) Endocrinology , vol.146 , pp. 4192-4199
    • De Souza, C.T.1    Araujo, E.P.2    Bordin, S.3    Ashimine, R.4    Zollner, R.L.5
  • 20
    • 65749101203 scopus 로고    scopus 로고
    • Inhibition of hypothalamic Foxo1 expression reduced food intake in diet-induced obesity rats
    • Ropelle E.R., Pauli J.R., Prada P., Cintra D.E., Rocha G.Z., et al. Inhibition of hypothalamic Foxo1 expression reduced food intake in diet-induced obesity rats. Journal of Physiology 2009, 587:2341-2351.
    • (2009) Journal of Physiology , vol.587 , pp. 2341-2351
    • Ropelle, E.R.1    Pauli, J.R.2    Prada, P.3    Cintra, D.E.4    Rocha, G.Z.5
  • 21
    • 79952484959 scopus 로고    scopus 로고
    • Consumption of a high-fat diet induces central insulin resistance independent of adiposity
    • Clegg D.J., Gotoh K., Kemp C., Wortman M.D., Benoit S.C., et al. Consumption of a high-fat diet induces central insulin resistance independent of adiposity. Physiology and Behavior 2011, 103:10-16.
    • (2011) Physiology and Behavior , vol.103 , pp. 10-16
    • Clegg, D.J.1    Gotoh, K.2    Kemp, C.3    Wortman, M.D.4    Benoit, S.C.5
  • 24
    • 84860451500 scopus 로고    scopus 로고
    • IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action
    • Sadagurski M., Leshan R.L., Patterson C., Rozzo A., Kuznetsova A., et al. IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action. Cell Metabolism 2012, 15:703-712.
    • (2012) Cell Metabolism , vol.15 , pp. 703-712
    • Sadagurski, M.1    Leshan, R.L.2    Patterson, C.3    Rozzo, A.4    Kuznetsova, A.5
  • 25
    • 0037288941 scopus 로고    scopus 로고
    • Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities
    • Niswender K.D., Schwartz M.W. Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities. Frontiers in Neuroendocrinology 2003, 24:1-10.
    • (2003) Frontiers in Neuroendocrinology , vol.24 , pp. 1-10
    • Niswender, K.D.1    Schwartz, M.W.2
  • 28
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    • Sarbassov D.D., Ali S.M., Kim D.H., Guertin D.A., Latek R.R., et al. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Current Biology 2004, 14:1296-1302.
    • (2004) Current Biology , vol.14 , pp. 1296-1302
    • Sarbassov, D.D.1    Ali, S.M.2    Kim, D.H.3    Guertin, D.A.4    Latek, R.R.5
  • 29
    • 33751348056 scopus 로고    scopus 로고
    • Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1
    • Guertin D.A., Stevens D.M., Thoreen C.C., Burds A.A., Kalaany N.Y., et al. Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Developmental Cell 2006, 11:859-871.
    • (2006) Developmental Cell , vol.11 , pp. 859-871
    • Guertin, D.A.1    Stevens, D.M.2    Thoreen, C.C.3    Burds, A.A.4    Kalaany, N.Y.5
  • 30
    • 33745576798 scopus 로고    scopus 로고
    • Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis
    • Kim M.S., Pak Y.K., Jang P.G., Namkoong C., Choi Y.S., et al. Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis. Nature Neuroscience 2006, 9:901-906.
    • (2006) Nature Neuroscience , vol.9 , pp. 901-906
    • Kim, M.S.1    Pak, Y.K.2    Jang, P.G.3    Namkoong, C.4    Choi, Y.S.5
  • 31
    • 41549108590 scopus 로고    scopus 로고
    • PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response
    • Belgardt B.F., Husch A., Rother E., Ernst M.B., Wunderlich F.T., et al. PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response. Cell Metabolism 2008, 7:291-301.
