Glucocorticoids in vivo induce both insulin hypersecretion and enhanced glucose sensitivity of stimulus-secretion coupling in isolated rat islets

Endocrinology

Volumn 151, Issue 1, 2010, Pages 85-95

  Rafacho, Alex ^a,b   Marroquí, Laura ^a   Taboga, Sebastião R ^b   Abrantes, Júlia L F ^c   Silveira, Leonardo R ^d   Boschero, Antonio C ^c   Carneiro, Everardo M ^c   Bosqueiro, José R ^b   Nadal, Angel ^a   Quesada, Ivan ^a  

^a MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^c UNIVERSITY OF CAMPINAS   (Brazil)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM ION; DEXAMETHASONE; GLUCOCORTICOID; GLUCOKINASE; GLUCOSE; GLUCOSE TRANSPORTER 2; INOSITOL 1,4,5 TRISPHOSPHATE; INSULIN; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PHOSPHOLIPASE C; POTASSIUM CHLORIDE; PROTEIN; PROTEIN KINASE C ALPHA; PYRUVATE KINASE; SODIUM CHLORIDE; TOLBUTAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOFLUORESCENCE; CONTROLLED STUDY; DRUG EFFICACY; FLUORESCENCE MICROSCOPY; GLUCOSE METABOLISM; HYPERINSULINEMIA; IN VIVO STUDY; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NONHUMAN; OXIDATION; PANCREAS ISLET; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN PHOSPHORYLATION; RAT; SECRETORY GRANULE; SIGNAL TRANSDUCTION; STIMULUS RESPONSE; TRANSMISSION ELECTRON MICROSCOPY; TREATMENT RESPONSE;

ADAPTATION, BIOLOGICAL; ANIMALS; CALCIUM; CELL SEPARATION; CELLS, CULTURED; DEXAMETHASONE; DRUG RESISTANCE; DRUG SYNERGISM; GLUCOCORTICOIDS; GLUCOSE; INSULIN; INSULIN RESISTANCE; ISLETS OF LANGERHANS; MALE; MITOCHONDRIA; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 73649126230     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2009-0704     Document Type: Article

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