    • (2008) Cell Metabolism , vol.7 , pp. 291-301
    • Belgardt, B.F.1    Husch, A.2    Rother, E.3    Ernst, M.B.4    Wunderlich, F.T.5
  • 32
    • 0026710057 scopus 로고
    • Inhibition of hypothalamic neuropeptide Y gene expression by insulin
    • Schwartz M.W., Sipols A.J., Marks J.L., Sanacora G., White J.D., et al. Inhibition of hypothalamic neuropeptide Y gene expression by insulin. Endocrinology 1992, 130:3608-3616.
    • (1992) Endocrinology , vol.130 , pp. 3608-3616
    • Schwartz, M.W.1    Sipols, A.J.2    Marks, J.L.3    Sanacora, G.4    White, J.D.5
  • 33
    • 54849426651 scopus 로고    scopus 로고
    • Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy
    • Bentzinger C.F., Romanino K., Cloetta D., Lin S., Mascarenhas J.B., et al. Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy. Cell Metabolism 2008, 8:411-424.
    • (2008) Cell Metabolism , vol.8 , pp. 411-424
    • Bentzinger, C.F.1    Romanino, K.2    Cloetta, D.3    Lin, S.4    Mascarenhas, J.B.5
  • 34
    • 77953200528 scopus 로고    scopus 로고
    • Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism
    • Kumar A., Lawrence J.C., Jung D.Y., Ko H.J., Keller S.R., et al. Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism. Diabetes 2010, 59:1397-1406.
    • (2010) Diabetes , vol.59 , pp. 1397-1406
    • Kumar, A.1    Lawrence, J.C.2    Jung, D.Y.3    Ko, H.J.4    Keller, S.R.5
  • 35
    • 79952374430 scopus 로고    scopus 로고
    • Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size
    • Gu Y., Lindner J., Kumar A., Yuan W., Magnuson M.A. Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size. Diabetes 2011, 60:827-837.
    • (2011) Diabetes , vol.60 , pp. 827-837
    • Gu, Y.1    Lindner, J.2    Kumar, A.3    Yuan, W.4    Magnuson, M.A.5
  • 36
    • 84860454425 scopus 로고    scopus 로고
    • Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c
    • Hagiwara A., Cornu M., Cybulski N., Polak P., Betz C., et al. Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c. Cell Metabolism 2012, 15:725-738.
    • (2012) Cell Metabolism , vol.15 , pp. 725-738
    • Hagiwara, A.1    Cornu, M.2    Cybulski, N.3    Polak, P.4    Betz, C.5
  • 37
    • 33748950810 scopus 로고    scopus 로고
    • Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability
    • Shiota C., Woo J.T., Lindner J., Shelton K.D., Magnuson M.A. Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Developmental Cell 2006, 11:583-589.
    • (2006) Developmental Cell , vol.11 , pp. 583-589
    • Shiota, C.1    Woo, J.T.2    Lindner, J.3    Shelton, K.D.4    Magnuson, M.A.5
  • 38
    • 84155191399 scopus 로고    scopus 로고
    • Role for mTOR signaling and neuronal activity in morphine-induced adaptations in ventral tegmental area dopamine neurons
    • Mazei-Robison M.S., Koo J.W., Friedman A.K., Lansink C.S., Robison A.J., et al. Role for mTOR signaling and neuronal activity in morphine-induced adaptations in ventral tegmental area dopamine neurons. Neuron 2011, 72:977-990.
    • (2011) Neuron , vol.72 , pp. 977-990
    • Mazei-Robison, M.S.1    Koo, J.W.2    Friedman, A.K.3    Lansink, C.S.4    Robison, A.J.5
  • 39
    • 77954755270 scopus 로고    scopus 로고
    • Dysregulation of the norepinephrine transporter sustains cortical hypodopaminergia and schizophrenia-like behaviors in neuronal rictor null mice
    • Siuta M.A., Robertson S.D., Kocalis H., Saunders C., Gresch P.J., et al. Dysregulation of the norepinephrine transporter sustains cortical hypodopaminergia and schizophrenia-like behaviors in neuronal rictor null mice. PLoS Biology 2010, 8:e1000393.
    • (2010) PLoS Biology , vol.8
    • Siuta, M.A.1    Robertson, S.D.2    Kocalis, H.3    Saunders, C.4    Gresch, P.J.5
  • 40
    • 84902339998 scopus 로고    scopus 로고
    • Deletion of Rictor in neural progenitor cells reveals contributions of mTORC2 signaling to tuberous sclerosis complex
    • Carson R.P., Fu C., Winzenburger P., Ess K.C. Deletion of Rictor in neural progenitor cells reveals contributions of mTORC2 signaling to tuberous sclerosis complex. Human Molecular Genetics 2012.
    • (2012) Human Molecular Genetics
    • Carson, R.P.1    Fu, C.2    Winzenburger, P.3    Ess, K.C.4
  • 41
    • 0032842478 scopus 로고    scopus 로고
    • Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety
    • Tronche F., Kellendonk C., Kretz O., Gass P., Anlag K., et al. Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nature Genetics 1999, 23:99-103.
    • (1999) Nature Genetics , vol.23 , pp. 99-103
    • Tronche, F.1    Kellendonk, C.2    Kretz, O.3    Gass, P.4    Anlag, K.5
  • 42
    • 0033922371 scopus 로고    scopus 로고
    • Preparation of PCR-quality mouse genomic DNA with hot sodium hydroxide and tris (HotSHOT)
    • Truett G.E., Heeger P., Mynatt R.L., Truett A.A., Walker J.A., et al. Preparation of PCR-quality mouse genomic DNA with hot sodium hydroxide and tris (HotSHOT). Biotechniques 2000, 29(52):54.
    • (2000) Biotechniques , vol.29 , Issue.52 , pp. 54
    • Truett, G.E.1    Heeger, P.2    Mynatt, R.L.3    Truett, A.A.4    Walker, J.A.5
  • 44
    • 77954470727 scopus 로고    scopus 로고
    • Induction of hypothalamic Sirt1 leads to cessation of feeding via agouti-related peptide
    • Sasaki T., Kim H.J., Kobayashi M., Kitamura Y.I., Yokota-Hashimoto H., et al. Induction of hypothalamic Sirt1 leads to cessation of feeding via agouti-related peptide. Endocrinology 2010, 151:2556-2566.
    • (2010) Endocrinology , vol.151 , pp. 2556-2566
    • Sasaki, T.1    Kim, H.J.2    Kobayashi, M.3    Kitamura, Y.I.4    Yokota-Hashimoto, H.5
  • 45
    • 47949104258 scopus 로고    scopus 로고
    • Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
    • Ikenoue T., Inoki K., Yang Q., Zhou X., Guan K.L. Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. EMBO Journal 2008, 27:1919-1931.
    • (2008) EMBO Journal , vol.27 , pp. 1919-1931
    • Ikenoue, T.1    Inoki, K.2    Yang, Q.3    Zhou, X.4    Guan, K.L.5
  • 46
    • 33646590947 scopus 로고    scopus 로고
    • Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake
    • Kitamura T., Feng Y., Kitamura Y.I., Chua S.C., Xu A.W., et al. Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake. Nature Medicine 2006, 12:534-540.
    • (2006) Nature Medicine , vol.12 , pp. 534-540
    • Kitamura, T.1    Feng, Y.2    Kitamura, Y.I.3    Chua, S.C.4    Xu, A.W.5
  • 47
    • 79954455756 scopus 로고    scopus 로고
    • PDK1-Foxo1 in agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure
    • Cao Y., Nakata M., Okamoto S., Takano E., Yada T., et al. PDK1-Foxo1 in agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure. PLoS One 2011, 6:e18324.
    • (2011) PLoS One , vol.6
    • Cao, Y.1    Nakata, M.2    Okamoto, S.3    Takano, E.4    Yada, T.5
  • 50
    • 48249100537 scopus 로고    scopus 로고
    • Central nervous system neuropeptide Y signaling modulates VLDL triglyceride secretion
    • Stafford J.M., Yu F., Printz R., Hasty A.H., Swift L.L., et al. Central nervous system neuropeptide Y signaling modulates VLDL triglyceride secretion. Diabetes 2008, 57:1482-1490.
    • (2008) Diabetes , vol.57 , pp. 1482-1490
    • Stafford, J.M.1    Yu, F.2    Printz, R.3    Hasty, A.H.4    Swift, L.L.5
  • 51
    • 34347215242 scopus 로고    scopus 로고
    • Homeostatic and non-homeostatic pathways involved in the control of food intake and energy balance
    • Berthoud H.R. Homeostatic and non-homeostatic pathways involved in the control of food intake and energy balance. Obesity (Silver Spring) 2006, 14(Suppl.5):S197-S200.
    • (2006) Obesity (Silver Spring) , vol.14 , Issue.SUPPL.5
    • Berthoud, H.R.1
  • 52
    • 0036791462 scopus 로고    scopus 로고
    • Leptin and insulin action in the central nervous system
    • (discussion S68-S84, S85-S27)
    • Porte D., Baskin D.G., Schwartz M.W. Leptin and insulin action in the central nervous system. Nutrition Reviews 2002, 60:S20-S29. (discussion S68-S84, S85-S27).
    • (2002) Nutrition Reviews , vol.60
    • Porte, D.1    Baskin, D.G.2    Schwartz, M.W.3
  • 53
    • 0029739826 scopus 로고    scopus 로고
    • Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice
    • Vaisse C., Halaas J.L., Horvath C.M., Darnell J.E., Stoffel M., et al. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nature Genetics 1996, 14:95-97.
    • (1996) Nature Genetics , vol.14 , pp. 95-97
    • Vaisse, C.1    Halaas, J.L.2    Horvath, C.M.3    Darnell, J.E.4    Stoffel, M.5
  • 54
    • 0037456304 scopus 로고    scopus 로고
    • STAT3 signalling is required for leptin regulation of energy balance but not reproduction
    • Bates S.H., Stearns W.H., Dundon T.A., Schubert M., Tso A.W., et al. STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 2003, 421:856-859.
    • (2003) Nature , vol.421 , pp. 856-859
    • Bates, S.H.1    Stearns, W.H.2    Dundon, T.A.3    Schubert, M.4    Tso, A.W.5
  • 55
    • 12944261926 scopus 로고    scopus 로고
    • Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATP channel activation
    • Mirshamsi S., Laidlaw H.A., Ning K., Anderson E., Burgess L.A., et al. Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATP channel activation. BMC Neuroscience 2004, 5:54.
    • (2004) BMC Neuroscience , vol.5 , pp. 54
    • Mirshamsi, S.1    Laidlaw, H.A.2    Ning, K.3    Anderson, E.4    Burgess, L.A.5
  • 56
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov D.D., Guertin D.A., Ali S.M., Sabatini D.M. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005, 307:1098-1101.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 57
    • 33749076673 scopus 로고    scopus 로고
    • SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
    • Jacinto E., Facchinetti V., Liu D., Soto N., Wei S., et al. SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 2006, 127:125-137.
    • (2006) Cell , vol.127 , pp. 125-137
    • Jacinto, E.1    Facchinetti, V.2    Liu, D.3    Soto, N.4    Wei, S.5
  • 58
    • 58649092475 scopus 로고    scopus 로고
    • MTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
    • Garcia-Martinez J.M., Alessi D.R. mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). Biochemical Journal 2008, 416:375-385.
    • (2008) Biochemical Journal , vol.416 , pp. 375-385
    • Garcia-Martinez, J.M.1    Alessi, D.R.2
  • 59
    • 58949084058 scopus 로고    scopus 로고
    • MTORC2 is the hydrophobic motif kinase for SGK1
    • Yan L., Mieulet V., Lamb R.F. mTORC2 is the hydrophobic motif kinase for SGK1. Biochemical Journal 2008, 416:e19-e21.
    • (2008) Biochemical Journal , vol.416
    • Yan, L.1    Mieulet, V.2    Lamb, R.F.3
  • 60
    • 84865761062 scopus 로고    scopus 로고
    • Mammalian target of rapamycin complex 1 (mTORC1) and 2 (mTORC2) control the dendritic arbor morphology of hippocampal neurons
    • Urbanska M., Gozdz A., Swiech L.J., Jaworski J. Mammalian target of rapamycin complex 1 (mTORC1) and 2 (mTORC2) control the dendritic arbor morphology of hippocampal neurons. Journal of Biological Chemistry 2012, 287:30240-30256.
    • (2012) Journal of Biological Chemistry , vol.287 , pp. 30240-30256
    • Urbanska, M.1    Gozdz, A.2    Swiech, L.J.3    Jaworski, J.4
  • 61
    • 84876742129 scopus 로고    scopus 로고
    • Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology
    • Thomanetz V., Angliker N., Cloetta D., Lustenberger R.M., Schweighauser M., et al. Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology. Journal of Cell Biology 2013, 201:293-308.
    • (2013) Journal of Cell Biology , vol.201 , pp. 293-308
    • Thomanetz, V.1    Angliker, N.2    Cloetta, D.3    Lustenberger, R.M.4    Schweighauser, M.5
  • 62
    • 84875647584 scopus 로고    scopus 로고
    • MTORC2 controls actin polymerization required for consolidation of long-term memory
    • Huang W., Zhu P.J., Zhang S., Zhou H., Stoica L., et al. mTORC2 controls actin polymerization required for consolidation of long-term memory. Nature Neuroscience 2013.
    • (2013) Nature Neuroscience
    • Huang, W.1    Zhu, P.J.2    Zhang, S.3    Zhou, H.4    Stoica, L.5
  • 64
    • 17844379717 scopus 로고    scopus 로고
    • Hypothalamic K(ATP) channels control hepatic glucose production
    • Pocai A., Lam T.K., Gutierrez-Juarez R., Obici S., Schwartz G.J., et al. Hypothalamic K(ATP) channels control hepatic glucose production. Nature 2005, 434:1026-1031.
    • (2005) Nature , vol.434 , pp. 1026-1031
    • Pocai, A.1    Lam, T.K.2    Gutierrez-Juarez, R.3    Obici, S.4    Schwartz, G.J.5
  • 65
    • 80055011903 scopus 로고    scopus 로고
    • Chronic reduction of insulin receptors in the ventromedial hypothalamus produces glucose intolerance and islet dysfunction in the absence of weight gain
    • Paranjape S.A., Chan O., Zhu W., Horblitt A.M., Grillo C.A., et al. Chronic reduction of insulin receptors in the ventromedial hypothalamus produces glucose intolerance and islet dysfunction in the absence of weight gain. American Journal of Physiology - Endocrinology and Metabolism 2011, 301:E978-E983.
    • (2011) American Journal of Physiology - Endocrinology and Metabolism , vol.301
    • Paranjape, S.A.1    Chan, O.2    Zhu, W.3    Horblitt, A.M.4    Grillo, C.A.5
  • 66
    • 0036267472 scopus 로고    scopus 로고
    • Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats
    • Obici S., Feng Z., Karkanias G., Baskin D.G., Rossetti L. Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nature Neuroscience 2002, 5:566-572.
    • (2002) Nature Neuroscience , vol.5 , pp. 566-572
    • Obici, S.1    Feng, Z.2    Karkanias, G.3    Baskin, D.G.4    Rossetti, L.5
  • 67
    • 67649813276 scopus 로고    scopus 로고
    • Sustained NPY overexpression in the PVN results in obesity via temporarily increasing food intake
    • Tiesjema B., la Fleur S.E., Luijendijk M.C., Adan R.A. Sustained NPY overexpression in the PVN results in obesity via temporarily increasing food intake. Obesity 2009, 17:1448-1450.
    • (2009) Obesity , vol.17 , pp. 1448-1450
    • Tiesjema, B.1    la Fleur, S.E.2    Luijendijk, M.C.3    Adan, R.A.4
  • 68
    • 79951867172 scopus 로고    scopus 로고
    • Neuropeptide Y and agouti-related peptide mediate complementary functions of hyperphagia and reduced energy expenditure in leptin receptor deficiency
    • Luo N., Marcelin G., Liu S.M., Schwartz G., Chua S. Neuropeptide Y and agouti-related peptide mediate complementary functions of hyperphagia and reduced energy expenditure in leptin receptor deficiency. Endocrinology 2011, 152:883-889.
    • (2011) Endocrinology , vol.152 , pp. 883-889
    • Luo, N.1    Marcelin, G.2    Liu, S.M.3    Schwartz, G.4    Chua, S.5
  • 69
    • 79960672953 scopus 로고    scopus 로고
    • Moderate long-term modulation of neuropeptide Y in hypothalamic arcuate nucleus induces energy balance alterations in adult rats
    • Sousa-Ferreira L., Garrido M., Nascimento-Ferreira I., Nobrega C., Santos-Carvalho A., et al. Moderate long-term modulation of neuropeptide Y in hypothalamic arcuate nucleus induces energy balance alterations in adult rats. PLoS One 2011, 6:22.
    • (2011) PLoS One , vol.6 , pp. 22
    • Sousa-Ferreira, L.1    Garrido, M.2    Nascimento-Ferreira, I.3    Nobrega, C.4    Santos-Carvalho, A.5
  • 70
    • 4644227229 scopus 로고    scopus 로고
    • Intracerebroventricular neuropeptide Y infusion precludes inhibition of glucose and VLDL production by insulin
    • van den Hoek A.M., Voshol P.J., Karnekamp B.N., Buijs R.M., Romijn J.A., et al. Intracerebroventricular neuropeptide Y infusion precludes inhibition of glucose and VLDL production by insulin. Diabetes 2004, 53:2529-2534.
    • (2004) Diabetes , vol.53 , pp. 2529-2534
    • van den Hoek, A.M.1    Voshol, P.J.2    Karnekamp, B.N.3    Buijs, R.M.4    Romijn, J.A.5
  • 71
    • 0016692353 scopus 로고
    • Modulation of the activity of insulin-dependent enzymes of lipogenesis by glucocorticoids
    • Diamant S., Shafrir E. Modulation of the activity of insulin-dependent enzymes of lipogenesis by glucocorticoids. European Journal of Biochemistry 1975, 53:541-546.
    • (1975) European Journal of Biochemistry , vol.53 , pp. 541-546
    • Diamant, S.1    Shafrir, E.2
  • 73
    • 73649126230 scopus 로고    scopus 로고
    • Glucocorticoids invivo induce both insulin hypersecretion and enhanced glucose sensitivity of stimulus-secretion coupling in isolated rat islets
    • Rafacho A., Marroqui L., Taboga S.R., Abrantes J.L., Silveira L.R., et al. Glucocorticoids invivo induce both insulin hypersecretion and enhanced glucose sensitivity of stimulus-secretion coupling in isolated rat islets. Endocrinology 2010, 151:85-95.
    • (2010) Endocrinology , vol.151 , pp. 85-95
    • Rafacho, A.1    Marroqui, L.2    Taboga, S.R.3    Abrantes, J.L.4    Silveira, L.R.5
  • 74
    • 84879285103 scopus 로고    scopus 로고
    • Regulation of lipid metabolism by glucocorticoids and 11beta-HSD1 in skeletal muscle
    • Morgan S.A., Gathercole L.L., Simonet C., Hassan-Smith Z.K., Bujalska I., et al. Regulation of lipid metabolism by glucocorticoids and 11beta-HSD1 in skeletal muscle. Endocrinology 2013, 154:2374-2384.
    • (2013) Endocrinology , vol.154 , pp. 2374-2384
    • Morgan, S.A.1    Gathercole, L.L.2    Simonet, C.3    Hassan-Smith, Z.K.4    Bujalska, I.5
  • 75
    • 0028873134 scopus 로고
    • Corticosterone decreases nonshivering thermogenesis and increases lipid storage in brown adipose tissue
    • Strack A.M., Bradbury M.J., Dallman M.F. Corticosterone decreases nonshivering thermogenesis and increases lipid storage in brown adipose tissue. American Journal of Physiology 1995, 268:R183-R191.
    • (1995) American Journal of Physiology , vol.268
    • Strack, A.M.1    Bradbury, M.J.2    Dallman, M.F.3
  • 77
    • 84884769887 scopus 로고    scopus 로고
    • Disrupting hypothalamic glucocorticoid receptors causes HPA axis hyperactivity and excess adiposity
    • Laryea G., Schutz G., Muglia L.J. Disrupting hypothalamic glucocorticoid receptors causes HPA axis hyperactivity and excess adiposity. Molecular Endocrinology 2013, 27:1655-1665.
    • (2013) Molecular Endocrinology , vol.27 , pp. 1655-1665
    • Laryea, G.1    Schutz, G.2    Muglia, L.J.3
  • 78
    • 33644911468 scopus 로고    scopus 로고
    • Characterization of the metabolic phenotypes of Cushing[U+05F3]s syndrome and growth hormone deficiency: a study of body composition and energy metabolism
    • Burt M.G., Gibney J., Ho K.K. Characterization of the metabolic phenotypes of Cushing[U+05F3]s syndrome and growth hormone deficiency: a study of body composition and energy metabolism. Clinical Endocrinology 2006, 64:436-443.
    • (2006) Clinical Endocrinology , vol.64 , pp. 436-443
    • Burt, M.G.1    Gibney, J.2    Ho, K.K.3
  • 79
    • 34249651956 scopus 로고    scopus 로고
    • Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production
    • Konner A.C., Janoschek R., Plum L., Jordan S.D., Rother E., et al. Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. Cell Metabolism 2007, 5:438-449.
    • (2007) Cell Metabolism , vol.5 , pp. 438-449
    • Konner, A.C.1    Janoschek, R.2    Plum, L.3    Jordan, S.D.4    Rother, E.5
  • 80
    • 35048903018 scopus 로고    scopus 로고
    • Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR
    • Geraghty K.M., Chen S., Harthill J.E., Ibrahim A.F., Toth R., et al. Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR. Biochemical Journal 2007, 407:231-241.
    • (2007) Biochemical Journal , vol.407 , pp. 231-241
    • Geraghty, K.M.1    Chen, S.2    Harthill, J.E.3    Ibrahim, A.F.4    Toth, R.5
  • 82
    • 43049116846 scopus 로고    scopus 로고
    • Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice
    • Hill J.W., Williams K.W., Ye C., Luo J., Balthasar N., et al. Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice. Journal of Clinical Investigation 2008, 118:1796-1805.
    • (2008) Journal of Clinical Investigation , vol.118 , pp. 1796-1805
    • Hill, J.W.1    Williams, K.W.2    Ye, C.3    Luo, J.4    Balthasar, N.5
  • 84
    • 77449144768 scopus 로고    scopus 로고
    • Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons
    • Lin H.V., Plum L., Ono H., Gutierrez-Juarez R., Shanabrough M., et al. Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons. Diabetes 2010, 59:337-346.
    • (2010) Diabetes , vol.59 , pp. 337-346
    • Lin, H.V.1    Plum, L.2    Ono, H.3    Gutierrez-Juarez, R.4    Shanabrough, M.5
  • 85
    • 0033023467 scopus 로고    scopus 로고
    • Interactions between the neuropeptide Y system and the hypothalamic-pituitary-adrenal axis
    • Krysiak R., Obuchowicz E., Herman Z.S. Interactions between the neuropeptide Y system and the hypothalamic-pituitary-adrenal axis. European Journal of Endocrinology 1999, 140:130-136.
    • (1999) European Journal of Endocrinology , vol.140 , pp. 130-136
    • Krysiak, R.1    Obuchowicz, E.2    Herman, Z.S.3


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